Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation.

PurposeTo report two cases of neurotrophic keratitis (NK) after micropulse transscleral cyclophotocoagulation (MP-TCP).ObservationsTwo patients with predisposing factors for decreased corneal sensation developed NK 1 month after MP-TCP. Both patients did not heal with initial treatment with topical antibiotic and preservative free artificial tears. One patient required use of a bandage contact lens and the other patient required tarsorrhaphy. Both eyes experienced recurrence of NK.Conclusions and importanceNK can be triggered after MP-TCP in patients with underlying predisposing factors for decreased corneal sensation. This uncommon but vision-threatening complication should be discussed preoperatively with high-risk patients as a possible adverse event after MP-TCP and followed closely postoperatively

Digitalization and real-time control to mitigate environmental impacts along rivers: Focus on artificial barriers, hydropower systems and European priorities

Hydropower globally represents the main source of renewable energy, and provides several benefits, e.g., water storage and flexibility; on the other hand, it may cause significant impacts on the environment. Hence sustainable hydropower needs to achieve a balance between electricity generation, impacts on ecosystems and benefits on society, supporting the achievement of the Green Deal targets. The implementation of digital, information, communication and control (DICC) technologies is emerging as an effective strategy to support such a trade-off, especially in the European Union (EU), fostering both the green and the digital transitions. In this study, we show how DICC can foster the environmental integration of hydropower into the Earth spheres, with focus on the hydrosphere (e.g., on water quality and quantity, hydropeaking mitigation, environmental flow control), biosphere (e.g., improvement of riparian vegetation, fish habitat and migration), atmosphere (reduction of methane emissions and evaporation from reservoirs), lithosphere (better sediment management, reduction of seepages), and on the anthroposphere (e.g., reduction of pollution associated to combined sewer overflows, chemicals, plastics and microplastics). With reference to the abovementioned Earth spheres, the main DICC applications, case studies, challenges, Technology Readiness Level (TRL), benefits and limitations, and transversal benefits for energy generation and predictive Operation and Maintenance (O&M), are discussed. The priorities for the European Union are highlighted. Although the paper focuses primarly on hydropower, analogous considerations are valid for any artificial barrier, water reservoir and civil structure which interferes with freshwater systems.Digitalization and real-time control to mitigate environmental impacts along rivers: Focus on artificial barriers, hydropower systems and European prioritiespublishedVersio

Numerical indications on the semiclassical limit of the flipped vertex

We introduce a technique for testing the semiclassical limit of a quantum gravity vertex amplitude. The technique is based on the propagation of a semiclassical wave packet. We apply this technique to the newly introduced "flipped" vertex in loop quantum gravity, in order to test the intertwiner dependence of the vertex. Under some drastic simplifications, we find very preliminary, but surprisingly good numerical evidence for the correct classical limit.Comment: 4 pages, 8 figure

Asymptotics of LQG fusion coefficients

The fusion coefficients from SO(3) to SO(4) play a key role in the definition of spin foam models for the dynamics in Loop Quantum Gravity. In this paper we give a simple analytic formula of the EPRL fusion coefficients. We study the large spin asymptotics and show that they map SO(3) semiclassical intertwiners into $SU(2)_L\times SU(2)_R$ semiclassical intertwiners. This non-trivial property opens the possibility for an analysis of the semiclassical behavior of the model.Comment: 14 pages, minor change

Introgression of peanut smut resistance from landraces to elite peanut cultivars (\u3ci\u3eArachis hypogaea\u3c/i\u3e L.)

Smut disease caused by the fungal pathogen Thecaphora frezii Carranza & Lindquist is threatening the peanut production in Argentina. Fungicides commonly used in the peanut crop have shown little or no effect controlling the disease, making it a priority to obtain peanut varieties resistant to smut. In this study, recombinant inbred lines (RILs) were developed from three crosses between three susceptible peanut elite cultivars (Arachis hypogaea L. subsp. hypogaea) and two resistant landraces (Arachis hypogaea L. subsp. fastigiata Waldron). Parents and RILs were evaluated under high inoculum pressure (12000 teliospores g-1 of soil) over three years. Disease resistance parameters showed a broad range of variation with incidence mean values ranging from 1.0 to 35.0% and disease severity index ranging from 0.01 to 0.30. Average heritability (h2) estimates of 0.61 to 0.73 indicated that resistance in the RILs was heritable, with several lines (4 to 7 from each cross) showing a high degree of resistance and stability over three years. Evidence of genetic transfer between genetically distinguishable germplasm (introgression in a broad sense) was further supported by simple-sequence repeats (SSRs) and Insertion/Deletion (InDel) marker genotyping. This is the first report of smut genetic resistance identified in peanut landraces and its introgression into elite peanut cultivars

