Thermal and hydraulic analysis of multilayered asphalt pavements as active solar collectors

The fulfillment of current environmental aims like reducing fossil fuel consumption or greenhouse gas emissions entails the development of new technologies that enable the use of cleaner, cheaper and renewable energies. Furthermore, the need to improve energy efficiency in buildings encourages scientists and engineers to find new ways of harvesting energy for later uses. The use of asphalt pavements as active solar collectors is introduced in this article. Several authors have studied the use of roads as an energy source before. However, a new technology is presented in which a multilayered pavement with a highly porous middle layer is used instead of a solar collector with an embedded pipe network. These collectors are fully integrated within the road infrastructure and may offer low cost solar energy for water heating. The paper includes a brief comment on the state-of-the-art. Then, a broad methodology is presented in which data, materials and procedures needed to run the tests are fully described. Finally, the results of the laboratory tests are stated and discussed. The prototype used in the laboratory provided excellent thermal efficiency. However, these good results contrast with the low flow rate levels registered during the tests. Thus, although this technology seems to be very promising, new experimental tests should be performed before an effective application is possible.This paper is based on the initial literature review for the Fenix Project. The development of the Fenix Project (www.proyectofenix.es) has been possible thanks to the financial contribution of the Center for Technological and Industrial Development (CDTI) within the framework of the Ingenio 2010 programme, through the CENIT Programme. The companies and research centers involved in the project wish to express their gratitude for the contribution

Caracterização socioeconómica das Cidades Alargadas de Aveiro-Ílhavo e Évora

Resumo indisponível

Qualidade de Vida: uma análise à escala local

O tema deste artigo enquadra-se no âmbito do projecto "Custos e Beneficos, à escala local, de uma Ocupação Dispersa". Esta investigação assenta a sua problemática na dispersão e procura chegar a mnclusões e recomendações sobre o fenómeno do alastramento da dispersão; e sobre cenários desejáveis de evolução da ocupação dispersa existente, no que respeita à infra-estrutura e/ou à mobilidade e/ou à carga construtiva. Assim, o objectivo do projecto, essencialmente operativo, é o de confrontar os custos e os beneficios (Qualidade de Vida) para uma diversidade de contextos territoriais, as cidades alargadas de Aveirol/ Íhavo e Évora e respectiva subdivisão em Unidades Territoriais de Base UTBs. Para atingir este objectivo, o percurso metodológico desta investigação integra, para além de outros objectivos específicos, a formulação do conceito de Qualidade de Vida e a sua tradução em algoritmo, que aqui desenvolvemos

Scutoids are a geometrical solution to three-dimensional packing of epithelia

As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in bent epithelia can undergo intercalations along the apico-basal axis. This phenomenon forces cells to have different neighbours in their basal and apical surfaces. As a consequence, epithelial cells adopt a novel shape that we term “scutoid”. The detailed analysis of diverse tissues confirms that generation of apico-basal intercalations between cells is a common feature during morphogenesis. Using biophysical arguments, we propose that scutoids make possible the minimization of the tissue energy and stabilize three-dimensional packing. Hence, we conclude that scutoids are one of nature's solutions to achieve epithelial bending. Our findings pave the way to understand the three-dimensional organization of epithelial organs.España Ministerio de Ciencia y Tecnología BFU2013-48988-C2-1-P and BFU2016-8079

Qual o valor da Qualidade de Vida? Um contributo e várias conjecturas metodológicas

Este estudo apresenta o fundamental da metodologia já desenvolvida até este momento pela equipa para a valoração, em termos monetários, de algumas dimensões da Qualidade de Vida (QdV), no âmbito do projecto FCT “Custos e Benefícios, à escala local, de uma Ocupação Dispersa”. Esta valoração constitui uma peça fundamental no estudo já que se refere à componente dos benefícios que as famílias, as empresas e as instituições parecem procurar quando tomam decisões de localização. O estudo tenta aferir a QdV a partir das preferências declaradas para obter a disponibilidade em pagar (Willingness to Pay) expressa pelos indivíduos para aceitar melhorar as suas “circunstâncias” (ou para evitar uma perda) ou o a sua disponibilidade em receber (Willingness to Accept) uma compensação para aceitar reduzir as suas “circunstâncias” (ou para prescindir de um benefício). Dada a natureza multidimensional, complexa e dinâmica do conceito de QdV, o estudo concentra a sua atenção num conjunto de 6 atributos (com duas concretizações cada, combinados dois a dois) associáveis a pedaços urbanos abstractos. As várias combinações possíveis são reduzidas após a aplicação do “quadrado latino” e forma a gerar 16 “conjuntos urbanos tipo” (também designados de “pedaços urbanos”) a partir dos quais se tentará valorar, em termos monetários, o correspondente “benefício”. Com este procedimento, o estudo procura dar um contributo para o desenho de políticas públicas neste domínio procurando fornecer critérios técnicos robustos de escolha, de decisão e de acção, aos decisores com responsabilidade na gestão do território local

Plasma Concentrations of Neurofilament Light Chain Protein and Brain-Derived Neurotrophic Factor as Consistent Biomarkers of Cognitive Impairment in Alcohol Use Disorder

For a long time, Substance Use Disorders (SUDs) were not considered a component in the etiology of dementia. The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders introduced substance-induced neurocognitive disorders, incorporating this notion to clinical practice. However, detection and monitoring of neurodegenerative processes in SUD patients remain a major clinical challenge, especially when early diagnosis is required. In the present study, we aimed to investigate new potential biomarkers of neurodegeneration that could predict cognitive impairment in SUD patients: the circulating concentrations of Neurofilament Light chain protein (NfL) and Brain-Derived Neurotrophic Factor (BDNF). Sixty SUD patients were compared with twenty-seven dementia patients and forty healthy controls. SUD patients were recruited and assessed using the Psychiatric Research Interview for Substance and Mental (PRISM) and a battery of neuropsychological tests, including the Montreal Cognitive Assessment test for evaluation of cognitive impairment. When compared to healthy control subjects, SUD patients showed increases in plasma NfL concentrations and NfL/BDNF ratio, as well as reduced plasma BDNF levels. These changes were remarkable in SUD patients with moderate–severe cognitive impairment, being comparable to those observed in dementia patients. NfL concentrations correlated with executive function and memory cognition in SUD patients. The parameters “age”, “NfL/BDNF ratio”, “first time alcohol use”, “age of onset of alcohol use disorder”, and “length of alcohol use disorder diagnosis” were able to stratify our SUD sample into patients with cognitive impairment from those without cognitive dysfunction with great specificity and sensibility. In conclusion, we propose the combined use of NfL and BDNF (NfL/BDNF ratio) to monitor substance-induced neurocognitive disorder.Instituto de Salud Carlos III (ISCIII], Ministerio de Ciencia e Innovación and European Regional Development Funds-European Union (ERDF-EU] grants “Proyectos de Investigación en Salud” PI19/01577, PI19/00886, PI20/01399 and PI22/00427; Grants Programa RICORS RIAPAD (Red de Investigación en Atención Primaria en Adicciones), Programa RETICS Red de Trastornos Adictivos, (RD16/0017/000); Ministerio de Sanidad, Delegación de Gobierno para el Plan Nacional sobre Drogas (PND 2022I020, PND2020/048, PND 2019/040]; Consejería de Salud y Familia, Junta de Andalucía (Neuro-RECA, RIC-0111-2019]. FJP (CPII19/00022] and AS (CPII19/00031] hold “Miguel Servet II” research contracts from the National System of Health, ISCIII, ERDF-EU. FJP also holds a “Nicolas Monardes” contract from Servicio Andaluz de Salud, Consejería de Salud y Familia, Junta de Andalucía (C1-0049-2019]. PA has a research contract (UMA-FEDERJA-076) funded by the Ministry of Economy and Knowledge—Regional Government of Andalucía and ERDF-EU. The funding sources had no further role in the study design; in the collection, analysis, and interpretation of data; in writing of the report; or in the decision to submit the paper for publication

Evaluation of the Damper Condition in Synchronous Motors through the Analysis of the Transient Stray Fluxes and Currents considering the Effect of the Remanent Magnetism

(c) 2021 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.[EN] This paper proposes the qualitative and quantitative analysis of stray-flux and current data under starting to detect damper faults in cylindrical rotor synchronous machines. These machines are typically employed in high power applications and their possible outages may imply huge costs for the industries or plants where they operate. The damper cage is a critical part of these machines and a potential source of catastrophic failures. However, few research works have provided feasible alternatives to monitor the condition of such element. This work analyses the viability of analyzing the electromotive force signals induced by the stray-flux in external coil sensors as well as current signals under starting to diagnose damper faults. The results obtained with laboratory machines with different levels of damper damage show that the analyses of those signals can provide very useful information for determining how the damper degrades over time. Moreover, the paper studies the effect of the remanent magnetism over the viability of the approaches and provides solutions to overcome this problem. The conclusions are valuable for field engineers since, nowadays, there are few available solutions that allow monitoring the condition of such element without motor disassembly.This work was supported in part by the Spanish "Ministerio de Ciencia Innovacion y Universidades" and in part by the FEDER program in the framework of the "Proyectos de I+D de Generacion de Conocimiento del Programa Estatal de Generacion de Conocimiento y Fortalecimiento Cientifico y Tecnologico del Sistema de I+D+i, Subprograma Estatal de Generacion de Conocimiento" (ref: PGC2018-095747-B-I00).Castro-Coronado, H.; Antonino-Daviu, JA.; Quijano-Lopez, A.; Llovera Segovia, P.; Fuster Roig, VL.; Serrano Iribarnegaray, L.; Dunai, L. (2021). Evaluation of the Damper Condition in Synchronous Motors through the Analysis of the Transient Stray Fluxes and Currents considering the Effect of the Remanent Magnetism. IEEE Transactions on Industry Applications. 57(5):4665-4674. https://doi.org/10.1109/TIA.2021.30894574665467457

Prospective secondary school teachers’ knowledge of correlation and regression

La finalidad del trabajo fue evaluar el conocimiento especializado del contenido sobre correlación y regresión de 65 futuros profesores de Educación Secundaria Obligatoria y Bachillerato. Después de trabajar con un proyecto estadístico basado en datos de las Naciones Unidas, los participantes analizaron el componente epistémico de la idoneidad didáctica (Godino, 2013) de dicho proyecto. El análisis de las producciones escritas de los participantes permite asignarles un nivel en cada uno de los indicadores, comparar sus conocimientos en dichos indicadores e identificar ejemplos de su conocimiento especializado sobre la correlación y regresión.The aim of this research was to evaluate the specialised content knowledge of correlation and regression in 65 prospective secondary and high school teachers. After working in a statistical workshop based on data from the United Nations, the participants analysed the epistemic component of didactic suitability (Godino, 2013) for this project. The analysis of the participants’ written productions in this task served to assign them a level in each indicator, compare their knowledge of these indicators and identify examples of participants’ specialised knowledge of correlation and regression

Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies

Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources, it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. For this reason, we performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways involved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drugThis research was funded by Andalusian Network of Clinical and Translational Research in Neurology (Neuro-RECA) of the Consejería de Salud y Familias de la Junta de Andalucía (Code: RIC-0111-2019). Partial funding for open access charge: Universidad de Málag

Natalizumab-immunogenicity evaluation in patients with infusion related events or disease exacerbations

IntroductionNatalizumab is a biologic drug for relapsing-remitting multiple sclerosis that may induce the generation of anti-drug antibodies in some patients. Anti-natalizumab antibodies (ANA) increase the risk of adverse events and reduce efficacy, being useful biomarkers for monitoring treatment response.MethodsRetrospective observational study including MS patients treated with natalizumab that experienced infusion-related events (IRE) or disease exacerbations (DE). ANA were tested by Elisa including a screening and a confirmation assay. Patients were further classified as transient (one positive result) or persistent (two or more positive results) ANA.ResultsA total of 1251 MS patients were included and 153 (12.3%) had ANA with at least one single point determination, which were more frequent among patients with IRE compared to those with DE (21,6% vs.10.8%) during the first six infusions. Two or more determinations ANA were performed in 184 patients, being 31.5% permanently positive and 7.1% transiently positive. Interestingly, 26.1% of patients that experienced DE had persistent ANA, while 2.6% were transient. In contrast, 43% of patients with IRE had persistent ANA, and 9.3% had transient antibodies. Patients with persistent antibodies had more frequently high levels at the first sampling compared to patients with transient ANA.ConclusionReal-world evidence shows that the presence of ANA is behind an important percentage of patients treated with natalizumab that experience IRE, as well as DE but in a lower degree. These findings support the need to systematically evaluate ANA towards a personalized management of these patients to avoid undesired complications