2,600 research outputs found
Modelos y organización de una unidad de consejo genético
Hereditary cancer affects 5-10% of the oncologic patients that we see ordinary in a medical oncology department. However, the great majority of the oncologist have a little knowledgement about this issue. The molecular and clinical advances in this field has provided us to detect high risk people to suffer some types of cancer, because they are germline mutation carriers in any susceptibility genes (genetic tests) and, also, the possibility of reduce the risk of suffering this disease almost in 100% of the cases (prophylactic surgery).In this paper we analyze the state-of-the-art in some aspects of hereditary cancer and its clinical management, also a little review about the psycological situations in this type of clinical counselling
Second record of Eustoma forneri Calzada, 1996 (Mollusca: Gastropoda) from the Hauterivian of Cinctorres (Maestrat basin)
Es fa la segona cita de l'espècie Eustoma forneri Calzada, 1996, ampliant la distribució geogràfica al municipi de Cinctorres dins la mateixa conca sedimentària del Maestrat on està la localitat tipus: Castellfort. També es tracta del mateix estrat tipus Hauterivià. S'indiquen algunes diferències respecte de l'holotip com ara el nombre de voltes i nombre de tubercles de la decoració de les voltes que es consideren dins la variació intraespecífica.lt is the second record of the species Eustomaforneri Calzada, 1996, expanding geographic distribution into Cinctorres municipality. The new locality is within the same sedimentary Maestrat basin where the type locality is: Castellfort. It also belongs to the same Hauterivian type strata. We show some differences from the holotype such as the number of whorls and number of decoration tubers of the whorls that are considered within the intraspecific variation of the taxon
Serum, Saliva, and Gingival Crevicular Fluid Osteocalcin: Their Relation to Periodontal Status and Bone Mineral Density in Postmenopausal Women
Background: Periodontitis and osteoporosis are characterized by the loss of bone mass. Osteocalcin levels have been postulated as a marker of inhibition of bone formation. The aim of the present study was to assess plasma, saliva, and gingival
crevicular fluid (GCF) levels of osteocalcin and correlate them with periodontitis and osteoporosis.
Methods: Seventy-three postmenopausal women, over 35 years old, were recruited for the study. Serum, saliva, and GCF osteocalcin were measured. Vertebral bone mineral density was measured by dual-energy x-ray absorptiometry. Differences between groups were assessed by analysis of variance (ANOVA), chi-square test, and non-parametric Kruskal-Wallis test.
Results: Thirty-four (46.6%) were classified in the normal healthy bone group, 11 women (15.1%) in the osteopenic group,
and 28 women (38.4%) in the osteoporotic group. No statistically significant differences between these densitometric groups were observed in probing depth (P = 0.24); clinical attachment level (P = 0.11); or mean osteocalcin concentrations in serum, saliva, and GCF. Twenty-seven (37.0%) of the women were classified without periodontitis (NPG) and 63.0% (N = 46) with periodontal disease (PG). There were no statistical differences in serum and saliva osteocalcin concentrations between these two groups. GCF osteocalcin concentrations were significantly higher in the PG women than in the NPG group (P = 0.008). Mean probing depth correlated significantly with GCF osteocalcin concentrations (r = 0.35; P = 0.002).
Conclusion: The results further support the concept that osteocalcin levels in GCF correlates with periodontal but not with
osteoporosis status
Consejo Genético
Hereditary cancer affects 5-10% of the oncologic patients that we see ordinary in a medical oncology department. However, the great majority of the oncologist have a little knowledgement about this issue. The molecular and clinical advances in this field has provided us to detect high risk people to suffer some types of cancer, because they are germline mutation carriers in any susceptibility genes (genetic tests) and, also, the possibility of reduce the risk of suffering this disease almost in 100% of the cases (prophylactic surgery). In this paper we analyze the state-of-the-art in some aspects of hereditary cancer and its clinical management, also a little revision about the psychological situations in this type of clinical counselling
Reacción liquenoide oral en relación con una restauración de amalgama de plata
La amalgama de plata es uno de los materiales de uso odontológico,
frente al que se pueden producir reacciones de hipersensibilidad.
