Efecto del vendaje propioceptivo subastragalino en combinación con un programa de ejercicio excéntrico en baloncestistas con inestabilidad crónica de tobillo

[Resumen] El esguince de tobillo constituye una de las principales lesiones en la población deportiva y si no se trata adecuademente acaba degenerando en una inestabilidad crónica (IC), una patología altamente frecuente en la traumatología deportiva. Estudios recientes verificaron, que ante esta entidad, un programa de rehabilitación temprano, es capaz de mejorar la fuerza, propiocepción y rango de movimiento. Además, se ha observado que el vendaje de contención, aumenta la autoeficiencia y la percepción de la estabilidad, constituyendo una vuelta temprana a la práctica deportiva. Sin embargo, todavía no se ha demostrado si un vendaje de carácter propioceptivo mejora el equilibrio y previene recidivas en esta población. OBJETIVOS: El objetivo principal de este proyecto es evaluar la eficacia del vendaje propioceptivo subastragalino en combinación con un programa de ejercicio excéntrico en baloncestistas con IC. MATERIAL Y MÉTODOS: Se llevará a cabo un ensayo clínico aleatorizado con enmascaramiento a simple ciego y controlado, en las instalaciones deportivas de la Federación Gallega de Baloncesto, de a provincia de A coruña, de febrero de 2019 a febrero de 2021. La población diana son jugadoras femeninas de baloncesto de entre 18 a 24 años de edad, que presenten inestabilidad crónica de tobillo, Se repartirán aleatoriamente en dos grupos. Un grupo de intervención que realizará un programa de ejercicio excéntrico combinado con un vendaje propioceptivo subastragalino, frente a un grupo control, que realizará el mismo programa de ejercicio combinado con un vendaje placebo. Las variables a recoger serán el control postural y de equilibrio y la percepción de inestabilidad de tobillo, medida con el Cumberland Ankle Inestability. Además, se registrarán el número de recidivas del esguince lateral externo durante un periodo de 12 meses.[Resumo] A escordadura de nocello constitúe unha das principais lesións na poboación deportiva e se non se trata adecuademente pode acabar por dexenerar nunha inestabilidade crónica (IC), unha patoloxía altamente frecuente na traumatoloxía deportiva. Estudos recentes verificaron, que ante esta entidade, un programa de rehabilitación precoz, é capaz de mellorar a forza, propiocepción e o rango de movemento.Ademáis, observouse que a vendaxe de contención, aumenta a autoeficacia e a percepción da estabilidade, constituíndo unha volta temprá á práctica deportiva. Con todo, aínda non se demostrou se unha vendaxe de carácter propioceptivo mellora o equilibrio e prevén recidivas nesta poboación. OBXECTIVOS: O obxectivo principal deste proxecto é avaliar a eficacia da vendaxe propioceptiva subastragalina en combinación cun programa de exercicio excéntrico en baloncestistas con IC. MATERIAL E MÉTODOS: Levarase a cabo un ensaio clínico aleatorizado con enmascaramento a simple cego e controlado, nas instalacións deportivas da Federación Galega de Baloncesto, da provincia da Coruña, de febreiro do 2019 a febreiro de 2021. A poboación diana son xogadoras femininas de baloncesto de entre 18 a 24 anos de idade, que presenten inestabilidade crónica de nocello, Repartiranse aleatoriamente en dous grupos. Un grupo de intervención que realizará un programa de exercicio excéntrico combinado cunha vendaxe propioceptivo subastragalino, fronte a un grupo control, que realizará o mesmo programa de exercicio combinado cunha vendaxe placebo. As variables para recoller serán o control postural e de equilibrio e a percepción de inestabilidade de nocello, medida co Cumberland Ankle Inestability. Ademáis rexistraranse o número de recidivas de escordadura lateral externo nun periodo de doce meses.[Abstract] The ankle sprain is one of the main injuries in the sports population and if it is not treated properly it ends up degenerating into chronic instability (CI) , a highly frequent pathology in sports traumatology. Recent studies verified that before this entity, an early rehabilitation program is capable of improving strength, proprioception and range of motion. In addition, it has been observed that the containment bandage increases self-efficiency and the perception of stability, constituting an early return to sports practice. However, it has not yet been demonstrated whether a proprioceptive bandage improves balance and prevents relapses in this population. OBJECTIVES: The main objective of this project is to evaluate the efficacy of the subtalar proprioceptive bandage in combination with an eccentric exercise program in CI basketball players. MATERIAL AND METHODS: A randomized, single-blind, controlled masking clinical trial will be conducted at the sports facilities of the Galician Basketball Federation in the province of A Coruña, from February 2019 to February 2021. The target population are female basketball players between 18 and 24 years of age, with chronic ankle instability. They will be randomly divided into two groups. An intervention group that will perform an eccentric exercise program combined with a subtalar proprioceptive bandage, versus a control group that will perform the same exercise program combined with a placebo bandage. The variables to be collected will be postural and balance control and the perception of ankle instability, measured with the Cumberland Ankle Instability. In addition, the number of recurrences of the external lateral sprain over a 12-month period will be recorded.Traballo fin de grao (UDC.FEP). Podoloxía. Curso 2018/201

