Peer review: beyond the call of duty?

The number of manuscripts submitted to most scholarly journals has increased tremendously over the last few decades, and shows no sign of leveling off. Increasingly, a key challenge faced by editors of scientific journals like the International Journal of Nursing Studies (IJNS) is to secure peer reviews in a timely fashion for the manuscripts they handle. We hear from editors of some journals that it is not uncommon to have to issue 10–15 invitations before one can secure the peer reviews needed to assess a given manuscript and although the IJNS generally fares better than this it is certainly true that a high proportion, probably a majority, of review invitations are declined.\ud \ud Most often, researchers declining invitations to review invoke the fact that they are too busy to add yet another item to their already overcommitted schedule. Some reviewers respond that administrators at their university or research center are actively discouraging them from engaging in an activity that seems to bear no tangible benefits. Yet, however one looks at it, peer reviewing is a crucial component of the publishing process. Nobody has yet come up with a viable alternative. Therefore, we need to find a way to convince our colleagues to peer review manuscripts more often. This can be done with a stick or with various types of carrots.\ud \ud One “stick”, occasionally envisaged by editors (e.g., Anon., 2009), is straightforward, at least to explain. For the peer-reviewing enterprise to function well, each researcher should be reviewing every year as many manuscripts as the number of reviews he or she is getting for his/her own papers. So, someone submitting 10 manuscripts in a given year should be willing to review 20 or 30 manuscripts during the same timeframe (assuming that each manuscript is reviewed by 2 or 3 individuals, as is commonly the case). If this person does not meet the required quota of reviews, there would be some restrictions imposed on the submission of any new manuscript for publication. Boehlert et al. (2009) have advocated such a “stick” in the case of the submission of grant proposals.\ud \ud However, the implementation of such an automatic accounting of reviewing activities is fraught with difficulties. For one thing, it would not prevent reviewers from defeating the system by writing short, useless reviews just to make the number. To eliminate that loophole, someone would have to assess whether reviews meet minimal standards of quality before they can be counted in the annual or running total. There would need to be allowances, for example to allow young researchers to get established in their career. This raises the prospect of a complex and potentially expensive system somewhat akin to carbon trading where credits for reviewing are granted and then traded with a verification system to ensure that no one cheats.\ud \ud An alternative approach, instead of sanctioning bad reviewing practices, would be to reward good ones. Currently the IJNS publishes the names of all reviewers annually. Other journals go a step further for example by giving awards to outstanding reviewers (Baveye et al., 2009). The lucky few who are so singled out by such awards see their reviewing efforts validated. But fundamentally, these awards do not change the unsupportive atmosphere in which researchers review manuscripts. The problem has to be attacked at its root, in the current culture of universities and research centers, where administrators tend to equate research productivity with the number of articles published and the amount of extramural funding brought in. Annual activity reports occasionally require individuals to mention the number of manuscripts or grant proposals reviewed, but these data are currently unverifiable, and therefore, are generally assumed not to matter at all for promotions or salary adjustments.\ud \ud There may be ways out of this difficulty. All the major publishers have information on who reviews what, how long reviewers take to respond to invitations, how long it takes them to send in their reviews. All it would take, in addition, would be for editors or associate editors who receive reviews to assess and record their usefulness, and one would have a very rich data set, which, if it were made available to universities and research centers in a way that preserves the anonymity of the peer-review process, could be used fruitfully to evaluate individuals’ reviewing performance and impact. Of course, one would have to agree on what constitutes a “useful” review. Pointing out typos and syntax errors in a manuscript is useful, but not hugely so. Identifying problems and offering ways to overcome them, proposing advice on how to analyze data better, or editing the text to increase its readability are all ways to make more substantial contributions. Generally, one might consider that there is a usefulness gradation from reviews focused on finding flaws in a manuscript to those focused on helping authors improve their text. Debate among scientists could result in a reliable set of guidelines on how to evaluate peer reviews.\ud \ud Beyond making statistics available to decision makers, other options are also available to raise the level of visibility and recognition of peer reviews (Baveye, 2010). Right or wrong, universities and research centers worldwide now rely more and more on some type of scientometric index, like the h-index (Hirsch, 2005), to evaluate the “impact” of their researchers. In other cases, such as the UK, the basis on which institutions are funded is linked to schemes which have measures such as the impact factor at their core (Nolan et al., 2008 M. Nolan, C. Ingleton and M. Hayter, The research excellence framework (REF): a major impediment to free and informed debate?, International Journal of Nursing Studies 45 (4) (2008), pp. 487–488. Article | PDF (202 K) | View Record in Scopus | Cited By in Scopus (4)Nolan et al., 2008). While many researchers see bibliometric analysis as a legitimate tool to explore discipline's activities and knowledge sources (see for example [Beckstead and Beckstead, 2006], [Oermann et al., 2008] and [Urquhart, 2006]), previous editorials in the IJNS have noted this trend and expressed disquiet at the distorting effect it could have on academic practice when used to pass judgments on quality ([Ketefian and Freda, 2009] and [Nolan et al., 2008]).\ud \ud Many of these indices implicitly encourage researchers to publish more articles, which in turn may detract researchers from engaging in peer reviewing. Certainly, none of the current indices encompass in any way the significant impact individuals can have on a discipline via their peer reviewing. But one could conceive of scientometric indexes that would include some measure of peer-reviewing impact, calculated on the basis of some of the data mentioned earlier. Clearly, such developments will not happen overnight. Before any of them can materialize, a necessary first step is for researchers to discuss with their campus administration, or the managers of their research institution, the crucial importance of peer reviewing and the need to have this activity valued in the same way that research, teaching, and outreach are. A debate along these lines is long overdue.\ud \ud Academic peer review is a necessary part of the publication process but while publication is recognised and valued, peer review is not. Even without the pressures of reward based on publication-based measures there is a potential for those less civic-minded authors to benefit from, but not contribute to, the peer-review system. Current scientometrics actively encourage and reward such behavior in a way that is, ultimately, not sustainable. Once administrators perceive that there is a need in this respect, are convinced that it will not cost a fortune to give peer reviewing more attention, and formulate a clear demand to librarians and publishers to help move things forward, there is hope that this perverse incentive in the current system can be removed. Otherwise the future of the current model of peer review looks bleak and we may indeed have to look forward to a complex bureaucratic system in which review credits are traded.\ud \ud For now, although the IJNS can count itself lucky because the problem affects this journal less than many others, in common with other journals we must thank our peer reviewers who are acting above and beyond the call of duty as it is perceived by many institutions. Without their efforts, journals like this cannot maintain their high standards. It is time for us to lend our weight to calls for a wide-ranging debate in order to ensure that these efforts are properly acknowledged and rewarded when judging the extent and quality of an academic's scientific contribution

