Endovascular treatment for acute basilar artery occlusion: Descriptive analysis of the experience in a comprehensive stroke centre

Objectives: To describe the clinical and epidemiological characteristics of patients with basilar artery occlusion (BAO) treated with mechanical thrombectomy (MT) in Aragón, and to compare its anaesthetic management, technical effectivity, security, and prognosis with those of anterior circulation. Methods: 322 patients from the prospective registry of mechanical thrombectomies from Aragon were assessed: 29 with BAO and 293 with an anterior circulation large vessel occlusion. Baseline characteristics, procedural, clinical and safety outcomes variables were compared. Results: Out of 29 patients with BAO that underwent endovascular therapy (62.1% men; average age 69.8 ± 14.05 years) 18 (62.1%) received endovascular therapy (EVT) alone and 11 (37.9%) EVT plus intravenous thrombolysis. Atherothrombotic stroke was the most common etiology (41%). The BAO group had longer Door-to-groin (160 vs 141 min; P = 0.043) and Onset-to-reperfusion times (340 vs 297 min; P = 0.005), and higher use of general anaesthesia (60.7% vs 14.7%; P < 0.01). No statistically significant difference was found for Procedure time (60 vs 50 min; P = 0.231) nor the rate of successful recanalization (72.4% vs 82.7%; P = 0.171). Functional independence at 90 days was significantly worse in the BAO group (17.9% vs 38.2%; P < 0.01). Conclusions: Patients with basilar artery occlusion had higher morbimortality despite similar angiographic results. Mechanical thrombectomy for BAOs is a safe and effective procedure in selected patients. A consensus about the effect of anaesthesia has yet to be reached, for BAO general anaesthesia remains the most frequently used technique

Stabilization of a Large Paleo-Landslide Reactivated Because of the Works to Install a New Ski Lift in Formigal Skiing Resort

The paper presents the study and stabilization of a paleo-landslide reactivated because of the excavation works carried out at its foot to construct a new lift in Formigal skiing resort. Inclinometers were installed and surface movements were controlled by GPS techniques in order to analyse the sliding surface and to define the stabilization measures to undertake. The data obtained from the instrumentation was used to perform a back-analysis that allowed to determine the kinematics of the movement as well as to define the appropriate stabilization measures. Presently, the evolution of the movement is controlled by GPS

Irreducible numerical semigroups having Toms decomposition

In this article we prove that if S is an irreducible numerical semigroup and S is generated by an interval or S has multiplicity 3 or 4, then it enjoys Toms decomposition. We also prove that if a numerical semigroup can be expressed as an expansion of a numerical semigroup generated by an interval, then it is irreducible and has Toms decomposition

Prevalence, characteristics, and impact of adverse events in 34 Madrid hospitals. The ESHMAD study

Introduction: Adverse Events (AE) are one of the main problems in healthcare. Therefore, many policies have been developed worldwide to mitigate their im pact. The Patient Safety Incident Study in Hospitals in the Community of Madrid (ESHMAD) measures the results of them in the region. Methods: Cross-sectional study, conducted in May 2019, in hospitalised patients in 34 public hospitals using the Harvard Medical Practice Study methodology. A logistic regression model was carried out to study the association of the variables with the presence of AE, calibrated and adjusted by patient. Results: A total of 9975 patients were included, estimating a prevalence of AE of 11.9%. A higher risk of AE was observed in patients with surgical procedures (OR[CI95%]: 2.15[1.79 to 2.57], vs. absence), in Intensive Care Units (OR[CI95%]: 1.60[1.17 to 2.17], vs. Medical) and in hospitals of medium complexity (OR[CI95%]: 1.45[1.12 to 1.87], vs. low complexity). A 62.6% of AE increased the length of the stay or it was the cause of admission, and 46.9% of AE were considered prevent able. In 11.5% of patients with AE, they had contributed to their death. Conclusions: The prevalence of AE remains similar to the previously estimated one in studies developed with the same methodology. AE keep leading to longer hospital stays, contributing to patient's death, showing that it is necessary to put focus on patient safety again. A detailed analysis of these events has enabled the detection of specific areas for improvement according to the type of care, centre and patient

