Alterações oftalmológicas decorrentes da desnutrição

INTRODUCTION: Malnutrition is a process that generates numerous consequences for the human body, especially in the development of ocular comorbidities. The effect of this impact on people has been a source of study in the literature. OBJECTIVE: To seek understanding about ophthalmological alterations due to malnutrition. METHOLOGY: A literature search was carried out based on the descriptor “malnutrition'' and "eyes changes” in the PubMed database. A total of 290 articles were found, of which, after using filters and exclusion parameters, they were 10 articles were selected, in addition, two books were used, the “Guide to clinical nutrition in childhood and adolescence” and “Ophthalmology for graduation.” All literature used for this document lists ophthalmological alterations resulting from malnutrition. RESULTS: It was found that the low intake and malabsorption of nutrients and minerals has consequences for different ocular tissues. CONCLUSION: It is important to understand about ophthalmological changes due to malnutrition, in order to obtain an early diagnosis and avoid the appearance of optical deformities.  ANTECEDENTES: La desnutrición es un proceso que genera numerosas consecuencias para el organismo humano, especialmente en el desarrollo de comorbilidades oculares. El efecto de este impacto en el hombre ha sido fuente de estudio en la literatura. OBJETIVO: Buscar comprensión sobre las alteraciones oftalmológicas por desnutrición. METODOLOGÍA: Se realizó una búsqueda bibliográfica basada en el descriptor “malnutrición” y “eyes changes” en la base de datos PubMed. Se encontraron un total de 290 artículos, de los cuales, luego de utilizar filtros y parámetros de exclusión, se seleccionaron 10 artículos. , además, se utilizaron dos libros, la “Guía de nutrición clínica en la niñez y la adolescencia” y “Oftalmología para la graduación”. Toda la literatura utilizada para este documento enumera las alteraciones oftalmológicas derivadas de la desnutrición. RESULTADOS: Se encontró que la baja ingesta y la malabsorción de nutrientes y minerales tiene consecuencias para los diferentes tejidos oculares. CONCLUSIÓN: Es importante conocer los cambios oftalmológicos por desnutrición, para obtener un diagnóstico precoz y evitar la aparición de deformidades ópticas.INTRUDUÇÃO: A desnutrição é um processo que gera inúmeras consequências para o corpo humano, sobretudo no desenvolvimento de comorbidades oculares. O efeito desse impacto no homem tem sido fonte de estudo na literatura. OBJETIVO: Buscar entendimento sobre as alterações oftalmológicas devido a desnutrição. METOLOGIA: Foi realizada uma busca literária com base no descritor “malnutrition’’ e "eyes changes” na base de dados do PubMed. Ao total, foram encontrados 290 artigos, dos quais, após a utilização de filtros e de parâmetros de exclusão, foram selecionados 10 artigos, além disso, foram utilizados dois livros, o “Guia de nutrição clínica na infância e na adolescência” e “Oftalmologia para a graduação”. Todas as literaturas utilizadas para esse documento relacionam alterações oftalmológicas decorrentes da desnutrição. RESULTADOS: Foi constatado que a baixa ingestão e a má absorção de nutrientes e de minerais gera consequências para diversos tecidos oculares. CONCLUSÃO: É relevante entender sobre as modificações oftalmológicas devido a desnutrição, em busca de obter diagnóstico precoce e evitar o aparecimento de deformidades ópticas

The antioxidant and anti-inflammatory properties of lycopene in mice lungs exposed to cigarette smoke.