The B subunit of Escherichia coli heat-labile toxin alters the development and antigen-presenting capacity of dendritic cells

Escherichia coli’s heat-labile enterotoxin (Etx) and its non-toxic B subunit (EtxB) have been characterized as adjuvants capable of enhancing T cell responses to co-administered antigen. Here, we investigate the direct effect of intravenously administered EtxB on the size of the dendritic and mye-loid cell populations in spleen. EtxB treatment appears to enhance the development and turnover of dendritic and myeloid cells from precursors within the spleen. EtxB treatment also gives a dendritic cell (DC) population with higher viability and lower activation status based on the reduced expression of MHC-II, CD80 and CD86. In this respect, the in vivo effect of EtxB differs from that of the highly inflammatory mediator lipopolysaccharide. In in vi-tro bone marrow cultures, EtxB treatment was also found to enhance the development of DC from precursors dependent on Flt3L. In terms of the in vivo effect of EtxB on CD4 and CD8 T cell responses in mice, the interaction of EtxB directly with DC was demonstrated following conditional deple-tion of CD11c+ DC. In summary, all results are consistent with EtxB displaying adjuvant ability by enhancing the turnover of DC in spleen, leading to newly mature myeloid and DC in spleen, thereby increasing DC capacity to perform as antigen-presenting cells on encounter with T cells

Pollinators, “mustard oil” volatiles, and fruit production in flowers of the dioecious tree Drypetes natalensis (Putranjivaceae)

