87 research outputs found
Biogenic carbonate mercury and marine temperature records reveal global influence of Late Cretaceous Deccan Traps
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155784/1/Meyer_et_al_2019_Biogenic_carbonate_mercury.pd
The symptomatology of climacteric syndrome: whether associated with the physical factors or psychological disorder in perimenopausal/postmenopausal patients with anxietyâdepression disorder
- Author
- A Cooper
- AL Seritan
- B Sierra
- BB Sherwin
- Borong Zhou
- C Dowrick
- C Travers
- CC Colenda
- CM Kimber
- DJ Stein
- DM Herrington
- EB Gold
- G Mancia
- GA Greendale
- J Ryan
- JE Cooper
- JG Greene
- Jiajia Hu
- JJ Kim
- JM Malacara
- JP Ioannidis
- JT Bromberger
- L Olsen
- M Hamilton
- MA Lermer
- MF Folstein
- Ming Zhang
- ML Brandi
- MR Soules
- N Kobayashi
- RC Petersen
- RQ Chen
- S Katz-Bearnot
- V Kakkar
- W Rief
- Xiaofang Sun
- Yanhua Deng
- YP Zheng
- ZX Zhang
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
The insertion/deletion (I/D) polymorphism in the Angiotensin-converting enzyme gene and cancer risk: a meta-analysis
- Author
- A Yaren
- A Yaren
- AJ Turner
- B Gold
- B Yigit
- BR Meyer
- C Rocken
- C Rocken
- CA Haiman
- Can Tian
- CM Chung
- CS Alves
- D Campa
- DE Sierra
- DF Easton
- DJ Hunter
- E Bardi
- E Vairaktaris
- E Vairaktaris
- G Kitsios
- G Thomas
- GM Petersen
- H Arima
- H Song
- Hong Fan
- Honglang Huang
- HW Wang
- I Landa
- Jie He
- Jie Zhang
- Jin Huang
- K Srivastava
- KT Cheon
- L Holla
- L Le Marchand
- L Liu
- LA Kiemeney
- M Freitas-Silva
- M Nacak
- M Sugimoto
- M Toma
- N Nikiteas
- QZ Zhang
- R Ruiter
- R van der Knaap
- TF Zhao
- TJ Tunny
- TM Feulner
- U Eriksson
- V Vasku
- WP Koh
- Xiaobo Li
- XJ Ding
- Y Goto
- Y Tong
- Y Zhang
- Yao Deng
- YG Zhang
- Yonggang Zhang
- Zhangpeng Xiang
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>The insertion/deletion (I/D) polymorphism in the <it>Angiotensin-converting enzyme </it>(<it>ACE</it>) gene has been implicated in susceptibility to cancer, but a large number of studies have reported inconclusive results. The aim of this study is to assess the association between the I/D polymorphism in the <it>ACE </it>gene and cancer risk by meta-analysis.</p> <p>Methods</p> <p>A search was performed in Pubmed database, Embase database, Chinese Biomedical (CBM) database, China National Knowledge Infrastructure (CNKI) database and Weipu database, covering all studies until August 31, 2010. Statistical analysis was performed by using Revman4.2 and STATA 10.0.</p> <p>Results</p> <p>A total of 25 case-control studies comprising 3914 cancer patients and 11391 controls were identified. No significant association was found between the I/D polymorphism and over all cancer risks (OR = 0.88, 95%CI = 0.73-1.06, P = 0.17 for DD+DI vs. II). In the subgroup analysis by ethnicity, no significant association was found among Asians and Europeans for the comparison of DD+DI vs. II. In the subgroup analysis by cancer types, no significant associations were found among lung cancer, breast cancer, prostate cancer, colorectal cancer, gastric cancer for the comparison of DD+DI vs. II. Results from other comparative genetic models also indicated the lack of associations between this polymorphism and cancer risks.</p> <p>Conclusions</p> <p>This meta-analysis suggested that the <it>ACE </it>D/I polymorphism might not contribute to the risk of cancer.</p
The effect of type of femoral component fixation on mortality and morbidity after hip hemiarthroplasty:A systematic review and meta-analysis
- Author
- A Leizorovicz
- A Stang
- AA Faraj
- AA Fisher
- AD Skyrme
- AF Lynch
- Ahmed Elsehili
- Ali Narvani
- AP Foster
- Arshad Khaleel
- Ashwin Unnithan
- Asser Sallam
- B Sadr
- B Viberg
- C Rogmark
- CC Hong
- D Vidovic
- D Wilson
- DJ Costain
- DK Dhanwal
- E Cenni