Eficacia y optimización de la rehabilitación temprana en pacientes ancianos con fractura de cadera

Traballo Fin de Grao en Enfermaría. Curso 2021-2022Introducción: Debido al cambio gradual en el estilo de vida y el aumento de esperanza de vida media, la fractura de cadera es ya considerada como una epidemia socio-sanitaria de nuestro siglo. Su elevada incidencia va en aumento repercutiendo no solo a quien la sufre, sino también a su entorno y a la sociedad general. Es por ello de vital importancia establecer un programa de rehabilitación terapéutico óptimo. Objetivos: Evaluar la eficacia de la rehabilitación temprana en pacientes ancianos que han sufrido una fractura de cadera. Metodología: Se realiza una revisión bibliográfica en las bases de datos Pubmed, Scielo y PEDRO. Los criterios de inclusión fueron artículos, metanálisis, revisiones, revisiones sistemáticas de los últimos 10 años en español, inglés y portugués, para individuos mayores de 65 años de edad que sufrieron una fractura de cadera. Resultados: La mayoría de las guías actuales coinciden en que la implementación de un programa de rehabilitación óptimo, mejora el nivel de dependencia, la movilidad y la recuperación funcional de los pacientes ancianos tras fractura de cadera. Además, la implementación de un programa terapéutico individualizado constituye un gran apoyo psicológico para los pacientes y su entorno más cercano. Conclusión: Se evidencia que un programa de ejercicio terapéutico temprano en pacientes ancianos con fractura de cadera ayuda en su recuperación; Funcional, social y psicológica. Sin embargo, se necesita más investigación para determinar la duración y la intensidad óptimas en el ejercicio.Introducción: Debido ao cambio gradual no estilo de vida e o aumento de esperanza de vida media, a fractura de cadeira é xa considerada como unha epidemia socio-sanitaria do noso século. A súa elevada incidencia vai en aumento repercutindo non só a quen a sofre, senón tamén á súa contorna e á sociedade xeral. É por iso de vital importancia establecer un programa de rehabilitación terapéutico óptimo. Obxectivo: Avaliar a eficacia da rehabilitación temperá en pacientes anciáns que sufrirón unha fractura de cadeira Metodoloxía: Realízase unha revisión bibliográfica nas bases de datos Pubmed, Scielo e PEDRO. Os criterios de inclusión foron artigos, metanálisis, revisións, revisións sistemáticas dos últimos 10 anos en español, inglés e portugués, para individuos maiores de 65 anos de idade que sufriron unha fractura de cadeira. Resultados: A maioría das guías actuais coinciden en que a implementación dun programa de rehabilitación óptimo, mellora o nivel de dependencia, a mobilidade e a recuperación funcional dos pacientes anciáns tras fractura de cadeira. Ademais, a implementación dun programa terapéutico individualizado constitúe un gran apoio psicolóxico para os pacientes e a súa contorna máis próxima Conclusions: Evidénciase que un programa de exercicio terapéutico temperán en pacientes anciáns con fractura de cadeira axuda na súa recuperación; funcional, social e psicolóxica.Con todo, necesítase máis investigación para determinar a duración e a intensidade óptimas no exercicio.Introduction: Due to the gradual change in lifestyle and the increase in average life expectancy, hip fracture is already considered a socio-health epidemic of our century. Its high incidence is increasing, affecting not only the sufferer, but also his or her environment and society in general. It is therefore of vital importance to establish an optimal therapeutic rehabilitation programme. Objective: To assess the effectiveness of early rehabilitation in elderly patients who have suffered a hip fracture. Methodology: A literature review was carried out in the Pubmed, Scielo and PEDRO databases. The inclusion criteria were articles, meta-analyses, reviews, systematic reviews of the last 10 years in Spanish, English and Portuguese, for individuals over 65 years of age who suffered a hip fracture. Results: Most current guidelines agree that the implementation of an optimal rehabilitation programme improves the level of dependency, mobility and functional recovery of elderly patients after hip fracture. In addition, the implementation of an individualized therapeutic programme is a great psychological support for patients and their immediate environment. Conclusions: There is evidence that an early therapeutic exercise programme in elderly hip fracture patients helps in their recovery; functionally, socially and psychologically. However, more research is needed to determine the optimal duration and intensity of exercise

