ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Perioperative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery

International audienc

Options for monitoring and estimating historical carbon emissions from forest degradation in the context of REDD+

Measuring forest degradation and related forest carbon stock changes is more challenging than measuring deforestation since degradation implies changes in the structure of the forest and does not entail a change in land use, making it less easily detectable through remote sensing. Although we anticipate the use of the IPCC guidance under the United Framework Convention on Climate Change (UNFCCC), there is no one single method for monitoring forest degradation for the case of REDD+ policy. In this review paper we highlight that the choice depends upon a number of factors including the type of degradation, available historical data, capacities and resources, and the potentials and limitations of various measurement and monitoring approaches. Current degradation rates can be measured through field data (i.e. multi-date national forest inventories and permanent sample plot data, commercial forestry data sets, proxy data from domestic markets) and/or remote sensing data (i.e. direct mapping of canopy and forest structural changes or indirect mapping through modelling approaches), with the combination of techniques providing the best options. Developing countries frequently lack consistent historical field data for assessing past forest degradation, and so must rely more on remote sensing approaches mixed with current field assessments of carbon stock changes. Historical degradation estimates will have larger uncertainties as it will be difficult to determine their accuracy. However improving monitoring capacities for systematic forest degradation estimates today will help reduce uncertainties even for historical estimates

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe

Estimation of absorbed PAR across Scandinavia from satellite measurements Part I: Incident PAR

The primary productivity of a plant community can be modeled as the product of the amount of photosynthetically active radiation (PAR) absorbed by the canopy and a light use efficiency factor, where the amount of absorbed PAR (APAR) is the product of the fractional absorption and the amount of incident PAR. By implementing a method, PARcalc, using atmospheric data from the Moderate Resolution Imaging Spectroradiometer (MODIS), incident PAR is estimated in this study. In addition, since many PAR datasets are generated by converting shortwave radiation into PAR, the ratio of PAR to shortwave radiation was also investigated. PARcalc models the photosynthetic photon flux density (PPFD) as a product of atmospheric transmittance, the cosine of the Sun zenith angle, and the solar constant. The atmospheric transmittance includes the attenuation of radiation by Rayleigh and aerosol scattering, and absorption by water and ozone. A cloud transmittance factor which is primarily a function of the cloud optical thickness is added in order to cope with cloudy conditions. The model was implemented at two sites in Sweden, Asa and Norunda, where in situ measurements of PPFD were made during the spring and summer of 2004. Modeled time-series were evaluated against the measurements, and daily sums of PPFD were calculated by fitting of a sine function in combination with linear interpolation of the instantaneous estimates from sunrise to sunset. This gave correlation coefficients at Norunda and Asa of 0.80 and 0.77, respectively, when comparing modeled and measured daily insolation. The average relative errors were 24% and 25%. Corresponding figures for five day averages were 0.91 and 0.86; and 9.3% and 11.9%. Instantaneous estimates of PPFD were modeled with correlation coefficients of 0 88-0 93 and average relative errors from 17.0%. These numbers were acquired when using measured values for determining cloudiness; the corresponding figures when the method is fully implemented using satellite data are 0.84 to 0.71 and 24.9%, respectively. The ratio of PAR to shortwave radiation was measured at Norunda 1 Jan to 31 Oct 2004 and was found to vary between 0.27 and 0.48 on a daily basis with an average of 0.43 for the whole period.(c) 2007 Elsevier Inc. All rights reserved

Comparison of carbon assimilation estimates over tropical forest types in India based on different satellite and climate data products

Carbon assimilation defined as the overall rate of fixation of carbon through the process of photosynthesis is central to the climate change research. The present study compares the two well-known algorithms in satellite based carbon assimilation estimation, the Vegetation Photosynthesis Model (VPM) and the MOD 17A2 GPP Model, over the tropical forest types in India for a period of two years (September, 2006-August, 2008). The results indicate that the evergreen forest assimilate carbon at a higher rate while the rate is lower for montane grasslands. The comparison between the model results shows that there are large differences between these estimates, and that the spatial resolution of the input datasets plays a larger role than the algorithms of the models. The comparison exercise will be helpful for the refinement and development of the existing and future GPP models by incorporating the empirical environmental conditions. (C) 2011 Elsevier B.V. All rights reserved

Embryonic cardiomyocyte, but not autologous stem cell transplantation, restricts infarct expansion, enhances ventricular function, and improves long-term survival

Contains fulltext : 118371.pdf (publisher's version ) (Open Access)AIMS: Controversy exists in regard to the beneficial effects of transplanting cardiac or somatic progenitor cells upon myocardial injury. We have therefore investigated the functional short- and long-term consequences after intramyocardial transplantation of these cell types in a murine lesion model. METHODS AND RESULTS: Myocardial infarction (MI) was induced in mice (n = 75), followed by the intramyocardial injection of 1-2x10(5) luciferase- and GFP-expressing embryonic cardiomyocytes (eCMs), skeletal myoblasts (SMs), mesenchymal stem cells (MSCs) or medium into the infarct. Non-treated healthy mice (n = 6) served as controls. Bioluminescence and fluorescence imaging confirmed the engraftment and survival of the cells up to seven weeks postoperatively. After two weeks MRI was performed, which showed that infarct volume was significantly decreased by eCMs only (14.8+/-2.2% MI+eCM vs. 26.7+/-1.6% MI). Left ventricular dilation was significantly decreased by transplantation of any cell type, but most efficiently by eCMs. Moreover, eCM treatment increased the ejection fraction and cardiac output significantly to 33.4+/-2.2% and 22.3+/-1.2 ml/min. In addition, this cell type exclusively and significantly increased the end-systolic wall thickness in the infarct center and borders and raised the wall thickening in the infarct borders. Repetitive echocardiography examinations at later time points confirmed that these beneficial effects were accompanied by better survival rates. CONCLUSION: Cellular cardiomyoplasty employing contractile and electrically coupling embryonic cardiomyocytes (eCMs) into ischemic myocardium provoked significantly smaller infarcts with less adverse remodeling and improved cardiac function and long-term survival compared to transplantation of somatic cells (SMs and MSCs), thereby proving that a cardiomyocyte phenotype is important to restore myocardial function