150 research outputs found
Differences of the game between the football Spanish team and its rivals.
El objeto de este estudio, analizando la accioÌn de juego en fuÌtbol, describe el uso de los contextos de interaccioÌn que la seleccioÌn espanÌola de fuÌtbol y sus rivales hicieron en los campeonatos internacionales. Para ello, 13 partidos fueron observados y codificados (seis de la Eurocopa 2008 y siete del Mundial 2010) gracias a un sistema taxonoÌmico ad hoc previamente definido. Los datos fueron registrados usando un software especiÌfico. DespueÌs, coordenadas polares fueron desarrolladas usando soÌlo como conductas criterio los contextos de interaccioÌn. Los resultados obtenidos describen que EspanÌa y sus oponentes no hicieron el mismo uso del espacio de juego en sus partidos (maÌs ofensivo para los primeros), mostrando la dimensioÌn diacroÌnica de los eventos y combinando las perspectivas prospectiva y retrospectiva. Esto nos permite saber el componente estrateÌgico del uso de los contextos de interaccioÌn hechos por los equipos en la competicioÌn y optimizar programas de entrenamiento especiÌficos.Este estudio es parte del proyecto titulado Avances TecnoloÌgicos y MetodoloÌgicos en la AutomatizacioÌn de Estudios observacionales en deporte, financiado por DireccioÌn General de InvestigacioÌn de EspanÌa, Ministerio de Ciencia e InnovacioÌn (PSI2008-01179) en el periÌodo 2008-2011. No existen conflictos de intereses para esta investigacioÌn
IcnologĂa de vertebrados de la facies Buntsandstein de Mallorca
Se describen, por primera vez en Mallorca, hasta cinco tipos diferentes de icnitas y pistas de vertebrados continentales dentro de las facies cuarzoareniticas y limosas rojas de la facies Buntsandstein del Triåsico inferio
Modelling impacts of precision irrigation on crop yield and in-field water management
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/),Precision irrigation technologies are being widely promoted to resolve challenges regarding improving crop productivity under conditions of increasing water scarcity. In this paper, the development of an integrated modelling approach involving the coupling of a water application model with a biophysical crop simulation model (Aquacrop) to evaluate the in-field impacts of precision irrigation on crop yield and soil water management is described. The approach allows for a comparison between conventional irrigation management practices against a range of alternate so-called âprecision irrigationâ strategies (including variable rate irrigation, VRI). It also provides a valuable framework to evaluate the agronomic (yield), water resource (irrigation use and water efficiency), energy (consumption, costs, footprint) and environmental (nitrate leaching, drainage) impacts under contrasting irrigation management scenarios. The approach offers scope for including feedback loops to help define appropriate irrigation management zones and refine application depths accordingly for scheduling irrigation. The methodology was applied to a case study in eastern England to demonstrate the utility of the framework and the impacts of precision irrigation in a humid climate on a high-value field crop (onions). For the case study, the simulations showed how VRI is a potentially useful approach for irrigation management even in a humid environment to save water and reduce deep percolation losses (drainage). It also helped to increase crop yield due to improved control of soil water in the root zone, especially during a dry season
Near UV-Blue Excitable Green-Emitting Nanocrystalline Oxide
Green-emitting Eu-activated powders were produced by a two-stage method consisting of pressure-assisted combustion synthesis and postannealing in ammonia. The as-synthesized powders exhibited a red photoluminescence (PL) peak located at λ = 616 nm when excited with λ = 395 nm UV. This emission peak corresponds to the 5 D 0 â 7 F 2 transition in Eu 3+ . After annealing in ammonia, the PL emission changed to an intense broad-band peak centered at λ = 500 nm, most likely produced by 4f 6 5d 1 â 4f 7 electronic transitions in Eu 2+ . This green-emitting phosphor has excitation band in the near UV-blue region (λ = 300-450 nm). Xray diffraction analysis reveals mainly the orthorhombic EuAlO 3 and Al 2 O 3 phases. Transmission electron microscopy observations showed that the grains are formed by faceted nanocrystals (âŒ4 nm) of polygonal shape. The excellent excitation and emission properties make these powders very promising to be used as phosphors in UV solid-state diodes coupled to activate white-emitting lamps
Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer
Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: GarcĂa, I.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: BaladrĂłn, I.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: Solares, M.. Hospital Materno RamĂłn GonzĂĄlez Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: HernĂĄndez, I.. Isotope Center; CubaFil: Perera, Y.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: MartĂnez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: GonzĂĄlez, Y. M.. Medical-surgical Research Center; CubaFil: AncĂzar, J. A.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: GonzĂĄlez, L.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: CasacĂł, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: LĂłpez Saura, P. A.. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: GĂłmez, R.. Elea Laboratories; ArgentinaFil: Perea RodrĂguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de IngenierĂa GenĂ©tica y BiotecnologĂa; Cub
Prevalence of and Risk Factors for Biliary Carriage of Bacteria Showing Worrisome and Unexpected Resistance Traits
Data on biliary carriage of bacteria and, specifically, of bacteria with worrisome and unexpected resistance traits (URB) are lacking.
