The Cost of Integration: Grounding the Integration Debate in Black Experience

This thesis joins the dialogue in political philosophy about the potential necessity for residential integration of poor urban Black people in the U.S. into whiter neighborhoods to correct for injustices (historical and contemporary). Specifically, this thesis examines the disagreement between Tommie Shelby and Elizabeth Anderson over whether residential integration based on race is a requirement of justice. I contribute to their debate by grounding it in the lived experience of Black people, as filtered through a racially sensitive phenomenological framework. I do this by remembering and calling forth the voice of bell hooks, who was forced to shoulder the cost of school integration efforts as a child. I use Sara Ahmed’s phenomenological account of whiteness to illustrate that the costs of integration which bell hooks faced decades ago remain relevant and have important implications for any contemporary residential integration efforts

Asynchronous processing for latent fingerprint identification on heterogeneous CPU-GPU systems

Latent fingerprint identification is one of the most essential identification procedures in criminal investigations. Addressing this task is challenging as (i) it requires analyzing massive databases in reasonable periods and (ii) it is commonly solved by combining different methods with very complex data-dependencies, which make fully exploiting heterogeneous CPU-GPU systems very complex. Most efforts in this context focus on improving the accuracy of the approaches and neglect reducing the processing time. Indeed, the most accurate approach was designed for one single thread. This work introduces the fastest methodology for latent fingerprint identification maintaining high accuracy called Asynchronous processing for Latent Fingerprint Identification (ALFI). ALFI fully exploits all the resources of CPU-GPU systems using asynchronous processing and fine-coarse parallelism for analyzing massive databases. Our approach reduces idle times in processing and exploits the inherent parallelism of comparing latent fingerprints to fingerprint impressions. We analyzed the performance of ALFI on Linux and Windows operating systems using the well-known NIST/FVC databases. Experimental results reveal that ALFI is in average 22x faster than the state-of-the-art algorithm, reaching a value of 44.7x for the best-studied case

A broadened scope for the use of hydrazones as neutral nucleophiles in the presence of H-bonding organocatalysts

Using thioureas as H-bonding organocatalysts, nitroalkenes can be activated for the conjugate addition of hydrazones as neutral nucleophiles. Formaldehyde derivatives react at the azomethine carbon as expected, whereas hydrazones from enolizable aldehydes behave as ene-hydrazines and react at the α-carbon instead. Ionic liquids were found to decrease the reaction times considerably compared to commonly used solvents, whereas alternative activation by Lewis acids resulted in decomposition of reactants

Transverse ratchet effect and superconducting vortices: simulation and experiment

A transverse ratchet effect has been measured in magnetic/ superconducting hybrid films fabricated by electron beam lithography and magnetron sputtering techniques. The samples are Nb films grown on top of an array of Ni nanotriangles. Injecting an ac current parallel to the triangle reflection symmetry axis yields an output dc voltage perpendicular to the current, due to a net motion of flux vortices in the superconductor. The effect is reproduced by numerical simulations of vortices as Langevin particles with realistic parameters. Simulations provide an intuitive picture of the ratchet mechanism, revealing the fundamental role played by the random intrinsic pinning of the superconductor

New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.

Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures that may cause pain and infectious complications. Considering the limitations of both procedures, and the recurrence and resistance to BC treatment, it is necessary to develop a new non-invasive methodology for early diagnosis and multiple evaluations in patients under follow-up for bladder cancer. In recent years, liquid biopsy has proven to be a very useful diagnostic tool for the detection of tumor biomarkers. This non-invasive technique makes it possible to analyze single tumor components released into the peripheral circulation and to monitor tumor progression. Numerous biomarkers are being studied and interesting clinical applications for these in BC are being presented, with promising results in early diagnosis, detection of microscopic disease, and prediction of recurrence and response to treatment

