Light Engineering of the Polariton Landscape in Semiconductor Microcavities

We demonstrate a method to create potential barriers with polarized light beams for polaritons in semiconductor microcavities. The form of the barriers is engineered via the real space shape of a focalised beam on the sample. Their height can be determined by the visibility of the scattering waves generated in a polariton fluid interacting with them. This technique opens up the way to the creation of dynamical potentials and defects of any shape in semiconductor microcavities.Comment: 4 pages, 5 figure

Comment on "Linear wave dynamics explains observations attributed to dark-solitons in a polariton quantum fluid"

In a recent preprint (arXiv:1401.1128v1) Cilibrizzi and co-workers report experiments and simulations showing the scattering of polaritons against a localised obstacle in a semiconductor microcavity. The authors observe in the linear excitation regime the formation of density and phase patterns reminiscent of those expected in the non-linear regime from the nucleation of dark solitons. Based on this observation, they conclude that previous theoretical and experimental reports on dark solitons in a polariton system should be revised. Here we comment why the results from Cilibrizzi et al. take place in a very different regime than previous investigations on dark soliton nucleation and do not reproduce all the signatures of its rich nonlinear phenomenology. First of all, Cilibrizzi et al. consider a particular type of radial excitation that strongly determines the observed patterns, while in previous reports the excitation has a plane-wave profile. Most importantly, the nonlinear relation between phase jump, soliton width and fluid velocity, and the existence of a critical velocity with the time-dependent formation of vortex-antivortex pairs are absent in the linear regime. In previous reports about dark soliton and half-dark soliton nucleation in a polariton fluid, the distinctive dark soliton physics is supported both by theory (analytical and numerical) and experiments (both continuous wave and pulsed excitation).Comment: 4 pages, 2 figure

Spatially and polarization resolved plasmon mediated transmission through continuous metal films

The experimental demonstration and characterization is made of the plasmon-mediated resonant transmission through an embedded undulated continuous thin metal film under normal incidence. 1D undulations are shown to enable a spatially resolved polarisation filtering whereas 2D undulations lead to spatially resolved, polarization independent transmission. Whereas the needed submicron microstructure lends itself in principle to CD-like low-cost mass replication by means of injection moulding and embossing, the present paper demonstrates the expected transmission effects on experimental models based on metal-coated photoresist gratings. The spectral and angular dependence in the neighbourhood of resonance are investigated and the question of the excess losses exhibited by surface plasmons is discusse

Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model

Ferrociphenol (Fc-diOH) is a new molecule belonging to the fast-growing family of organometallic anti-cancer drugs. In a previous study, we showed promising in vivo results obtained after the intratumoural subcutaneous administration of the new drug-carrier system Fc-diOH-LNCs on a 9L-glioma model. To further increase the dose of this lipophilic entity, we have created a series of prodrugs of Fc-diOH. The phenol groups were protected by either an acetyl (Fc-diAc) or by the long fatty-acid chain of a palmitate (Fc-diPal). LNCs loaded with Fc-diOH prodrugs have to be activated in situ by enzymatic hydrolysis. We show here that the protection of diphenol groups with palmitoyl results in the loss of Fc-diOH in vitro activity, probably due to a lack of in situ hydrolysis. On the contrary, protection with an acetate group does not affect the strong, in vitro, antiproliferative effect of ferrocifen-loaded-LNCs neither the reduction of tumour volume observed on an ectopic model, confirming that acetate is easily cleaved by cell hydrolases. Moreover, the cytostatic activity of Fc-diOH-LNCs is confirmed on an orthotopic glioma model since the difference in survival time between the infusion of 0.36 mg/rat Fc-diOH-LNCs and blank LNCs is statistically significant. By using LNCs or Labrafac to carry the drug, a dose-effect ranging from 0.005 to 2.5mg of Fc-diOH per animal can be evidenced

Sleep disorders and suicide attempts following discharge from residential treatment

IntroductionSuicide is a significant public health concern and its prevention remains a top clinical priority of the Veterans Health Administration. Periods of transition in care (e.g., moving from inpatient to outpatient care) represent a period of increased risk. Sleep disorders are prevalent amongst Veterans and are modifiable risk factor for suicide. The present study examined the relationship of sleep disorders to time to suicide attempt amongst Veterans known to have attempted suicide in the 180 days following discharge from a Mental Health Residential Rehabilitation Treatment Program.MethodThe present sample was comprised of all Veterans enrolled in services with the Veterans Health Administration known to have attempted suicide following discharge from a Mental Health Residential Rehabilitation Treatment Program during Fiscal Years 13 and 14 (N = 1,489). To create this sample, electronic medical record data were extracted from two VHA data sources: the Corporate Data Warehouse and the Suicide Prevention Application Network.ResultsCox regression models revealed that Veterans with a sleep disturbance (N = 1,211) had a shorter time to suicide attempt than those without a sleep disturbance [Hazard Ratio (HR) = 1.16, CI (1.02–1.32)]. A subsequent Cox regression model including age, insomnia, nightmare disorder, and alcohol dependence revealed that sleep-related breathing disorders [HR = 1.19, CI (1.01–1.38)], alcohol dependence [HR = 1.16, CI (1.02–1.33)], and age group were associated with increased risk.ConclusionFindings indicate that sleep disturbance, primarily driven by sleep-related breathing disorders, was associated with time to suicide attempt in this sample of high-risk Veterans known to have attempted suicide in the 180 days following their discharge from a Mental Health Residential Rehabilitation Treatment Program. These findings reveal an opportunity to reduce risk through the screening and treatment of sleep disorders in high-risk populations