Lycopene is a carotenoid with knownantioxidant and anti-inflammatory properties.Weaimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 ?Mof lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25%, 0.5%, 0.625%, 1.25%, 2.25%, 5% and 10% cigarette smoke extract (CSE) for 3, 6 and 24 h to assess cell viability and measurement of intracellular reactive oxygen species (ROS). For the in vivo study, 40 micewere divided into 5 groups: a control exposed to ambient air (CG), a vehicle-control group that received 200 ?l of sunflower oil by orogastric gavage, a group exposed to CS and two groups administered lycopene (diluted in sunflower oil) at doses of either 25 or 50 mg/kg/day prior to exposure to CS (LY25+CS and LY50+CS). The total treatment time lasted 5 days. A cell viability decreasewas observed at 10- and 25-?Mconcentrations of lycopene in 3, 6 and 24 h compared with CG. Therewas an increase ofROS production in 24 h in CS compared with CG. Lycopene concentrations of 1 ?Mand 2 ?Mwere able to reduce the production of ROS in 24 h comparedwith CS. In the bronchoalveolar lavage fluid, the total number of leukocytes increased in the CS group compared with the control groups (CG). Administrationwith lycopene at the highest dose suppressed this CS-induced increase in leukocytes. Lipid peroxidation and DNA damage increased in the CS group comparedwith that in the controls, and this increase was suppressed by lycopene at the highest dose. In contrast, superoxide dismutase activity decreased in the CS group compared with that in the controls. Catalase activity also increased in the CS group compared with that in both control groups, and this increase was suppressed in LY25+CS and LY50+CS. There was an increase in the levels of tumor necrosis factor-?, interferon-? and interleukin-10 after exposure to CS, and these effects were suppressed by both doses of lycopene. These data elucidate the role of lycopene as an antioxidant and anti-inflammatory agent in these two models of short-term exposure to CS

Mental health and burnout syndrome among postgraduate students in medical and multidisciplinary residencies during the COVID-19 pandemic in Brazil : protocol for a prospective cohort study

Background: The COVID-19 pandemic has led to high levels of physical, psychological, and social stress among health care professionals, including postgraduate students in medical and multidisciplinary residencies. This stress is associated with the intense fear of occupational exposure to SARS-CoV-2, the virus known to cause COVID-19. These professionals are at risk of developing physical and mental illnesses not only due to the infection but also due to prolonged exposure to multidimensional stress and continued work overload. Objective: This study aims to evaluate the prevalence of symptoms suggestive of mental disorders and burnout syndrome and determine the risk factors for burnout among postgraduate students in medical and multidisciplinary residencies in Brazil during the COVID-19 pandemic. Methods: For this prospective cohort study with parallel groups, participants were recruited between July and September 2020 to achieve a sample size of at least 1144 participants. Research instruments such as Depression, Anxiety, and Stress Scale; Patient Health Questionnaire; Brief Resilient Coping Scale; and Oldenburg Burnout Inventory will be used to collect data. Data will be collected in 2 waves: the first wave will include data related to sample characterization and psychosocial evaluation, and the second wave will be launched 12 weeks later and will include an evaluation of the incidence of burnout as well as correlations with the potential predictive factors collected in the first wave. Additionally, we will collect data regarding participants’ withdrawal from work. Results: The recruitment took place from July 29 to September 5, 2020. Data analyses for this phase is already in progress. The second phase of the study is also in progress. The final data collection began on December 1, 2020, and it will be completed by December 31, 2020. Conclusions: We believe the findings of this study will help evaluate the impact of the COVID-19 pandemic on the mental health conditions of health professionals in Brazil as well as contribute to the planning and implementation of appropriate measures that can alleviate these mental health challenges. International Registered Report Identifier (IRRID): DERR1-10.2196/2429

Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development

12 pags., 4 figs., 3 tabs.SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including anti-virals. Within the international Covid19-NMR consortium, we have identified binders targeting the RNA genome of SCoV2. We established protocols for the production and NMR characterization of more than 80 % of all SCoV2 proteins. Here, we performed an NMR screening using a fragment library for binding to 25 SCoV2 proteins and identified hits also against previously unexplored SCoV2 proteins. Computational mapping was used to predict binding sites and identify functional moieties (chemotypes) of the ligands occupying these pockets. Striking consensus was observed between NMR-detected binding sites of the main protease and the computational procedure. Our investigation provides novel structural and chemical space for structure-based drug design against the SCoV2 proteome.Work at BMRZ is supported by the state of Hesse. Work in Covid19-NMR was supported by the Goethe Corona Funds, by the IWBEFRE-program 20007375 of state of Hesse, the DFG through CRC902: “Molecular Principles of RNA-based regulation.” and through infrastructure funds (project numbers: 277478796, 277479031, 392682309, 452632086, 70653611) and by European Union’s Horizon 2020 research and innovation program iNEXT-discovery under grant agreement No 871037. BY-COVID receives funding from the European Union’s Horizon Europe Research and Innovation Programme under grant agreement number 101046203. “INSPIRED” (MIS 5002550) project, implemented under the Action “Reinforcement of the Research and Innovation Infrastructure,” funded by the Operational Program “Competitiveness, Entrepreneurship and Innovation” (NSRF 2014–2020) and co-financed by Greece and the EU (European Regional Development Fund) and the FP7 REGPOT CT-2011-285950—“SEE-DRUG” project (purchase of UPAT’s 700 MHz NMR equipment). The support of the CERM/CIRMMP center of Instruct-ERIC is gratefully acknowledged. This work has been funded in part by a grant of the Italian Ministry of University and Research (FISR2020IP_02112, ID-COVID) and by Fondazione CR Firenze. A.S. is supported by the Deutsche Forschungsgemeinschaft [SFB902/B16, SCHL2062/2-1] and the Johanna Quandt Young Academy at Goethe [2019/AS01]. M.H. and C.F. thank SFB902 and the Stiftung Polytechnische Gesellschaft for the Scholarship. L.L. work was supported by the French National Research Agency (ANR, NMR-SCoV2-ORF8), the Fondation de la Recherche Médicale (FRM, NMR-SCoV2-ORF8), FINOVI and the IR-RMN-THC Fr3050 CNRS. Work at UConn Health was supported by grants from the US National Institutes of Health (R01 GM135592 to B.H., P41 GM111135 and R01 GM123249 to J.C.H.) and the US National Science Foundation (DBI 2030601 to J.C.H.). Latvian Council of Science Grant No. VPP-COVID-2020/1-0014. National Science Foundation EAGER MCB-2031269. This work was supported by the grant Krebsliga KFS-4903-08-2019 and SNF-311030_192646 to J.O. P.G. (ITMP) The EOSC Future project is co-funded by the European Union Horizon Programme call INFRAEOSC-03-2020—Grant Agreement Number 101017536. Open Access funding enabled and organized by Projekt DEALPeer reviewe

Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications

The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave the way to understanding the SARS-CoV-2 molecular components in detail. The research in COVID19-NMR and the resources provided through the consortium are fully disclosed to accelerate access and exploitation. NMR investigations of the viral molecular components are designated to provide the essential basis for further work, including macromolecular interaction studies and high-throughput drug screening. Here, we present the extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the consortium’s collective efforts. We provide protocols for the large-scale production of more than 80% of all SARS-CoV-2 proteins or essential parts of them. Several of the proteins were produced in more than one laboratory, demonstrating the high interoperability between NMR groups worldwide. For the majority of proteins, we can produce isotope-labeled samples of HSQC-grade. Together with several NMR chemical shift assignments made publicly available on covid19-nmr.com, we here provide highly valuable resources for the production of SARS-CoV-2 proteins in isotope-labeled form