- E Langslet
- E Yurdakul
- F Frihagen
- F Taylor
- FF Lin
- G Grammatopoulos
- G Kankanala
- H Cicek
- HD Veldman
- HP Bezwada
- IA Lennox
- JC Branco
- JE Gjertsen
- JF Keating
- JP Deangelis
- JY Choi
- K Cheng
- K Holvik
- K Morris
- KM Fallon
- KR Bell
- KR Tripuraneni
- LD Dorr
- Lukas Ernstbrunner
- M Bhandari
- M Khorami
- Mahmoud Morsi
- MB Petersen
- MG Donaldson
- MI Parker
- Mohamed Imam
- Mohamed Shehata
- MT Clarke
- Muhammad Shawqi
- N Heidari
- O Talsnes
- O Talsnes
- OE Dahl
- OE Dahl
- OE Dahl
- OE Dahl
- P Marchetti
- Paul Trikha
- Puneet Monga
- R Chana
- RJ Emery
- RJ Khan
- RJ Sierra
- RP Baker
- S Ng Man Sun
- S Santini
- S Sonne-Holm
- SB Shewale
- T Li
- T Yli-Kyyny
- T Yli-Kyyny
- V Juliebo
- W Figved
- WH Harris
- WH Lo
- X Luo
- Y Ozturkmen
- YH Kim
- YS Prashanth
- ZD Ng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/08/2020
- Field of study
Background: Hip hemiarthroplasty is a well-established treatment of displaced femoral neck fracture, although debate exists over whether cemented or uncemented fixation is superior. Uncemented prostheses have typically been used in younger, healthier patients and cemented prostheses in older patients with less-stable bone. Also, earlier research has suggested that bone cement has cytotoxic effects and may trigger cardiovascular and respiratory adverse events. Questions/Purposes: The aim of this systematic review and meta-analysis was to compare morbidity and mortality rates after cemented and uncemented hemiarthroplasty for the treatment of displaced femoral neck fractures in elderly patients. Methods: Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched seven medical databases for randomized clinical trials and observational studies. We compared cemented and uncemented hemiarthroplasty using the Harris Hip Score (HHS), as well as measures of postoperative pain, mortality, and complications. Data were extracted and pooled as risk ratios or standardized mean difference with their corresponding 95% confidence intervals in a meta-analysis model. Results: The meta-analysis included 34 studies (12 randomized trials and 22 observational studies), with a total of 42,411 patients. In the pooled estimate, cemented hemiarthroplasty was associated with less risk of postoperative pain than uncemented hemiarthroplasty. There were no significant differences between groups regarding HHS or rates of postoperative mortality, pulmonary embolism, cardiac arrest, myocardial infarction, acute cardiac arrhythmia, or deep venous thrombosis. Conclusions: While we found that cemented hemiarthroplasty results in less postoperative pain than uncemented hemiarthroplasty in older patients with femoral neck fracture, the lack of significant differences in functional hip scores, mortality, and complications was surprising. Further high-level research is needed
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. C. Ma
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- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
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- Abeliovich H.
- Abildgaard M. H.
- Abudu Y. P.
- Acevedo-Arozena A.
- Adamopoulos I. E.
- Adeli K.
- Adolph T. E.
- Adornetto A.
- Aflaki E.
- Agam G.
- Agarwal A.
- Aggarwal B. B.
- Agnello M.
- Agostinis P.
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- Aits S.
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- Akkoc Y.
- Akoumianaki T.
- Akpinar H. A.
- Al-Abd A. M.
- Al-Akra L.
- Al-Gharaibeh A.
- Alaoui-Jamali M. A.
- Alberti S.
- Alcocer-Gomez E.
- Alessandri C.
- Ali M.
- Alim Al-Bari M. A.
- Aliwaini S.
- Alizadeh J.
- Almacellas E.
- Almasan A.
- Alonso A.
- Alonso G. D.
- Altan-Bonnet N.
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- Zaragoza P.
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- Zorzano A.
- Zou W.
