29 research outputs found
Effects of sodium nitrite reduction, removal or replacement on cured and cooked meat for microbiological growth, food safety, colon ecosystem, and colorectal carcinogenesis in Fischer 344 rats
Get PDFEpidemiological and experimental evidence indicated that processed meat consumption is associated with colorectal cancer risks. Several studies suggest the involvement of nitrite or nitrate additives via N-nitroso-compound formation (NOCs). Compared to the reference level (120 mg/kg of ham), sodium nitrite removal and reduction (90 mg/kg) similarly decreased preneoplastic lesions in F344 rats, but only reduction had an inhibitory effect on Listeria monocytogenes growth comparable to that obtained using the reference nitrite level and an effective lipid peroxidation control. Among the three nitrite salt alternatives tested, none of them led to a significant gain when compared to the reference level: vegetable stock, due to nitrate presence, was very similar to this reference nitrite level, yeast extract induced a strong luminal peroxidation and no decrease in preneoplastic lesions in rats despite the absence of NOCs, and polyphenol rich extract induced the clearest downward trend on preneoplastic lesions in rats but the concomitant presence of nitrosyl iron in feces. Except the vegetable stock, other alternatives were less efficient than sodium nitrite in reducing L. monocytogenes growth
Cerebral small vessel disease genomics and its implications across the lifespan
Get PDFWhite matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were associated with altered white matter integrity (p = 2.5×10-7) in brain images from 1,738 young healthy adults, providing insight into the lifetime impact of SVD genetic risk. Mendelian randomization suggested causal association of increasing WMH-volume with stroke, Alzheimer-type dementia, and of increasing blood pressure (BP) with larger WMH-volume, notably also in persons without clinical hypertension. Transcriptome-wide colocalization analyses showed association of WMH-volume with expression of 39 genes, of which four encode known drug targets. Finally, we provide insight into BP-independent biological pathways underlying SVD and suggest potential for genetic stratification of high-risk individuals and for genetically-informed prioritization of drug targets for prevention trials.Peer reviewe
L'introduction du néogothique dans les édifices de culte en Belgique au tournant du XXe siècle: le cas de la collégiale Sainte-Waudru de Mons. Unité de style, "dé-baroquisation" et nouveaux retables d'autel
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La collégiale Saints-Pierre-et-Guidon d’Anderlecht à la fin du XIXe siècle :‘ dé-baroquisation ’, retables néogothiques et essor du culte de saint Joseph
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notices « Reliquaire de saint Antoine » et « Reliquaire de saint Landry »
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Le culte de Notre-Dame de Tongre à Mons :la Sedes Sapientiae miraculeuse comme source d'inspiration d'un retable néogothique inédit
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Du bon usage des Primitifs flamands en Belgique au début du XXe siècle :les retables néogothiques de Sainte-Waudru à Mons
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Un collage néogothique attribuable à François-Joseph Coppejans (1867-1947) et l’image du Christ féminin, de sainte Libérata à Félicien Rops
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