Quality of information given to surgical patients with abdominal cancer

Objective. To evaluate the need for information in patients with abdominal neoplasms. Methods. The sample consisted of 100 patients hospitalized in a surgical ward for patients with abdominal neoplasms at the National Institute of Cancer José de Alencar Gomes da Silva / INCA, in the period between June and December 2016. To collect the data, the Brazilian Portuguese version of the European Organization for Research and Treatment of Cancer (EORTC) information module questionnaire (QLQ-INFO25) was used. Results. In general, for most items, the patients showed satisfaction with the amount of information received. The items referring to the disease, examinations, treatment and general information stand out, with an average score of more than 80%. For some items, however, there is dissatisfaction with the amount of information received, especially those related to the cause of the disease, aspects of out-of-hospital and home care, different places of care and aspects of self-help, with a satisfaction level of less than 40%. Conclusion. Despite the high level of satisfaction with the information received, it was observed that almost all patients would like more information, which makes us recommend that, as part of the care, the information offered to these patients about the treatment and the evolutionary process of the disease should be enhanced. Descriptors: abdominal neoplasms; oncology nursing; patient satisfaction.Objetivo. Avaliar a necessidade de informação em pacientes portadores de neoplasias abdominais. Método. A amostra foi composta por 100 pacientes internados em enfermaria cirúrgica, destinada aos pacientes portadores de neoplasias abdominais do Instituto Nacional do Câncer José de Alencar Gomes da Silva/INCA, no período entre junho e dezembro de 2016. Para a coleta de dados foi utilizado o questionário versão Português- Brasil QLQ-INFO25 da EORTC. Resultados. De uma forma geral, para a maioria dos itens, os pacientes demonstraram satisfação com a quantidade de informação recebida. Destacam-se os itens referentes à doença, exames, tratamento e informações gerais, com mais de 80% de média. Entretanto, para alguns itens há insatisfação na quantidade de informação recebida, especialmente aqueles ligados à causa da doença, aspectos do cuidado extra- hospitalar e domiciliar, diferentes locais de cuidado e aspectos de autoajuda, com grau de satisfação inferior a 40%. Conclusão. Apesar do alto nível de satisfação das informações recebidas, observou-se que quase a totalidade dos pacientes gostaria de mais informações, o que nos leva a acreditar que oferecer continuamente informações a respeito do tratamento e do processo evolutivo da doença, deve ser um processo constante no cuidado destes pacientes.Objetivo. Evaluar la necesidad de información en pacientes con tumores abdominales como proceso continuo para su cuidado. Métodos. La muestra consistió en 100 pacientes ingresados en la sala de cirugía, destinada a pacientes con cáncer abdominal del Instituto José de Alencar Gomes da Silva / Instituto Nacional de INCA, entre junio y diciembre de 2016. Para la colección de datos se utilizó la versión portuguesa del cuestionario QLQ-INFO25 la EORTC. Resultados. En general, para la mayoría de los artículos, los pacientes se mostraron satisfechos con la cantidad de información recibida. Cabe destacar los artículos relacionados con la enfermedad, examen, tratamiento, e información general, con más del 80% de la media. Sin embargo, para algunos artículos hay insatisfacción en la cantidad de información recibida, especialmente los vinculados a la causa de la enfermedad, los aspectos del hospital y el lugar de cuidado, así como los diferentes sitios de atención y aspectos de autoayuda, con un grado de satisfacción inferior al 40%. Conclusión. A pesar del alto nivel de satisfacción de la información recibida, se observó que casi todos los pacientes les gustaría obtener aún más, lo que nos lleva a creer que proporcionar continuamente información sobre el tratamiento y el proceso de evolución de la enfermedad debe ser un proceso constante en el cuidado de estos pacientes

