3,637 research outputs found
Fractional generalization of Fick's law: a microscopic approach
In the study of transport in inhomogeneous systems it is common to construct
transport equations invoking the inhomogeneous Fick law. The validity of this
approach requires that at least two ingredients be present in the system.
First, finite characteristic length and time scales associated to the dominant
transport process must exist. Secondly, the transport mechanism must satisfy a
microscopic symmetry: global reversibility. Global reversibility is often
satisfied in nature. However, many complex systems exhibit a lack of finite
characteristic scales. In this Letter we show how to construct a generalization
of the inhomogeneous Fick law that does not require the existence of
characteristic scales while still satisfying global reversibility.Comment: 4 pages. Published versio
Continuous Time Random Walks in periodic systems: fluid limit and fractional differential equations on the circle
In this article, the continuous time random walk on the circle is studied. We
derive the corresponding generalized master equation and discuss the effects of
topology, especially important when Levy flights are allowed. Then, we work out
the fluid limit equation, formulated in terms of the periodic version of the
fractional Riemann-Liouville operators, for which we provide explicit
expressions. Finally, we compute the propagator in some simple cases. The
analysis presented herein should be relevant when investigating anomalous
transport phenomena in systems with periodic dimensions.Comment: 14 pages, 1 figure. References added. Published versio
Tuning the Mass of Chameleon Fields in Casimir Force Experiments
We have calculated the chameleon pressure between two parallel plates in the presence of an intervening medium that affects the mass of the chameleon field. As intuitively expected, the gas in the gap weakens the chameleon interaction mechanism with a screening effect that increases with the plate separation and with the density of the intervening medium. This phenomenon might open up new directions in the search of chameleon particles with future long range Casimir force experiments
Fluctuation-dissipation theorem and flux noise in overdamped Josephson junction arrays
The form of the fluctuation-dissipation theorem for a resistively shunted
Josephson juction array is derived with the help of the method which
explicitely takes into acoount screening effects. This result is used to
express the flux noise power spectrum in terms of frequency dependent sheet
impedance of the array. The relation between noise amplitude and parameters of
the detection coil is analysed for the simplest case of a single-loop coil.Comment: ReVTeX, 8 page
Characterizing a new class of variability in GRS 1915+105 with simultaneous INTEGRAL/RXTE observations
We report on the analysis of 100 ks INTEGRAL observations of the Galactic
microquasar GRS 1915+105. We focus on INTEGRAL Revolution number 48 when the
source was found to exhibit a new type of variability as preliminarily reported
in Hannikainen et al. (2003). The variability pattern, which we name , is
characterized by a pulsing behaviour, consisting of a main pulse and a shorter,
softer, and smaller amplitude precursor pulse, on a timescale of 5 minutes in
the JEM-X 3-35 keV lightcurve. We also present simultaneous RXTE data. From a
study of the individual RXTE/PCA pulse profiles we find that the rising phase
is shorter and harder than the declining phase, which is opposite to what has
been observed in other otherwise similar variability classes in this source.
The position in the colour-colour diagram throughout the revolution corresponds
to State A (Belloni et al. 2000) but not to any previously known variability
class. We separated the INTEGRAL data into two subsets covering the maxima and
minima of the pulses and fitted the resulting two broadband spectra with a
hybrid thermal--non-thermal Comptonization model. The fits show the source to
be in a soft state characterized by a strong disc component below ~6 keV and
Comptonization by both thermal and non-thermal electrons at higher energies.Comment: Accepted for publication in A&A. 11 pages, 10 figures, 4 in colour.
Original figures can be found at
http://www.astro.helsinki.fi/~diana/grs1915_rev48. Author affiliations
correcte
Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer
Background:
Cytoglobin (Cygb) was first described in 2002 as an intracellular globin of unknown function. We have previously shown the downregulation of cytoglobin as a key event in a familial cancer syndrome of the upper aerodigestive tract.
Methods:
Cytoglobin expression and promoter methylation were investigated in sporadic head and neck squamous cell carcinoma (HNSCC) using a cross-section of clinical samples. Additionally, the putative mechanisms of Cygb expression in cancer were explored by subjecting HNSCC cell lines to hypoxic culture conditions and 5-aza-2-deoxycitidine treatment.
Results:
In clinically derived HNSCC samples, CYGB mRNA expression showed a striking correlation with tumour hypoxia (measured by HIF1A mRNA expression P=0.013) and consistent associations with histopathological measures of tumour aggression. CYGB expression also showed a marked negative correlation with promoter methylation (P=0.018). In the HNSCC cell lines cultured under hypoxic conditions, a trend of increasing expression of both CYGB and HIF1A with progressive hypoxia was observed. Treatment with 5-aza-2-deoxycitidine dramatically increased CYGB expression in those cell lines with greater baseline promoter methylation.