The Putranjivaceae is an enigmatic family, notable for being the only lineage outside the Capparales to possess the glucosinolate biochemical pathway, which forms the basis of an induced chemical defense system against herbivores (the “ mustard oil bomb ” ). We investigated the pollination biology and fl oral scent chemistry of Drypetes natalensis (Putranjivaceae), a dioecious subcanopy tree with fl owers borne on the stem (caulifl ory). Flowering male trees were more abundant than female ones and produced about 10-fold more fl owers. Flowers of both sexes produce copious amounts of nectar on disc-like nectaries accessible to short-tongued insects. The main fl ower visitors observed were cetoniid beetles, bees, and vespid wasps. Pollen load analysis indicated that these insects exhibit a high degree of fi delity to D. natalensis fl owers. Insects effectively transfer pollen from male to female plants resulting in about 31% of female fl owers developing fruits with viable seeds. Cetoniid beetles showed signifi cant orientation toward the scent of D. natalensis fl owers in a Y-maze olfactometer. The scents of male and female fl owers are similar in chemical composition and dominated by fatty acid derivatives and isothiocyanates from the glucosinolate pathway. The apparent constitutive emission of isothiocyanates raises interesting new questions about their functional role in flowers

Novel enantiopure bis(pyrrolo)tetrathiafulvalene donors exhibiting chiral crystal packing arrangements

Two novel enantiopure bis(pyrrolo[3,4-d])tetrathiafulvalene derivatives, substrates for preparing chiral conducting materials, show chiral crystal packing arrangements in which successive layers are rotated in accordance with an exact or approximate 43 axis. The corresponding donors containing fused dihydropyrrolegroups, and thus four more hydrogen atoms, form stacks along a crystal axis

The interfacial structure of polymeric surfactant stabilised air-in-water foams

Small-angle neutron scattering was used to probe the interfacial structure of nitrogen-in-water foams created using a series of tri-block polymeric surfactants of the poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (EOx–POy–EOx) range, from which the nature of the polymeric interface could be characterised. The data follow a pronounced Q−4 decay, along with a number of inflexions and weak but well-defined peaks. These characteristics were well-described by a model embodying paracrystalline stacks of adsorbed polymer layers, whose formation is induced by the presence of the air–water interface, adsorbed at the flat air–water (film lamellae) interface. A minimum of approximately five paracrystalline polymer layers of thickness of the order of 85–160 Å, interspersed with somewhat thicker (400 Å) films of continuous aqueous phase were found to best fit the data. The thickness of the layer (L) was shown to follow a relationship predicted by anchor block dominated polymer adsorption theories from non-selective solvents, L EO1PO1/3. The insight gained from these studies should permit a more rational design of polymeric stabilisers for hydrophilic polyurethane foams

Surfactant modulated interactions of hydrophobically modified ethoxylated urethane (HEUR) polymers with penetrable surfaces

Hypothesis Adsorption of hydrophobically modified ethoxylated urethane polymers (HEURs) at the soft colloid interfaces of emulsion droplets will stabilise oil-in-water emulsions (a) via steric stabilisation induced by adsorption of the polymer at the droplet surfaces through the hydrophobic groups, and (b) via continuous phase viscosity enhancement through polymer self-association. Both of these mechanisms will be modulated by the presence of the surfactant, sodium dodecylsulfate (SDS). Experiments Dodecane-in-water emulsions stabilised by three HEUR polymers with different structural composition were examined in the absence and presence of SDS by NMR spectroscopy and small-angle neutron scattering (SANS). The effect of adsorption of the polymer to the dodecane droplet surfaces, and the conformation of the self-associating polymer in the aqueous solution were quantified. Findings All emulsions were stable for days-weeks. Diffusion data showed the formation of oil droplets of hundreds of nm in size in the presence of all three HEURs, here denoted C6-L-(EO100-L)9-C6, C10-L-(EO200-L)4-C10, and C18-L-(EO200-L)7-C18, where EOx represents a block of ethylene oxide of x monomers, L denotes the linker group, and Cn the length of the hydrophobic end-group. No significant changes in droplet size across this series of polymers was observed. Collectively, the results point to adsorption of the polymer to the droplet surfaces, which results in a small decrease in the effective polymer solution concentration, thereby driving to significant changes in the structure and dynamics of the system. Evident in the SANS data in particular, is a subtle balance between the characteristic features reflecting polymer self-association, and those associated with polymer structures commensurate with a larger length-scale, dependent on the system composition. Surprisingly, the polymer and polymer/SDS complex in the presence of oil show slightly greater diffusive rates relative to the analogous systems in the absence of the oil. Finally, the partitioning of the three polymers in phase-separated samples was studied by 1H NMR, and it was shown that the C18-L-(EO200-L)7-C18 exhibited a greater partitioning in the oil phase compared with C6-L-(EO100-L)9-C6 and C10-L-(EO200-L)4-C10, an observation that may be understood in terms of the structural composition of the HEURs. The SDS showed a positive correlation between its partitioning in the two layers with the polymer partitioning, evidence of a strong interaction between the surfactant and the polymer, consistent with the behaviour observed in the oil-free system