Physicochemical Characterization of Ionic Liquid Binary Mixtures Containing 1-Butyl-3-methylimidazolium as the Common Cation

FCT/MEC (Portugal), through "Investigador FCT 2014" (IF/00190/2014 to A.B.P and IF/00210/2014 to J.M.M.A.),; Projects PTD C/EQU-EQU/29737/2017; PTDC/QEQFTT/32,89/2014; IF/00210/2014/CP1244/CT0003. This work was also supported by the Associate Laboratory for Green Chemistry LAQV (financed by national funds from FCT/MCTES (UID/QUI/50006/2019)) and cofinanced by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265).Mixing ionic liquids (as well as mixing an inorganic salt in an ionic liquid) constitutes an easy, elegant methodology for obtaining new ionic materials. In this study, 3 ionic liquids (ILs) sharing a common cation were synthesized and mixed in 9 different proportions giving rise to 27 binary mixtures. Specifically, 1-butyl-3-methylimidazolium nitrate, [C4C1Im][NO3], 1-butyl-3-methylimidazolium chloride, [C4C1Im]Cl, and 1-butyl-3-methylimidazolium methanesulfonate, [C4C1Im][CH3SO3], were synthesized and characterized. They all share 1-butyl-3-methylimidazolium as the common archetypal cation. None of them (or any of their binary mixtures) is liquid at room temperature (T = 298.15 K), and two of them are only in the liquid state above temperatures of 343-353 K. Despite belonging to commonly used families of ILs, their handling and the study of their liquid properties (neat and mixtures) have become particularly difficult, mainly because of their tendency to solidify and their high viscosity (caused by hydrogen-bonded networks). The main goal of this work is to evaluate the thermal, dynamic, and volumetric properties of these compounds and their mixtures as well as the solid-liquid equilibria of their binary mixtures. Thermal properties, such as melting and glass-transition temperatures, were determined or calculated. Therefore, both density and viscosity have been measured and were used for the calculation of the isobaric thermal expansion coefficient, molar volumes, excess molar volumes, and viscosity deviations to linearity.authorsversionpublishe

Electrocatalytic Palladium Nanoclusters as Versatile Indicators of Bioassays: Rapid Electroanalytical Detection of SARS-CoV-2 by Reverse Transcription Loop-Mediated Isothermal Amplification

Quantitative polymerase chain reaction (qPCR) is considered the gold standard for pathogen detection. However, improvement is still required, especially regarding the possibilities of decentralization. Apart from other reasons, infectious diseases demand on-site analysis to avoid pathogen spreading and increase treatment efficacy. In this paper, the detection of SARS-CoV-2 is carried out by reverse transcription loop-mediated isothermal amplification, which has the advantage of requiring simple equipment, easily adaptable to decentralized analysis. It is proposed, for the first time, the use of palladium nanoclusters (PdNCs) as indicators of the amplification reaction at end point. The pH of the medium decreases during the reaction and, in turn, a variation in the catalytic activity of PdNCs on the oxygen reduction reaction (ORR) can be electrochemically observed. For the detection, flexible and small-size screen-printed electrodes can be premodified with PdNCs, which together with the use of a simple and small electrochemical equipment would greatly facilitates their integration in field-deployable devices. This would allow a faster detection of SARS-CoV-2 as well as of other future microbial threats after an easy adaptation

Brain atrophy and clinical characterization of adults with mild cognitive impairment and different cerebrospinal fluid biomarker profiles according to the AT(N) research framework of Alzheimer’s disease