Conclusion:
We conclude that the CYGB gene is regulated by both promoter methylation and tumour hypoxia in HNSCC and that increased expression of this gene correlates with clincopathological measures of a tumour's biological aggression.</p
Normative and self-perceived orthodontic treatment need of a Peruvian university population
BACKGROUND: Previous studies on orthodontic treatment need in young adults have shown that up to 50% had malocclusions that needed orthodontic treatment. The aims of this study were to assess the normative and self-perceived need for orthodontic treatment using the Index of Orthodontic Treatment Need (IOTN) and to determine if the treatment need levels were influenced by sex, age and socio-economic status (SES) in a sample of Peruvian young adults. METHODS: 281 first-year students (157 male and 124 female students) with a mean age of 18.1 +/- 1.6 years were randomly selected and evaluated through the Dental Health Component (DHC) and Aesthetic Component (AC) of the IOTN. Structured interview and clinical examination were used to assess the students. Descriptive statistics and Chi-square tests were used for data analysis with statistical significance set at P < 0.05. RESULTS: An intra-examiner reliability of 0.89 was obtained (weighted Kappa). The percentage of students according to SES was 51.2%, 40.6% and 8.2% corresponding to low, medium and high SES respectively. The percentage of students with DHC grades 4–5 was 29.9% whereas the percentage of students with AC grades 8–10 was 1.8%. There were no significant differences in the distribution of normative and self-perceived orthodontic treatment need based on sex, age and SES comparisons. CONCLUSION: Normative orthodontic treatment need was not matched by a similar level of self-perceived treatment need in these young adults. Sex, age and SES were non-significant factors associated with levels of treatment need
Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of cellular responses including survival, activation, differentiation and proliferation and are now recognised to have a key role in a number of physiological and pathophysiological processes in the lung. PI-3Ks contribute to the pathogenesis of asthma by influencing the proliferation of airways smooth muscle and the recruitment of eosinophils, and affect the balance between the harmful and protective responses in pulmonary inflammation and infection by the modulation of granulocyte recruitment, activation and apoptosis. In addition they also seem to exert a critical influence on the malignant phenotype of small cell lung cancer. PI-3K isoforms and their downstream targets thus provide novel therapeutic targets for intervention in a broad spectrum of respiratory diseases
The transition into veterinary practice: Opinions of recent graduates and final year students
Background
The transition from veterinary student to member of the veterinary profession is known to be challenging. This study aimed to determine and compare the opinions of final year veterinary students and recent graduates on graduate attributes that ease this transition.
Methods
The study was carried out across 3 veterinary schools in the United Kingdom. Paper based or electronic surveys were used. Final year students in the 3 schools were surveyed either electronically (school A) or on paper (schools B and C). Student cohort sizes were 112, 227 and 102 respectively. Recent graduates were contacted either at a reunion event (school A) or electronically from database records (school B and school C). Cohort sizes of contacted graduates were 80, 175 and 91 respectively. Respondents were asked to rate 42 individual attributes on a 5 point Likert scale. Focus groups with final year students and recent graduates and telephone interviews with recent graduates were carried out. Data were analysed by two researchers through a combination of manual coding and thematic analysis. Data were grouped into broad themes then sorted into narrower themes. Data were then searched for counter examples.
Results
Response rates for final year students were 34% (school A), 36% (school B) and 40% (school C). Response rates for recent graduates were 56% (school A), 20% (school B) and 11% (school C). There was a high level of agreement between the cohorts with respect to communication skills, problem solving and decision making skills, recognition of own limitations and the ability to cope with pressure all rated unanimously important or very important. Business acumen, knowledge of veterinary practice management and research skills were the 3 attributes ranked at the bottom of the list. Nine attributes were identified with a significantly different (p < 0.05) ranking between the cohorts. Final year students ranked veterinary clinical knowledge, knowledge of veterinary public health and zoonotic issues, veterinary legislation and veterinary practice management, commitment to continuing professional development and ability to evaluate information higher than recent graduates. Recent graduates ranked the attributes of integrity, friendliness and compassion higher than final year students.
Conclusions
Recent graduates and final year students rate highly the attributes which help foster the client/veterinarian relationship. Recent graduates reflect that a focus on knowledge based attributes is less important once in practice when compared to final year. The study confirms the importance to recent graduates and final year students of attributes considered as non-technical in the transition to working in the veterinary profession
Early Emergence of Ethnic Differences in Type 2 Diabetes Precursors in the UK: The Child Heart and Health Study in England (CHASE Study)
Peter Whincup and colleagues carry out a cross-sectional study examining ethnic differences in precursors of of type 2 diabetes among children aged 9–10 living in three UK cities
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