A prospective study (April 2010 to December 2011) was performed that included all patients admitted for<48 h for elective
laparoscopic cholecystectomy in a Spanish hospital. Bile samples were cultured and epidemiological/clinical data recorded. Logistic
regression models (stepwise) were performed using bactobilia or bactobilia by URB as dependent variables. Models (P<
0.001) showing the highest R2 values were considered. A total of 198 patients (40.4% males; age, 55.3 17.3 years) were included.
Bactobilia was found in 44 of them (22.2%). The presence of bactobilia was associated (R2 Cox, 0.30) with previous biliary endoscopic
retrograde cholangiopancreatography (ERCP) (odds ratio [OR], 8.95; 95% confidence interval [CI], 2.96 to 27.06; P<
0.001), previous admission (OR, 2.82; 95% CI, 1.10 to 7.24; P 0.031), and age (OR, 1.09 per year; 95% CI, 1.05 to 1.12; P<
0.001). Ten out of the 44 (22.7%) patients with bactobilia carried URB: 1 Escherichia coli isolate (CTX-M), 1 Klebsiella pneumoniae
isolate (OXA-48), 3 high-level gentamicin-resistant enterococci, 1 vancomycin-resistant Enterococcus isolate, 3 Enterobacter
cloacae strains, and 1 imipenem-resistant Pseudomonas aeruginosa strain. Bactobilia by URB (versus those by non-URB)
was only associated (R2 Cox, 0.19) with previous ERCP (OR, 11.11; 95% CI, 1.98 to 62.47; P 0.006). For analyses of patients
with bactobilia by URB versus the remaining patients, previous ERCP (OR, 35.284; 95% CI, 5.320 to 234.016; P<0.001), previous
intake of antibiotics (OR, 7.200; 95% CI, 0.962 to 53.906; P 0.050), and age (OR, 1.113 per year of age; 95% CI, 1.028 to
1.206; P 0.009) were associated with bactobilia by URB (R2 Cox, 0.19; P<0.001). Previous antibiotic exposure (in addition to
age and previous ERCP) was a risk driver for bactobilia by URB. This may have implications in prophylactic/therapeutic
measures
La Base de Datos de Fallas Activas en el Cuaternario de Iberia (QAFI v.2.0)
ABSTRACT. The Quaternary Active Faults Database of Iberia (QAFI) is an initiative lead by the Institute of Geology and Mines of Spain
(IGME) for building a public repository of scientific data regarding faults having documented activity during the last 2.59 Ma
(Quaternary). QAFI also addresses a need to transfer geologic knowledge to practitioners of seismic hazard and risk in Iberia by
identifying and characterizing seismogenic fault-sources. QAFI is populated by the information freely provided by more than 40
Earth science researchers, storing to date a total of 262 records. In this article we describe the development and evolution of the database, as well as its internal architecture. Additionally, a first global analysis of the data is provided with a special focus on length
and slip-rate fault parameters. Finally, the database completeness and the internal consistency of the data are discussed. Even though
QAFI v.2.0 is the most current resource for calculating fault-related seismic hazard in Iberia, the database is still incomplete and
requires further review.RESUMEN. La Base de Datos de Fallas Activas de Iberia (QAFI) es una iniciativa promovida por el Instituto Geológico y Minero de España
(IGME) para construir un repositorio pĂșblico de informaciĂłn cientĂfica sobre fallas con actividad en los Ășltimos 2,59 Ma (Cuaternario).