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- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
A Roadmap for HEP Software and Computing R&D for the 2020s
- Author
- Albrecht Johannes
- Alves Antonio Augusto, Jr
- Amadio Guilherme
- Andronico Giuseppe
- Anh-Ky Nguyen
- Aphecetche Laurent
- Apostolakis John
- Asai Makoto
- Atzori Luca
- Babik Marian
- Bagliesi Giuseppe
- Bandieramonte Marilena
- Banerjee Sunanda
- Barisits Martin
- Bauerdick Lothar A. T.
- Belforte Stefano
- Benjamin Douglas
- Bernius Catrin
- Bhimji Wahid
- Bianchi Riccardo Maria
- Bird Ian
- Biscarat Catherine
- Blomer Jakob
- Bloom Kenneth
- Boccali Tommaso
- Bockelman Brian
- Bold Tomasz
- Bonacorsi Daniele
- Boveia Antonio
- Bozzi Concezio
- Bracko Marko
- Britton David
- Buckley Andy
- Buncic Predrag
- Calafiura Paolo
- Campana Simone
- Canal Philippe
- Canali Luca
- Carlino Gianpaolo
- Castro Nuno
- Cattaneo Marco
- Cerminara Gianluca
- Cervantes Villanueva Javier
- Chang Philip
- Chapman John
- Chen Gang
- Childers Taylor
- Clarke Peter
- Clemencic Marco
- Cogneras Eric
- Coles Jeremy
- Collier Ian
- Colling David
- Corti Gloria
- Cosmo Gabriele
- Costanzo Davide
- Couturier Ben
- Cranmer Kyle
- Cranshaw Jack
- Cristella Leonardo
- Crooks David
- Crépé-Renaudin Sabine
- Currie Robert
- Dallmeier-Tiessen SĂŒnje
- De Cian Michel
- De Roeck Albert
- De Kaushik
- Delgado Peris Antonio
- Derue Frédéric
- Di Girolamo Alessandro
- Di Guida Salvatore
- Dimitrov Gancho
- Doglioni Caterina
- Dotti Andrea
- Duellmann Dirk
- Duflot Laurent
- Dykstra Dave
- Dziedziniewicz-Wojcik Katarzyna
- Dziurda Agnieszka
- Egede Ulrik
- Elmer Peter
- Elmsheuser Johannes
- Elvira V. Daniel
- Eulisse Giulio
- Farrell Steven
- Ferber Torben
- Filipcic Andrej
- Fisk Ian
- Fitzpatrick Conor
- Flix José
- Formica Andrea
- Forti Alessandra
- Foundation HEP Software
- Franzoni Giovanni
- Frost James
- Fuess Stu
- Gaede Frank
- Ganis Gerardo
- Gardner Robert
- Garonne Vincent
- Gellrich Andreas
- Genser Krzysztof
- George Simon
- Geurts Frank
- Gheata Andrei
- Gheata Mihaela
- Giacomini Francesco
- Giagu Stefano
- Giffels Manuel
- Gingrich Douglas
- Girone Maria
- Gligorov Vladimir V.
- Glushkov Ivan
- Gohn Wesley
- Gonzalez Lopez Jose Benito
- GonzĂĄlez Caballero Isidro
- GonzĂĄlez FernĂĄndez Juan R.
- Govi Giacomo
- Grandi Claudio
- Grasland Hadrien
- Gray Heather
- Grillo Lucia
- Guan Wen
- Gutsche Oliver
- Gyurjyan Vardan
- Hanushevsky Andrew
- Hariri Farah
- Hartmann Thomas
- Harvey John
- Hauth Thomas
- Hegner Benedikt
- Heinemann Beate
- Heinrich Lukas
- Heiss Andreas
- Hernåndez José M.
- Hildreth Michael
- Hodgkinson Mark
- Hoeche Stefan
- Holzman Burt
- Hristov Peter
- Huang Xingtao
- Ivanchenko Vladimir N.
- Ivanov Todor
- Iven Jan
- Jashal Brij
- Jayatilaka Bodhitha
- Jones Roger
- Jouvin Michel
- Jun Soon Yung
- Kagan Michael
- Kalderon Charles William
- Kane Meghan
- Karavakis Edward
- Katz Daniel S.
- Kcira Dorian
- Keeble Oliver
- Kersevan Borut Paul
- Kirby Michael
- Klimentov Alexei
- Klute Markus
- Komarov Ilya
- Konstantinov Dmitri
- Koppenburg Patrick
- Kowalkowski Jim
- Kreczko Luke
- Kuhr Thomas
- Kutschke Robert
- Kuznetsov Valentin
- Lampl Walter
- Lancon Eric
- Lange David
- Lassnig Mario
- Laycock Paul
- Leggett Charles
- Letts James
- Lewendel Birgit
- Li Teng
- Lima Guilherme
- Linacre Jacob
- Linden Tomas
- Livny Miron
- Lo Presti Giuseppe
- Lopienski Sebastian
- Love Peter
- Lyon Adam
- Magini NicolĂČ
- Marshall Zachary L
- Martelli Edoardo
- Martin-Haugh Stewart
- Mato Pere
- Mazumdar Kajari
- McCauley Thomas
- McFayden Josh
- McKee Shawn
- McNab Andrew
- Mehdiyev Rashid
- Meinhard Helge
- Menasce Dario
- Mendez Lorenzo Patricia
- Mete Alaettin Serhan
- Michelotto Michele
- Mitrevski Jovan
- Moneta Lorenzo
- Morgan Ben
- Mount Richard
- Moyse Edward
- Murray Sean
- Nairz Armin
- Neubauer Mark S
- Norman Andrew
- Novaes SĂ©rgio
- Novak Mihaly
- Oyanguren Arantza
- Ozturk Nurcan
- Pacheco Pages Andres
- Paganini Michela
- Pansanel Jerome
- Pascuzzi Vincent R.
- Patrick Glenn
- Pearce Alex
- Pearson Ben
- Pedro Kevin
- Perdue Gabriel
- Perez-Calero Yzquierdo Antonio
- Perrozzi Luca
- Petersen Troels
- Petric Marko
- Petzold Andreas
- Piedra JĂłnatan
- Piilonen Leo
- Piparo Danilo
- Pivarski Jim
- Pokorski Witold
- Polci Francesco
- Potamianos Karolos
- Psihas Fernanda
- Puig Navarro Albert
- Quast GĂŒnter
- Raven Gerhard
- Reuter JĂŒrgen
- Ribon Alberto
- Rinaldi Lorenzo
- Ritter Martin
- Robinson James
- Rodrigues Eduardo
- Roiser Stefan
- Rousseau David
- Roy Gareth
- Rybkine Grigori
- Sailer Andre
- Sakuma Tai
- Santana Renato
- Sartirana Andrea
- Schellman Heidi
- SchovancovĂĄ Jaroslava
- Schramm Steven
- Schulz Markus
- SciabĂ Andrea
- Seidel Sally
- Sekmen Sezen
- Serfon Cedric
- Severini Horst
- Sexton-Kennedy Elizabeth
- Seymour Michael
- Sgalaberna Davide
- Shapoval Illya
- Shiers Jamie
- Shiu Jing-Ge
- Short Hannah
- Siroli Gian Piero
- Skipsey Sam
- Smith Tim
- Snyder Scott
- Sokoloff Michael D
- Spentzouris Panagiotis
- Stadie Hartmut
- Stark Giordon
- Stewart Gordon
- Stewart Graeme
- SĂĄnchez Arturo
- SĂĄnchez-HernĂĄndez Alberto
- Taffard Anyes
- Tamponi Umberto
- Templon Jeff
- Tenaglia Giacomo
- Tsulaia Vakhtang
- Tunnell Christopher
- Vaandering Eric
- Valassi Andrea
- Vallecorsa Sofia
- Valsan Liviu
- Van Gemmeren Peter
- Vernet Renaud
- Viren Brett
- Vlimant Jean-Roch
- Voss Christian
- Votava Margaret
- Vuosalo Carl
- VĂĄzquez Sierra Carlos
- Wartel Romain
- Watts Gordon T.