Severe Hypoalbuminemia at Day 90 Predicts Worse Nonrelapse Mortality and Overall Survival after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome

Because patients who undergo allogeneic hematopoietic cell transplantation (allo-HCT) remain in the vicinity of the transplant center for approximately 90 days posttransplantation, identifying prognostic factors to determine those at immediate higher risk of mortality is essential. A normal serum albumin level generally denotes healthiness. We evaluated the prognostic significance of day 90 hypoalbuminemia (and other clinical, pharmacologic, and laboratory variables) in 163 patients, median age 48 years (range, 19-69 years), who underwent allo-HCT for acute myelogenous leukemia (n = 124) or myelodysplastic syndrome (n = 39). Day 90 hypoalbuminemia (serum albumin <3.0 g/dL) was associated with worse nonrelapse mortality (NRM) and poor overall survival (OS). The estimated 1- and 2-year cumulative incidence rates of NRM were 48% and 52%, respectively, and the corresponding OS rates were 7% and 3%. Serum albumin level <3.0 g/dL and Karnofsky score <80 at day 90 were strong independent predictors of worse NRM and OS in multivariate analysis. These results support day 90 hypoalbuminemia as an adverse prognostic marker for NRM and OS after allo-HCT for acute myelogenous leukemia and myelodysplastic syndrome

Triadin/Junctin Double Null Mouse Reveals a Differential Role for Triadin and Junctin in Anchoring CASQ to the jSR and Regulating Ca2+ Homeostasis

Triadin (Tdn) and Junctin (Jct) are structurally related transmembrane proteins thought to be key mediators of structural and functional interactions between calsequestrin (CASQ) and ryanodine receptor (RyRs) at the junctional sarcoplasmic reticulum (jSR). However, the specific contribution of each protein to the jSR architecture and to excitation-contraction (e-c) coupling has not been fully established. Here, using mouse models lacking either Tdn (Tdn-null), Jct (Jct-null) or both (Tdn/Jct-null), we identify Tdn as the main component of periodically located anchors connecting CASQ to the RyR-bearing jSR membrane. Both proteins proved to be important for the structural organization of jSR cisternae and retention of CASQ within them, but with different degrees of impact. Our results also suggest that the presence of CASQ is responsible for the wide lumen of the jSR cisternae. Using Ca2+ imaging and Ca2+ selective microelectrodes we found that changes in e-c coupling, SR Ca2+content and resting [Ca2+] in Jct, Tdn and Tdn/Jct-null muscles are directly correlated to the effect of each deletion on CASQ content and its organization within the jSR. These data suggest that in skeletal muscle the disruption of Tdn/CASQ link has a more profound effect on jSR architecture and myoplasmic Ca2+ regulation than Jct/CASQ association

Long-Term IGF-I Exposure Decreases Autophagy and Cell Viability

A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been found to have protective effects against multiple forms of damage in acute settings. The increase in longevity seen in response to reduced IGF-I signaling suggests that there may be differences between the acute and chronic impact of IGF-I signaling. We have examined the possibility that long-term stimulation with IGF-I may have a negative impact at the cellular level using quiescent human fibroblasts. We find that fibroblast cells exposed to IGF-I for 14 days have reduced long-term viability as judged by colony forming assays, which is accompanied by an accumulation of senescent cells. In addition we observe an accumulation of cells with depolarized mitochondria and a reduction in autophagy in the long-term IGF-I treated cultures. An examination of mice with reduced IGF-I levels reveals evidence of enhanced autophagy and fibroblast cells derived from these mice have a larger mitochondrial mass relative to controls indicating that changes in mitochondrial turnover occurs in animals with reduced IGF-I. The results indicate that chronic IGF-I stimulation leads to mitochondrial dysfunction and reduced cell viability

