SO(10) Cosmic Strings and SU(3) Color Cheshire Charge

Certain cosmic strings that occur in GUT models such as $SO(10)$ can carry a magnetic flux which acts nontrivially on objects carrying $SU(3)_{color}$ quantum numbers. We show that such strings are non-Abelian Alice strings carrying nonlocalizable colored ``Cheshire" charge. We examine claims made in the literature that $SO(10)$ strings can have a long-range, topological Aharonov-Bohm interaction that turns quarks into leptons, and observe that such a process is impossible. We also discuss flux-flux scattering using a multi-sheeted formalism.Comment: 37 Pages, 8 Figures (available upon request) phyzzx, iassns-hep-93-6, itp-sb-93-6

Averaged Methods for Vortex-String Evolution

We discuss friction-dominated vortex-string evolution using a new analytic model recently developed by the authors. By treating the average string velocity, as well as the characteristic lengthscale, as dynamical variables, we can provide a quantitative picture of the complete evolution of a vortex-string network. Previously known scaling laws are confirmed, and new quantitative predictions regarding loop production and evolution are made.Comment: REVTeX, 21 pages, 23 .eps files included. Submitted to Phys. Rev. B. Minor changes---but some key concepts clarifie

Cosmic Vortons and Particle Physics Constraints

We investigate the cosmological consequences of particle physics theories that admit stable loops of superconducting cosmic string - {\it vortons}. General symmetry breaking schemes are considered, in which strings are formed at one energy scale and subsequently become superconducting in a secondary phase transition at what may be a considerably lower energy scale. We estimate the abundances of the ensuing vortons, and thereby derive constraints on the relevant particle physics models from cosmological observations. These constraints significantly restrict the category of admissible Grand Unified theories, but are quite compatible with recently proposed effects whereby superconducting strings may have been formed close to the electroweak phase transition.Comment: 33 pages, 2 figures, RevTe

Baryon number violation, baryogenesis and defects with extra dimensions

In generic models for grand unified theories(GUT), various types of baryon number violating processes are expected when quarks and leptons propagate in the background of GUT strings. On the other hand, in models with large extra dimensions, the baryon number violation in the background of a string is not trivial because it must depend on the mechanism of the proton stabilization. In this paper we argue that cosmic strings in models with extra dimensions can enhance the baryon number violation to a phenomenologically interesting level, if the proton decay is suppressed by the mechanism of localized wavefunctions. We also make some comments on baryogenesis mediated by cosmological defects. We show at least two scenarios will be successful in this direction. One is the scenario of leptogenesis where the required lepton number conversion is mediated by cosmic strings, and the other is the baryogenesis from the decaying cosmological domain wall. Both scenarios are new and have not been discussed in the past.Comment: 20pages, latex2e, comments and references added, to appear in PR

Scattering from Electroweak Strings

The scattering of a charged fermion from an electroweak string is studied. Owing to an amplification of the wave function at the core radius, the cross sections for helicity flip processes can be largely enhanced. For $0 <\sin^2 \theta_w < 1/2$ (where $\theta_w$ is the Weinberg angle), $\omega \sim k \sim m_e$ and $kR \ll 1$, we show that the helicity flip differential cross section for electrons is of the order $m_e^{-1}$ and is independent of angle. We compare our results with those obtained in calculations of rates for baryon number violating processes in the core of a cosmic string. In that case, while the enhancement is a general phenomenon, its actual magnitude is extremely sensitive to the fractional flux carried by the string core. Apart from showing the existence of a similar enhancement effect for non-topological strings, our results indicate that in some models the magnitude of enhancement can be rendered much less sensitive to the value of the parameters in the theories. Scattering of particles off semi-local strings and axion strings are also considered.Comment: Replaced with revised version "Tex with phyzzx, 18 pages, CALT-68-1921 Non-trivial changes made: discussion on axion strings corrected. Overlap with a recently revised version of hep-ph/9311202 note

Overshadowing depends on cue and reinforcement sensitivity but not schizotypy

There is evidence for impaired selective learning mechanisms in individuals high in schizotypy. Overshadowing provides a direct test of selective learning based on cue salience and has previously been reported to be impaired in relation to schizotypy scores. The present study tested for overshadowing using food allergy and Lego construction task variants. Both variants used the same number of conditioned stimulus (CS) cues and the same number of learning trials. CS cues were trained in compound pairs or in isolation and overshadowing was subsequently tested on trials followed by negative versus positive outcomes. Participants also completed the O-LIFE to measure schizotypy and BIS-BAS scales to measure reinforcement sensitivity. Learning was demonstrated for both cue variants; however overshadowing emerged only in the Lego variant and only on the trials followed by the negative outcome. Contrary to expectations, there was no evidence for any relationship between overshadowing and O-LIFE scores. However, there was evidence of a positive relationship between overshadowing and BAS-Drive as well as a negative relationship with BIS-Anxiety, for the trials followed by the positive outcome in the food allergy variant. These results suggest that the development of overshadowing depends on cue and reinforcement sensitivity, but not necessarily on schizotypy

