Morphological characteristics of ant assemblages (Hymenoptera: Formicidae) differ among contrasting biomes

The environment is thought to strongly shape the ecology and evolution of species. Similar environments may cause species to look the same or converge upon particular traits. Dissimilar environments can cause species to look different or to diverge in their traits. These ideas have been explored at the single species level or within restricted geographic areas for ants. We ask whether the signature of environmental filtering can be detected within ant faunas at the biogeographic scale. We quantify differences in the morphological traits of ant faunas between two contrasting biomes: a rainforest in Costa Rica and a desert in Iran. Lists of species from each habitat type were compiled, and measurements of ten functional traits were taken from scaled images. Body size, relative femur length, and tibia length were significantly smaller in Costa Rica suggesting species in more complex environments are smaller in response to environmental complexity. Relative eye width was also smaller in Costa Rica, and individuals were lighter in colour. Eye size and body pigmentation showed differences which may be a result of altered foraging patterns or protection against UV-B irradiance. The Costa Rican fauna also had a much wider trait space (higher functional richness), and Iranian species occupied a narrow range in terms of mandible and leg size suggesting species invest less in foraging specialism in unproductive environments. Significant differences in morphological traits and their degree of overlap can therefore be observed in ant faunas occupying contrasting biomes. We suggest that this is due to the environment influencing the trait composition of these faunas at biogeographic scales

Thermal Density Functional Theory in Context

This chapter introduces thermal density functional theory, starting from the ground-state theory and assuming a background in quantum mechanics and statistical mechanics. We review the foundations of density functional theory (DFT) by illustrating some of its key reformulations. The basics of DFT for thermal ensembles are explained in this context, as are tools useful for analysis and development of approximations. We close by discussing some key ideas relating thermal DFT and the ground state. This review emphasizes thermal DFT's strengths as a consistent and general framework.Comment: Submitted to Spring Verlag as chapter in "Computational Challenges in Warm Dense Matter", F. Graziani et al. ed

The prediction of preference for unfamiliar urban places

Preferences for unfamiliar urban environments were studied as a function of urban categories, viewing time, and four predictor variables: complexity, coherence, identifiability, and mystery. A nonmetric factor analysis of the preference ratings for the longest viewing-time condition yielded five dimensions: Contemporary Life, Alley/Factory, Urban Nature, Unusual Architecture, and Older Buildings. The five categories differed significantly in preference, with Urban Nature by far the most preferred and Alley/Factory distinctly disliked. The combination of low coherence and high complexity characterizes the least liked Alley/Factory category, while the role of mystery in the urban setting is highlighted by the most preferred Urban Nature category. The results point to various ways in which the urban environment could be more responsive to people's preferences.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43513/1/11111_2005_Article_BF01359051.pd

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)

Elevation–diversity patterns through space and time: ant communities of the Maloti-Drakensberg Mountains of southern Africa

Aim Patterns of biological diversity are often investigated across space but little work has attempted to explore the consistency of such observations through time. Here, our aim was to understand the patterns of diversity for a functionally critical taxon, the ants (Hymenoptera: Formicidae), through space and time using an extensive dataset collected across an elevational gradient. In addition, we evaluated the importance of two key postulated drivers of elevational diversity patterns: temperature and available area. Location The Maloti-Drakensberg Mountains of southern Africa. Methods We sampled epigaeic ant communities biannually for 7 years (2006–2012) at eight different elevational sites. We then used an information theoretic approach combined with generalized linear mixed models to: (1) describe diversity patterns through space and time; (2) assess the importance of different abiotic drivers; and (3) understand how much spatio-temporal variation can be explained by these drivers. Simple regression approaches were also used to test for differences in seasonal variation along the elevational gradient. Results We found clear mid-elevational peaks of species density and evenness measures. Abundance patterns were complex. The spatial distributions of all three metrics changed across seasons and years. Temperature variables had important roles in explaining both species density and abundance patterns, whilst species density was also influenced by available area. In conjunction, we found much greater seasonal variability in species density at low elevations. This variation was independent of differences in species pool size. Main conclusions We found patterns of ant diversity that are strongly modulated by temporal change. There was a consistent and strong signature of seasonality on the elevation–diversity patterns of the ants, whilst annual changes throughout the study period had a weaker influence. We conclude that both spatial and temporal patterns are driven primarily by temperature, with only a weak influence of available elevational area. This study is the first to describe the spatio-temporal distribution of a suite of community-level metrics along an elevational gradient and implies that temporal variation should be considered more carefully in studies of invertebrate diversity, particularly with respect to elevation and the mechanisms that may be maintaining diversity patterns

A study of sand-lime brick

Bibliography: p. 77-79.Published also as T.R. Ernest's thesis (Ph. D.) University of Illinois, 1910, under title: Sand-lime brick. 1912

Dominance–diversity relationships in ant communities differ with invasion

The relationship between levels of dominance and species richness is highly contentious, especially in ant communities. The dominance-impoverishment rule states that high levels of dominance only occur in species-poor communities, but there appear to be many cases of high levels of dominance in highly diverse communities. The extent to which dominant species limit local richness through competitive exclusion remains unclear, but such exclusion appears more apparent for non-native rather than native dominant species. Here we perform the first global analysis of the relationship between behavioral dominance and species richness. We used data from 1,293 local assemblages of ground-dwelling ants distributed across five continents to document the generality of the dominance-impoverishment rule, and to identify the biotic and abiotic conditions under which it does and does not apply. We found that the behavioral dominance–diversity relationship varies greatly, and depends on whether dominant species are native or non-native, whether dominance is considered as occurrence or relative abundance, and on variation in mean annual temperature. There were declines in diversity with increasing dominance in invaded communities, but diversity increased with increasing dominance in native communities. These patterns occur along the global temperature gradient. However, positive and negative relationships are strongest in the hottest sites. We also found that climate regulates the degree of behavioral dominance, but differently from how it shapes species richness. Our findings imply that, despite strong competitive interactions among ants, competitive exclusion is not a major driver of local richness in native ant communities. Although the dominance-impoverishment rule applies to invaded communities, we propose an alternative dominance-diversification rule for native communities

Restraint minimisation in mental health care: legitimate or illegitimate force? An ethnographic study

Coercive practices, such as physical restraint, are used globally to respond to violent, aggressive and other behaviours displayed by mental health service users.1 A number of approaches have been designed to aid staff working within services to minimise the use of restraint and other restrictive practices. One such approach, the ‘REsTRAIN Yourself’ (RYS) initiative, has been evaluated in the UK. Rapid ethnography was used to explore the aspects of organisational culture and staff behaviour exhibited by teams of staff working within 14 acute admission mental health wards in the North West region of the English NHS. Findings comprise four core themes of space and place; legitimation; meaningful activity; and, therapeutic engagement that represent characteristics of daily life on the wards before and after implementation of the RYS intervention. Tensions between staff commitments to therapeutic relations and constraining factors were revealed in demarcations of ward space and limitations on availability of meaningful activities. The physical, relational and discursive means by which ward spaces are segregated prompts attention to the observed materialities of routine care. Legitimation was identified as a crucial discursive practice in the context of staff reliance upon coercion. Trauma‐informed care represents a potentially alternative legitimacy