Infant self-regulation and body mass index in early childhood

BACKGROUND: Poor self-regulation during preschool and early school age years is associated with rapid weight gain. However, the association between self-regulatory capacities in infancy and weight status in early childhood has not been well studied. Objective: Examine prospective associations between infant self-regulation and body mass index (BMI) in early childhood. We hypothesized that infants exhibiting less optimal self-regulation would be at greater risk of obesity at 3–5 years of life. METHODS: We used data from 5750 children in the Early Childhood Longitudinal Study-Birth Cohort (ECLS-B), excluding premature infants and infants small or large for gestational age. Our primary predictor was infant self-regulation measured at age 9 months by parent completion of the Infant Toddler Symptom Checklist (ITSC). We defined child obesity at preschool and kindergarten age (approximately 4 years and 5–6 years respectively) as a body mass index (BMI) ≥ 95th percentile for age and sex by US Centers for Disease Control growth charts. We created logistic regression models comparing risk of obesity at preschool and kindergarten age in infants with ITSC scores ≥ 6 to infants with scores < 6, controlling for covariates. RESULTS: Twenty-one percent of children with ITSC scores ≥ 6 at 9 months were obese at preschool age compared to 16% of children with lower ITSC scores. At kindergarten age this difference decreased to 18% vs. 16% respectively. After adjusting for covariates, infants with ITSC scores ≥ 6 had 32% increased odds of being obese at preschool age (aOR 1.32; 95% CI: 1.03, 1.70) though this association decreased at kindergarten age (aOR 1.07; 95% CI: 0.79, 1.45). CONCLUSIONS: Poor infant self-regulation at 9 months is associated with an increased risk of obesity at preschool entry but not at kindergarten entry. Helping parents manage and respond to children’s self-regulation difficulties prior to preschool age may serve as a focal point for future interventions.2016-12-01T00:00:00

Reconstructing the spectrum of the pregalactic density field from astronomical data

In this paper we evaluate the spectrum of the pregalactic density field on scales $1h^{-1}Mpc < r < 100h^{-1}$Mpc from a variety of astronomical data. APM data on $w(\theta)$ in six narrow magnitude is used, after correcting to possible evolutionary effects, to constrain the spectrum of galaxy clustering on scales $10h^{-1}Mpc < r < 50-100h^{-1}Mpc$. Fitting power spectra of CDM models to the data at all depths requires $\Omega h=0.2$ if the primordial index $n=1$ and $\Omega h=0.3$ if the spectrum is tilted with $n=0.7$. Then we compare the peculiar velocity field predicted by the APM spectrum of galaxy (light) distribution with the actual velocity data. The two fields are consistent and the comparison suggests that the bias factor is scale independent with $\Omega^{0.6}/b\simeq$(0.2-0.3). The next dataset used comes from the cluster correlation data. We calculate in detail the amplification of the cluster correlation function due to gravitational clustering and use the data on both the slope of the cluster correlation function and its amplitude-richness dependence. Cluster masses are normalized using the Coma cluster. We find that CDM models are hard to reconcile with all the three datasets: APM data on $w(\theta)$, the data on cluster correlation function, and the data on the latter's amplitude-richness dependence. We show that the data on the amplitude-richness dependence can be used directly to obtain the spectrum of the pregalactic density field. Applying the method to the data, we recover the density field on scales between 5 and 25$h^{-1}$Mpc whose slope is in good agreement with the APM data on the same scales. Requiring the two amplitudes to be the same, fixes the value of $\Omega$ to be 0.3 in agreement with observations of the dynamics of the Coma cluster. Finally we use the dataComment: to be published in Ap.J - minor revision + typos correcte

A prospective study of the impact of serial troponin measurements on the diagnosis of myocardial infarction and hospital and six-month mortality in patients admitted to ICU with non-cardiac diagnoses.

