4 research outputs found
La inteligencia emocional como factor amortiguador del burnout académico y potenciador del engagement académico
Los futuros profesionales de enfermerÃa requieren de una formación integral que incluya aspectos teóricos y el desarrollo de habilidades emocionales. Estas últimas, hacen referencia al desarrollo de la Inteligencia emocional, la cual, según las investigaciones de la última década, tendrÃa una relación con un mejor ajuste a las exigencias del medio universitario y/o laboral. El objetivo de esta investigación fue relacionar los niveles de inteligencia emocional con los niveles del SÃndrome de Burnout y Engagement académico en estudiantes de enfermerÃa de una Universidad del norte del paÃs, por medio de un estudio cuantitativo, correlacional, no experimental, transversal. La muestra fue de 189 alumnos de enfermerÃa, de ambos sexos, cursando entre el primer y octavo semestre de la malla académica, donde se realizó un muestreo probabilÃstico aleatorio. Los resultados evidenciaron correlación entre los factores de claridad y regulación emocional con ambos factores de Engagement (predisposición y satisfacción). Por otro lado, al correlacionar inteligencia emocional con Burnout académico, se evidenció, que el único factor que correlacionó con las 3 dimensiones de Burnout fue regulación emocional. Además, se demostró que a mayor claridad emocional menor serÃa el agotamiento y mayor la realización personal. Finalmente, se mostró que mayores niveles de Burnout correlacionaron con menores niveles de satisfacción con los estudios
Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy
Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus
Erratum: Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy
Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/ MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus
Corrigendum: Analysis of the common genetic component of large-vessel vasculitides through a meta-Immunochip strategy (Scientific Reports (2017) 7 (43953) DOI: 10.1038/srep43953)
Giant cell arteritis (GCA) and Takayasu\u2019s arteritis (TAK) are major forms of large-vessel vasculitis (LVV)
that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping
data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated.
The HLA region harboured the main disease-specific associations. GCA was mostly associated with
class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/
MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced
in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately.
Consequently, no significant genetic correlation between these two diseases was observed when
HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B
gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets
(rs755374, P = 7.54E-07; ORGCA = 1.19, ORTAK = 1.50). This marker was confirmed as novel GCA risk
factor using four additional cohorts (PGCA = 5.52E-04, ORGCA = 1.16). Taken together, our results provide
evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common
susceptibility factors were suggested, especially within the IL12B locus