Tomás Segovia: la palabra como verdad de la experiencia

Tomás Segovia, exiled from the 1939 civil war, rather than settle for that situation, has developed throughout his career reflections on exile not as timely or particular event, but as the human condition. Thus, the original exile reveals a series of attitudes towards the language that already cannot refer to a historical event, but rather are of the task of the writer and intellectual: resistance and nakedness of the language into an equally naked imaginary space.Tomás Segovia, exiliado a partir de la guerra civil del 39, en lugar de conformarse con esa situación, ha elaborado a lo largo de su trayectoria reflexiones en torno al exilio no como suceso puntual o particular, sino como condición del hombre. Así, el exilio originario revela una serie de actitudes hacia el lenguaje que ya no pueden remitirse a un suceso histórico, sino que más bien revisten la tarea del escritor y del intelectual: resistencia y desnudez del lenguaje en un espacio imaginario igualmente desnudo

De Ulises al Hijo Pródigo: un proceso de sustitución en la literatura mexicana hacia 1920.

El artículo quiere dar cuenta del motivo del Hijo Pródigo en la literatura mexicana de la década de los años veinte del siglo pasado. El personaje de la parábola desde su aparición fue relegando a otro viajero que había concitado el interés y la curiosidad en los primeros años de esa década, Ulises, de resonancias vasconcelistas. La complejidad del pródigo explica la seducción que operó sobre jóvenes poetas mexicanos, en particular, Xavier Villaurrutia, Gilbeto Owen y Salvador Novo.   The article wants to give an account of the reason for the prodigal son in Mexican literature of the Decade of the twenties of the last century. The character of the parable from his appearance was relegating another traveller who had aroused interest and curiosity in the early years of that decade, Ulysses, of resonance vasconcelistas. The complexity of the prodigal explains the seduction that operated on young Mexican poets, in particular, Xavier Villaurrutia, Gilbeto Owen and Salvador Novo

"Cosmópolis" (1919-1922): entre el modernismo y la vanguardia

Cosmópolis (1919-1922) has often been considered by critics as a modernist magazine. Of course, the literary and cultural temperature of the publication obeys in part to the fin-de-siècle sensibility. However, the interest and curiosity that from the beginning showed towards the incipient avant-garde in Spanish language has seldom been emphasized. It was not less the coexistence with publications markedly avant-garde as Cervantes (1916-1920) and Grecia (1918-1920), who shared with Cosmópolis collaborators and writers. This text aims to demonstrate the close links of this magazine with the avant-garde until it becomes a decisive platform for its dissemination.Cosmópolis, revista aparecida en Madrid entre 1919-1920, suele adscribirse al modernismo o, al menos, a la corriente finisecular que llega a los aledaños de la tercera década del siglo XX. Sin embargo, no se le ha dado suficiente importancia a que obró como plataforma de una vanguardia que comenzaba a sobresalir en el mundo hispánico. Si el cosmopolitismo caracteriza a Cosmópolis y a su primer director, Enrique Gómez Carrillo, ylos vincula con el modernismo, el mismo cosmopolitismo opera como puerta de entrada a la nueva literatura. Así, la publicación convive con otras abiertamente vanguardistas como Cervantes, Grecia, etcétera, pero no les va a la zaga en su interés y curiosidad por esos movimientos. El artículo pretende determinar las muestras más sobresalientes a aparecidas en Cosmópolis asociadas con la vanguardia. &nbsp

Diario de un pintor. Viaje y escritura cotidiana de Ramón Gaya

Diario de un pintor es un cuaderno de viaje que el pintor-poeta español, Ramón Gaya, redactó a lo largo de un año; testimonio de un viaje exactamente de un año entre el 19 de junio de 1952 y el 18 de junio de 1953. El cuaderno presenta los desplazamientos geográficos de su autor por Europa: Francia, Italia, España o Portugal se suceden en sus anotaciones; pero lo verdaderamente relevante no es ya el testimonio del viaje, sino sobre todo su manera de entender el arte y la propia escritura, de modo que Diario de un pintor es un doble viaje: hacia fuera y hacia dentro, respetando de este modo las convenciones del diario privado

