University commission on Disability: management experience at the National University of La Plata

La Comisión Universitaria sobre Discapacidad de la UNLP, fue gestada hace más de trece años con el fin de lograr la plena inclusión en el sistema universitario, que todos puedan ingresar y transitar la universidad para estudiar, trabajar y participar de las diversas propuestas que la misma genera. Este trabajo pretende transmitir el camino transitado por la Comisión: sus acciones pasadas más relevantes, su experiencia de gestión, sus objetivos y ejes de trabajo, así como también aquellas acciones que se encuentran en proceso de implementación. El trabajo interdisciplinario es el que da sustento a nuestras prácticas y las jerarquiza. La Comisión está convencida que la temática necesita del aporte permanentemente de todos los claustros universitarios: docentes, no docentes y alumnos; atravesar todas las áreas de acción: docencia, extensión e investigación, promoviendo la reflexión y una actitud proactiva que favorezca el acceso a la Universidad y la erradicación de todo tipo de discriminación.Fil: Castignani, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata; ArgentinaFil: Hanlon, Paula. Universidad Nacional de La Plata; ArgentinaFil: Lujan, María. Universidad Nacional de La Plata; ArgentinaFil: Katz, Sandra Lea. Universidad Nacional de La Plata; ArgentinaFil: Peiró, Mabel. Universidad Nacional de La Plata; Argentin

The GENIE System: classifying documents by combining mixed-techniques

Today, the automatic text classification is still an open problem and its implementation in companies and organizations with large volumes of data in text format is not a trivial matter. To achieve optimum results many parameters come into play, such as the language, the context, the level of knowledge of the issues discussed, the format of the documents, or the type of language that has been used in the documents to be classified. In this paper we describe a multi-language rule-based pipeline system, called GENIE, used for automatic document categorisation. We have used several business corpora in order to test the real capabilities of our proposal, and we have studied the results of applying different stages of the pipeline over the same data to test the influence of each step in the categorization process. The results obtained by this system are very promising, and in fact, the GENIE system is already being used on real production environments with very good results

CRISIS EN LAS EMPRESAS: CASO DEL COVID-19 EN LA INDUSTRIA ALIMENTARIA ESPAÑOLA

EN ESTE TRABAJO EXPLICO LOS DIFERENTES INDICADORES MACROECONÓMICOS DURANTE LA COVID-19 EN EL SECTOR ALIMENTARIO ESPAÑOL. DE ESTA FORMA, PODEMOS VER EL IMPACTO QUE TUVO EL COVID-19 EN ESTE SECTOR QUE TAN IMPORTANTE Y NECESARIO ES PARA EL PAÍS. <br /

Antibody-drug conjugates, immune-checkpoint inhibitors, and their combination in advanced non-small cell lung cancer

Antibody-drug conjugates, Immune-checkpoint inhibitors; Non-small cell lung cancerConjugats de fàrmac-anticòs; Inhibidors de punts de control immunitaris; Càncer de pulmó de cèl·lules no petitesConjugados de fármaco-anticuerpo; Inhibidores de puntos de control inmunitarios; Cáncer de pulmón de células no pequeñasIntroduction Advanced non-small cell lung cancer (aNSCLC) is an incurable disease. The effort to develop treatments with more effective systemic agents continues. This has led to the FDA approval of one antibody–drug conjugate (ADC) and eight immune checkpoint inhibitors (ICIs) for patients with aNSCLC. Areas covered Due to the demonstrated efficacy of ADCs and ICIs in aNSCLC, treatment combining both agents merits attention. This article, therefore, explores the use of ADCs and ICIs in patients with NSCLC, assesses the scientific rationale for combination treatment, and provides an overview of ongoing trials. It also presents some early efficacy and safety results of such combination use. Expert opinion It is not clear whether ADC-immunotherapy has a significant impact on those with a targetable oncogenic driver alteration since targeted therapies are effective. However, in aNSCLC without a targetable oncogenic driver alteration, the combination of ADCs and ICIs has potential and remains an area of active clinical research

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy

Cancer; Immunosuppression mechanisms; Tumor microenvironmentCáncer; Mecanismos de inmunosupresión; Microambiente tumoralCàncer; Mecanismes d'immunosupressió; Microambient tumoralThe efficacy of cancer therapies is limited to a great extent by immunosuppressive mechanisms within the tumor microenvironment (TME). Numerous immune escape mechanisms have been identified. These include not only processes associated with tumor, immune or stromal cells, but also humoral, metabolic, genetic and epigenetic factors within the TME. The identification of immune escape mechanisms has enabled the development of small molecules, nanomedicines, immune checkpoint inhibitors, adoptive cell and epigenetic therapies that can reprogram the TME and shift the host immune response towards promoting an antitumor effect. These approaches have translated into series of breakthroughs in cancer therapies, some of which have already been implemented in clinical practice. In the present article the authors provide an overview of some of the most important mechanisms of immunosuppression within the TME and the implications for targeted therapies against different cancers

Into the Thermus Mobilome: Presence, Diversity and Recent Activities of Insertion Sequences Across Thermus spp.

