Untersuchung zur Lernkultur in Online-Kursen

Ausgehend von einer veränderten, durch Lern- und Kompetenzorientierung geprägten Lernkultur analysieren die Autorinnen zwölf mehrwöchige Online-Kurse mit insgesamt 130 Teilnehmer/innen. Die Autorinnen nehmen ein Klima der hohen Wertschätzung unter den Lernenden wahr sowie gegenseitiges Feedback in den Reflexions- und Diskussionsprozessen, welches das Lernen verstärkt. Die Hypothese, dass in rein virtuellen, mehrwöchigen Weiterbildungskursen eine veränderte Lernkultur gefördert und gelebt wird, wird mittels halbstrukturierter Interviews sowie qualitativer Inhaltsanalyse der Beiträge in den Diskussionsforen untersucht. (DIPF/ Orig.

Case reports in the Lancet: From neurophobia to global pandemics.

While neurology remains the best-represented specialty, it was Hematology and Rheumatology cases that were more often reported by non-specialists. The overall distribution by country has also changed, reflecting recent outbreaks of infectious agents

A newly reconciled dataset for identifying sea level rise and variability in Dublin Bay

We provide an updated sea level dataset for Dublin for the period 1938–2016 at yearly resolution. Using a newly collated sea level record for Dublin Port, as well as two nearby tide gauges at Arklow and Howth Harbour, we perform data quality checks and calibration of the Dublin Port record by adjusting the biased high water level measurements that affect the overall calculation of mean sea level (MSL). To correct these MSL values, we use a novel Bayesian linear regression that includes the mean low water values as a predictor in the model. We validate the re-created MSL dataset and show its consistency with other nearby tide gauge datasets. Using our new corrected dataset, we estimate a rate of sea level rise of 1.1 mm yr−1 during 1953–2016 (95 % credible interval from 0.6 to 1.6 mm yr−1 ), and a rate of 7 mm yr−1 during 1997–2016 (95 % credible interval from 5 to 8.8 mm yr−1). The overall sea level rise is in line with expected trends, but large multidecadal variability has led to higher rates of rise in recent years

The geological history of the Isle of Wight : an overview of the ‘diamond in Britain's geological crown’

The geology of the Isle of Wight has attracted both the amateur and professional geologist alike for well over two centuries. It presents a cornucopia of things geological and offers a window into the fascinating story of the geological history and landscape development of southern England, as well as an important teaching resource for all levels of study from primary education through to academic research. This paper provides a geological framework and a summary of the history of research as context for the papers in this issue can be placed. Inevitably, it can only offer a précis of the huge amount of information available, but it is hoped will also give added impetus to further investigation of the literature or, indeed, new research. The island offers a field workshop for topics such as lithostratigraphy, sequence stratigraphy, tectonics and climate change; studies that are becoming ever more international in their influence. There are 15 Sites of Special Scientific Interest designated because of their geological importance and a number of these are internationally significant. After a brief discussion on the concealed geology, this paper concentrates on an outline of the near-surface geology on the coast and inland, and introduces a different view on the structure of the Cretaceous and Palaeogene strata. The enigmatic Quaternary deposits are discussed particularly with reference to the development of the Solent River, human occupation and climate change

Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies ▿

The restricted neutralization breadth of vaccine-elicited antibodies is a major limitation of current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the efficient identification of vaccines with enhanced capacity for eliciting cross-reactive neutralizing antibodies (NAbs) and to assess the overall breadth and potency of vaccine-elicited NAb reactivity, we assembled a panel of 109 molecularly cloned HIV-1 Env pseudoviruses representing a broad range of genetic and geographic diversity. Viral isolates from all major circulating genetic subtypes were included, as were viruses derived shortly after transmission and during the early and chronic stages of infection. We assembled a panel of genetically diverse HIV-1-positive (HIV-1+) plasma pools to assess the neutralization sensitivities of the entire virus panel. When the viruses were rank ordered according to the average sensitivity to neutralization by the HIV-1+ plasmas, a continuum of average sensitivity was observed. Clustering analysis of the patterns of sensitivity defined four subgroups of viruses: those having very high (tier 1A), above-average (tier 1B), moderate (tier 2), or low (tier 3) sensitivity to antibody-mediated neutralization. We also investigated potential associations between characteristics of the viral isolates (clade, stage of infection, and source of virus) and sensitivity to NAb. In particular, higher levels of NAb activity were observed when the virus and plasma pool were matched in clade. These data provide the first systematic assessment of the overall neutralization sensitivities of a genetically and geographically diverse panel of circulating HIV-1 strains. These reference viruses can facilitate the systematic characterization of NAb responses elicited by candidate vaccine immunogens