Avaliação clínica dos sintomas de pacientes com câncer de cabeça e pescoço

Objective: to evaluate the most frequent symptoms showed by patients with cancer of head and neck, and associated factors.Methodology: cross-sectional study conducted with 77 patients of service of head and neck surgery of the National Institute of Cancer (Brazil). It was used the Memorial Symptom Assessment Scale (MSAS), adapted to Brazil. It was estimated the prevalence of symptoms, as well as its association with demographic and clinical variables, assessed through Chi-squared and ANOVA tests.Results: the most prevalent symptoms were: dry mouth (62.5 %), sadness (60 %), concerns (53.75 %), nervousness (48.75 %) and cough (46.25 %). Difference in the physical symptoms of low frequency (PHYS-L) was identified for the age group, with greater complaint among young people (p < 0.01). On the global scale (TMSAS) there was greater complaint of outpatients than that of hospitalized patients (p = 0.05). There was greater complaint of symptoms of low frequency among patients without metastasis (p = 0.05).Conclusion: if it is taken into account the appearance of multiple symptoms in cancer patients, forms able to assess these in a broader way are necessary, which allow the nurse to get a better understanding of the complexity of the groups of symptoms and improve clinical interventions in the nursing process.Objetivo: avaliar os sintomas mais frequentes apresentados pelos pacientes com câncer de cabeça e pescoço e fatores associados.Metodologia: trata-se de um estudo transversal realizado com 77 pacientes do serviço de cirurgia de cabeça e pescoço do Instituto Nacional de Câncer (Brasil). Foi utilizado o Memorial Symptom Assessment Scale (MSAS), adaptado ao Brasil. Foi avaliada a prevalência dos sintomas, bem como sua associação com variáveis demográficas e clínicas por meio dos testes de qui- quadrado e de ANOVA.Resultados: os sintomas mais prevalentes foram boca seca (62,5 %), tristeza (60 %), preocupações (53,75 %), nervosismo (48,75 %) e tosse (46,25 %). Quanto à faixa etária, identificou-se diferença nos sintomas físicos de baixa frequência (PHYS-L), com maior queixa entre os jovens (p < 0,01). Na escala global (TMSAS) houve queixa maior dos pacientes ambulatoriais comparados aos internados (p = 0,05). Houve, ainda, queixa maior de sintomas de baixa frequência entre pacientes sem metástase (p = 0,05).Conclusão: considerando-se a ocorrência de múltiplos sintomas no paciente oncológico, é necessário ter métodos que sejam capazes de avaliar, de forma mais ampla, os sintomas. Dessa forma, o enfermeiro terá melhor compreensão da complexidade dos grupos de sintomas, permitindo aperfeiçoar as intervenções clínicas no processo de enfermagem.Objetivo: evaluar los síntomas más frecuentes presentados por los pacientes con cáncer de cabeza y cuello y factores asociados.Metodología: estudio transversal realizado con 77 pacientes del servicio de cirugía de cabeza y cuello del Instituto Nacional de Cáncer (Brasil). Se utilizó el Memorial Symptom Assessment Scale (MSAS) adaptado a Brasil. Se estimó la prevalencia de los síntomas, así como su asociación con variables demográficas y clínicas, evaluada a través de las pruebas de chi cuadrado y de ANOVA.Resultados: los síntomas más prevalentes fueron boca seca (62,5 %), tristeza (60 %), preocupaciones (53,75 %), nerviosismo (48,75 %) y tos (46,25 %). Para el grupo de edad se identificó diferencia en los síntomas físicos de baja frecuencia (PHYS-L), con mayor queja entre los jóvenes (p < 0,01). En la escala global (TMSAS) hubo mayor queja de los pacientes ambulatorios que de los pacientes internados (p = 0,05). Se produjo una queja mayor de síntomas de baja frecuencia entre pacientes sin metástasis (p = 0,05).Conclusión: si se tiene en cuenta la aparición de múltiples síntomas en el paciente oncológico, son necesarias formas capaces de evaluar estos de manera más amplia, que permitan al enfermero una mejor comprensión de la complejidad de los grupos de síntomas y perfeccionar las intervenciones clínicas en el proceso de enfermería

Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms

Avaliação global e miltidimensional de sintomas em pacientes com neoplasias abdominaisEvaluación global y multidimensional de síntomas en pacientes con neoplasias abdominalesObjective: To evaluate symptoms among patients with abdominal cancer and associated factors. Materials and methods: A cross-sectional study with 100 patients. The prevalence of symptoms was evaluated through the Memorial Symptom Assessment Scale (MSAS) and its association with demographic and clinical variables using chi-square and ANOVA tests. Results: The most prevalent symptoms were weight loss (64.0 %), pain (56.0 %), dry mouth (50.0 %), “I do not look more myself” (48.0 %) and lack of energy (45.0 %). There was a significant difference between sex and high-frequency (PHYS-H) (p = 0.001) and low-frequency (PHYS-L) physical symptoms (p = 0.004), and for general scale (TMSAS) (p = 0.002); (p = 0.001), general range (p = 0.027) and borderline significance for the global scale (GDI) (p = 0.051); high-frequency physical symptoms (p = 0.022), low-frequency physical symptoms (p = 0.034) and the overall scale (p = 0.034). There was one major complaint regarding the severity of high-frequency physical symptoms in patients with liver cancer (p = 0.018). Conclusion: Symptoms of physical and psychological aspects in cancer patients were associated with gender, race, marital status and tumor location. There is a need for tools to assess symptoms and enable health professionals to intervene more effectively.To reference this article / Para citar este artículo / Para citar este artigoLira AL, de Freitas TC, Martins T, Guimarães D, Silva MR, Drumond C, Guimarães RM. Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms. Aquichan 2019; 19(1): e1914. DOI: 10.5294/aqui.2019.19.1.4Received: 15/07/2018Approved: 15/01/2019Avaliação global e miltidimensional de sintomas em pacientes com neoplasias abdominaisEvaluación global y multidimensional de síntomas en pacientes con neoplasias abdominalesObjetivo: evaluar los síntomas entre los pacientes con cáncer abdominal y factores asociados. Materiales y método: estudio transversal realizado con 100 pacientes. Se evaluó la prevalencia de los síntomas, a través de la Memorial Symptom Assessment Scale (MSAS), y su asociación con variables demográficas y clínicas, por medio de pruebas de chi cuadrado y ANOVA. Resultados: los síntomas más prevalentes fueron pérdida de peso (64,0 %), dolor (56,0 %), boca seca (50,0 %), “No me siento yo mismo” (48,0 %) y falta de energía (45,0 %). Hay una diferencia significativa entre el sexo y los síntomas físicos de alta frecuencia (PHYS-H) (p = 0,001) y de baja frecuencia (PHYS-L) (p = 0,004), y para escala general (TMSAS) (p = 0,002); entre la raza y los síntomas físicos de alta frecuencia (p = 0,008), la escala general (p = 0,027) y la significancia limítrofe para la escala global (GDI) (p = 0,051); el estado civil y los síntomas físicos de alta frecuencia (p = 0,022), los síntomas físicos de baja frecuencia (p = 0,034) y la escala general (p = 0,034). Hubo una queja mayor en relación a la gravedad de los síntomas físicos de alta frecuencia en pacientes con cáncer de hígado (p = 0,018). Conclusión: síntomas de aspectos físicos y psicológicos en pacientes oncológicos se han asociado al sexo, la raza, el estado civil y la localización del tumor. Existe la necesidad de instrumentos para que los síntomas sean evaluados y permitan que los profesionales de la salud puedan intervenir de manera más eficaz.To reference this article / Para citar este artículo / Para citar este artigoLira AL, de Freitas TC, Martins T, Guimarães D, Silva MR, Drumond C, Guimarães RM. Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms. Aquichan 2019; 19(1): e1914. DOI: 10.5294/aqui.2019.19.1.4Received: 15/07/2018Approved: 15/01/2019Avaliação global e miltidimensional de sintomas em pacientes com neoplasias abdominaisEvaluación global y multidimensional de síntomas en pacientes con neoplasias abdominalesObjetivo: avaliar sintomas entre pacientes com câncer abdominal e fatores associados. Materiais e método: estudo transversal realizado com 100 pacientes. Foi avaliada a prevalência dos sintomas, através do Memorial Symptom Assessment Scale (MSAS), e sua associação com variáveis demográficas e clínicas, por meio de testes de qui quadrado e ANOVA. Resultados: os sintomas mais prevalentes foram perda de peso (64,0 %), dor (56,0 %), boca seca (50,0 %), “Eu não pareço mais eu mesmo” (48,0 %) e falta de energia (45,0 %). Há diferença significativa entre sexo e sintomas físicos de alta frequência (PHYS-H) (p = 0,001) e de baixa frequência (PHYS-L) (p = 0,004), e para escala geral (TMSAS) (p = 0,002); entre raça e sintomas físicos de alta frequência (p = 0,008), escala geral (p = 0,027) e significância limítrofe para a escala global (GDI) (p = 0,051); estado civil e sintomas físicos de alta frequência (p = 0,022), sintomas físicos de baixa frequência (p = 0,034) e a escala geral (p = 0,034). Houve uma queixa maior em relação à gravidade de sintomas físicos de alta frequência em pacientes com câncer de fígado (p = 0,018). Conclusão: sintomas de aspectos físico e psicológico em pacientes oncológicos foram associados a sexo, raça, estado civil e localização do tumor. Há necessidade de instrumentos para que os sintomas sejam avaliados e permitam que profissionais de saúde possam intervir de maneira mais eficaz.To reference this article / Para citar este artículo / Para citar este artigoLira AL, de Freitas TC, Martins T, Guimarães D, Silva MR, Drumond C, Guimarães RM. Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms. Aquichan 2019; 19(1): e1914. DOI: 10.5294/aqui.2019.19.1.4Received: 15/07/2018Approved: 15/01/201

Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms

Avaliação global e miltidimensional de sintomas em pacientes com neoplasias abdominais Evaluación global y multidimensional de síntomas en pacientes con neoplasias abdominales Objetivo: avaliar sintomas entre pacientes com câncer abdominal e fatores associados. Materiais e método: estudo transversal realizado com 100 pacientes. Foi avaliada a prevalência dos sintomas, através do Memorial Symptom Assessment Scale (MSAS), e sua associação com variáveis demográficas e clínicas, por meio de testes de qui quadrado e ANOVA. Resultados: os sintomas mais prevalentes foram perda de peso (64,0 %), dor (56,0 %), boca seca (50,0 %), “Eu não pareço mais eu mesmo” (48,0 %) e falta de energia (45,0 %). Há diferença significativa entre sexo e sintomas físicos de alta frequência (PHYS-H) (p = 0,001) e de baixa frequência (PHYS-L) (p = 0,004), e para escala geral (TMSAS) (p = 0,002); entre raça e sintomas físicos de alta frequência (p = 0,008), escala geral (p = 0,027) e significância limítrofe para a escala global (GDI) (p = 0,051); estado civil e sintomas físicos de alta frequência (p = 0,022), sintomas físicos de baixa frequência (p = 0,034) e a escala geral (p = 0,034). Houve uma queixa maior em relação à gravidade de sintomas físicos de alta frequência em pacientes com câncer de fígado (p = 0,018). Conclusão: sintomas de aspectos físico e psicológico em pacientes oncológicos foram associados a sexo, raça, estado civil e localização do tumor. Há necessidade de instrumentos para que os sintomas sejam avaliados e permitam que profissionais de saúde possam intervir de maneira mais eficaz. To reference this article / Para citar este artículo / Para citar este artigo Lira AL, de Freitas TC, Martins T, Guimarães D, Silva MR, Drumond C, Guimarães RM. Global and Multidimensional Symptom Assessments in Patients Presenting Abdominal Neoplasms. Aquichan 2019; 19(1): e1914. DOI: 10.5294/aqui.2019.19.1.4 Received: 15/07/2018 Approved: 15/01/201

Avaliação global e miltidimensional de sintomas em pacientes com neoplasias abdominais

Objective: To evaluate symptoms among patients with abdominal cancer and associated factors. Materials and methods: A cros-s-sectional study with 100 patients. The prevalence of symptoms was evaluated through the Memorial Symptom Assessment Scale (MSAS) and its association with demographic and clinical variables using chi-square and ANOVA tests. Results: The most prevalent symptoms were weight loss (64.0 %), pain (56.0 %), dry mouth (50.0 %), “I do not look more myself” (48.0 %) and lack of energy (45.0 %). There was a significant difference between sex and high-frequency (PHYS-H) (p = 0.001) and low-frequency (PHYS-L) physical symp-toms (p = 0.004), and for general scale (TMSAS) (p = 0.002); (p = 0.001), general range (p = 0.027) and borderline significance for the global scale (GDI) (p = 0.051); high-frequency physical symptoms (p = 0.022), low-frequency physical symptoms (p = 0.034) and the overall scale (p = 0.034). There was one major complaint regarding the severity of high-frequency physical symptoms in patients with liver cancer (p = 0.018). Conclusion: Symptoms of physical and psychological aspects in cancer patients were associated with gender, race, marital status and tumor location. There is a need for tools to assess symptoms and enable health professionals to intervene more effectively.Objetivo: avaliar sintomas entre pacientes com câncer abdominal e fatores associados. Materiais e método: estudo transversal realizado com 100 pacientes. Foi avaliada a prevalência dos sintomas, através do Memorial Symptom Assessment Scale (MSAS), e sua associação com variáveis demográficas e clínicas, por meio de testes de qui quadrado e ANOVA. Resultados: os sintomas mais prevalentes foram perda de peso (64,0 %), dor (56,0 %), boca seca (50,0 %), “Eu não pareço mais eu mesmo” (48,0 %) e falta de energia (45,0 %).Há diferença significativa entre sexo e sintomas físicos de alta frequência (PHYS-H) (p = 0,001) e de baixa frequência (PHYS-L) (p = 0,004), e para escala geral (TMSAS) (p = 0,002); entre raça e sintomas físicos de alta frequência (p = 0,008), escala geral (p = 0,027) e signifi-cância limítrofe para a escala global (GDI) (p = 0,051); estado civil e sintomas físicos de alta frequência (p = 0,022), sintomas físicos de baixa frequência (p = 0,034) e a escala geral (p = 0,034). Houve uma queixa maior em relação à gravidade de sintomas físicos de alta frequência em pacientes com câncer de fígado (p = 0,018). Conclusão: sintomas de aspectos físico e psicológico em pacientes oncoló-gicos foram associados a sexo, raça, estado civil e localização do tumor. Há necessidade de instrumentos para que os sintomas sejam avaliados e permitam que profissionais de saúde possam intervir de maneira mais eficaz.Objetivo: evaluar los síntomas entre los pacientes con cáncer abdominal y factores asociados. Materiales y método: estudio trans-versal realizado con 100 pacientes. Se evaluó la prevalencia de los síntomas, a través de la Memorial Symptom Assessment Scale (MSAS), y su asociación con variables demográficas y clínicas, por medio de pruebas de chi cuadrado y ANOVA. Resultados: los síntomas más prevalentes fueron pérdida de peso (64,0 %), dolor (56,0 %), boca seca (50,0 %), “No me siento yo mismo” (48,0 %) y falta de energía (45,0 %). Hay una diferencia significativa entre el sexo y los síntomas físicos de alta frecuencia (PHYS-H) (p = 0,001) y de baja frecuencia (PHYS-L) (p = 0,004), y para escala general (TMSAS) (p = 0,002); entre la raza y los síntomas físicos de alta frecuencia (p = 0,008), la escala general (p = 0,027) y la significancia limítrofe para la escala global (GDI) (p = 0,051); el estado civil y los síntomas físicos de alta frecuencia (p = 0,022), los síntomas físicos de baja frecuencia (p = 0,034) y la escala general (p = 0,034). Hubo una queja mayor en relación a la gravedad de los síntomas físicos de alta frecuencia en pacientes con cáncer de hígado (p = 0,018). Conclusión: síntomas de aspectos físicos y psicológicos en pacientes oncológicos se han asociado al sexo, la raza, el estado civil y la localización del tumor. Existe la necesidad de instrumentos para que los síntomas sean evaluados y permitan que los profesionales de la salud puedan intervenir de manera más eficaz