: A high level of transposon-mediated genome rearrangement is a common trait among microorganisms isolated from thermal environments, probably contributing to the extraordinary genomic plasticity and horizontal gene transfer (HGT) observed in these habitats. In this work, active and inactive insertion sequences (ISs) spanning the sequenced members of the genus Thermus were characterized, with special emphasis on three T. thermophilus strains: HB27, HB8, and NAR1. A large number of full ISs and fragments derived from different IS families were found, concentrating within megaplasmids present in most isolates. Potentially active ISs were identified through analysis of transposase integrity, and domestication-related transposition events of ISTth7 were identified in laboratory-adapted HB27 derivatives. Many partial copies of ISs appeared throughout the genome, which may serve as specific targets for homologous recombination contributing to genome rearrangement. Moreover, recruitment of IS1000 32 bp segments as spacers for CRISPR sequence was identified, pointing to the adaptability of these elements in the biology of these thermophiles. Further knowledge about the activity and functional diversity of ISs in this genus may contribute to the generation of engineered transposons as new genetic tools, and enrich our understanding of the outstanding plasticity shown by these thermophiles.post-print2.276 K

Trajectory analysis of suicidal ideation in Spanish college students using ecological momentary assessment

Suicide is a preventable death in young people. It is well known that suicide behavior is a multicausal phenomenon. However, suicidal ideation (SI) commonly underlies suicide, and Ecological Momentary Assessment (EMA) can help us to better characterize it and its risk and protective factors in the short term. We aimed, first, to investigate the estimated prevalence and trajectories of SI in a community sample of Spanish college students using an EMA methodology and, second, explore the associations between risk and protective factors and SI categorized as moderate or lo

Snail1 transcription factor controls telomere transcription and integrity

Besides controlling epithelial-to-mesenchymal transition (EMT) and cell invasion, the Snail1 transcriptional factor also provides cells with cancer stem cell features. Since telomere maintenance is essential for stemness, we have examined the control of telomere integrity by Snail1. Fluorescence in situ hybridization (FISH) analysis indicates that Snail1-depleted mouse mesenchymal stem cells (MSC) have both a dramatic increase of telomere alterations and shorter telomeres. Remarkably, Snail1-deficient MSC present higher levels of both telomerase activity and the long non-coding RNA called telomeric repeat-containing RNA (TERRA), an RNA that controls telomere integrity. Accordingly, Snail1 expression downregulates expression of the telomerase gene (TERT) as well as of TERRA 2q, 11q and 18q. TERRA and TERT are transiently downregulated during TGF-induced EMT in NMuMG cells, correlating with Snail1 expression. Global transcriptome analysis indicates that ectopic expression of TERRA affects the transcription of some genes induced during EMT, such as fibronectin, whereas that of TERT does not modify those genes. We propose that Snail1 repression of TERRA is required not only for telomere maintenance but also for the expression of a subset of mesenchymal genes

Carm1-arginine methylation of the transcription factor C/EBPα regulates transdifferentiation velocity

Developmental biology; Gene regulation; Transcription factorBiologia del desenvolupament; Regulació gènica; Factor de transcripcióBiología del desarrollo; Regulación génica; Factor de transcripciónHere, we describe how the speed of C/EBPα-induced B cell to macrophage transdifferentiation (BMT) can be regulated, using both mouse and human models. The identification of a mutant of C/EBPα (C/EBPαR35A) that greatly accelerates BMT helped to illuminate the mechanism. Thus, incoming C/EBPα binds to PU.1, an obligate partner expressed in B cells, leading to the release of PU.1 from B cell enhancers, chromatin closing and silencing of the B cell program. Released PU.1 redistributes to macrophage enhancers newly occupied by C/EBPα, causing chromatin opening and activation of macrophage genes. All these steps are accelerated by C/EBPαR35A, initiated by its increased affinity for PU.1. Wild-type C/EBPα is methylated by Carm1 at arginine 35 and the enzyme’s perturbations modulate BMT velocity as predicted from the observations with the mutant. Increasing the proportion of unmethylated C/EBPα in granulocyte/macrophage progenitors by inhibiting Carm1 biases the cell’s differentiation toward macrophages, suggesting that cell fate decision velocity and lineage directionality are closely linked processes.TG was supported by the Center for Genomic Regulation, Barcelona, the Spanish Ministry of Economy, Industry and Competitiveness, (Plan Estatal PID2019-109354GB-100), AGAUR (SGR 006713) and the 4D-Genome European Research Council Synergy grant. KSZ was supported by the NIH grant R01GM36477. We have used ChatGPT to improve parts of the text

University commission on Disability: management experience at the National University of La Plata

La Comisión Universitaria sobre Discapacidad de la UNLP, fue gestada hace más de trece años con el fin de lograr la plena inclusión en el sistema universitario, que todos puedan ingresar y transitar la universidad para estudiar, trabajar y participar de las diversas propuestas que la misma genera. Este trabajo pretende transmitir el camino transitado por la Comisión: sus acciones pasadas más relevantes, su experiencia de gestión, sus objetivos y ejes de trabajo, así como también aquellas acciones que se encuentran en proceso de implementación. El trabajo interdisciplinario es el que da sustento a nuestras prácticas y las jerarquiza. La Comisión está convencida que la temática necesita del aporte permanentemente de todos los claustros universitarios: docentes, no docentes y alumnos; atravesar todas las áreas de acción: docencia, extensión e investigación, promoviendo la reflexión y una actitud proactiva que favorezca el acceso a la Universidad y la erradicación de todo tipo de discriminación.Facultad de Ciencias Naturales y MuseoFacultad de Bellas ArtesFacultad de Humanidades y Ciencias de la Educació