Geologic Setting of the Harvard Conglomerate, Harvard, Massachusetts

Guidebook for field trips to the Boston area and vicinity : 68th annual meeting, New England Intercollegiate Geological Conference, October 8-10, 1976: Trip F-

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Date of Acceptance: 28/07/2015 The authors are grateful to the staff of the Medical Research Facility for their help with the animal care. This work was supported by the NHS Endowment fund 09/03 and the Wellcome Trust (WT080782MF). We thank Merck & Co. Inc., Rathway NJ, USA for the supply of DFU.Peer reviewedPublisher PD

Prokaryotic respiration and production in the meso- and bathypelagic realm of the eastern and western North Atlantic basin

We measured prokaryotic production and respiration in the major water masses of the North Atlantic down to a depth of,4,000 m by following the progression of the two branches of North Atlantic Deep Water (NADW) in the oceanic conveyor belt. Prokaryotic abundance decreased exponentially with depth from 3 to 0.4 3 105 cells mL21 in the eastern basin and from 3.6 to 0.3 3 105 cells mL21 in the western basin. Prokaryotic production measured via 3H-leucine incorporation showed a similar pattern to that of prokaryotic abundance and decreased with depth from 9.2 to 1.1 mmol C m23 d21 in the eastern and from 20.6 to 1.2 mmol C m23 d21 in the western basin. Prokaryotic respiration, measured via oxygen consumption, ranged from about 300 to 60 mmol C m23 d21 from,100 m depth to the NADW. Prokaryotic growth efficiencies of,2 % in the deep waters (depth range 1,200–4,000 m) indicate that the prokaryotic carbon demand exceeds dissolved organic matter input and surface primary production by 2 orders of magnitude. Cell-specific prokaryotic production was rather constant throughout the water column, ranging from 15 to 32 3 1023 fmol C cell21 d21 in the eastern and from 35 to 58

CBT for difficult-to-treat depression: self-regulation model

Background:Cognitive behavioural therapy (CBT) is an effective treatment for depression but a significant minority of clients do not complete therapy, do not respond to it, or subsequently relapse. Non-responders, and those at risk of relapse, are more likely to have adverse childhood experiences, early-onset depression, co-morbidities, interpersonal problems and heightened risk. This is a heterogeneous group of clients who are currently difficult to treat.Aim:The aim was to develop a CBT model of depression that will be effective for difficult-to-treat clients who have not responded to standard CBT.Method:The method was to unify theory, evidence and clinical strategies within the field of CBT to develop an integrated CBT model. Single case methods were used to develop the treatment components.Results:A self-regulation model of depression has been developed. It proposes that depression is maintained by repeated interactions of self-identity disruption, impaired motivation, disengagement, rumination, intrusive memories and passive life goals. Depression is more difficult to treat when these processes become interlocked. Treatment based on the model builds self-regulation skills and restructures self-identity, rather than target negative beliefs. A bespoke therapy plan is formed out of ten treatment components, based on an individual case formulation.Conclusions:A self-regulation model of depression is proposed that integrates theory, evidence and practice within the field of CBT. It has been developed with difficult-to-treat cases as its primary purpose. A case example is described in a concurrent article (Barton et al., 2022) and further empirical tests are on-going

Evaluation of phenotype-driven gene prioritization methods for Mendelian diseases.

Yuan et al. recently described an independent evaluation of several phenotype-driven gene prioritization methods for Mendelian disease on two separate, clinical datasets. Although they attempted to use default settings for each tool, we describe three key differences from those we currently recommend for our Exomiser and PhenIX tools. These influence how variant frequency, quality and predicted pathogenicity are used for filtering and prioritization. We propose that these differences account for much of the discrepancy in performance between that reported by them (15-26% diagnoses ranked top by Exomiser) and previously published reports by us and others (72-77%). On a set of 161 singleton samples, we show using these settings increases performance from 34% to 72% and suggest a reassessment of Exomiser and PhenIX on their datasets using these would show a similar uplift

Kinematic Comparison of Dolphin Kicking Performed in a Prone and Supine Body Position

Underwater dolphin kicking has become an essential element in competitive swimming but little research has been performed to provide an understanding of this movement. PURPOSE: To examine hip and knee kinematics of prone and supine dolphin kicking as they relate to speed. METHODS: Six collegiate swimmers (1.77±0.07 m, 72.4±7.6 kg, 19.8±1.0 yrs) experienced with dolphin kicking completed six 10 m maximal effort underwater kicking trials; three trials in a prone position and three trials in a supine position. An underwater camera was calibrated using a projective scaling technique and subsequently used to record each trial at 60 Hz. Twelve body landmarks were digitized from the video recordings to determine whole body center of mass location and hip and knee joint angles. Data were filtered using a fourth order Butterworth low-pass digital filter with cutoff frequencies individually determined for each coordinate or each landmark. Linear velocity of the center of mass was computed using the first central difference method. Hip and knee joint ranges of motion (ROM) were compared between body positions using a 2x2 (joint x body position) repeated measures ANOVA. Kick rate (KR) and horizontal velocity of the center of mass were compared between body positions using a two-tailed dependent t-test. RESULTS: Neither horizontal velocity (t(4)=0.308, p=0.774) nor kicking rate (t(4)=0.371, p=0.730) were different between body positions (Table 1). ROM was significantly greater in the knee than the hip (F(1,4)=110.967, p 2=0.965). ROM was not affected by body position (F(1,4)=1.068, p=0.36, 2=0.211). ROM did not interact between joint and body position (F(1,4)=1.461, p=0.818, 2=0.015). CONCLUSION: Despite some recent suggestions that a supine dolphin kick may be more effective than a prone dolphin kick, no kinematic difference were observed in this sample of swimmers. Table 1. Dolphin Kicking Kinematics. PRONE SUPINE KNEE ROM (degrees) 69.7±4.5 73.6.7±6.7 HIP ROM (degrees) 37.7±8.3 40.5±9.0 HORIZONTAL VELOCITY (m/s) 1.82±1.13 1.80±1.04 KICK RATE (kicks/min) 135.0±71.9 136.4±67.

