24 research outputs found
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60â109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
âTypicalâ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (â€â18 years: 69, 48, 23; 85%), older adults (â„â70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each Pâ<â0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
Utilisation de l'oxygĂšne en salle de naissance (enquĂȘte dans les maternitĂ©s françaises)
TOURS-BU MĂ©decine (372612103) / SudocSudocFranceF
Macroinvertebrate identity mediates the effects of litter quality and microbial conditioning on leaf litter recycling in temperate streams
International audienc
Effets de la qualitĂ© de la litiĂšre et de son conditionnement sur les traits dâalimentation de 11 macroinvertĂ©brĂ©s aquatiques
International audienc
Functional importance of freshwater amphipods in the leaf litter recycling process: the role of leaf litter characteristics
International audienceImpact of leaf characteristics on the keystone amphipod species for litter decomposition process
Functional importance of freshwater amphipods in the leaf litter recycling process : the role of leaf litter characteristics
International audienc
Studying One and Two-Finger Perception of Tactile Directional Cues
ISBN: 978-3-319-42324-1 ; 978-3-319-42323-4International audienceIn this paper, we study the perception of tactile directional cues by one or two fingers, using either the index, middle, or ring finger, or any of their combination. Therefore, we use tactile devices able to stretch the skin of the fingertips in 2 DOF along four directions: horizontal, vertical, and the two diagonals. We measure the recognition rate in each direction, as well as the subjective preference, depending on the (couple of) finger(s) stimulated. Our results show first that using the index and/or middle finger performs significantly better than using the ring finger on both qualitative and quantitative measures. The results when comparing one versus two-finger configurations are more contrasted. The recognition rate of the diagonals is higher when using one finger than two, whereas two fingers enable a better perception of the horizontal direction. These results pave the way to other studies on one versus two-finger perception, and raise methodological considerations for the design of multi-finger tactile devices
COBRAPed cohort: Do sensitization patterns differentiate children with severe asthma from those with a milder disease?
International audienceAbstract Background It is unclear whether sensitization patterns differentiate children with severe recurrent wheeze (SRW)/severe asthma (SA) from those with nonâsevere recurrent wheeze (NSRW)/nonâsevere asthma (NSA). Our objective was to determine whether sensitization patterns can discriminate between children from the French COBRAPed cohort with NSRW/NSA and those with SRW/SA. Methods IgE to 112 components (câsIgE) (ImmunoCAPÂź ISAC) were analyzed in 125 preschools (3â6âyears) and 170 schoolâage children (7â12âyears). Supervised analyses and clustering methods were applied to identify patterns of sensitization among children with positive câsIgE. Results We observed câsIgE sensitization in 51% of preschool and 75% of schoolâage children. Sensitization to house dust mite (HDM) components was more frequent among NSRW than SRW (53% vs. 24%, p <â.01). Sensitization to nonâspecific lipid transfer protein (nsLTP) components was more frequent among SA than NSA (16% vs. 4%, p <â.01) and associated with an FEV1/FVCâ<ââ1.64 z âscore. Among sensitized children, seven clusters with varying patterns were identified. The two broader clusters identified in each age group were characterized by âfew sensitizations, mainly to HDM.â One cluster ( n =â4) with âmultiple sensitizations, mainly to grass pollen, HDM, PRâ10, and nsLTPâ was associated with SA in schoolâage children. Conclusions Although children with wheeze/asthma display frequent occurrences and high levels of sensitization, sensitization patterns did not provide strong signals to discriminate children with severe disease from those with milder disease. These results suggest that the severity of wheeze/asthma may depend on both IgEâ and nonâIgEâmediated mechanisms
Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort
International audienc
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings.</p