effects of the pre-season period

Study aim: To assess changes in physical fitness of amateur soccer players after a pre-season training period and baseline fitness dependencies. Material and methods: Twenty-one amateur soccer players were assessed during the pre-season. The following physical vari ables were assessed before and after a two-month pre-season training period: (i) cardiorespiratory fitness, (ii) strength and power, and (iii) change of direction (COD). Results: Significant decreases were found for countermovement jump (CMJ) (p < 0.001; d = 1.161), drop jump (DJ) (p = 0.014; d = 0.958), and horizontal jump (HJ) (p = 0.042; d = 0.640), while no significant changes were found for the overall variables from the beginning to the end of pre-season. Fit players revealed significant decreases for CMJ (p = 0.002; d = ?2.495), DJ (p = 0.004; d = ?1.760), HJ (p = 0.028; d = ?1.005), COD deficit (p = 0.034; d = 1.013), and maximal aerobic speed (MAS) (p = 0.026; d = ?4.053). No significant changes were found for unfit players. Conclusions: Amateur soccer coaches should consider assessing physical qualities at the beginning of pre-season and use the free-of-charge monitoring tools such as session-rate of perceived exertion (s-RPE) during the training process.D915-7373-ED16 | Cesar LeaoN/

DEFENSORIA PÚBLICA DO RIO DE JANEIRO E SUA CLIENTELA

O objetivo do artigo é conhecer melhor a Defensoria Pública do Rio de Janeiro a partir do cruzamento de olhares entre os defensores públicos e os seus assistidos. Para isso, foram feitas pesquisas de campo com esses dois grupos. O resultado ao qual chegamos é de que a Defensoria Pública no Brasil goza de um baixo status social, que hoje, no Rio de Janeiro, é uma carreira jurídica que tende a experimentar um processo de feminização, e que pela proximidade/identificação com os pobres, os defensores públicos estão conscientes dos principais problemas sociais brasileiros. Por esta proximidade com os pobres, os defensores públicos do Rio de Janeiro se veem com a missão de defendê-los, desempenhando, ao mesmo tempo uma atividade profissional missionária e assistencial.  Por sua vez, os assistidos reforçam, nos próprios defensores públicos, esse senso de missão social à medida que esperam que estes façam ainda mais e melhor do que têm feito. Palavras-chave: Defensoria Pública. Acesso à justiça. Desigualdade social

Neonatal anthropometry: a tool to evaluate the nutritional status and predict early and late risks

Neonatal anthropometry is an inexpensive, noninvasive and convenient tool for bedside evaluation, especially in sick and fragile neonates. Anthropometry can be used in neonates as a tool for several purposes: diagnosis of foetal malnutrition and prediction of early postnatal complications; postnatal assessment of growth, body composition and nutritional status; prediction of long-term complications including metabolic syndrome; assessment of dysmorphology; and estimation of body surface. However, in this age group anthropometry has been notorious for its inaccuracy and the main concern is to make validated indices available. Direct measurements, such as body weight, length and body circumferences are the most commonly used measurements for nutritional assessment in clinical practice and in field studies. Body weight is the most reliable anthropometric measurement and therefore is often used alone in the assessment of the nutritional status, despite not reflecting body composition. Derived indices from direct measurements have been proposed to improve the accuracy of anthropometry. Equations based on body weight and length, mid-arm circumference/head circumference ratio, and upper-arm cross-sectional areas are among the most used derived indices to assess nutritional status and body proportionality, even though these indices require further validation for the estimation of body composition in neonates

Simulation study of linear mixed models with contaminated normal distribution in animal breeding