- Wenaus Torre
- Wenzel Sandro
- Williams Mike
- Winklmeier Frank
- Wissing Christoph
- Wuerthwein Frank
- Wynne Benjamin
- Xiaomei Zhang
- Yang Wei
- Yazgan Efe
- Publication venue
- Publication date
- 18/12/2017
- Field of study
Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
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- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
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- Aflaki E
- Agam G
- Agarwal A
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- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
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- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
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- AntĂłn Z
- Anwar T
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- Murakawa T
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- Mysorekar IU
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- Stenmark H
- Sterneckert J
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- Stupack DG
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- Subauste CS
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- Sudhandiran G
- Sue CM
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- Sunahara KKS
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- Titorenko VI
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- Tomar D
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- Tong BC-K
- Tong C
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- Tooze SA
- Torgersen ML
- Torii S
- Torres-LĂłpez L
- Torriglia A
- Towers CG
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- Toyokuni S
- Trajkovic V
- Tramontano D
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- Travassos LH
- Trelford CB
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- Trougakos IP
- Tsao BP
- Tschan MP
- Tse H-F
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- Tsugawa H
- Tsvetkov AS
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- Tumtas Y
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- Turner BJ
- Tuxworth RI
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- van Wijk SJL
- Vandenberghe W
- Vanhorebeek I
- Vannier-Santos MA
- Vannini N
- Vanrell MC
- Vantaggiato C
- Varano G
- Varela-Nieto I
- Varga M
- Vasconcelos MH
- Vats S
- Vavvas DG
- Vega-Naredo I
- Vega-Rubin-de-Celis S
- Velasco G
- Vellai T
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- Velotti F
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- Waguri S
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- Wang B
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- Wang D
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- Wang W
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- Wang X
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- Warnsmann V
- Watada H
- Watanabe E
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- Wehman AM
- Wei H
- Wei L
- Wei T
- Wei Y
- WeiergrÀber OH
- Weihl CC
- Weindl G
- Weiskirchen R
- Wells A
- Wen RH
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- Weykopf B
- Wheatley SP
- Whitton JL
- Whitworth AJ
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- Wildenberg ME
- Wileman T
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- Wodrich H
- Woehlbier U
- Wollert T
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- Wong JH
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- Wu A-G
- Wu C
- Wu J
- Wu J
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- Wu M
- Wu S
- Wu S
- Wu S-Y
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- Wu WKK
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- Xavier RJ
- Xia H
- Xia L
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- Xiang G
- Xiang J
- Xiang M
- Xiang W
- Xiao B
- Xiao G
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- Xiao H-T
- Xiao J
- Xiao L
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- Xiao Y
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- Xu C
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- Yakhine-Diop SMS
- Yamaguchi M
- Yamaguchi O
- Yamamoto A
- Yamashina S
- Yan S
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- Yanagi Y
- Yang C
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- Yao H
- Yao S
- Yao X
- Yao Y-G
- Yao Y-M
- Yasui T
- Yazdankhah M
- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
- Yin Y
- Yin Z
- Yin Z
- Ying M
- Ying Z
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- Yiu SPT
- Yoo YH
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- Yoshimori T
- Yousefi B
- Yu B
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- Yu J
- Yu J
- Yu L
- Yu M-L
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- Yu WH
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- Yuan S-SF
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- Yuan Z
- Yue J
- Yue Z
- Yun J
- Yung RL
- Zacks DN
- Zaffagnini G
- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
- Zeng J-D
- Zhan L
- Zhang B
- Zhang DD
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H-L
- Zhang J
- Zhang J
- Zhang J-P
- Zhang KYB
- Zhang L
- Zhang L
- Zhang L
- Zhang L
- Zhang LW
- Zhang M
- Zhang P
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
The Forward Physics Facility at the High-Luminosity LHC
- Author
- Abraham Roshan Mammen
- Alameddine Jean-Marco
- An Di
- Anchordoqui Luis A.
- Arakawa Jason
- Araki Takeshi
- Arduini Gianluigi
- Ariga Akitaka
- Ariga Tomoko
- Asai Kento
- Bacchetta Alessandro
- Bai Weidong
- Bakhti Pouya
- Balantekin A. Baha
- Balazs Kincso
- Barman Basabendu
- Barman Rahool Kumar
- Barr Alan J.
- Batell Brian
- Battistin Michele
- Bauer Brian
- Bauer Martin
- Beacom John F.
- Becker Mathias
- Berlin Asher
- Bernlochner Florian
- Bertone Caterina
- Bertuzzo Enrico
- Bhattacharya Atri
- Bian Jianming
- Bishai Mary
- Boeckh Tobias
- Bonvini Marco
- Boogert Stewart T.
- Bortoletto Daniela
- Boveia Antonio
- Boyarsky Alexey
- Boyd Jamie
- Bramante Joseph
- Brdar Vedran
- Brenner Lydia
- Brodsky Stanley J.
- Burgard Carsten
- Camargo-Molina José Eliel
- Carli Tancredi
- Carmona Adrian
- Casper David W.
