A retrospective study of 50 cases of lower limb soft tissue infection and its different modalities of presentation and its management

Background: Soft tissue infections are common in everyday practice. They show great variations in their severity. Skin and soft tissue infections are usually preceded by minor traumatic events. Among them soft tissue bacterial infections of lower limbs are more common. Patients having diabetes makes the scenario even worst. Diagnosis, intervention and treatment of these infections are very important. This study aims at understanding the pathology involved for lower limb soft tissue infections, spectrum of organisms and different treatment modalities in various age group and gender.Methods: 50 cases of lower limb soft tissue infections were included in this study. Detailed history, clinical examination, investigations, pre-operative preparation, intraoperative details and post-operative management were included.Results: 94% patients were having history of trauma.88% patients were having history of diabetes. Staphylococcus aureus was the most common (43%) organism cultured from swabs followed by pseudomonas (36%) out of total cases. Minimum stay in hospital was of 4 days to a maximum of 34 days. Most of the patients were managed with regular dressing and debridement.Conclusions: The patients sought treatment only when they had extensive lesions which affect their daily living. Health education regarding foot care forms an integral part of surgical management of lower limb soft tissue infections. Readmissions are mainly due to inadequate local control or fluctuating blood sugar levels and improper foot care due to illiteracy, poverty, ignorance and lack of adequate primary care facilities

Advanced Scoliosis Impact on COPD: Worsened Outcomes Due to Lack of Motivational Interviewing and Shared Decision Making - A Case Report

The case presented describes an advanced COPD patient with a history of progressive scoliotic curvature who presented multiple times with complaints of worsening respiratory symptoms. Thus, it is important to emphasize how the lack of meaningful patient communication and patient participation in the plan of care can lead to increased symptoms of anxiety, declining quality of life, and unnecessary medical testing. In addition, the case explores how applying a holistic combination of strategies including motivational interviewing, shared-decision making and proper communication can improve the level of patient care

Health Science Academy

Panel Chair: Katherine Bel

Alternative RNA splicing: contribution to pain and potential therapeutic strategy

Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pre-mRNA splicing. This review highlights the known alternative splice variants of many channels, receptors and growth factors important in nociception and pain. Recently, pharmacological control of alternative splicing has been proposed as potential therapy in cancer, wet age-related macular degeneration, retroviral infections and pain. In this review we consider the effects that known splice variants of molecules key to nociception/pain have on nociceptive processing and/or analgesic action, and the potential for control of alternative pre-mRNA splicing as a novel analgesic strategy

Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design

We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant

Sustainable housing : looking at social and cultural aspects of traditional Indian settlement

RESEARCH QUESTION: How social and cultural housing issues can be addressed through the traditional practice of Indian settlement? ABSTRACT: This research aims to strategize a comprehensive design, establishing a link between the traditional and current practice of housing. The intent is to provide the various housing issues; energy waste, social-cultural aspects, ignored the specific need of environment and local people, missing regional architecture characteristics. Social and environmental factors in the housing sectors have been affected by the forces of globalization during the rapid urbanization. In the last three decades, housing construction tends to reflect the requirements of the global market instead of local architecture or social demands. The concept of regional housing is selected as a stepping stone of this research project to provide guidelines for the current housing practice. Hence, the research question: “How social and environmental issues can be addressed through the traditional practice of Indian settlement?” Every year, mass migration has created a shortage of housing. However, modern rapid housing construction has given a roof to migrants at the cost of losing the local identity and characteristic of the city. A large number of migrants comes from the north of Gujarat villages or small towns, who are still rooted in their culture and believes. It is a crucial necessity to understand their lifestyle, needs, and provide good living ambience for the betterment of life and maintain the identity of the local architecture. As per the current scenario, the findings indicate that Ahmedabad, Gujarat is the first Heritage city of India declared by UNESCO. Belonging from Gujarat and having deep connections to Ahmedabad city, because of its rich heritage and culture, the observation of the city raised the need to reidentify the housing practice in the city with the social and environmental value of local heritage architecture. Design methodology incorporates the comparative investigation of spatial form in traditional and current housing practice. It might provide some useful insights providing different type of activities and environment requirements, to develop a typical housing model which will hold the local architectural identity for the local people. Regional housing is a relatively new approach which will consider different factors in the design process, such as location, climate, accessibility, people, construction techniques, and the vernacular environmental approach. Few planned and successful housing projects, provide the inferences to develop the best possible strategy for this approach

The impact of an ICU delirium order set on the discontinuation rates of antipsychotics upon delirium resolution: An Interim Analysis

Pharmacy residents have the opportunity to complete a research project during their residency training, which provides them with skills on how to conduct and manage a research project. Projects often represent an area of interest and need that has been recognized by the host institution’s pharmacy department. Projects are presented as a poster at an annual CSHP Ontario Branch Residency Research Night, and many eventually go on to be published in a peer-reviewed journal.Abstract Introduction: To date, trials have only investigated short-term use of antipsychotics for ICU delirium. Observational studies show that among ICU patients who are newly initiated on antipsychotics, 47-84% have antipsychotics continued upon ICU transfer. Order sets may help standardize delirium management and ensure antipsychotic discontinuation upon delirium resolution. Objective: To determine if an ICU delirium order set will decrease the proportion of patients continued on antipsychotics upon delirium resolution or ICU transfer. Methods: A retrospective, single-centre, pre-post cohort study is being conducted. The pre-implementation cohort includes adult ICU patients started on scheduled antipsychotics within 48 hours of positive CAM-ICU screens between August 1, 2014 and November 30, 2015. For our interim analysis, the post-implementation cohort includes patients started on scheduled antipsychotics using the ICU delirium order set between February 22, 2016 and April 22, 2016 however, enrollment will continue until 50 patients are reached. The primary outcome is the proportion of patients continued on scheduled antipsychotics 24 hours after delirium resolution or ICU transfer. Results: CAM-ICU screening was completed at least once per nursing shift 89% of the time in the pre-implementation cohort (n=26). In this cohort, antipsychotics were continued 24 hours after delirium resolution or ICU transfer in 12 patients. Among 15 patients with delirium resolution during their ICU admission, scheduled antipsychotics were continued in 10 patients. In the post-implementation cohort (n=3), 1 patient had delirium resolution during their ICU admission and was continued on antipsychotics beyond delirium resolution. Conclusion: As this is an interim analysis, direct comparisons between the pre and post- implementation cohorts cannot be made. Delirium screening, a key aspect of delirium management, was completed routinely in the majority of patients in the pre-implementation cohort. In this cohort, a number of patients were continued on antipsychotics despite resolution of delirium

On network security and internet vulnerability

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