Mapping long-period soil resonances in the Kathmandu basin using microtremors

This study reports the geostatistical analysis of a set of 40 single-station horizontal-to-vertical spectral ratio (HVSR) passive seismic survey data collected in the Kathmandu basin (Nepal). The Kathmandu basin is characterized by a heterogeneous sedimentary cover and by a complex geo-structural setting, inducing a high spatial variability of the bedrock depth. Due to the complex geological setting, the interpretation and analysis of soil resonance periods derived from the HVSR surveys is challenging, both from the perspective of bedrock depth estimation as well as of seismic-site effects characterization. To exploit the available information, the HVSR data are analyzed by means of a geostatistical approach. First, the spatial continuity structure of HVSR data is investigated and interpreted taking into consideration the geological setting and available stratigraphic and seismic information. Then, the exploitation of potential auxiliary variables, based on surface morphology and distance from outcropping bedrock, is evaluated. Finally, the mapping of HVSR resonance periods, together with the evaluation of interpolation uncertainty, is obtained by means of kriging with external drift interpolation. This work contributes to the characterization of local seismic response of the Kathmandu basin. The resulting map of soil resonance periods is compatible with the results of preceding studies and it is characterized by a high spatial variability, even in areas with a deep bedrock and long resonance periods

Estimating the burden of minor ailment consultations in general practices and emergency departments through retrospective review of routine data in North East Scotland

Minor ailment attendances in general practices and emergency departments (EDs) place significant burden on health care resources

Algorithmic transparency of conversational agents

A lack of algorithmic transparency is a major barrier to the adoption of artificial intelligence technologies within contexts which require high risk and high consequence decision making. In this paper we present a framework for providing transparency of algorithmic processes. We include important considerations not identified in research to date for the high risk and high consequence context of defence intelligence analysis. To demonstrate the core concepts of our framework we explore an example application (a conversational agent for knowledge exploration) which demonstrates shared human-machine reasoning in a critical decision making scenario. We include new findings from interviews with a small number of analysts and recommendations for future research

The health and wellbeing of offshore workers: a narrative review of the published literature.

Recent developments within the offshore industry have highlighted the role that health and wellbeing plays in ensuring the safety and longevity of the offshore workforce. Developing an understanding of the overall health and wellbeing of offshore workers could aid future developments. This narrative review aims to identify and synthesise the relevant published literature on offshore health and wellbeing. The Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, Medical Literature Analysis and Retrieval System Online, PsycArticles, and Web of Science databases were searched with publication search dates limited from January 1994 to November 2014. Twenty-six studies were identified and covered aspects of occupational stress; mental wellbeing; body mass index; diet; physical activity; musculoskeletal disorder; smoking; alcohol and drug use; shift work amongst offshore workers. This narrative review has highlighted a lack of high quality and relevant research. There is a particular need to research workers' participation in self care activities and the resultant influence of domains on health and well being. NOTE: publisher link is not currently working (last checked 2019-01-25

Views of healthcare professionals on complementary and alternative medicine use by patients with diabetes:a qualitative study

BackgroundRecent estimates indicate that a significant proportion of diabetic patients globally, up to 51%, are utilizing complementary and alternative medicine (CAM). To improve patient-provider communication and optimize prescribed treatments, healthcare professionals (HCPs) must understand the factors associated with CAM use among diabetic patients. There is a dearth of literature on HCPs perspectives on CAM use by diabetic patients. This study explored HCPs knowledge, perspective, and views on their diabetic patients’ use of CAM.MethodsQualitative study using one-to-one semi-structured interviews conducted with 22 HCPs involved in the care of diabetic patients (6 endocrinologists, 4 general practitioners, 4 nurses and 8 pharmacists). Participants were recruited through general practices, community pharmacies and a diabetic centre in Saudi Arabia. Data were analyzed using thematic analysis.ResultsFive key themes resulted from the analysis. HCPs generally demonstrated negative perceptions toward CAM, particularly regarding their evidence-based effectiveness and safety. Participants described having limited interactions with diabetic patients regarding CAM use due to HCPs’ lack of knowledge about CAM, limited consultation time and strict consultation protocols. Participants perceived convenience as the reason why patients use CAM. They believed many users lacked patience with prescribed medications to deliver favourable clinical outcomes and resorted to CAM use. ConclusionsHCPs have noted inadequate engagement with diabetic patients regarding CAM due to a lack of knowledge and resources. To ensure the safe use of CAM in diabetes and optimize prescribed treatment outcomes, one must address the communication gap by implementing a flexible consultation protocol and duration. Additionally, culturally sensitive, and evidence-based information should be available to HCPs and diabetic patients. <br/

