Atome Hôtel : un web-documentaire pour revisiter le tableau périodique des éléments

Rendre attractif et ludique, le tableau périodique des éléments, cet icône de la chimie : tel est l’objectif que s’est fixé le service de culture scientifique de l’université de Montpellier. Les initiateurs de l'opération présentent les différentes étapes de ce projet qui a finalement pris la forme d’un web-documentaire, fruit d’une collaboration étroite entre des scientifiques et une équipe créative spécialisée dans le multimédia

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

mars-avril 2016

Vous avez dit "médiateur scientifique" ? Médiateur scientifique est aujourd'hui un métier en mal de reconnaissance. D'ailleurs, il n'a pas la même appellation selon les structures dans lesquelles il s'exerce : animateur, guide, interprète scientifique, chargé ou assistant de médiation scientifique... Et pourtant, bien souvent la mission remplie est sensiblement identique d'un établissement à l'autre : le médiateur scientifique transmet aux publics des connaissances relatives aux sciences et facilite l'accès des visiteurs aux contenus exposés en présentant les informations scientifiques de manière attractive. Parallèlement à ces activités en présence du public, les médiateurs, selon les organismes, remplissent également des missions d'aide à la conception d'exposition, de gestion de projets, de communication... Deux des articles de la Lettre de l'OCIM sont consacrés à cette problématique avec un premier texte qui revient sur la création de l'Ecole de la médiation destinée à répondre aux besoins de formation des professionnels de ce secteur et un second qui présente les résultats d'une enquête menée auprès des médiateurs. Une réflexion concernant la diffusion des données libres sur les collections et la présentation d'un web-documentaire complètent un sommaire qui s'enrichit d'une nouvelle rubrique "Quoi de neuf ?" apparue en 2015 à l'occasion des 30 ans de l'OCIM et qui s'installe désormais durablement dans la revue. Serge Lochot, rédacteur en chef de la Lettre de l'OCIM

Ozone exposure triggers insulin resistance through muscle c-Jun N-terminal kinase activation

International audienceA growing body of evidence suggests that exposure to traffic-related air pollution is a risk factor for type 2 diabetes. Ozone, a major photochemical pollutant in urban areas, is negatively associated with fasting glucose and insulin levels, but most aspects of this association remain to be elucidated. Using an environmentally realistic concentration (0.8 parts per million), we demonstrated that exposure of rats to ozone induced whole-body insulin resistance and oxidative stress, with associated endoplasmic reticulum (ER) stress, c-Jun N-terminal kinase (JNK) activation, and disruption of insulin signaling in skeletal muscle. Bronchoalveolar lavage fluids from ozone-treated rats reproduced this effect in C2C12 myotubes, suggesting that toxic lung mediators were responsible for the phenotype. Pretreatment with the chemical chaperone 4-phenylbutyric acid, the JNK inhibitor SP600125, or the antioxidant N-acetylcysteine alleviated insulin resistance, demonstrating that ozone sequentially triggered oxidative stress, ER stress, and JNK activation to impair insulin signaling in muscle. This study is the first to report that ozone plays a causative role in the development of insulin resistance, suggesting that it could boost the development of diabetes. We therefore provide a potential mechanism linking pollutant exposure and the increased incidence of metabolic diseases

Coupling in vitro gastrointestinal lipolysis and Caco-2 cell cultures for testing the absorption of different food emulsions

International audienc