Median knock-down time as a new method for evaluating insecticide-treated textiles for mosquito control

<p>Abstract</p> <p>Background</p> <p>Insecticide treated bed nets are major tools for the Roll Back Malaria campaign. There are two types of Long-Lasting Insecticide-treated Nets (LNs) on the market: coated nets and insecticide-incorporated nets. Nets provided to this market need a recommendation from the World Health Organization to be purchased by donors and NGOs. During laboratory study (phase I), the first step consists in evaluating the wash resistance of a new LN product. When insecticide-incorporated nets are washed, it takes time to regenerate the insecticidal activity, i.e. insecticide must migrate to the net surface to be accessible to mosquitoes. The interval of time required for regeneration must be carefully determined to ensure the accuracy of further results. WHOPES procedures currently recommend the determination of the regeneration time by using mortality data. However, as mortality cannot exceed 100%, a LN that regenerates a surface concentration exceeding the dosage for 100% mortality, will have its regeneration time underestimated.</p> <p>Methods</p> <p>The Median Knock Down Time (MKDT) was determined as function of insecticide dosage on an inert surface, glass, and on polyester nettings using an acetone solution or a simple emulsion. Dosage response was also established for mortality data. The same method was then applied to a commercially polyethylene netting, currently under WHOPES evaluation, to determine the dynamics of regeneration as function of repeated washings. The deltamethrin content of these nets was estimated by Capillary Gas Chromatography (GC-ECD).</p> <p>Results</p> <p>MKDT was a linear function of log insecticide dosage on glass as on nettings. Mortality data were either 0 or 100% for most concentrations except for a narrow range. MKDT was log linear function of total deltamethrin content in a commercial polyethylene net exposed to washings. The regeneration time of this net increased with the number of washes and MKDT became higher. A new, easy and rapid method to determine MKDT is suggested.</p> <p>Discussion</p> <p>The MKDT is linearly correlated to log dosage on a given substrate and shows no saturation as mortality data do. It is suited to determine regeneration time of a product that is exposed to a stress, like washing or heating, where the process impacts on the bio-availability of the insecticide. Mortality data are useful for measuring product efficacy, whereas MKDT are better to measure dynamics of surface concentration like regeneration after a stressing process. Change in MKDT can be used to illustrate the loss of insecticide due to washing, but the slope of the curve is product and surface-dependent.</p

The occupancy-abundance relationship and sampling designs using occupancy to monitor populations of Asian bears

Designing a population monitoring program for Asian bears presents challenges associated with their low densities and detectability, generally large home ranges, and logistical or resource constraints. The use of an occupancy-based method to monitor bear populations can be appropriate under certain conditions given the mechanistic relationship between occupancy and abundance. The form of the occupancy\u2013abundance relationship is dependent on species-specific characteristics such as home range size and population density, as well as study area size. To assess the statistical power of tests to detect population change of Asian bears, we conducted a study using a range of scenarios by simulating spatially explicit individual-based capture-recapture data from a demographically open model. Simulations assessed the power to detect changes in population density via changes in site-level occupancy or abundance through time, estimated using a standard occupancy model or a Royle-Nichols model, both with point detectors (representing camera traps). We used IUCN Red List criteria as a guide in selection of two population decline scenarios (20% and 50%), but we chose a shorter time horizon (10 years = 1 bear generation), meaning that declines were steeper than used for IUCN criteria (3 generations). Our simulations detected population declines of 50% with high power (&gt;0.80) and low false positive rates (FPR: incorrectly detecting a decline) (&lt;0.10) when detectors were spaced at &gt; 0.67 times the home range diameter (home-range spacing ratio: HRSR, a measure of spatial correlation), such that bears would tend to overlap no more than two detectors. There was high (0.85) correlation between realized occupancy and N in these scenarios. The FPR increased as the HRSR decreased because of spatial correlation in the occupancy process induced when individual home ranges overlap multiple detectors. The mean statistical power to detect more gradual population declines (20% in 10 years) with HRSR &gt; 0.67 was low for occupancy models 0.22 (maximum power 0.67) and Royle-Nichols models (0.24; maximum power 0.67), suggesting that declines of this magnitude may not be described reliably with 10 years of monitoring. Our results demonstrated that under many realistic scenarios that we explored, false positive rates were unacceptably high. We highlight that when designing occupancy studies, the spacing between point detectors be at least 0.67 times the diameter of the home range size of the larger sex (e.g., males) when the assumptions of the spatial capture-recapture model used for simulation are met