Field Trials for the Empirical Characterization of the Low Voltage Grid Access Impedance From 35 kHz to 500 kHz

The access impedance of low-voltage (LV) power networks is a major factor related to the performance of the narrow-band power line communications (NB-PLCs) and, in a wider sense, to electromagnetic compatibility (EMC) performance. Up to date, there is still a lack of knowledge about the frequency-dependent access impedance for frequencies above 9 kHz and up to 500 kHz, which is the band where the NB-PLC operates. The access impedance affects the transmission of the NB-PLC signal, and it determines the propagation of the non-intentional emissions that may disturb other electrical devices, including malfunctioning or reduced lifetime of equipment. This paper presents the results of field measurements of the LV access impedance up to 500 kHz in different scenarios, with measurement locations close to end users and near transformers. The results provide useful information to analyze the characteristics of the LV access impedance, including variation with frequency, ranges of values for different frequency bands, and analysis of specific phenomena. Moreover, the results reveal a diverse frequency-dependent behavior of the access impedance in different scenarios, depending on the grid topology, the number of end users (that is, number and type of connected loads), and the type of transformation center. Overall, the results of this paper offer a better understanding of the transmission of NB-PLC signals and EMC-related phenomena.The authors would like to thank Iberdrola for the availability and the collaboration of authorized staff for carrying out the field trials

Baseline characteristics of severe asthma patients initiating biologic treatment worldwide

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Cri-du-chat syndrome mimics Silver-Russell syndrome depending on the size of the deletion: a case report

BackgroundSilver-Russell Syndrome (SRS) is a rare growth-related genetic disorder mainly characterized by prenatal and postnatal growth failure. Although molecular causes are not clear in all cases, the most common mechanisms involved in SRS are loss of methylation on chromosome 11p15 (approximate to 50%) and maternal uniparental disomy for chromosome 7 (upd(7)mat) (approximate to 10%).Case presentationWe present a girl with clinical suspicion of SRS (intrauterine and postnatal growth retardation, prominent forehead, triangular face, mild psychomotor delay, transient neonatal hypoglycemia, mild hypotonia and single umbilical artery). Methylation and copy number variations at chromosomes 11 and 7 were studied by methylation-specific multiplex ligation-dependent probe amplification and as no alterations were found, molecular karyotyping was performed. A deletion at 5p15.33p15.2 was identified (arr[GRCh37] 5p15.33p15.2(25942-11644643)x1), similar to those found in patients with Cri-du-chat Syndrome (CdCS). CdCS is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-), whose main feature is a high-pitched mewing cry in infancy, accompanied by multiple congenital anomalies, intellectual disability, microcephaly and facial dysmorphism.ConclusionsThe absence of some CdCS features in the current patient could be due to the fact that in her case the critical regions responsible do not lie within the identified deletion. In fact, a literature review revealed a high degree of concordance between the clinical manifestations of the two syndromes.The costs of the publication and molecular analyses of this research were funded by grants from Instituto de Salud Carlos III (Institute of Health Carlos III) of the Spanish Ministry of Economy and Competitiveness, co-financed by the European Regional Development Fund (PI16/00073), the Department of Health of the Basque Government (GV2016111105; GV2017111040), and the University of the Basque Country UPV/EHU (PIF17/29)

Clinical Characteristics of Patients with Severe Asthma by Different Elevated Biomarkers Classifications : patients from Spain in the ISAR Registry

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Baseline disease burden in severe asthma patients treated with biologics, and eligible but not treated : Spanish patients in the ISAR Registry

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Rapidly progressive Bronchiolitis Obliterans Organising Pneumonia presenting with pneumothorax, persistent air leak, acute respiratory distress syndrome and multi-organ dysfunction: a case report

<p>Abstract</p> <p>Introduction</p> <p>Bronchiolitis Obliterans Organising Pneumonia (BOOP) may often present initially as a recurrent spontaneous pneumothorax and then develop multi-system complications.</p> <p>Case presentation</p> <p>A 17-year-old boy presented with a pneumothorax, which developed into rapidly progressive Bronchiolitis Obliterans Organising Pneumonia (BOOP). He developed multi-organ dysfunction (including adult respiratory distress syndrome, oliguric renal failure, acute coronary syndrome, cardiac failure and a right atrial thrombus) which necessitated prolonged intensive care. Diagnosis was confirmed on open lung biopsy and he responded well to treatment with corticosteroids.</p> <p>Conclusion</p> <p>BOOP is exquisitely sensitive to oral corticosteroids but if the diagnosis is not considered in such patients and appropriate treatment instituted early, BOOP may often lead to prolonged hospital admission with considerable morbidity.</p

Asthma phenotyping in primary care : applying the International Severe Asthma Registry eosinophil phenotype algorithm across all asthma severities.

Funding: The OPCRD is established and maintained by Optimum Patient Care (OPC) Ltd. This study was funded by AstraZeneca and conducted collaboratively with the OPRI Pte Ltd and OPC Global Ltd. Acknowledgements We thank James Zangrilli, MD, and the entire ISAR Steering Committee for their valued contribution to the design of the study and interpretation of findingsPeer reviewedPublisher PD

Mejora de estabilidad vertical con fijador externo pre-tensado: un estudio biomecánico en modelo sintético con fractura pélvica inestable tipo Tile C

En el tratamiento de emergencia de las fracturas del anillo pélvico, los fijadores externos convencionales no consiguen producir compresión en los elementos óseos posteriores ni dar estabilidad suficiente en fracturas verticalmente inestables. El fijador externo pretensado diseñado por nuestro equipo produce compresión en todo el anillo pélvico, dotándolo de potencial para mejorar el cierre del anillo fracturado y su estabilidad vertical. El objetivo de este trabajo es comprobar si la aplicación de fijación externa mediante barra curva de fibra de carbono conectada a clavos de Schanz supra-acetabulares mejora la estabilidad del anillo pélvico con lesión tipo Tile C1.2 cuando se realiza el montaje con la barra pretensada que con el montaje estándar.Sociedad Española de Cirugía Ortopédica y Traumatología (SECOT). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Cluster analysis of inflammatory biomarker expression in the International Severe Asthma Registry (ISAR)

Funding: ISAR is conducted by Optimum Patient Care Global Ltd, and co-funded by OPC Global Ltd and AstraZeneca.Peer reviewedPublisher PD

DNA Status on Thawed Semen from Fighting Bull: A Comparison Between the SCD and the SCSA Tests

P. 424-431The assessment of sperm chromatin status is compulsory in a complete spermiogram. Here we applied the sperm chromatin structure assay (SCSA) and the sperm chromatin dispersion (SCD) test to assess the chromatin status of three fighting bulls. Cryopreserved semen (two straws/bull) were analysed by duplicate after thawing and after 6 h at 37°C with and without oxidative stress (1 mm FE2+). Results (SCD: percentage of spermatozoa with halo; SCSA: SD‐DFI, %DFI and HDS) were analysed for differences between bulls and treatments, sensitivity and specificity (receiver operating characteristic curves) and repeatability (repeatability coefficients as 2SD of duplicate differences).%DFI for the three bulls was below 2% at 0 h, indicating no risk for fertility according to previous reports. It increased slightly for two of the bulls after FE2+ treatment (%DFI < 5%) and more pronouncedly for the other bull (C, %DFI∼10%), which merits further investigation. SCD rendered higher percentage of halos for bull C, but could not discriminate between samples with and without oxidizing treatment (AUC: 0.52). SCSA (%DFI) showed a high discriminating ability between treatments (AUC: 0.96). The repeatability coefficient was also higher for SCD (5.9) than for %DFI (1.8), indicating lower repeatability for SCD. Overall, %DFI might be the most useful parameter for assessing sperm chromatin on fighting bull. SCD might yield different information than SCSA, hence further research is warranted.S