'En la masmédula'. La voz sin yo, sin vos

Este artículo estudia el poemario de Oliverio Girando 'En la masmédula', especialmente los aspectos sintácticos, morfológicos y fonéticos que muestran la desaparición del sujeto. This paper is focused on the poem book 'En la masmédula' by Oliverio Girondo, and it analyses the syntactic, morphologic and phonetic means by which the subject vanishes in the poetic text

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis Due to Behçet's Disease: National Multicenter Study of 177 Cases

Objective: To compare the efficacy of infliximab (IFX) versus adalimumab (ADA) as a first-line biologic drug over 1 year of treatment in a large series of patients with refractory uveitis due to Behçet's disease (BD). Methods: We conducted an open-label multicenter study of IFX versus ADA for BD-related uveitis refractory to conventional nonbiologic treatment. IFX or ADA was chosen as the first-line biologic agent based on physician and patient agreement. Patients received 3-5 mg/kg intravenous IFX at 0, 2, and 6 weeks and every 4-8 weeks thereafter, or 40 mg subcutaneous ADA every other week without a loading dose. Ocular parameters were compared between the 2 groups. Results: The study included 177 patients (316 affected eyes), of whom 103 received IFX and 74 received ADA. There were no significant baseline differences between treatment groups in main demographic features, previous therapy, or ocular sign severity. After 1 year of therapy, we observed an improvement in all ocular parameters in both groups. However, patients receiving ADA had significantly better outcomes in some parameters, including improvement in anterior chamber inflammation (92.31% versus 78.18% for IFX; P = 0.06), improvement in vitritis (93.33% versus 78.95% for IFX; P = 0.04), and best-corrected visual acuity (mean ± SD 0.81 ± 0.26 versus 0.67 ± 0.34 for IFX; P = 0.001). A nonsignificant difference was seen for macular thickness (mean ± SD 250.62 ± 36.85 for ADA versus 264.89 ± 59.74 for IFX; P = 0.15), and improvement in retinal vasculitis was similar between the 2 groups (95% for ADA versus 97% for IFX; P = 0.28). The drug retention rate was higher in the ADA group (95.24% versus 84.95% for IFX; P = 0.042). Conclusion: Although both IFX and ADA are efficacious in refractory BD-related uveitis, ADA appears to be associated with better outcomes than IFX after 1 year of follow-up

Anti-IL-6 Receptor Tocilizumab in Refractory Graves? Orbitopathy: National Multicenter Observational Study of 48 Patients

Graves’ orbitopathy (GO) is the most common extrathyroidal manifestation of Graves’ disease (GD). Our aim was to assess the e cacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were the best-corrected visual acuity (BVCA), Clinical Activity Score (CAS) and intraocular pressure (IOP). These outcome variables were assessed at baseline, 1st, 3rd, 6th and 12th month after TCZ therapy onset. The severity of GO was assessed according to the European Group on Graves’ Orbitopathy (EUGOGO). We studied 48 (38 women and 10 men) patients (95 eyes); mean age standard deviation 51 11.8 years. Before TCZ and besides oral glucocorticoids, they had received IV methylprednisolone (n = 43), or selenium (n = 11). GO disease was moderate (n =29) or severe (n = 19) and dysthyroid optic neuropathy (DON) (n = 7). TCZ was used in monotherapy (n = 45) or combined (n = 3) at a dose of 8 mg/kg IV every four weeks (n = 43) or 162 mg/s.c. every week (n = 5). TCZ yielded a significant improvement in all of the main outcomes at the 1st month that was maintained at one year. Comparing the baseline with data at 1 year all of the variables improved; BCVA (0.78 0.25 vs. 0.9 0.16; p = 0.0001), CAS (4.64 1.5 vs. 1.05 1.27; p = 0.0001) and intraocular pressure (IOP) (19.05 4.1 vs. 16.73 3.4 mmHg; p = 0.007). After a mean follow-up of 16.1 2.1 months, low disease activity (CAS 3), was achieved in 88 eyes (92.6%) and TCZ was withdrawn in 29 cases due to low disease activity (n = 25) or ine cacy (n = 4). No serious adverse events were observed. In conclusion, TCZ is a useful and safe therapeutic option in refractory GO treatment.This work was also partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from “Instituto de Salud Carlos III” (ISCIII) (Spain)