Approximate variational coupled cluster theory

We show that it is possible to construct an accurate approximation to the variational coupled cluster method, limited to double substitutions, from the minimization of a functional that is rigorously extensive, exact for isolated two-electron subsystems and invariant to transformations of the underlying orbital basis. This approximate variational coupled cluster theory is a modification and enhancement of our earlier linked pair functional theory. It is first motivated by the constraint that the inverse square root of the matrix that transforms the cluster amplitudes must exist. Low-order corrections are then included to enhance the accuracy of the approximation of variational coupled cluster, while ensuring that the computational complexity of the method never exceeds that of the standard traditional coupled cluster method. The effects of single excitations are included by energy minimization with respect to the orbitals defining the reference wavefunction. The resulting quantum chemical method is demonstrated to be a robust approach to the calculation of molecular electronic structure and performs well when static correlation effects are strong

HST Imaging Polarimetry of the Gravitational Lens FSC10214+4724

We present imaging polarimetry of the extremely luminous, redshift 2.3 IRAS source FSC10214+4724. The observations were obtained with HST's Faint Object Camera in the F437M filter, which is free of strong emission lines. The 0.7 arcsec long arc is unresolved to 0.04 arcsec FWHM in the transverse direction, and has an integrated polarization of 28 +/- 3 percent, in good agreement with ground-based observations. The polarization position angle varies along the arc by up to 35 deg. The overall position angle is 62 +/- 3 deg east of north. No counterimage is detected to B = 27.5 mag ($3\sigma$), giving an observed arc to counterimage flux ratio greater than 250, considerably greater than the flux ratio of 100 measured previously in the I-band. This implies that the configuration of the object in the source plane at the B-band is different from that at I-band, and/or that the lensing galaxy is dusty.Comment: 17 pages, 3 figures. Accepted for publication in Astronomical Journal, February 199

Meningococcal disease in children in Merseyside, England:a 31 year descriptive study

Meningococcal disease (MCD) is the leading infectious cause of death in early childhood in the United Kingdom, making it a public health priority. MCD most commonly presents as meningococcal meningitis (MM), septicaemia (MS), or as a combination of the two syndromes (MM/MS). We describe the changing epidemiology and clinical presentation of MCD, and explore associations with socioeconomic status and other risk factors. A hospital-based study of children admitted to a tertiary children's centre, Alder Hey Children's Foundation Trust, with MCD, was undertaken between 1977 to 2007 (n = 1157). Demographics, clinical presentations, microbiological confirmation and measures of deprivation were described. The majority of cases occurred in the 1-4 year age group and there was a dramatic fall in serogroup C cases observed with the introduction of the meningococcal C conjugate (MCC) vaccine. The proportion of MS cases increased over the study period, from 11% in the first quarter to 35% in the final quarter. Presentation with MS (compared to MM) and serogroup C disease (compared to serogroup B) were demonstrated to be independent risk factors for mortality, with odds ratios of 3.5 (95% CI 1.18 to 10.08) and 2.18 (95% CI 1.26 to 3.80) respectively. Cases admitted to Alder Hey were from a relatively more deprived population (mean Townsend score 1.25, 95% CI 1.09 to 1.41) than the Merseyside reference population. Our findings represent one of the largest single-centre studies of MCD. The presentation of MS is confirmed to be a risk factor of mortality from MCD. Our study supports the association between social deprivation and MCD

Uniform Consistency of Nonstationary Kernel-Weighted Sample Covariances for Nonparametric Regression

We obtain uniform consistency results for kernel-weighted sample covariances in a nonstationary multiple regression framework that allows for both fixed design and random design coefficient variation. In the fixed design case these nonparametric sample covariances have different uniform asymptotic rates depending on direction, a result that differs fundamentally from the random design and stationary cases. The uniform asymptotic rates derived exceed the corresponding rates in the stationary case and confirm the existence of uniform super-consistency. The modelling framework and convergence rates allow for endogeneity and thus broaden the practical econometric import of these results. As a specific application, we establish uniform consistency of nonparametric kernel estimators of the coefficient functions in nonlinear cointegration models with time varying coefficients or functional coefficients, and provide sharp convergence rates. For the fixed design models, in particular, there are two uniform convergence rates that apply in two different directions, both rates exceeding the usual rate in the stationary case