AdemĂĄs, la QAFI persigue establecer una base sobre la que facilitar la transferencia de conocimiento geolĂłgico al ĂĄmbito
tecnolĂłgico de la gestiĂłn del riesgo sĂsmico en Iberia, en particular en la identificaciĂłn y caracterizaciĂłn de fuentes sismogĂ©nicas
tipo falla. La QAFI se ha construido a partir de la informaciĂłn proporcionada de modo altruista por mĂĄs de 40 investigadores en
ciencias de la Tierra conteniendo actualmente un total de de 262 registros. En este artĂculo se describe la concepciĂłn y evoluciĂłn de
la base de datos, y su arquitectura interna. Ademås, se ofrece un primer anålisis global de los datos que contiene, con especial interés
en parĂĄmetros tan importantes como la longitud y tasa de deslizamiento de las fallas. Finalmente se discuten dos temas cruciales
en cualquier base de datos: su completitud y la homogeneidad de los datos. Se concluye que QAFI v.2.0, pese a ser la fuente mĂĄs
actualizada de informaciĂłn disponible en Iberia sobre peligrosidad sĂsmica de fallas concretas, dista aun de ser completa, por lo que
nuevas revisiones y versiones deberĂĄn seguir llevĂĄndose a cabo en el futuro
Commissioning of the CALIFA Barrel Calorimeter of the RB Experiment at FAIR
CALIFA is the high efficiency and energy resolution calorimeter for the
RB experiment at FAIR, intended for detecting high energy charged
particles and -rays in inverse kinematics direct reactions. It
surrounds the reaction target in a segmented configuration of Barrel and
Forward End-Cap pieces. The CALIFA Barrel consists of 1952 detection units made
of CsI(Tl) long-shaped scintillator crystals, and it is being commissioned
during the Phase0 experiments at FAIR. The first setup for the CALIFA Barrel
commissioning is presented here. Results of detector performance with
-rays are obtained, and show that the system fulfills the design
requirements
The Quaternary Active Faults Database of Iberia (QAFI v.2.0)
The Quaternary Active Faults Database of Iberia (QAFI) is an initiative lead by the Institute of Geology and Mines of Spain (IGME) for building a public repository of scientific data regarding faults having documented activity during the last 2.59 Ma (Quaternary). QAFI also addresses a need to transfer geologic knowledge to practitioners of seismic hazard and risk in Iberia by identifying and characterizing seismogenic fault-sources. QAFI is populated by the information freely provided by more than 40 Earth science researchers, storing to date a total of 262 records. In this article we describe the development and evolution of the database, as well as its internal architecture. Aditionally, a first global analysis of the data is provided with a special focus on length and slip-rate fault parameters. Finally, the database completeness and the internal consistency of the data are discussed. Even though QAFI v.2.0 is the most current resource for calculating fault-related seismic hazard in Iberia, the database is still incomplete and requires further review
OGG1 inhibition triggers synthetic lethality and enhances the effect of PARP inhibitor olaparib in BRCA1-deficient TNBC cells
Background: PARP1 plays a critical role in the base excision repair (BER) pathway, and PARP1 inhibition leads to specific cell death, through a synthetic lethal interaction, in the context of BRCA1/2 deficiency. To date, up to five different PARP inhibitors (PARPi), have been approved, nevertheless, the acquisition of resistance to PARPi is common and there is increasing interest in enhancing responses and expand their use to other tumour types.
Methods: We hypothesized that other BER members could be additional synthetic lethal partners with mutated BRCA genes. To test this, we decided to evaluate the glycosylase OGG1 as a potential candidate, by treating BRCA1 proficient and deficient breast cancer cells with PARPi olaparib and the OGG1 inhibitor TH5478.
Results: Knocking out BRCA1 in triple-negative breast cancer cell lines causes hypersensitivity to the OGG1 inhibitor TH5487. Besides, TH5487 enhances the sensitivity to the PARP inhibitor olaparib, especially in the context of BRCA1 deficiency, reflecting an additive interaction.
Discussion: These results provide the first evidence that OGG1 inhibition is a promising new synthetic lethality strategy in BRCA1-deficient cells, and could lead to a new framework for the treatment of hereditary breast and ovarian cancer
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