Synthesis of bis(ethylenedithio)tetrathiafulvalene (BEDT-TTF) derivatives functionalised with two, four or eight hydroxyl groups

Short synthetic routes to a range of BEDT-TTF derivatives functionalised with two, four or eight hydroxyl groups are reported, of interest because of their potential for introducing hydrogen bonding between donor and anion into their radical cation salts. The cycloaddition of 1,3-dithiole-2,4,5-trithione with alkenes to construct 5,6-dihydro-1,3-dithiolo[4,5-b]1,4-dithiin-2-thiones is a key step, with homo- or hetero-coupling procedures and O-deprotection completing the syntheses. The first synthesis of a single diastereomer of tetrakis(hydroxymethyl)BEDT-TTF, the cis, trans product, was achieved by careful choice of O-protecting groups to facilitate separation of homo- and hetero-coupled products. Cyclisation of the trithione with enantiopure 1R,2R,5R,6R-bis(O,O-isopropylidene)hex-3-ene-1,2,5,6-tetrol (from D-mannitol) gave two separable diastereomeric thiones, which can be transformed to enantiomeric BEDT-TTF derivatives with four or eight hydroxyl groups

Quantifying the micellar structure formed from hydrocarbon-fluorocarbon surfactants

Many technological formulations contain mixtures of surfactants, each contributing some distinct property. Characteristics of each surfactant are often modulated in the mixture, based on the interactions between the various components present. Here, the mixing of the hydrocarbon surfactant cetyltrimethyl ammonium bromide (C16TAB) and the fluorocarbon surfactant, Zonyl-FSN-100 with average chemical structure of C8F17C2H4 (OC2H4)9OH, is quantified, in particular, the size and shape of the micelles and their critical micelle concentration (CMC). The CMC data suggest there are specific interactions between the two components which are strongly antagonistic. Small-angle neutron scattering (SANS) has been used to quantify the size and shape of the micelle, and these data indicate that the single component FSN-100 forms disc-like micelles with a small aggregation number (~65) and the C16TAB forms globular, charged micelles with a larger aggregation number (135). The aggregation number of the mixed micelle is substantially greater than either of the pure species. Overall, a detailed study of CTAB, FSN-100 and their mixture systems will be presented in this paper

pH-Dependent Chiral Recognition of D- and L-Arginine Derived Polyamidoamino Acids by Self-assembled Sodium Deoxycholate

D- and L-arginine-based polyamidoamino acids, called D- and L-ARGO7, retain the chirality and acid/base properties of the parent -amino acids and show pH-dependent self-structuring in water. The ability of the ARGO7 chiral isomers to selectively interact with chiral biomolecules and/or surfaces was studied by choosing sodium deoxycholate (NaDC) as a model chiral biomolecule for its ability to self-assembly into globular micelles, showing enantio-selectivity. To this purpose, mixtures of NaDC with D-, L- or D,L-ARGO7, respectively, in water were analysed by circular dichroism (CD) spectroscopy and small-angle neutron scattering (SANS) at different levels of acidity expressed in terms of pD and concentrations. Differences in the CD spectra indicated chiral discrimination for NaDC/ARGO7 mixtures in the gel phase (pD 7.30) but not in the solution phase (pD 9.06). SANS measurements confirmed large scale structural perturbation induced by this chiral discrimination in the gel phase yet no modulation of the structure in the solution phase. Together, these techniques shed light on the mechanism by which ARGO7 stereoisomers modify the morphology of NaDC micelles as a function of pH. This work demonstrates chirality-dependent interactions that drive structural evolution and phase behaviour of NaDC, opening the way for designing novel smart drug delivery systems