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

Mammalian carboxylesterase (CES or Ces) genes encode enzymes that participate in xenobiotic, drug, and lipid metabolism in the body and are members of at least five gene families. Tandem duplications have added more genes for some families, particularly for mouse and rat genomes, which has caused confusion in naming rodent Ces genes. This article describes a new nomenclature system for human, mouse, and rat carboxylesterase genes that identifies homolog gene families and allocates a unique name for each gene. The guidelines of human, mouse, and rat gene nomenclature committees were followed and “CES” (human) and “Ces” (mouse and rat) root symbols were used followed by the family number (e.g., human CES1). Where multiple genes were identified for a family or where a clash occurred with an existing gene name, a letter was added (e.g., human CES4A; mouse and rat Ces1a) that reflected gene relatedness among rodent species (e.g., mouse and rat Ces1a). Pseudogenes were named by adding “P” and a number to the human gene name (e.g., human CES1P1) or by using a new letter followed by ps for mouse and rat Ces pseudogenes (e.g., Ces2d-ps). Gene transcript isoforms were named by adding the GenBank accession ID to the gene symbol (e.g., human CES1_AB119995 or mouse Ces1e_BC019208). This nomenclature improves our understanding of human, mouse, and rat CES/Ces gene families and facilitates research into the structure, function, and evolution of these gene families. It also serves as a model for naming CES genes from other mammalian species

Addressing statistical biases in nucleotide-derived protein databases for proteogenomic search strategies

[Image: see text] Proteogenomics has the potential to advance genome annotation through high quality peptide identifications derived from mass spectrometry experiments, which demonstrate a given gene or isoform is expressed and translated at the protein level. This can advance our understanding of genome function, discovering novel genes and gene structure that have not yet been identified or validated. Because of the high-throughput shotgun nature of most proteomics experiments, it is essential to carefully control for false positives and prevent any potential misannotation. A number of statistical procedures to deal with this are in wide use in proteomics, calculating false discovery rate (FDR) and posterior error probability (PEP) values for groups and individual peptide spectrum matches (PSMs). These methods control for multiple testing and exploit decoy databases to estimate statistical significance. Here, we show that database choice has a major effect on these confidence estimates leading to significant differences in the number of PSMs reported. We note that standard target:decoy approaches using six-frame translations of nucleotide sequences, such as assembled transcriptome data, apparently underestimate the confidence assigned to the PSMs. The source of this error stems from the inflated and unusual nature of the six-frame database, where for every target sequence there exists five “incorrect” targets that are unlikely to code for protein. The attendant FDR and PEP estimates lead to fewer accepted PSMs at fixed thresholds, and we show that this effect is a product of the database and statistical modeling and not the search engine. A variety of approaches to limit database size and remove noncoding target sequences are examined and discussed in terms of the altered statistical estimates generated and PSMs reported. These results are of importance to groups carrying out proteogenomics, aiming to maximize the validation and discovery of gene structure in sequenced genomes, while still controlling for false positives

New Zealand blackcurrant extract enhances fat oxidation during prolonged cycling in endurance-trained females.

PURPOSE: New Zealand blackcurrant (NZBC) extract has previously been shown to increase fat oxidation during prolonged exercise, but this observation is limited to males. We examined whether NZBC intake also increases fat oxidation during prolonged exercise in females, and whether this was related to greater concentrations of circulating fatty acids. METHODS: In a randomised, crossover, double-blind design, 16 endurance-trained females (age: 28 ± 8 years, BMI: 21.3 ± 2.1 kg·m-2, VO2max: 43.7 ± 1.1 ml·kg-1·min-1) ingested 600 mg·day-1NZBC extract (CurraNZ™) or placebo (600 mg·day-1microcrystalline cellulose) for 7 days. On day 7, participants performed 120 min cycling at 65% VO2max, using online expired air sampling with blood samples collected at baseline and at 15 min intervals throughout exercise for analysis of glucose, NEFA and glycerol. RESULTS: NZBC extract increased mean fat oxidation by 27% during 120 min moderate-intensity cycling compared to placebo (P = 0.042), and mean carbohydrate oxidation tended to be lower (P = 0.063). Pre-exercise, plasma NEFA (P = 0.034) and glycerol (P = 0.051) concentrations were greater following NZBC intake, although there was no difference between conditions in the exercise-induced increase in plasma NEFA and glycerol concentrations (P > 0.05). Mean fat oxidation during exercise was moderately associated with pre-exercise plasma NEFA concentrations (r = 0.45, P = 0.016). CONCLUSIONS: Intake of NZBC extract for 7 days elevated resting concentrations of plasma NEFA and glycerol, indicative of higher lipolytic rates, and this may underpin the observed increase in fat oxidation during prolonged cycling in endurance-trained females

OSIRIS-REx Contamination Control Strategy and Implementation

OSIRIS-REx will return pristine samples of carbonaceous asteroid Bennu. This manuscript describes how pristine was defined based on expectations of Bennu and on a realistic understanding of what is achievable with a constrained schedule and budget, and how that definition flowed to requirements and implementation. To return a pristine sample, the OSIRIS-REx spacecraft sampling hardware was maintained at Level 100 A/2 and less than 180 nanograms per square centimeter of amino acids and hydrazine on the sampler head through precision cleaning, control of materials, and vigilance. Contamination is further characterized via witness material exposed to the spacecraft assembly and testing environment as well as in space. This characterization provided knowledge of the expected background and will be used in conjunction with archived spacecraft components for comparison with the samples when they are delivered to Earth for analysis. Most of all, the cleanliness of the OSIRIS-REx spacecraft was achieved through communication between scientists, engineers, managers, and technicians