- Celiberto Francesco Giovanni
- Cerutti Francesco
- Chachamis Grigorios
- Chang Spencer
- Charitonidis Nikolaos
- Chauhan Garv
- Chen Thomas Y.
- Chen Xin
- Chiang Cheng-Wei
- Citron Matthew
- Coccaro Andrea
- Cohen Timothy
- Coleman Alan
- Conceição Ruben
- Cooper-Sarkar Amanda
- Copello Emanuele
- Cornago Angel Navascues
- Corso Jean-Pierre
- Darmé Luc
- Darvishi Neda
- Das Arindam
- Davoudiasl Hooman
- De Lellis Giovanni
- De Roeck Albert
- de Vries Jordy
- Dembinski Hans P.
- Demidov Sergey
- deNiverville Patrick
- Denton Peter B.
- Deppisch Frank F.
- Dev P. S. Bhupal
- Di Crescenzo Antonia
- Di Matteo Armando
- Di Valentino Eleonora
- Dienes Keith R.
- Diwan Milind V.
- Dobre Radu
- Doglioni Caterina
- Domingues Mendes Luis M.
- Dova MarĂa Teresa
- Dreiner Herbi K.
- Du Yong
- Dutta Bhaskar
- DuVernois Michael A.
- DuwentÀster Pit
- DâAgnolo Raffaele Tito
- DâOnofrio Monica
- Ekstedt Andreas
- Elie Lucie
- Ellis Sebastian A. R.
- Elsen Eckhard
- Enberg Rikard
- Escalante del Valle Alberto
- Essig Rouven
- Farrar Glennys R.
- Farzan Yasaman
- Fedynitch Anatoli
- Fellers Deion
- Feng Jonathan L.
- Fieg Max
- Firu Elena
- Foguel Ana Luisa
- Foldenauer Patrick
- Foroughi-Abari Saeid
- Fortin Jean-François
- Friedland Alexander
- Fuchs Elina
- Fucilla Michael
- Funchal Renata Zukanovich
- Gallmeister Kai
- Galon Iftah
- Garcia Alfonso
- Garcia Isabel Garcia
- GarcĂa Canal Carlos A.
- Garzelli Maria Vittoria
- Gauld Rhorry
- Ghosh Sumit
- Ghoshal Anish
- Gibson Stephen
- Gil da Silveira Gustavo
- Giuli Francesco
- Giunti Carlo
- Goldfarb Steven
- Goncalves Dorival
- Gonçalves Victor P.
- Gorbunov Dmitry
- Goswami Srubabati
- Grau Silvia
- Guler A. Murat
- Guzzi Marco
- Gwenlan Claire
- Gwilliam Carl
- GĂŒnther Julian Y.
- Haas Andrew
- Hakulinen Timo
- Halzen Francis
- Han Tao
- Harland-Lang Lucian
- Harris Steven P.
- Harz Julia
- Haungs Andreas
- Heeck Julian
- Helo Herrera Juan Carlos
- Hentschinski Martin
- Hill Christopher S.
- Hirsch Martin
- Hobbs Timothy J.
- Hryczuk Andrzej
- Hsu Shih-Chieh
- Hu Zhen
- Huang Fei
- Huffman B. Todd
- Höche Stefan
- Iacobucci Giuseppe
- Illana Jose I.
- Inada Tomohiro
- Infantino Angelo
- Insolia Antonio
- Ishak Mustapha
- Ismail Ahmed
- Ismail Ameen
- Jacobsson Richard
- Jaeckel Joerg
- Jana Sudip
- Jeong Yu Seon
- JeĆŸo Tomas
- Jho Yongsoo
- JodĆowski Krzysztof
- Kabat Daniel
- Kalashnikov Dmitry
- Kanai Takumi
- Katori Teppei
- Kelly Kevin J.
- Ken Enrique Kajomovitz
- Keppel Cynthia
- Khalek Rabah Abdul
- Khoze Valery
- Kim Jongkuk
- Klasen Michael
- Klein Spencer R.
- Kling Felix
- Ko Pyungwon
- Komatsu Masahiro
- Kotko Piotr
- KovaĆĂk Karol
- Krauss Frank
- Kribs Graham D.
