1,414 research outputs found

    An architecture for reliable distributed computer-controlled systems

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    In Distributed Computer-Controlled Systems (DCCS), both real-time and reliability requirements are of major concern. Architectures for DCCS must be designed considering the integration of processing nodes and the underlying communication infrastructure. Such integration must be provided by appropriate software support services. In this paper, an architecture for DCCS is presented, its structure is outlined, and the services provided by the support software are presented. These are considered in order to guarantee the real-time and reliability requirements placed by current and future systems

    Evaluation of Antibiotic Resistance Emerging from use of Antibiotics in CAFOs

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    Action research and democracy

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    This contribution explores the relationship between research and learning democracy. Action research is seen as being compatible with the orientation of educational and social work research towards social justice and democracy. Nevertheless, the history of action research is characterized by a tension between democracy and social engineering. In the social-engineering approach, action research is conceptualized as a process of innovation aimed at a specific Bildungsideal. In a democratic approach action research is seen as research based on cooperation between research and practice. However, the notion of democratic action research as opposed to social engineering action research needs to be theorized. So called democratic action research involving the implementation by the researcher of democracy as a model and as a preset goal, reduces cooperation and participation into instruments to reach this goal, and becomes a type of social engineering in itself. We argue that the relationship between action research and democracy is in the acknowledgment of the political dimension of participation: ‘a democratic relationship in which both sides exercise power and shared control over decision-making as well as interpretation’. This implies an open research design and methodology able to understand democracy as a learning process and an ongoing experiment

    Probing the CP nature of the Higgs coupling in tt¯h events at the LHC

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    The determination of the CP nature of the Higgs coupling to top quarks is addressed in this paper, using t¯th events produced in √s=13  TeV proton-proton collisions at the LHC. Dileptonic final states are employed, with two oppositely charged leptons and four jets, corresponding to the decays t→bW+→bℓ+νℓ, ¯t→¯bW−→¯bℓ−¯νℓ, and h→b¯b. Pure scalar (h=H), pure pseudoscalar (h=A), and CP-violating Higgs boson signal events, generated with MadGraph5_aMC@NLO, are fully reconstructed through a kinematic fit. We furthermore generate samples that have both a CP-even and a CP-odd component in the t¯th coupling in order to probe the ratio of the two components. New angular distributions of the decay products, as well as CP angular asymmetries, are explored in order to separate the scalar from the pseudoscalar components of the Higgs boson and reduce the contribution from the dominant irreducible background, t¯tb¯b. Significant differences between the angular distributions and asymmetries are observed, even after the full kinematic fit reconstruction of the events, allowing to define the best observables for a global fit of the Higgs couplings parameters.info:eu-repo/semantics/publishedVersio

    North-South dialogues: reflecting on working transnationally with young men, masculinities and gender justice

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    Dialoguing across national borders and specifically global North-South centres and margins has increasingly been viewed as a way to enhance critical and feminist studies and engagement with men and masculinities. This article draws on narratives generated by a group of researchers in South Africa and Finland who have been engaged in a transnational research project that included a strong focus on young men, masculinities and gender and sexual justice. The piece provides an account of the nuanced and complex experiences and dynamics involved in transnational research collaboration, particularly within the framework on historical and continued inequalities between the global North and South. While obvious benefits are raised, this experience also foregrounds a range of challenges and constraints involved in transnational research collaboration within this field and possibly many others. Key learnings gleaned from this analysis of reported experiences and thoughts include the importance of careful, considered and critical reflexivity at all moments and at all levels, both in interpersonal and intergroup relations, as well as in public representation of collaborative work

    Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model

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    PURPOSE: To study susceptibility to glaucoma injury as it may be affected by mutations in ocular connective tissue components. METHODS: Mice homozygous for an N-ethyl-N-nitrosourea induced G257D exchange (Gly to Asp) missense mutation (Aca23) in their collagen 8A2 gene were studied to measure intraocular pressure (IOP), axial length and width, number of retinal ganglion cells (RGC), and inflation responses. Three month old homozygous Aca23 mutant and wild type (WT) mice had 6 weeks exposure to elevated IOP induced by polystyrene microbead injection. Additional Aca23 and matched controls were studied at ages of 10 and 18 months. RESULTS: Aca23 mice had no significant difference from WT in IOP level, and in both strains IOP rose with age. In multivariable models, axial length and width were significantly larger in Aca23 than WT, became larger with age, and were larger after exposure to glaucoma (n=227 mice). From inflation test data, the estimates of scleral stress resultants in Aca23 mice were similar to age-matched and younger WT C57BL/6 (B6) mice, while the strain estimates for Aca23 were significantly less than those for either WT group in the mid-sclera and in some of the more anterior scleral measures (p<0.001; n=29, 22, 20 eyes in Aca23, older WT, younger WT, respectively). With chronic IOP elevation, Aca23 eyes increased 9% in length and 7% in width, compared to untreated fellow eyes (p<0.05, <0.01). With similar elevated IOP exposure, WT eyes enlarged proportionately twice as much as Aca23, increasing in length by 18% and in nasal-temporal width by 13% (both p<0.001, Mann-Whitney test). In 4 month old control optic nerves, mean RGC axon number was not different in Aca23 and WT (46,905±7,592, 43,628±11,162, respectively; p=0.43, Mann-Whitney test, n=37 and 29). With chronic glaucoma, Aca23 mice had a mean axon loss of only 0.57±17%, while WT mice lost 21±31% (median loss: 1% versus 10%, n=37, 29, respectively; p=0.001; multivariable model adjusting for positive integral IOP exposure). CONCLUSIONS: The Aca23 mutation in collagen 8α2 is the first gene defect found to alter susceptibility to experimental glaucoma, reducing RGC loss possibly due to differences in mechanical behavior of the sclera. Detailed study of the specific changes in scleral connective tissue composition and responses to chronic IOP elevation in this strain could produce new therapeutic targets for RGC neuroprotection

    The ChaMP Extended Stellar Survey (ChESS): Photometric and Spectroscopic Properties of Serendipitously Detected Stellar X-Ray Sources

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    We present 348 X-ray-emitting stars identified from correlating the Extended Chandra Multiwavelength Project (ChaMP), a wide-area serendipitous survey based on archival X-ray images, with the Sloan Digital Sky Survey (SDSS). We use morphological star/galaxy separation, matching to an SDSS quasar catalog, an optical color-magnitude cut, and X-ray data-quality tests to create our catalog, the ChaMP Extended Stellar Survey (ChESS), from a sample of 2121 matched ChaMP/SDSS sources. Our cuts retain 92% of the spectroscopically confirmed stars in the original sample while excluding 99.6% of the 684 spectroscopically confirmed extragalactic sources. Fewer than 3% of the sources in our final catalog are previously identified stellar X-ray emitters. For 42 catalog members, spectroscopic classifications are available in the literature. We present new spectral classifications and Hα measurements for an additional 79 stars. The catalog is dominated by main-sequence stars; we estimate the fraction of giants in ChESS is ~10%. We identify seven giant stars (including a possible Cepheid and an RR Lyrae star) as ChaMP sources, as well as three cataclysmic variables. We derive distances from ~10 to 2000 pc for the stars in our catalog using photometric parallax relations appropriate for dwarfs on the main sequence and calculate their X-ray and bolometric luminosities. These stars lie in a unique space in the L_X-distance plane, filling the gap between the nearby stars identified as counterparts to sources in the ROSAT All Sky Survey and the more distant stars detected in deep Chandra and XMM-Newton surveys. For 36 newly identified X-ray-emitting M stars we calculate LHα/Lbol. The quantities LHα/Lbol and L_X/L_bol are linearly related below L_X/L_bol ~ 3 × 10⁻⁴, while L_Hα/L_bol appears to turn over at larger L_X/L_bol values. Stars with reliable SDSS photometry have an ~0.1 mag blue excess in u − g, likely due to increased chromospheric continuum emission. Photometric metallicity estimates suggest that the sample is evenly split between the young and old disk populations of the Galaxy; the lowest activity sources belong to the old disk population, a clear signature of the decay of magnetic activity with age. Future papers will present analyses of source variability and comparisons of this catalog to models of stellar activity in the Galactic disk

    Empathy: a review of the concept

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    The inconsistent definition of empathy has had a negative impact on both research and practice. The aim of this article is to review and critically appraise a range of definitions of empathy and, through considered analysis, to develop a new conceptualisation. From the examination of 43 discrete definitions, 8 themes relating to the nature of empathy emerged: “distinguishing empathy from other concepts”; “cognitive or affective?”; “congruent or incongruent?”; “subject to other stimuli?”; “self/other distinction or merging?”; “trait or state influences?”; “has a behavioural outcome?”; and “automatic or controlled?” The relevance and validity of each theme is assessed and a new conceptualisation of empathy is offered. The benefits of employing a more consistent and complete definition of empathy are discussed
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