The Path to European Integration: A Historical Institutionalist Perspective, CES Germany & Europe Working Papers, No. 05.2, 25 October 1994

Many European and American observers of the EC have criticized "intergovemmentalist" ac­ counts for exaggerating the extent of member state control over the process of European integra­ tion. This essay seeks to ground these criticisms in a "historical institutionalist" account that stresses the need to study European integration as a political process which unfolds over time. Such a perspective highlights the limits of member-state control over long-term institutional de­ velopment, due to preoccupation with shorHerm concerns, the ubiquity of unintended conse­ quences, and processes that "lock in" past decusions and make reassertions of member-state control difficult. Brief examination of the evolution of social policy in the EC suggests the limita­ tions of treating the EC as an international regime facilitating collective action among essentially sovereign states. It is ore useful to view integration as a "path-dependent" process that has pro­ duced a fragmented but still discernible "multitiered" European polity

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets maternal mRNAs through incomplete base-pairing with piRNAs and can induce their destabilization in the somatic part of the embryo. Paradoxically, these Aub-dependent unstable mRNAs encode germ cell determinants that are selectively stabilized in the germ plasm. Here we show that piRNAs and Aub actively protect germ cell mRNAs in the germ plasm. Aub directly interacts with the germline-specific poly(A) polymerase Wispy, thus leading to mRNA polyadenylation and stabilization in the germ plasm. These results reveal a role for piRNAs in mRNA stabilization and identify Aub as an interactor of Wispy for mRNA polyadenylation. They further highlight the role of Aub and piRNAs in embryonic patterning through two opposite functions

Profit cycle dynamics by Kawika Pierson.

Thesis (Ph. D.)--Massachusetts Institute of Technology, Sloan School of Management, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 102-105).My thesis consists of three essays investigating the existence, causes, and mitigation of profit cycles at an industry level. The first essay examines profit cycles by proposing that the industry-specific features of how competition acts on a firm are important determinants of how mean reversion manifests in firm earnings. The evidence suggests that because competition has inertia, caused by the time to build productive capacity specific to each industry, earnings do not smoothly revert to the mean, but instead cycle around it. Since these findings affect research that uses expected earnings models, lags of capital expenditure are used as a proxy for competition in a regression model of firm earnings and are shown to be significant determinants of the earnings reported. The second essay seeks to explain why aggregate airline industry profits have displayed cyclicality since deregulation in 1978. In order to better understand the causes of these profit cycles, I build a large-scale model of the airline industry that includes more endogenous feedbacks than previous models, as well as formulations for several strategies that have been employed by airlines to mitigate the cycles. While I find that, consistent with earlier research, the delay in acquiring capacity is an important determinant of the behavior of airline profits, I also show that multiple negative feedback loops are involved in the intensity and periodicity of the profit cycle in the airline industry. Specifically, analysis of my model suggests that the growing reliance on yield management as a tool for determining ticket prices has exacerbated the volatility of airline industry profits. The third essay focuses on the insurance industry, where the delay in building productive capacity is short. I build and analyze a parsimonious model of the property-casualty insurance industry, and show results which suggest that delays in adjusting the characteristics of underwritten insurance policies are responsible for the oscillatory behavior. Simulations where the industry increases both the target level of capital reserves, and the attention paid to the adequacy of that level, show significantly reduced profit variance.Ph.D

e-Flooding: Crisis Management through Two Temporal Loops

Floods, particularly fast ones, are recurrent natural disasters with a large impact on people and infrastructures. In order to mitigate their impact most countries created regulatory frameworks to coordinate the large number of actors participating to the response of these crises. Several levels from rescue to infrastructure restoration are involved. This article proposes to improve the management of risk and resilience in areas subject to flash floods. The innovative autonomic approach presented in this article is twofold: A short-term feedback loop using a large range of information to help managing the current flood; A long-term feedback loop aiming at improving the resilience of the area to reduce the impact of future crises. The originality of these two loops consists in their link which helps improving the quality of both by feeding each other. This article also describes a scenario showing several benefits of the proposed approach

A formative evaluation of online information to support abortion access in England, Northern Ireland and the Republic of Ireland.

To evaluate web-based information on accessing abortion services retrieved through internet searches in different jurisdictions from the perspective of service users. To provide a formative evaluative mechanism for enabling user-focused design of abortion access information web pages.Web searches were conducted in three countries-England, Northern Ireland, and the Republic of Ireland-using two search engines in the summer of 2016. Four search terms were used and the first two pages of results were analysed. The perspective of someone seeking abortion services was used. Sources were evaluated using a five-item tool combining user-based indicators identified in other instruments and a question on jurisdictional accuracy.A total of 619 web pages were retrieved through initial searches, 83 of which related to accessing services; 22 pages were retrieved from the Republic of Ireland, 31 from Northern Ireland, and 30 from England. Fewer than a third (n=31) were judged as good or excellent by the tool. The jurisdictional relevancy of information retrieved varied; almost half of all results in each country provided information that was either inaccurate within or irrelevant to the jurisdiction where the search took place.If online information is to support abortion access, the circumstances and perspective of the user requires more attention. Designers of abortion information pages online need to ensure that information about access is relevant to the jurisdiction in which users are based

The Partisan Politics of New Social Risks in Advanced Postindustrial Democracies: Social Protection for Labor Market Outsiders

Advanced postindustrialization generates numerous challenges for the European social model. Central among these challenges is declining income, unstable employment, and inadequate training of semi- and unskilled workers. In this chapter, I assess the partisan basis of support for social policies that address the needs of these marginalized workers. I specifically consider the impacts of postindustrial cleavages among core constituencies of social democratic parties on the capacity of these parties to pursue inclusive social policies. I argue – and find support for in empirical analyses – that encompassing labor organization is the most important factor in strengthening the ability of left parties to build successful coalitions in support of outsider-friendly policies. I go beyond existing work on the topic by considering the full array of postindustrial cleavages facing left parties, by more fully elaborating why encompassing labor organization is crucial, and by considering a more complete set of measures of outsider policies than extant work. I compare my arguments and findings to important new work that stresses coalition building and partisan politics but minimizes the role of class organization