Reservoir dogs and the noir male : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Media Studies at Massey University

This thesis presents a study of the noir male - the protagonist from the body of films known as film noir The purpose of the study is to show that a composite of the noir male character can be found constructed in Quentin Tarantino's 1992 directorial debut, Reservoir Dogs. This is achieved through a comparative study of film noir theory, especially as it relates to the noir male character, and Reservoir Dogs and it's characters. There are three parts. First is the establishment of the theoretical approach of neoformalism, predominantly as defined by Kristin Thompson in her 1988 text, Breaking the Glass Armor: Neoformalist Film Analysis. The second part is an examination of the theory of film noir, in order to draw a clear picture of what constitutes the characteristics of the noir male and his supporting environment. This includes the origins of film noir and the noir male; visual style; the urban setting; chronology of noir, common themes; the femme fatale; the noir protagonist himself; and neo noir It is a premise of the thesis that the nature of the noir male is encapsulated in, and reflected by, the common components of film noir films. This premise is supported in the discussion. The third part is a reading of Reservoir Dogs, with a focus on the characters and their interaction with the film, and each other. This includes discussion of the social influences which mark the environment of noir, the popular culture influence; the way Reservoir Dogs and noir challenge the spectator; discussion of the chronological structure of Reservoir Dogs, the relationship of transgression, which characterizes the noir male's interaction with the femme fatale role; the urban setting, and the theme and mood of film noir Drawing together these parts it is possible to conclude that the characters of Reservoir Dogs, supported by the environment and relationships created in the film, form a composite representation of the noir male

New markers and linkage data

New markers and linkage dat

Domains of Need in a High Secure Hospital Setting:A Model for Streamlining Care and Reducing Length of Stay

There are financial and humanitarian consequences to unmet need amongst service users of high secure hospital care, not least in terms of length of stay. This article presents two reviews of high secure service user needs. They provide support for the sequencing of interventions to meet service user needs and the utility of a structured framework for their review. Through analyses of these reviews, eight domains of need were identified: Therapeutic Engagement, Risk Reduction, Education, Occupational, Mental Health Recovery, Physical Health Restoration, Cultural and Spiritual Needs, Care Pathway Management. A model is presented, within which logically sequenced, timely and relevant interventions could be framed in order to provide a comprehensive and streamlined pathway through a high secure hospital

5,5′-Bis[(trimethyl­silyl)meth­yl]-2,2′-bipyridine

The mol­ecule of the title compound, C18H28N2Si2, occupies a special position on an inversion centre. The Si—CH2—C(ipso) plane is approximately orthogonal to the plane of the pyridine rings, the corresponding dihedral angle being 82.0 (2)°

Assessing Impact of COVID-19 and the Early Impact of Minimum Pricing for Alcohol on the Wider Population of Drinkers

This report represents one of four on going studies commissioned by Welsh Government to evaluate Minimum Pricing of Alcohol legislation introduced into Wales in Mar 2020. This report focuses on the assessment of impact on the wider population of drinkers and presents findings from research conducted nine months post-implementation of MPA in Wales (the second wave of the evaluation). The findings provide an important account of the early impact of MPA on drinkers in the wider population as well as the impact of COVID-19 and lockdown

From secretome analysis to immunology: chitosan induces major alterations in the activation of dendritic cells via a TLR4-dependent mechanism

Dendritic cells are known to be activated by a wide range of microbial products, leading to cytokine production and increased levels of membrane markers such as major histocompatibility complex class II molecules. Such activated dendritic cells possess the capacity to activate na\"ive T cells. In the present study we demonstrated that immature dendritic cells secrete both the YM1 lectin and lipocalin-2. By testing the ligands of these two proteins, chitosan and siderophores, respectively, we also demonstrated that chitosan, a degradation product of various fungal and protozoal cell walls, induces an activation of dendritic cells at the membrane level, as shown by the up-regulation of membrane proteins such as class II molecules, CD80 and CD86 via a TLR4-dependent mechanism, but is not able to induce cytokine production. This led to the production of activated dendritic cells unable to stimulate T cells. However, costimulation with other microbial products overcame this partial activation and restored the capacity of these activated dendritic cells to stimulate T cells. In addition, successive stimulation with chitosan and then by lipopolysaccharide induced a dose-dependent change in the cytokinic IL-12/IL-10 balance produced by the dendritic cells

Pseudomonas aeruginosa pilin activates the inflammasome

IL-1 beta is produced from inactive pro-IL-1 beta by activation of caspase-1 brought about by a multi-subunit protein platform called the inflammasome. Many bacteria can trigger inflammasome activity through flagellin activation of the host protein NLRC4. However, strains of the common human pathogen Pseudomonas aeruginosa lacking flagellin can still activate the inflammasome. We set out to identify what non-flagellin components could produce this activation. Using mass spectroscopy, we identified an inflammasome-activating factor from P. aeruginosa as pilin, the major component of the type IV bacterial pilus. Purified pilin introduced into mouse macrophages by liposomal delivery activated caspase-1 and led to secretion of mature IL-1 beta, as did recombinant pilin purified from Escherichia coli. This was dependent on caspase-1 but not on the host inflammasome proteins NLRC4, NLRP3 or ASC. Mutants of P. aeruginosa strain PA103 lacking pilin did not activate the inflammasome following infection of macrophages with live bacteria. Type III secretion remained intact in the absence of pili, showing this was not due to a lack of effector delivery. Our observations show pilin is a novel activator of the inflammasome in addition to flagellin and the recently described PrgJ protein family, the basal body rod component of the type III apparatu

24-month Review of the Introduction of Minimum Pricing for Alcohol in Wales: Appendices

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24-Month Review of the Introduction of Minimum Pricing for Alcohol in Wales: Summary

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