- Kuehn Susanne
- Kulkarni Suchita
- Kumar Jason
- Kumar Karan
- Kundu Saumyen
- Kuo Jui-Lin
- Kusina Aleksander
- KÀrkkÀinen Timo J.
- Köhler Dominik
- Laletin Maxim
- Le Roux Chiara
- Lee Claire
- Lee Hye-Sung
- Lee Seung J.
- Lefebvre Helena
- Leszczynska Agnieszka
- Li Jinmian
- Li Lingfeng
- Li Shuailong
- Li Yichen
- Lie Ki
- Lillard Benjamin
- Lin Huey-Wen
- Liu Wei
- Liu Zhen
- Lonjon Mickael
- Lowette Steven
- Lyu Kun-Feng
- LĂłpez Francisco MartĂnez
- Maciula Rafal
- Marfatia Danny
- MaseĆek RafaĆ
- Masip Manuel
- Masouminia Mohammad R.
- Matchev Konstantin
- McCauley Thomas
- McFayden Josh
- Medina-Tanco Gustavo
- Menjo Hiroaki
- Mikulenko Oleksii
- Miloi MÇadÇlina Mihaela
- Miramonti Lino
- Mohammed Mohammed M. A.
- Mohan Kirtimaan A.
- Mohlabeng Gopolang
- Moretti Stefano
- Moretti Théo
- MorfĂn Jorge G.
- Mosel Ulrich
- Mosny Martin
- Muzakka Khoirul F.
- Muzio Marco Stein
- Nadolsky Pavel
- Nakano Toshiyuki
- Nangia Saurabh
- Nath Pran
- Navarria Francesco L.
- Neagu Alina Tania
- Nelles Anna
- Neuhaus Friedemann
- Nevay Laurence J.
- Ninin Pierre
- Nocera Emanuele R.
- Nomura Takaaki
- Nunes Rui
- Nunez Carlos
- Ochoa-Ricoux J. Pedro
- Okada Nobuchika
- Okui Kazuaki
- Olinto Angela V.
- Olness Fred
- Onel Yasar
- Osborne John
- Otono Hidetoshi
- Ovchynnikov Maksym
- Pandey Vishvas
- Pandini Carlo
- Papa Alessandro
- Pasechnik Roman
- Paul Thomas C.
- Pei Junle
- Peon Guillermo
- Perez Gilad
- Petersen Brian A.
- Pickering Luke
- Pierog Tanguy
- Plehn Tilman
- Plestid Ryan
- Plum Matthias
- PlÀtzer Simon
- Poddar Tanmay Kumar
- Potamianos Karolos
- Preda Titi
- Prim Markus
- PĂ©rez de los Heros Carlos
- Queitsch-Maitland Michaela
- QuĂlez Pablo
- Rai Mudit
- Rajaee Meshkat
- Raut Digesh
- Reimitz Peter
- Reina Laura
- Reininghaus Maximilian
- Reno Mary Hall
- Resnati Filippo
- Rhode Wolfgang
- Richardson Peter
- Ritz Adam
- Rizzo Thomas G.
- Robens Tania
- Rojo Juan
- Rokujo Hiroki
- Roszkowski Leszek
- Ruhe Tim
- Ruiz Richard
- Ruiz-ChĂłliz Elisa
- Sabate-Gilarte Marta
- Sabio Vera Agustin
- Sandrock Alexander
- Sarcevic Ina
- Sarkar Subir
- Sato Osamu
- Scherb Christiane
- Schienbein Ingo
- Schmieden Kristof
- Schnell Gunar
- Schott Matthias
- Schroeder Frank G.
- Schulz Holger
- Schwaller Pedro
- Sciutto Sergio J.
- Sengupta Dipan
- Sevilla Sergio Gonzalez
- Sfyrla Anna
- Shadmi Yael
- Shchutska Lesya
- Shimomura Takashi
- Shipsey Ian
- Shively Savannah R.
- Shoemaker Ian M.
- Sierra Carlos VĂĄzquez
- Silvetti Federico
- Singh Rajeev
- Sinha Kuver
- Sjöstrand Torbjörn
- Sobczyk Jan T.
- Soldin Dennis
- Song Huayang
- Soreq Yotam
- Soriano Jorge F.
- Sousa A.
- Stasto Anna
- Stuart David
- Stupak John, III
- Su Shufang
- Su Wei
- Suarez Indara
- Suarez Rebeca Gonzalez
- Szczurek Antoni
- Tabrizi Zahra
- Tait Tim M. P.