Objetivou-se com esse trabalho comparar estimativas de componentes de vari?ncias obtidas por meio de modelos lineares mistos Gaussianos e Robustos, via Amostrador de Gibbs, em dados simulados. Foram simulados 50 arquivos de dados com 1.000 animais cada um, distribu?dos em cinco gera??es, em dois n?veis de efeito fixo e tr?s valores fenot?picos distintos para uma caracter?stica hipot?tica, com diferentes n?veis de contamina??o. Exceto para os dados sem contamina??o, quando os modelos foram iguais, o modelo Robusto apresentou melhores estimativas da vari?ncia residual. As estimativas de herdabilidade foram semelhantes em todos os modelos, mas as an?lises de regress?o mostraram que os valores gen?ticos preditos com uso do modelo Robusto foram mais pr?ximos dos valores gen?ticos verdadeiros. Esses resultados sugerem que o modelo linear normal contaminado oferece uma alternativa flex?vel para estima??o robusta em melhoramento gen?tico animal.Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais (FAPEMIG)Empresa de Pesquisa Agropecu?ria de Minas Gerais (EPAMIG)Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico (CNPq)Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES)The objective of this study was to compare Gaussian and Robust linear mixed models for the estimation of variance components by REML and Gibbs Sampling, using data from fifty simulated populations consisting of 1,000 animals distributed in 5 generations. Two levels of fixed effect and three hypothetical phenotypic values for a trait, with different levels of contamination were used in the simulations. Additive and residual variance estimates were similar for both REML and Bayesian inference using the Gaussian and Robust model. The best estimates of residual variance in the presence of contaminants were obtained by the Robust model. Estimates of heritability were similar for all models, but regression analyses indicated that predicted genetic values obtained by the robust model were more similar to real breeding values. These results suggest that the contaminated normal linear model is a flexible alternative for robust estimation in animal breeding

Anesthesia of Epinephelus marginatus with essential oil of Aloysia polystachya: an approach on blood parameters

This study investigated the anesthetic potential of the essential oil (EO) of Aloysia polystachya in juveniles of dusky grouper (Epinephelus marginatus). Fish were exposed to different concentrations of EO of A. polystachya to evaluate time of induction and recovery from anesthesia. In the second experiment, fish were divided into four groups: control, ethanol and 50 or 300 mu L L-1 EO of A. polystachya, and each group was submitted to induction for 3.5 min and recovery for 5 or 10 min. The blood gases and glucose levels showed alterations as a function of the recovery times, but Na+ and K+ levels did not show any alteration. In conclusion, the EO from leaves of A. polystachya is an effective anesthetic for dusky grouper, because anesthesia was reached within the recommended time at EO concentrations of 300 and 400 mu L L-1. However, most evaluated blood parameters showed compensatory responses due to EO exposure.Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul/Programa de Apoio a Nucleos de Excelencia (FAPERGS/PRONEX) [10/0016-8]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [470964/2009-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES)info:eu-repo/semantics/publishedVersio

Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis

INTRODUCTION: Metaplastic breast carcinomas constitute a heterogeneous group of neoplasms, accounting for less than 1% of all invasive mammary carcinomas. Approximately 70–80% of metaplastic breast carcinomas overexpress the epidermal growth factor receptor (EGFR). Human epidermal growth factor receptor (HER)2 and EGFR have attracted much attention in the medical literature over the past few years owing to the fact that humanized monoclonal antibodies against HER2 and therapies directed against the extracellular ligand-binding domain or the intracellular tyrosine kinase domain of EGFR have proven successful in treating certain types of human cancer. We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas. METHOD: Twenty-five metaplastic breast carcinomas were immunohistochemically analyzed using a monoclonal antibody (31G7) for EGFR and two antibodies for HER2 (Herceptest and CB11) and scored using the Herceptest scoring system. Gene amplification was evaluated by chromogenic in situ hybridization using Zymed Spot-Light EGFR and HER2 amplification probe. The results were evaluated by bright field microscopy under 40× and 63× objective lenses. RESULTS: Nineteen (76%) metaplastic breast carcinomas exhibited EGFR ovexpression, and among these EGFR amplification (defined either by large gene clusters or >5 signals/nucleus in >50% of neoplastic cells) was detected in seven cases (37%): three carcinomas with squamous differentiation and four spindle cell carcinomas. One case exhibited HER2 overexpression of grade 2+ (>10% of cells with weak to moderate complete membrane staining), but HER2 gene amplification was not detected. CONCLUSION: Metaplastic breast carcinomas frequently overexpressed EGFR, which was associated with EGFR gene amplification in one-third of cases. Our findings suggest that some patients with metaplastic breast carcinomas might benefit from novel therapies targeting EGFR. Because most metaplastic breast carcinomas overexpress EGFR without gene amplification, further studies to evaluate EGFR activating mutations are warranted