Integración de los paneles de vuelo del satélite Cubebug-1

Se describe la integración de los paneles de vuelo de la misión satelital CUBEBUG-1. Éstos se integraron a partir de un convenio firmado entre la CNEA y la empresa DISARMISTA SRL para la integración de 6 módulos solares de esta misión satelital. Los paneles están constituidos por 3 módulos con 2 subcadenas conectadas en serie y 3 módulos de una subcadena cada uno Estos módulos se realizaron con celdas de de triple juntura (ATJ) marca EMCORE de descarte Se presentan los parámetros eléctricos más relevantes de las celdas utilizadas y las verificaciones funcionales que se realizaron luego de la integración de los paneles.The integration of flight solar panels of CUBEBUG-1 satellital mission is presented. This panels has been integrated from a agreement between CNEA and DISARMISTA SRL for the integration of 6 flight solar panels for CUBEBUG-1 satellital mission. The panels integration has been done using substrings of 2 solar cells connected in series, the cells used was from EMCORE advance triple junction (ATJ) non flight solar cells. The panels itself, are constituted for 3 modules with 2 substrings connected in series and 3 modules with one substring each one. The solar cells relevant electrical parameters and the curves of functional verifications after the integration are presented.Fil: Bolzi, Claudio Gustavo. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Bruno, C. J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Cabot, P.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Carella, E.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Di Santo, J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Duran, Julio Cesar. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Fernández Vázquez, J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Godfrin, Elena María. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Goldbeck, V.. Comision Nacional de Energia Atomica. Centro Atomico Constituyentes. Departamento de Materiales; ArgentinaFil: Gonzalez, L.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Moglioni, A.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Muñoz, S.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Olima, José María. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Plá, Juan Francisco Esteban. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, J. I.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Raggio, D.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Socolovsky, Hernan Pablo. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Tamasi, Mariana Julia Luisa. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Integración de los paneles de vuelo del satélite Cubebug-1

Se describe la integración de los paneles de vuelo de la misión satelital CUBEBUG-1. Éstos se integraron a partir de un convenio firmado entre la CNEA y la empresa DISARMISTA SRL para la integración de 6 módulos solares de esta misión satelital. Los paneles están constituidos por 3 módulos con 2 subcadenas conectadas en serie y 3 módulos de una subcadena cada uno Estos módulos se realizaron con celdas de de triple juntura (ATJ) marca EMCORE de descarte Se presentan los parámetros eléctricos más relevantes de las celdas utilizadas y las verificaciones funcionales que se realizaron luego de la integración de los paneles.The integration of flight solar panels of CUBEBUG-1 satellital mission is presented. This panels has been integrated from a agreement between CNEA and DISARMISTA SRL for the integration of 6 flight solar panels for CUBEBUG-1 satellital mission. The panels integration has been done using substrings of 2 solar cells connected in series, the cells used was from EMCORE advance triple junction (ATJ) non flight solar cells. The panels itself, are constituted for 3 modules with 2 substrings connected in series and 3 modules with one substring each one. The solar cells relevant electrical parameters and the curves of functional verifications after the integration are presented.Fil: Bolzi, Claudio Gustavo. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Bruno, C. J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Cabot, P.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Carella, E.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Di Santo, J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Duran, Julio Cesar. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Fernández Vázquez, J.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Godfrin, Elena María. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Goldbeck, V.. Comision Nacional de Energia Atomica. Centro Atomico Constituyentes. Departamento de Materiales; ArgentinaFil: Gonzalez, L.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Moglioni, A.. Comisión Nacional de Energía Atómica. Centro Atómico Constituyentes; ArgentinaFil: Muñoz, S.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Olima, José María. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Plá, Juan Francisco Esteban. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez, J. I.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Raggio, D.. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Socolovsky, Hernan Pablo. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; ArgentinaFil: Tamasi, Mariana Julia Luisa. Comision Nacional de Energía Atómica. Gerencia del Área de Investigación y Aplicaciones no Nucleares. Gerencia Física (CAC). Grupo Energía Solar; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin