55 research outputs found
The Ionization Fraction in Dense Molecular Gas II: Massive Cores
We present an observational and theoretical study of the ionization fraction
in several massive cores located in regions that are currently forming stellar
clusters. Maps of the emission from the J = 1-> O transitions of C18O, DCO+,
N2H+, and H13CO+, as well as the J = 2 -> 1 and J = 3 -> 2 transitions of CS,
were obtained for each core. Core densities are determined via a large velocity
gradient analysis with values typically 10^5 cm^-3. With the use of
observations to constrain variables in the chemical calculations we derive
electron fractions for our overall sample of 5 cores directly associated with
star formation and 2 apparently starless cores. The electron abundances are
found to lie within a small range, -6.9 < log10(x_e) < -7.3, and are consistent
with previous work. We find no difference in the amount of ionization fraction
between cores with and without associated star formation activity, nor is any
difference found in electron abundances between the edge and center of the
emission region. Thus our models are in agreement with the standard picture of
cosmic rays as the primary source of ionization for molecular ions. With the
addition of previously determined electron abundances for low mass cores, and
even more massive cores associated with O and B clusters, we systematically
examine the ionization fraction as a function of star formation activity. This
analysis demonstrates that the most massive sources stand out as having the
lowest electron abundances (x_e < 10^-8).Comment: 35 pages (8 figures), using aaspp4.sty, to be published in
Astrophysical Journa
Assessment of myocardial oxidative metabolism in aortic valve disease using positron emission tomography with C-11 acetate
C-11 acetate has recently been introduced as a tracer of myocardial oxidative metabolism with the use of positron emission tomography. To evaluate this approach in the pressure- or volume-loaded heart, C-11 acetate clearance rate constants were determined in 22 patients with chronic aortic valve disease and in nine normal subjects. Global myocardial C-11 clearance was significantly higher in patients with predominant aortic stenosis (n = 11) or aortic regurgitation (n = 11) than in normal subjects (0.069 +/- 0.017 min-1 and 0.072 +/- 0.010 min-1 compared with 0.050 +/- 0.004 min-1, p r = 0.73, P = 0.0001) for all studies. However, analysis of patient subgroups demonstrated that this correlation held only for aortic stenosis (r = 0.79, p r = 0.89, p < 0.005) but not in patients with aortic regurgitation. Normalization of C-11 acetate clearance rate constants for gradient-corrected rate-pressure product were significantly lower in patients with loaded ventricles, particularly in the presence of a low ejection fraction, compared to normal subjects. Possible mechanisms include myocardial adaptation through hypertrophy or depressed contractility, which would both tend to reduce oxygen consumption under any given load. Serial comparison of C-11 acetate kinetics and noninvasive indexes of oxygen demand may provide assessment of disease progression in pathologic ventricular loading.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30196/1/0000584.pd
Visualizing the Kinematics of Planet Formation
A stunning range of substructures in the dust of protoplanetary disks is
routinely observed across a range of wavelengths. These gaps, rings and spirals
are highly indicative of a population of unseen planets, hinting at the
possibility of current observational facilities being able to capture
planet-formation in action. Over the last decade, our understanding of the
influence of a young planet on the dynamical structure of its parental disk has
progressed significantly, revealing a host of potentially observable features
which would betray the presence of a deeply embedded planet. In concert, recent
observations have shown that subtle perturbations in the kinematic structure of
protoplanetary disks are found in multiple sources, potentially the
characteristic disturbances associated with embedded planets. In this work, we
review the theoretical background of planet-disk interactions, focusing on the
kinematical features, and the current methodologies used to observe these
interactions in spatially and spectrally resolved observations. We discuss the
potential pit falls of such kinematical detections of planets, providing
best-practices for imaging and analysing interferometric data, along with a set
of criteria to use as a benchmark for any claimed detection of embedded
planets. We finish with a discussion on the current state of simulations in
regard to planet-disk interactions, highlighting areas of particular interest
and future directions which will provide the most significant impact in our
search for embedded planets. This work is the culmination of the 'Visualizing