La forma más frecuente es la aparición de una
reacción liquenoide, que afecta a la mucosa oral en contacto
directo con la restauración de amalgama y que está producida
por una reacción de hipersensibilidad retardada tipo IV, como
respuesta inmune mediada por células frente al mercurio o a
algún otro componente de la amalgama dental. En este trabajo
presentamos un caso de reacción liquenoide oral (RLO) asociada
a una restauración de amalgama de plata. Una mujer de 38 años
de edad solicitó asistencia odontológica para el tratamiento de
la caries del diente #37, realizándose una preparación cavitaria
clase I de Black, que se rellenó con amalgama de plata. Pasados
19 meses, la paciente volvió al consultorio dental, apreciándose
una zona atrófica, ligeramente eritematosa, en la mucosa yugal
izquierda, justamente en la región de mucosa contactante con
el molar restaurado con amalgama de plata. La mucosa yugal
derecha tenía un aspecto normal. La paciente había sentido cierta
sensación rara en esa zona al comer comidas picantes. No había
recibido ningún tipo de tratamiento desde la anterior visita, ni
presentaba antecedentes alérgicos. Tras la toma de biopsia, el
estudio anatomopatológico demostró cambios histológicos compatibles
con liquen plano oral. La paciente decidió no recambiar
la restauración, por valorar que no tenía molestias importantes
y no deseaba someterse de nuevo al tratamiento. Las restauraciones
de otros dientes se le realizaron con resina compuesta,
sin que se produjese reacción alguna en la mucosa.Hypersensitivity to mercury associated with amalgam restorations
may occur and present in one of two different ways. Most
commonly it presents as an oral lichenoid reaction affecting
oral mucosa in direct contact with an amalgam restoration and
represents a delayed, type IV, cell mediated immune response to
mercury or one of the other constituents of the dental amalgam.
We report a case of oral lichenoid reaction associated to amalgam
restoration. A 38 year-old woman presented a caries lesion
of tooth #37. A Black's class I preparation was performed and
filled with amalgam. After 19 months, intra-oral examination revealed atrophic lesion, lightly erythematous, affecting the left
buccal mucous. The lesion contacted directly with the amalgam
restoration in the lower first molar. The right buccal mucosa
was normal. His medical history was unremarkable, he was
taking no medication and had no known allergies. However, the
patient had felt certain rare sensation in that zone when eating
sharp meals. Biopsy showed histological changes compatible
with oral lichen planus. The patient decided not to change again
the restoration, because she did not have important annoyances
and she did not wish to be treated again. Other restorations
were performed with composite resins, and no reaction was
evidenced in the mucosa
Segona cita d’Eustoma forneri Calzada, 1996 (Mollusca: Gastropoda) de l’Hauterivià de Cinctorres (conca del Maestrat)
Es fa la segona cita de l’espècie Eustoma forneri Calzada, 1996, ampliant la distribució geogràfica almunicipi de Cinctorres dins la mateixa conca sedimentària del Maestrat on està la localitat tipus:Castellfort. També es tracta del mateix estrat tipus Hauterivià. S’indiquen algunes diferències respectede l’holotip com ara el nombre de voltes i nombre de tubercles de la decoració de les voltes que esconsideren dins la variació intraespecífica.Second record of Eustoma forneri Calzada, 1996 (Mollusca: Gastropoda) from theHauterivian of Cinctorres (Maestrat basin) It is the second record of the species Eustoma forneri Calzada, 1996, expanding geographic distribution into Cinctorres municipality. The new locality is within the same sedimentary Maestrat basin where thetype locality is: Castellfort. It also belongs to the same Hauterivian type strata. We show some differencesfrom the holotype such as the number of whorls and number of decoration tubers of the whorls that areconsidered within the intraspecific variation of the taxon
JPEG Compressed Images Can Bypass Protections Against AI Editing
Recently developed text-to-image diffusion models make it easy to edit or
create high-quality images. Their ease of use has raised concerns about the
potential for malicious editing or deepfake creation. Imperceptible
perturbations have been proposed as a means of protecting images from malicious
editing by preventing diffusion models from generating realistic images.
However, we find that the aforementioned perturbations are not robust to JPEG
compression, which poses a major weakness because of the common usage and
availability of JPEG. We discuss the importance of robustness for additive
imperceptible perturbations and encourage alternative approaches to protect
images against editing.Comment: 8 pages, 8 figure
A Multi-Temporal Object-Based Image Analysis to Detect Long-Lived Shrub Cover Changes in Drylands
Climate change and human actions condition the spatial distribution and structure of vegetation, especially in drylands. In this context, object-based image analysis (OBIA) has been used to monitor changes in vegetation, but only a few studies have related them to anthropic pressure. In this study, we assessed changes in cover, number, and shape of Ziziphus lotus shrub individuals in a coastal groundwater-dependent ecosystem in SE Spain over a period of 60 years and related them to human actions in the area. In particular, we evaluated how sand mining, groundwater extraction, and the protection of the area affect shrubs. To do this, we developed an object-based methodology that allowed us to create accurate maps (overall accuracy up to 98%) of the vegetation patches and compare the cover changes in the individuals identified in them. These changes in shrub size and shape were related to soil loss, seawater intrusion, and legal protection of the area measured by average minimum distance (AMD) and average random distance (ARD) analysis. It was found that both sand mining and seawater intrusion had a negative effect on individuals; on the contrary, the protection of the area had a positive effect on the size of the individuals’ coverage. Our findings support the use of OBIA as a successful methodology for monitoring scattered vegetation patches in drylands, key to any monitoring program aimed at vegetation preservation
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