INTRODUCTION: Troponin T (cTnT) elevation is common in patients in the Intensive Care Unit (ICU) and associated with morbidity and mortality. Our aim was to determine the epidemiology of raised cTnT levels and contemporaneous electrocardiogram (ECG) changes suggesting myocardial infarction (MI) in ICU patients admitted for non-cardiac reasons. METHODS: cTnT and ECGs were recorded daily during week 1 and on alternate days during week 2 until discharge from ICU or death. ECGs were interpreted independently for the presence of ischaemic changes. Patients were classified into four groups: (i) definite MI (cTnT ≥15 ng/L and contemporaneous changes of MI on ECG), (ii) possible MI (cTnT ≥15 ng/L and contemporaneous ischaemic changes on ECG), (iii) troponin rise alone (cTnT ≥15 ng/L), or (iv) normal. Medical notes were screened independently by two ICU clinicians for evidence that the clinical teams had considered a cardiac event. RESULTS: Data from 144 patients were analysed (42% female; mean age 61.9 (SD 16.9)). A total of 121 patients (84%) had at least one cTnT level ≥15 ng/L. A total of 20 patients (14%) had a definite MI, 27% had a possible MI, 43% had a cTNT rise without contemporaneous ECG changes, and 16% had no cTNT rise. ICU, hospital and 180-day mortality was significantly higher in patients with a definite or possible MI. CONCLUSIONS: The majority of critically ill patients (84%) had a cTnT rise and 41% met criteria for a possible or definite MI of whom only 20% were recognised clinically. Mortality up to 180 days was higher in patients with a cTnT rise

Department of Internal Medicine-Pediatrics Posters - 2019

Department of Internal Medicine-Pediatrics Posters - 2019https://scholarlycommons.libraryinfo.bhs.org/research_education/1012/thumbnail.jp

Vancomycin Susceptibility within Methicillin-resistant Staphylococcus aureus Lineages

Methicillin-resistant Staphylococcus aureus (MRSA) with reduced vancomycin susceptibility (VISA, vancomycin-intermediate S. aureus) has been reported from many countries. Whether resistance is evolving regularly in different genetic backgrounds or in a single clone with a genetic predisposition, as early results suggest, is unclear. We have studied 101 MRSA with reduced vancomycin susceptibility from nine countries by multilocus sequence typing (MLST) and characterization of SCCmec (staphylococcal chromosomal cassette mec) and agr (accessory gene regulator). We found nine genotypes by MLST, with isolates within all five major hospital MRSA lineages. Most isolates (88/101) belonged to two of the earliest MRSA clones that have global prevalence. Our results show that reduced susceptibility to vancomycin has emerged in many successful epidemic lineages with no clear clonal disposition. Increasing antimicrobial resistance in genetically distinct pandemic clones may lead to MRSA infections that will become increasingly difficult to treat

CENSORS: A Combined EIS-NVSS Survey Of Radio Sources. I. Sample definition, radio data and optical identifications

A new sample of radio sources, with the designated name CENSORS (A Combined EIS-NVSS Survey Of Radio Sources), has been defined by combining the NRAO VLA Sky Survey (NVSS) at 1.4 GHz with the ESO Imaging Survey (EIS) Patch D, a 3 by 2 degree region of sky centred at 09 51 36.0, -21 00 00 (J2000). New radio observations of 199 NVSS radio sources with NVSS flux densities S(1.4GHz) > 7.8mJy are presented, and compared with the EIS I-band imaging observations which reach a depth of I~23; optical identifications are obtained for over two-thirds of the ~150 confirmed radio sources within the EIS field. The radio sources have a median linear size of 6 arcseconds, consistent with the trend for lower flux density radio sources to be less extended. Other radio source properties, such as the lobe flux density ratios, are consistent with those of brighter radio source samples. From the optical information, 30-40% of the sources are expected to lie at redshifts z >~ 1.5. One of the key goals of this survey is to accurately determine the high redshift evolution of the radio luminosity function. These radio sources are at the ideal flux density level to achieve this goal; at redshifts z~2 they have luminosities which are around the break of the luminosity function and so provide a much more accurate census of the radio source population at those redshifts than the existing studies of extreme, high radio power sources. Other survey goals include investigating the dual--population unification schemes for radio sources, studying the radio luminosity dependence of the evolution of radio source environments, and understanding the radio power dependence of the K-z relation for radio galaxies.Comment: Accepted for publication in MNRAS. 28 pages plus 36 reduced resolution jpeg figures. A postscript version with full resolution figures included in the text is available from http://www.roe.ac.uk/~pnb/censors.ps.g

Serum Calcium to Phosphorous (Ca/P) Ratio is a simple, inexpensive, and accurate tool in the diagnosis of primary hyperparathyroidism