the Kinematics of Planet Formation' workshop, held in October 2019 at the
Center for Computational Astrophysics at the Flatiron Institute in New York
City.Comment: To be submitted to PASA. Comments welcom
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa
We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env from subtypes A, B and C, given alone or as boost following a DNA plasmid vaccine expressing the same HIV-1 proteins plus Nef, in 114 healthy HIV-uninfected African adults.Volunteers were randomized to 4 groups receiving the rAd5 vaccine intramuscularly at dosage levels of 1Ă10(10) or 1Ă10(11) particle units (PU) either alone or as boost following 3 injections of the DNA vaccine given at 4 mg/dose intramuscularly by needle-free injection using BiojectorÂź 2000. Safety and immunogenicity were evaluated for 12 months. Both vaccines were well-tolerated. Overall, 62% and 86% of vaccine recipients in the rAd5 alone and DNA prime - rAd5 boost groups, respectively, responded to the HIV-1 proteins by an interferon-gamma (IFN-Îł) ELISPOT. The frequency of immune responses was independent of rAd5 dosage levels. The highest frequency of responses after rAd5 alone was detected at 6 weeks; after DNA prime - rAd5 boost, at 6 months (end of study). At baseline, neutralizing antibodies against Ad5 were present in 81% of volunteers; the distribution was similar across the 4 groups. Pre-existing immunity to Ad5 did not appear to have a significant impact on reactogenicity or immune response rates to HIV antigens by IFN-Îł ELISPOT. Binding antibodies against Env were detected in up to 100% recipients of DNA prime - rAd5 boost. One volunteer acquired HIV infection after the study ended, two years after receipt of rAd5 alone.The HIV-1 rAd5 vaccine, either alone or as a boost following HIV-1 DNA vaccine, was well-tolerated and immunogenic in African adults. DNA priming increased the frequency and magnitude of cellular and humoral immune responses, but there was no effect of rAd5 dosage on immunogenicity endpoints.ClinicalTrials.gov NCT00124007
Distinct genital tract HIV-specific antibody profiles associated with Tenofovir gel.
CAPRISA, 2016.Abstract available in PDF file
Ulnar-sided wrist pain. II. Clinical imaging and treatment
Pain at the ulnar aspect of the wrist is a diagnostic challenge for hand surgeons and radiologists due to the small and complex anatomical structures involved. In this article, imaging modalities including radiography, arthrography, ultrasound (US), computed tomography (CT), CT arthrography, magnetic resonance (MR) imaging, and MR arthrography are compared with regard to differential diagnosis. Clinical imaging findings are reviewed for a more comprehensive understanding of this disorder. Treatments for the common diseases that cause the ulnar-sided wrist pain including extensor carpi ulnaris (ECU) tendonitis, flexor carpi ulnaris (FCU) tendonitis, pisotriquetral arthritis, triangular fibrocartilage complex (TFCC) lesions, ulnar impaction, lunotriquetral (LT) instability, and distal radioulnar joint (DRUJ) instability are reviewed
Global prevalence and genotype distribution of hepatitis C virus infection in 2015 : A modelling study
Publisher Copyright: © 2017 Elsevier LtdBackground The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality with the recent launch of direct acting antiviral therapies. Reliable disease burden estimates are required for national strategies. This analysis estimates the global prevalence of viraemic HCV at the end of 2015, an update ofâand expansion onâthe 2014 analysis, which reported 80 million (95% CI 64â103) viraemic infections in 2013. Methods We developed country-level disease burden models following a systematic review of HCV prevalence (number of studies, n=6754) and genotype (n=11â342) studies published after 2013. A Delphi process was used to gain country expert consensus and validate inputs. Published estimates alone were used for countries where expert panel meetings could not be scheduled. Global prevalence was estimated using regional averages for countries without data. Findings Models were built for 100 countries, 59 of which were approved by country experts, with the remaining 41 estimated using published data alone. The remaining countries had insufficient data to create a model. The global prevalence of viraemic HCV is estimated to be 1·0% (95% uncertainty interval 0·8â1·1) in 2015, corresponding to 71·1 million (62·5â79·4) viraemic infections. Genotypes 1 and 3 were the most common cause of infections (44% and 25%, respectively). Interpretation The global estimate of viraemic infections is lower than previous estimates, largely due to more recent (lower) prevalence estimates in Africa. Additionally, increased mortality due to liver-related causes and an ageing population may have contributed to a reduction in infections. Funding John C Martin Foundation.publishersversionPeer reviewe
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