High-pressure theoretical and experimental study of HgWO4

This is an Author's Accepted Manuscript of an article published in Lopez-Solano, J.; Rodriguez-Hernandez, P.; Muñoz, A.; Santamaria-Perez, D. et al.(2011). High-pressure theoretical and experimental study of HgWO4. High Pressure Research. 31(1):58-63. doi:10.1080/08957959.2010.521735HgWO 4 at ambient pressure is characterized using a combination of ab initio calculations, X-ray diffraction and Raman scattering measurements. The effect of low pressure and temperature on the structural stability is analysed. Extending our ab initio study to the range of higher pressures, a sequence of stable phases up to 30GPa is proposed. © 2011 Taylor & Francis.We thank J.M. Menendez for his help in the use of the GIBBS code. This work has been supported by the Spanish MEC under Projects MAT2007-65990-C03-01/03, MAT2010-21270-C04-03/04 and CSD-2007-00045 and by the "Vicerrectorado de Innovacion y Desarrollo de la UPV" (PAID-05-2009 through project UPV2010-0096). We gratefully acknowledge computational time provided by the "Red Espanola de Supercomputacion" at the supercomputer "Atlante". S. R. acknowledges financial support from the "Vicerrectorado de Investigacion de la UPV" through grant PAID-02-09-3085.Lopez-Solano, J.; Rodriguez-Hernandez, P.; Muñoz, A.; Santamaria-Perez, D.; Manjón Herrera, FJ.; Ray, S.; Gomis Hilario, O.... (2011). High-pressure theoretical and experimental study of HgWO4. High Pressure Research. 31(1):58-63. https://doi.org/10.1080/08957959.2010.521735S5863311Manjón, F. J., & Errandonea, D. (2009). Pressure-induced structural phase transitions in materials and earth sciences. physica status solidi (b), 246(1), 9-31. doi:10.1002/pssb.200844238Errandonea, D., Manjón, F. J., Garro, N., Rodríguez-Hernández, P., Radescu, S., Mujica, A., … Tu, C. Y. (2008). Combined Raman scattering andab initioinvestigation of pressure-induced structural phase transitions in the scintillatorZnWO4. Physical Review B, 78(5). doi:10.1103/physrevb.78.054116Ruiz-Fuertes, J., López-Moreno, S., Errandonea, D., Pellicer-Porres, J., Lacomba-Perales, R., Segura, A., … González, J. (2010). High-pressure phase transitions and compressibility of wolframite-type tungstates. Journal of Applied Physics, 107(8), 083506. doi:10.1063/1.3380848Lacomba-Perales, R., Errandonea, D., Martinez-Garcia, D., Rodríguez-Hernández, P., Radescu, S., Mujica, A., … Polian, A. (2009). Phase transitions in wolframite-typeCdWO4at high pressure studied by Raman spectroscopy and density-functional theory. Physical Review B, 79(9). doi:10.1103/physrevb.79.094105Manjón, F. J., López-Solano, J., Ray, S., Gomis, O., Santamaría-Pérez, D., Mollar, M., … Muñoz, A. (2010). High-pressure structural and lattice dynamical study ofHgWO4. Physical Review B, 82(3). doi:10.1103/physrevb.82.035212Kresse, G., & Hafner, J. (1993). Ab initiomolecular dynamics for liquid metals. Physical Review B, 47(1), 558-561. doi:10.1103/physrevb.47.558Kresse, G., & Furthmüller, J. (1996). Efficient iterative schemes forab initiototal-energy calculations using a plane-wave basis set. Physical Review B, 54(16), 11169-11186. doi:10.1103/physrevb.54.11169Blöchl, P. E. (1994). Projector augmented-wave method. Physical Review B, 50(24), 17953-17979. doi:10.1103/physrevb.50.17953Perdew, J. P., Ruzsinszky, A., Csonka, G. I., Vydrov, O. A., Scuseria, G. E., Constantin, L. A., … Burke, K. (2008). Restoring the Density-Gradient Expansion for Exchange in Solids and Surfaces. Physical Review Letters, 100(13). doi:10.1103/physrevlett.100.136406Monkhorst, H. J., & Pack, J. D. (1976). Special points for Brillouin-zone integrations. Physical Review B, 13(12), 5188-5192. doi:10.1103/physrevb.13.5188Blanco, M. A., Francisco, E., & Luaña, V. (2004). GIBBS: isothermal-isobaric thermodynamics of solids from energy curves using a quasi-harmonic Debye model. Computer Physics Communications, 158(1), 57-72. doi:10.1016/j.comphy.2003.12.001Kresse, G., Furthmüller, J., & Hafner, J. (1995). Ab initioForce Constant Approach to Phonon Dispersion Relations of Diamond and Graphite. Europhysics Letters (EPL), 32(9), 729-734. doi:10.1209/0295-5075/32/9/005Wahl, R., Vogtenhuber, D., & Kresse, G. (2008). SrTiO3andBaTiO3revisited using the projector augmented wave method: Performance of hybrid and semilocal functionals. Physical Review B, 78(10). doi:10.1103/physrevb.78.104116Jeitschko, W., & Sleight, A. W. (1973). The crystal structure of HgMoO4 and related compounds. Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry, 29(4), 869-875. doi:10.1107/s056774087300347

Informe técnico de experiencias d fertilización en el cultivo de maíz_Campaña 2020-2021

Este informe, corresponde a una Investigación Participativa del cual participaron INTA (AER de General Acha, EEA Anguil) una empresa privada (Spraytec) y productores de la zona de la localidad de Quehué. El objetivo fue evaluar la respuesta en rendimiento del cultivo de maíz a la aplicación de diferentes fuentes de fertilización.EEA AnguilFil: Leonhardt, Diego Armando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil. Agencia De Extensión Rural General Acha; ArgentinaFil: Herrera, Estela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil. Agencia De Extensión Rural General Acha; ArgentinaFil: Angolani, Daniel Hugo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil. Agencia De Extensión Rural General Acha; ArgentinaFil: Kloster, Nanci Soledad. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: Perez, Maria Micaela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: Fernandez, Romina. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; Argentin