Morphometric study in red varieties of iberian pig breed and Jabugo spotted

We are presenting a morphological study of the red varieties (Torbiscal, Retinto Portugués, Retinto Extremeño, Dorado Gaditano) of the Iberian pig breed and Jabugo Spotted, according to the Association of Breeders (AECERIBER) criteria. We have obtained significant differences among strains and sexes in the quantitative variables analysed also interaction between both factors has been detected. The qualitative variables have shown independence between strains and coat colour, type of hears, type of hair for males and females. Only the complementary particularities have been associated to the strains.Se presenta un estudio morfológico en las variedades rojas del cerdo Ibérico (Torbiscal, Retinto Portugués, Retinto Extremeño, Dorado Gaditano) y Manchado de Jabugo, según los criterios de catalogación de la asociación de criadores AECERIBER. En el estudio de las variables cuantitativas se deducen diferencias significativas entre estirpes y entre sexos y existencia de interacciones entre ambos factores. Para las variables cualitativas encontramos independencia entre el tipo de estirpe y el color de la capa, el tipo de orejas y el tipo de pelo para la muestra de machos y hembras mientras que en caso de las particularidades complementarias los machos presentan asociación para esta variable

Detrital zircon typology and U/Pb geochronology for the Miocene Ladrilleros-Juanchaco sedimentary sequence, Equatorial Pacific (Colombia) : new constraints on provenance and paleogeography in northwestern South America

Typology and internal texture analyses were performed on detrital zircons obtained from the Miocene sandstones of the Ladrilleros-Juanchaco sedimentary sequence (Colombia, Equatorial Pacific). This analysis was complemented with zircon U/Pb dating to identify typology-age associations as indicators of provenance of these sediments. Our results show that zircons with S and P dominant typology have internal structures/zoning that indicate mostly igneous and possibly some metamorphic origins. Morphometric results suggest little transport from source areas. Both typology and U/Pb data point to the Western Cordillera as the main source of the detrital materials of this sedimentary sequence. A paleogeographic reconstruction shows that during Late Miocene times there were significant portions of the Western Cordillera uplifted, eroding away and acting as a fluvio-topographic barrier blocking sediments from the Central Cordillera to reach the Pacific basins. Miocene plutons at the axis of the Western Cordillera were also probably exhumed and played a role as geomorphologically active massifs. This study demonstrates that typologic analysis on detrital zircon grains is a powerful tool as indicator of provenance and paleogeography in complex litho-tectonic areas where overlapping U/Pb signatures can lead to contradictory results

Lung metastases share common immune features regardless of primary tumor origin

BACKGROUND: Only certain disseminated cells are able to grow in secondary organs to create a metastatic tumor. Under the hypothesis that the immune microenvironment of the host tissue may play an important role in this process, we have categorized metastatic samples based on their immune features. METHODS: Gene expression data of metastatic samples (n=374) from four secondary sites (brain, bone, liver and lung) were used to characterize samples based on their immune and stromal infiltration using gene signatures and cell quantification tools. A clustering analysis was done that separated metastatic samples into three different immune categories: high, medium and low. RESULTS: Significant differences were found between the immune profiles of samples metastasizing in distinct organs. Metastases in lung showed a higher immunogenic score than metastases in brain, liver or bone, regardless of their primary site of origin. Also, they preferentially clustered in the high immune group. Samples in this cluster exhibited a clear inflammatory phenotype, higher levels of immune infiltrate, overexpression of programmed death-ligand 1 (PD-L1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) pathways and upregulation of genes predicting clinical response to programmed cell death protein 1 (PD-1) blockade (T-cell inflammatory signature). A decision tree algorithm was used to select CD74 as a biomarker that identify samples belonging to this high-immune subtype of metastases, having specificity of 0.96 and sensitivity of 1. CONCLUSIONS: We have found a group of lung-enriched metastases showing an inflammatory phenotype susceptible to be treated with immunotherapy

GCIMS: An R package for untargeted gas chromatography - Ion mobility spectrometry data processing

Gas-Chromatography coupled to Ion Mobility Spectrometry (GC-IMS) based metabolomics is an emerging technique for obtaining fast, reliable untargeted metabolic fingerprints of biofluids. The generated raw data is highly dimensional and complex, suffers from baseline problems, misalignments, long peak tails and strong non-linearities that must be corrected to extract chemically relevant features from samples. In this work, we present our GCIMS R package, which includes spectra loading, metadata handling, denoising, baseline correction, spectral and chromatographic alignment, peak detection, integration, and peak clustering to produce a peak table ready for multivariate data analysis. We discuss package design decisions, and, for illustration purposes, we show a case study of sex discrimination on the basis of the volatile compounds in urine samples. The GCIMS package provides a user-friendly workflow for non-code developers to process their raw data samples