- Takubo Yosuke
- Taoso Marco
- Tata Xerxes
- Thomas Brooks
- Thonet Pierre
- Thottoli Shafeeq Rahman
- Toranosuke Okumura
- Torrence Eric
- Torres Diego F.
- Tricoli Alessandro
- Trojanowski Sebastian
- TrĂłcsĂĄnyi ZoltĂĄn
- Tsai Yu-Dai
- Tuckler Douglas
- Unger Michael
- Valli Mauro
- Venters Tonia
- Verpoest Stef
- Vilela Cristovao
- Vincke Heinz
- Vishnudath K. N.
- Vormwald Benedikt
- Wang Lian-Tao
- Wang Zeren Simon
- Waterbury Michael
- Watts Gordon
- West Stephen M.
- Winkler Martin W.
- Wu Wenjie
- Xie Keping
- Xu Tao
- Xu Xun-Jie
- Yaeggy Barbara
- Yoon Chun Sil
- You Tevong
- Yu Ji-Young
- Yu Jiang-Hao
- Yuan Tianlu
- YĂŒksel Emin
- Zapp Korinna
- Zgura Ion Sorin
- Zhang Yongchao
- Zhang Yue
- Zhou Guanghui
- Publication venue
- Institute of Physics Publishing Ltd
- Publication date
- 23/01/2023
- Field of study
Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA)
- Author
- A Ishii
- A Sandler
- AI Molosh
- AM Kaplan
- AM Malfitano
- C Chabernaud
- CE Bearden
- D Ben Bashat
- D Evans
- D Haas
- DA Mayes
- DG Evans
- E Berry-Kravis
- ET Petersen
- F Mainberger
- F Pedregosa
- G Ertan
- H Ito
- IR Violante
- IR Violante
- J Goncalves
- JE Lainhart
- JK Liao
- JM Payne
- JT McCracken
- K Conners
- K Vermeulen
- KA Doyle-Thomas
- KH Karlsgodt
- KW Yeom
- L Beason-Held
- L Krab
- LE Arnold
- M Acosta
- M Aman
- M Kayano
- M Loitfelder
- M Mikkelsen
- MH Johnson
- National Institutes of Health Consensus Development Conference
- P Balestri
- P Mengotti
- PG Mullins
- Q Ling
- R Buchert
- S Garg
- S Garg
- S Hyman
- S Leucht
- S Sierra
- SJ Kiddle
- SK Sundaram
- SM Morris
- SN Tomson
- T van der Vaart
- V Mautner
- W Li
- Y Cui
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/ behaviour outcomes have shown mixed results. This trial breaks new ground by studying statin effects for the first time in younger children with NF1 and co-morbid autism and by using multiparametric imaging outcomes. Methods: A single-site triple-blind RCT of simvastatin vs. placebo was done. Assessment (baseline and 12-week endpoint) included peripheral MAPK assay, awake magnetic resonance imaging spectroscopy (MRS; GABA and glutamate+glutamine (Glx)), arterial spin labelling (ASL), apparent diffusion coefficient (ADC), resting state functional MRI, and autism behavioural outcomes (Aberrant Behaviour Checklist and Clinical Global Impression). Results: Thirty subjects had a mean age of 8.1 years (SD 1.8). Simvastatin was well tolerated. The amount of imaging data varied by test. Simvastatin treatment was associated with (i) increased frontal white matter MRS GABA (t(12) = â 2.12, p = .055), GABA/Glx ratio (t(12) = â 2.78, p = .016), and reduced grey nuclei Glx (ANCOVA p < 0.05, Mann-Whitney p < 0.01); (ii) increased ASL perfusion in ventral diencephalon (Mann-Whitney p < 0.01); and (iii) decreased ADC in cingulate gyrus (Mann-Whitney p < 0.01). Machine-learning classification of imaging outcomes achieved 79% (p < .05) accuracy differentiating groups at endpoint against chance level (64%, p = 0.25) at baseline. Three of 12 (25%) simvastatin cases compared to none in placebo met âclinical responderâ criteria for behavioural outcome. Conclusions: We show feasibility of peripheral MAPK assay and autism symptom measurement, but the study was not powered to test effectiveness. Multiparametric imaging suggests possible simvastatin effects in brain areas previously associated with NF1 pathophysiology and the social brain network
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