Introduction: This study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value. Methods: Structural MRI (sMRI) was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT(N) profiles, namely, A−T−(N)−: normal AD biomarkers; A+T−(N)−: AD pathologic change; and A+T+(N)+: prodromal AD. Sensitivity and specificity of these changes were also estimated. Results: An initial atrophy in medial temporal lobe (MTL) areas was found in the A+T−(N)− and A+T+(N)+ groups, spreading toward the parietal and frontal regions in A+T+(N)+ patients. These structural changes allowed distinguishing AT(N) profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status. Conclusion: sMRI is useful in the determination of the specific brain structural changes of AT(N) profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkersThis study was supported by grants from the Spanish Government, Ministerio de Ciencia e Innovación (PSI2017- 89389-C2-R and PID2020-114521RB-C21/C22); the Galician Government, Axudas para a Consolidación e Estruturación de Unidades de Investigación Competitivas do Sistema Universitario de Galicia: GRC (GI-1807- USC); Refs: ED431-2017/27 and ED431C-2021/04; all with ERDF/FEDER fundsS

The coagulation system helps control infection caused by the ciliate parasite Philasterides dicentrarchi in the turbot Scophthalmus maximus (L.)

This is the accepted manuscript of the following article: Blanco-Abad, V., Noia, M., Valle, A., Fontenla, F., Folgueira, I., & De Felipe, A. et al. (2018). The coagulation system helps control infection caused by the ciliate parasite Philasterides dicentrarchi in the turbot Scophthalmus maximus (L.). Developmental & Comparative Immunology, 87, 147-156. doi: 10.1016/j.dci.2018.06.001Many studies have shown that coagulation systems play an important role in the defence against pathogens in invertebrates and vertebrates. In vertebrates, particularly in mammals, it has been established that the coagulation system participates in the entrapment of pathogens and activation of the early immune response. However, functional studies investigating the importance of the fish coagulation system in host defence against pathogens are scarce. In the present study, injection of turbot (Scopthalamus maximus) with the pathogenic ciliate Philasterides dicentrarchi led to the formation of macroscopic intraperitoneal clots in the fish. The clots contained abundant, immobilized ciliates, many of which were lysed. We demonstrated that the plasma clots immobilize and kill the ciliates in vitro. To test the importance of plasma clotting in ciliate killing, we inhibited the process by adding a tetrapeptide known to inhibit fibrinogen/thrombin clotting in mammals. Plasma tended to kill P. dicentrarchi slightly faster when clotting was inhibited by the tetrapeptide, although the total mortality of ciliates was similar. We also found that kaolin, a particulate activator of the intrinsic pathway in mammals, accelerates plasma clotting in turbot. In addition, PMA-stimulated neutrophils, living ciliates and several ciliate components such as cilia, proteases and DNA also displayed procoagulant activity in vitro. Injection of fish with the ciliates generated the massive release of neutrophils to the peritoneal cavity, with formation of large aggregates in those fish with live ciliates in the peritoneum. We observed, by SEM, numerous fibrin-like fibres in the peritoneal exudate, many of which were associated with peritoneal leukocytes and ciliates. Expression of the CD18/CD11b gene, an integrin associated with cell adhesion and the induction of fibrin formation, was upregulated in the peritoneal leukocytes. In conclusion, the findings of the present study show that P. dicentrarchi induces the formation of plasma clots and that the fish coagulation system may play an important role in immobilizing and killing this parasiteThis work was financially supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 634429 (PARAFISHCONTROL), by the Ministerio de Economía y Competitividad (Spain) under grant agreement AGL2014-57125-R and by grant GPC2014/069 from the Xunta de Galicia (Spain)S

Lineamientos básicos del tratamiento etiológico de enfermedad de Chagas

La enfermedad de Chagas, endémica en 21 países de las Américas, afecta a entre 6 y 8 millones de personas en la Región1. Menos del 1% de esos pacientes son diagnosticados y tratados adecuadamente. Para superar las barreras de accesibilidad al diagnóstico y tratamiento, se propuso trabajar en la difusión de conceptos que el personal de salud debe conocer y mejorar.Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: Altcheh, Jaime Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; ArgentinaFil: Riarte, Adelina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: Freilij, Hector León. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Servicio de Parasitología y Chagas; ArgentinaFil: Fernández, Marisa Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología ; ArgentinaFil: Lloveras, Susana. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Pereiro, Ana. Fundación Mundo Sano; ArgentinaFil: Castellano, Luis Gerardo. Organización Panamericana de la Salud; Estados UnidosFil: Salvatella, Roberto. Organización Panamericana de la Salud; UruguayFil: Nicholls, Rubén S.. Organización Panamericana de la Salud; BrasilFil: Grupo de trabajo. No especifica