Primary hyperparathyroidism (PHPT) diagnosis is challenging and is based on serum calcium (Ca) and parathyroid hormone (PTH). Because serum Ca and phosphorous (P) are inversely related in PHPT, we investigated the diagnostic value of the serum Ca/P ratio in the diagnosis of PHPT. We report a single-center, case-controlled, retrospective study including 97 patients with documented PHPT and compared them with those of 96 controls (C). The main outcome measures were: serum PTH, 25-OH vitamin D, Ca, P, albumin, and creatinine. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the serum Ca/P ratio were calculated. The results were verified using an independent, anonymous set of data extracted from a laboratory database containing over 900 million entries. A total of 35 (36.1%) PHPT patients had normocalcemic PHPT (NCHPT). Ca and PTH were significantly higher in PHPT than in C (p < 0.0001). P was significantly lower in PHPT than in C (p < 0.0001). The Ca/P ratio was significantly higher in PHPT than in C (p < 0.0001). Receiver-operating characteristic (ROC) curves analyses identified a cutoff of 2.71 (3.5 if Ca and P are expressed in mg/dL) for Ca/P ratio with a sensitivity and specificity of 86% and 87%, respectively (p < 0.0001), confirmed by the independent, big data approach. In conclusion, Ca/P is a valuable tool for the diagnosis of PHPT and is of superior value compared to serum Ca alone, especially in NCPHT. Because Ca/P is simple, inexpensive, and easily accessible worldwide, this ratio is useful for PHPT diagnosis, especially in laboratory/medical settings relying on limited resources, such as low-income countries. © 2017 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research

Internal properties and environments of dark matter halos

We use seven high-resolution $N$-body simulations to study the correlations among different halo properties (assembly time, spin, shape and substructure), and how these halo properties are correlated with the large-scale environment in which halos reside. The large-scale tidal field estimated from halos above a mass threshold is used as our primary quantity to characterize the large-scale environment, while other parameters, such as the local overdensity and the morphology of large-scale structure, are used for comparison. For halos at a fixed mass, all the halo properties depend significantly on environment, particularly the tidal field. The environmental dependence of halo assembly time is primarily driven by local tidal field. The mass of the unbound fraction in substructure is boosted in strong tidal force region, while the bound fraction is suppressed. Halos have a tendency to spin faster in stronger tidal field and the trend is stronger for more massive halos. The spin vectors show significant alignment with the intermediate axis of the tidal field, as expected from the tidal torque theory. Both the major and minor axes of halos are strongly aligned with the corresponding principal axes of the tidal field. In general, a halo that can accrete more material after the formation of its main halo on average is younger, is more elongated, spins faster, and contains a larger amount of substructure. Higher density environments not only provide more material for halo to accrete, but also are places of stronger tidal field that tends to suppress halo accretion. The environmental dependencies are the results of these two competing effects. The tidal field based on halos can be estimated from observation, and we discuss the implications of our results for the environmental dependence of galaxy properties.Comment: Accepted for publication in MNRA

Staphylococcus aureus Keratinocyte Invasion Is Dependent upon Multiple High-Affinity Fibronectin-Binding Repeats within FnBPA

Staphylococcus aureus is a commensal organism and a frequent cause of skin and soft tissue infections, which can progress to serious invasive disease. This bacterium uses its fibronectin binding proteins (FnBPs) to invade host cells and it has been hypothesised that this provides a protected niche from host antimicrobial defences, allows access to deeper tissues and provides a reservoir for persistent or recurring infections. FnBPs contain multiple tandem fibronectin-binding repeats (FnBRs) which bind fibronectin with varying affinity but it is unclear what selects for this configuration. Since both colonisation and skin infection are dependent upon the interaction of S. aureus with keratinocytes we hypothesised that this might select for FnBP function and thus composition of the FnBR region. Initial experiments revealed that S. aureus attachment to keratinocytes is rapid but does not require FnBRs. By contrast, invasion of keratinocytes was dependent upon the FnBR region and occurred via similar cellular processes to those described for endothelial cells. Despite this, keratinocyte invasion was relatively inefficient and appeared to include a lag phase, most likely due to very weak expression of α5β1 integrins. Molecular dissection of the role of the FnBR region revealed that efficient invasion of keratinocytes was dependent on the presence of at least three high-affinity (but not low-affinity) FnBRs. Over-expression of a single high-affinity or three low-affinity repeats promoted invasion but not to the same levels as S. aureus expressing an FnBPA variant containing three high-affinity repeats. In summary, invasion of keratinocytes by S. aureus requires multiple high-affinity FnBRs within FnBPA, and given the importance of the interaction between these cell types and S. aureus for both colonisation and infection, may have provided the selective pressure for the multiple binding repeats within FnBPA