VE-Cadherin modulates ß-catenin/TCF-4 to enhance Vasculogenic Mimicry

Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment failure. In a previous study, we demonstrated that VE-Cadherin and its phosphorylation at Y658 modulated kaiso-dependent gene expression (CCND1 and Wnt 11) through a pathway involving Focal Adhesion kinase (FAK). In the present research, using a proteomic approach, we have found that ß-catenin/TCF-4 is associated with nuclear VE-cadherin and enhances the capacity of malignant melanoma cells to undergo VM in cooperation with VE-Cadherin; in addition, preventing the phosphorylation of Y658 of VEcadherin upon FAK disabling resulted in VE-Cadherin/ß-catenin complex dissociation, increased ß-catenin degradation while reducing TCF-4-dependent genes transcription (C-Myc and Twist-1). Uveal melanoma cells knockout for VE-Cadherin loses ß-catenin expression while the rescue of VE-Cadherin (but not of the phosphorylation defective VE-Cadherin Y658F mutant) permits stabilization of ß-catenin and tumor growth reduction in vivo experiments. In vivo, the concomitant treatment with the FAK inhibitor PF-271 and the anti-angiogenic agent bevacizumab leads to a strong reduction in tumor growth concerning the single treatment. In conclusion, the anomalous expression of VE-Cadherin in metastatic melanoma cells (from both uveal and cutaneous origins), together with its permanent phosphorylation at Y658, favors the induction of the aggressive VM phenotype through the cooperation of ß-catenin with VE-Cadherin and by enhancing TCF-4 genes-dependent transcription.This work was supported by grants from the Spanish Ministry of Economy and Competitiveness SAF2015-70520-R, the Spanish Ministry of Science and Technology RTI2018-098968-B-I00, CIBERONC ISCIII CB16/12/00421 and Junta de Andalucía, a project of Excellence from Junta de Andalucía P10-CTS-0662, P12-CTS-383 to FJO. Fundación Domingo Martínez to FJO. Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía (PAIDI 2020, POSTDOC_21_00865) to DD-B. Fundación Getthi ONC18PE01/2022 to DAE, AT

Hallazgos Paleontológicos en la Formación Chorrillo (Campaniano-Maastrichtiano, Cretácico Superior), Provincia de Santa Cruz, Patagonia, Argentina

The first fossil remains of vertebrates, invertebrates, plants and palynomorphs of the Chorrillo Formation (Austral Basin), about 30km to the SW of the town of El Calafate (Province of Santa Cruz), are described. Fossils include the elasmarian (basal Iguanodontia) Isasicursor santacrucensis gen. et sp. nov., the large titanosaur Nullotitan glaciaris gen. et sp. nov., both large and small Megaraptoridae indet., and fragments of sauropod and theropod eggshells. The list of vertebrates is also composed by the Neognathae Kookne yeutensis gen. et sp. nov., two isolated caudal vertebrae of Mammalia indet., and isolated teeth of a large mosasaur. Remains of fishes, anurans, turtles, and snakes are represented by fragmentary material of low taxonomical value, with the exception of remains belonging to Calyptocephalellidae. On the other hand, a remarkable diversity of terrestrial and freshwater gastropods has been documented, as well as fossil woods and palinological assemblages. The Chorrillo Formation continues south, in the Las Chinas River valley, southern Chile, where it is called Dorotea Formation. Both units share in their lower two thirds abundant materials of titanosaurs, whose remains cease to appear in the upper third, registering only elasmarians (Chorrillo Formation) and hadrosaurs (Dorotea Formation). Above both units there are levels with remains of invertebrates and marine reptiles. It is striking that the dinosaurs of the lower two thirds of the Chorrillo and Dorotea formations are represented by large basal titanosaurs and Megaraptoridae coelurosaurs, being the Saltasaurinae and Aeolosaurinae sauropods and Abelisauridae theropods totally absent. In contrast, these taxa are dominant components in sedimentary units of central and northern Patagonia (e.g., Allen, Los Alamitos, La Colonia formations). Such differences could reflect, in part, a greater antiquity (i.e., late Campanian-early Maastrichtian) for the Chorrillo fossils, or, more probably, different environmental conditions. Thus, knowledge of the biota of the southern tip of Patagonia is expanded, particularly those temporarily close to the K-Pg boundary.Fil: Novas, Fernando Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Agnolin, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentina. Universidad Maimónides; Argentina. Fundación de Historia Natural Félix de Azara; ArgentinaFil: Rozadilla, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Aranciaga Rolando, Alexis Mauro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Brissón Egli, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Motta, Matias Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Cerroni, Mauricio Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Ezcurra, Martin Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Martinelli, Agustín Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: D'angelo, Julia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Alvarez Herrera, Gerardo Paulino. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Gentil, Adriel Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Bogan, Sergio. Universidad Maimónides; ArgentinaFil: Chimento, Nicolás Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: García Marsa, Jordi Alexis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Lo Coco, Gastón Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Miquel, Sergio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Brito, Fátima Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Vera, Ezequiel Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; Argentina. Universidad de Buenos Aires; ArgentinaFil: Perez Loinaze, Valeria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Fernández, Mariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Salgado, Leonardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigación en Paleobiología y Geología; Argentina. Universidad Nacional de Río Negro; Argentin