Multi-time scale control of demand flexibility in smart distribution networks

This paper presents a multi-timescale control strategy to deploy electric vehicle (EV) demand flexibility for simultaneously providing power balancing, grid congestion management, and economic benefits to participating actors. First, an EV charging problem is investigated from consumer, aggregator, and distribution system operator’s perspectives. A hierarchical control architecture (HCA) comprising scheduling, coordinative, and adaptive layers is then designed to realize their coordinative goal. This is realized by integrating multi-time scale controls that work from a day-ahead scheduling up to real-time adaptive control. The performance of the developed method is investigated with high EV penetration in a typical residential distribution grid. The simulation results demonstrate that HCA efficiently utilizes demand flexibility stemming from EVs to solve grid unbalancing and congestions with simultaneous maximization of economic benefits to the participating actors. This is ensured by enabling EV participation in day-ahead, balancing, and regulation markets. For the given network configuration and pricing structure, HCA ensures the EV owners to get paid up to five times the cost they were paying without control

Evaluation of work-related psychosocial factors and regional musculoskeletal pain: results from a EULAR Task Force

Objectives: to establish whether review articles provide consistent conclusions on associations between workplace psychosocial factors and musculoskeletal pain and, if differences exist, to explore whether this is related to the methods used.Methods: reviews, reported up to February 2007, that included consideration of workplace psychosocial factors and upper limb, back or knee pain were identified through searches of multiple databases. The specific work-related psychosocial factors considered were job demands, support, job autonomy and job satisfaction. The conclusions of each review on one or more of the psychosocial/musculoskeletal pain associations were extracted.Results: 15 review articles were identified that considered one or more of the regional pain syndromes included in the study. For back pain, the most consistent conclusions (four reviews positive out of six) were with high job demands and low job satisfaction. The studies of upper limb pain were exclusively related to shoulder and/or neck pain, and the most consistent positive conclusions were with high and low job demands (four reviews positive out of six and two reviews positive out of three, respectively). For knee pain, only a single review was identified. For individual reviews of back and upper limb pain, there were marked differences in the number of associations concluded to be positive between reviews.Conclusions: the reasons for reviews coming to different conclusions included that they were often evaluating different bodies of evidence (according to their search criteria, the year when the review was conducted, the role that quality assessment played in whether studies contributed to evidence, and the combination of risk factors addressed in individual studies), but more important was whether the review specified explicit criteria for making conclusions on strength of evidence. These conclusions emphasise the importance of developing standardised methods for conducting such evaluations of existing evidence and the importance of new longitudinal studies for clarifying the temporal relationship between psychosocial factors and musculoskeletal pain in the workplac

The exon junction complex senses energetic stress and regulates contractility and cell architecture in cardiac myocytes

The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocytes, we examined the cellular distribution of two EJC components eukaryotic translation initiation factor 4A isoform 3 (eIF4A3) and mago nashi homologue (Mago) in response to metabolic stress. There was significant relocalization of eIF4A3 and Mago from the nucleus to cytoplasm following 18 h of hypoxia. Treating myocytes with 50 mM NaN3 for 4 h to mimic the metabolic stress induced by hypoxia also resulted in significant relocalization of eIF4A3 and Mago to the cytoplasm. To examine whether the effects of metabolic stress on the EJC proteins were dependent on the metabolic sensor AMP kinase (AMPK), we treated myocytes with 1 μM dorsomorphin (DM) in combination with NaN3. DM augmented the translocation of Mago and eIF4A3 from the nucleus to the cytoplasm. Knockdown of eIF4A3 resulted in cessation of cell contractility 96 h post-treatment and a significant reduction in the number of intact sarcomeres. Cell area was significantly reduced by both hypoxia and eIF4A3 knockdown, whilst eIF4A3 knockdown also significantly reduced nuclear size. The reduction in nuclear size is unlikely to be related to apoptosis as it was reversed in combination with hypoxia. These data suggest for the first time that eIF4A3 and potentially other EJC members play an important role in the myocyte stress response, cell contractility and morphology

Assessing Quality of CORnet-NSW Infrastructure for Use in Regional New South Wales, Australia

CORSnet-NSW is a network of Global Navigation Satellite System (GNSS) Continuously Operating Reference Stations (CORS) covering the state of NSW and providing centimetre-level real-time positioning. This research paper aims to determine the level of accuracy and precision of CORSnet-NSW in regional parts of the network and compare them to that of traditional RTK under identical conditions. It investigates what effects satellite geometry and proximity to a CORS station have on NRTK measurements. It also verifies the CORSnet-NSW claim of network wide 2cm accuracy. The claim was found to be true at the 68% Confidence Interval. Changes in satellite geometry were not found to affect the results for the most part. It was also found that CORSnet-NSW precision was affected by the proximity of the rover to the base/calibration points more than its proximity to a CORSnet-NSW station. However, even though the CORSnet-NSW results were better than expected, traditional RTK remains the most precise and consistent method. This research paper provides GNSS users in regional NSW with the evidence they need to make informed decisions regarding which type of RTK method is fit for their purposes