Predicting progression of cognitive decline to dementia using dyadic patterns of subjective reporting: evidence from the CompAS longitudinal study

ObjectiveTo analyze the validity of self and informant reports, depressive symptomatology, and some sociodemographic variables to predict the risk of cognitive decline at different follow-up times.MethodsA total of 337 participants over 50 years of age included in the CompAS and classified as Cognitively Unimpaired (CU), Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) groups were assessed at baseline and three follow-ups. A short version of the QAM was administered to assess the severity of subjective cognitive complaints (SCCs), and the GDS-15 was used to evaluate the depressive symptoms. At each follow-up assessment, participants were reclassified according to the stability, regression or progression of their conditions. Logistic regression analysis was used to predict which CU, SCD and MCI participants would remain stable, regress or progress at a 3rd follow-up by using self- and informant-reported complaints, depressive symptomatology, age and education at baseline and 2nd follow-ups as the predictive variables.ResultsOverall, self-reported complaints predicted progression between the asymptomatic and presymptomatic stages. As the objective deterioration increased, i.e., when SCD progressed to MCI or dementia, the SCCs reported by informants proved the best predictors of progression. Depressive symptomatology was also a predictor of progression from CU to SCD and from SCD to MCI.ConclusionA late increase in self-reported complaints make valid estimates to predict subjective decline at asymptomatic stages. However, an early increase in complaints reported by informants was more accurate in predicting objective decline from asymptomatic stages. Both, early and late decrease in self-reported complaints successfully predict dementia from prodromic stage. Only late decrease in self-reported complaints predict reversion from prodromic and pre-symptomatic stages

Groundfish surveys in the Atlantic Iberian waters (ICES Divisions VIIIc and IXa): history and perspectives

Spanish Oceanogrnphic Institute (IEO) and Portuguese Research Inistitute (IPIMAR, ex-INIP) using their research vessels "Comide de Saavedra" and "Noruega" have conducted groundfish surveys in Spanish and Portuguese waters. The results of these surveys have been reported to the relevant ICES Working Groups, communicated to ICES Annual Conferences and/or published in journals of bioiogy and flsheries. Data collected from groundfish surveys were also the basis to carry out assemblage studies and to several advices to the Spanish, Porttuguese and European fishery administrations concerning the implementation of technical measures for fish stock management. This communication intends to give information about the past, the present and the future of these surveys, concerning objectives, methodology and publications. Critical aspects and solutions to improve some aspects are presented

Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes):a fish adapted to demersal life

12 páginas, 5 figuras.-- Antonio Figueras ... et al.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly citedThe turbot is a flatfish (Pleuronectiformes) with increasing commercial value, which has prompted active genomic research aimed at more efficient selection. Here we present the sequence and annotation of the turbot genome, which represents a milestone for both boosting breeding programmes and ascertaining the origin and diversification of flatfish. We compare the turbot genome with model fish genomes to investigate teleost chromosome evolution. We observe a conserved macrosyntenic pattern within Percomorpha and identify large syntenic blocks within the turbot genome related to the teleost genome duplication. We identify gene family expansions and positive selection of genes associated with vision and metabolism of membrane lipids, which suggests adaptation to demersal lifestyle and to cold temperatures, respectively. Our data indicate a quick evolution and diversification of flatfish to adapt to benthic life and provide clues for understanding their controversial origin. Moreover, we investigate the genomic architecture of growth, sex determination and disease resistance, key traits for understanding local adaptation and boosting turbot production, by mapping candidate genes and previously reported quantitative trait loci. The genomic architecture of these productive traits has allowed the identification of candidate genes and enriched pathways that may represent useful information for future marker-assisted selection in turbotThis work was funded by the Spanish Government: projects Consolider Ingenio: Aquagenomics (CSD2007-00002) and Metagenoma de la Península Ibérica (CSD2007-00005), Ministerio de Economía y Competitividad and European Regional Development Funds (AGL2012-35904), and Ministerio de Economía y Competitividad (AGL2014-51773 and AGL2014-57065-R); and Local Government Xunta de Galicia (GRC2014/010). P.P. and D.R. gratefully acknowledge the Spanish Ministerio de Educación for their FPU fellowships (AP2010-2408, AP2012-0254). Funding to pay the Open Access publication charges for this article was provided by the Ministerio de Economía y Competitividad (AGL2014-51773) and Xunta de Galicia (GRC2014/010)Peer reviewe