Tumor de Células Germinativas Primário da Próstata – descrição de um caso raro

info:eu-repo/semantics/publishedVersio

Hemostasia y tratamiento odontológico

La hemostasia es un mecanismo de defensa cuya finalidad es conservar la integridad vascular y evitar la pérdida de sangre. Actualmente la valoración de un paciente con historia de hematomas y hemorragias es un problema clínico frecuente, por lo que el odontólogo debe ser capaz de realizar un correcto diagnóstico y un tratamiento eficaz en los pacientes con alteraciones de la hemostasia. La mejor forma de evitar complicaciones hemorrágicas tras procedimientos quirúrgicos bucales es siempre la prevención y para ello es indispensable disponer de una historia clínica detallada del paciente. El propósito de esta revisión bibliográfica es recordar la patología más común en el área de las coagulopatías, así como incidir en el tratamiento y manejo odontológico de las alteraciones que se pueden encontrar con mayor frecuencia en el gabinete odontológico

Evaluación de la gestión del conocimiento a nivel operacional en las pequeñas y medianas empresas (pymes)

La presente investigación es un estudio exploratorio con el objetivo de valorar la gestión del conocimiento a nivel operacional entre las pequeñas y medianas empresas (pymes). Con base en investigaciones previas y tomando en cuenta las características propias de las pymes de Hermosillo, Sonora, México, se elaboró un instrumento para evaluar la gestión del conocimiento nivel operativo en las fases de adquisición, de distribución y almacenamiento, y de utilización, el cual se aplicó de modo aleatorio en las pymes del escenario de estudio, y se encontró que aunque algunas están trabajando fuertemente en este tema, la mayoría de las empresas apenas están incursionando en la gestión del conocimiento. También se encontró que los administradores de las pymes consideran que los aspectos de mayor interés para la utilización de la gestión del conocimiento son sus clientes, seguidos de la innovación de productos y servicios y la toma de decisiones

Transient shallow reservoirs beneath small eruptive centres: Constraints from Mg-Fe interdiffusion in olivine

Small eruptive centres commonly have more primitive lavas than those associated with stratovolcanoes, an observation that has been taken to indicate a short magma residence in the crust relative to those reservoirs below stratovolcanoes. The Caburgua cones of the Andean Southern Volcanic Zone from a basaltic small eruptive centre where this can be tested. Here, we use MELTS simulations, and the available thermobarometry data to determine the conditions of olivine crystal rim formation and the Mg-Fe diffusion modelling to determine the magma residence times of those rims in the crust. Results yield timescales varying from a few days to dozens of days, and if freezing is to be avoided, can only be explained by some form of storage or slow transport through at least one shallow magma body. The longest durations of magma residence seen in the olivine rim zones are up to 471 days. These timescales are shorter than those estimated (decadal) from the nearby, more-differentiated, and well-established stratovolcano, Villarrica, which has a dominantly basaltic andesite composition. For Caburgua cones, we propose the existence of a transient reservoir, in contrast to a long-lived reservoir such as that inferred beneath the adjacent Villarrica stratovolcano

Protocol per a la implantació d'eines didàctiques virtuals: competències i habilitats adquirides pels estudiants

L"adaptació al nou espai europeu d"educació superior (EEES) ha plantejat alguns canvis en l"enfocament de la formació universitària al nostre país. On abans era el docent el protagonista, ara és l"estudiant el que pren el rol d"actor principal de la seva formació, i l"aprenentatge s"orienta cap a una autonomia i reflexió més grans. En aquest escenari, les noves tecnologies ofereixen un ampli ventall d"opcions per millorar els processos formatius. En aquests sentit, el Grup d"Innovació Docent G IDEA ha participat activament en aquest procés d"adaptació des de ja fa uns quants anys, i ha creat una sèrie de recursos docents digitals que han estat àmpliament provats en diversos ensenyaments de la Facultat d"Economia i Empresa de la Universitat de Barcelona. L"objectiu d"aquest article és presentar el protocol dissenyat per l"equip d"investigadors del G IDEA per implantar aquestes eines didàctiques (webquestes i exercicis tutoritzats), i també els resultats d"una enquesta de satisfacció sobre les competències i habilitats adquirides pels nostres estudiants en la utilització dels recursos. Els resultats mostren, d"una banda, que no ha estat possible crear un mateix protocol aplicable a tots els recursos, a causa de les diferències en els objectius didàctics de les distintes eines docents implantades. D"altra banda, la valoració que els estudiants fan de la utilització de les eines és molt positiva, tot i que hi ha algunes diferències entre els recursos analitzats. Conèixer la valoració que l"alumnat fa d"aquests recursos permet al grup d"investigadors poder-los millorar i adequar al perfil dels estudiants perquè aquests en puguin treure el màxim profit possible

Pregnancy weight gain limitation by a supervised nutritional program influences placental NF-κB/IKK complex expression and oxidative stress

Objective: Nuclear factor kappa B (NF-κB) pathway and oxidative stress participate in endothelial dysfunction, which is one of the causes of preeclampsia. Among the human antioxidant mechanisms there are the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD). Our aim was to measure NF-κB, its inhibitor (IKK) and oxidative stress in placenta and umbilical cord of pregnant women submitted to a supervised nutritional program. Methods: Two groups were conformed: A) 14 pregnant women with individualized nutritional counseling and B) 12 pregnant women without nutritional guidance. NF-κB and IKK were assessed by real time PCR (RT-PCR). Enzymatic activity of CAT, GPx, lipoperoxidation (LPO) and SOD were also evaluated. Results: Pregnant women that followed-up a supervised nutritional program had lower level of systolic (p=0.03) and diastolic pressure (p=0.043) although they were heavier than a control group (p=0.048). Among all women, the Spearman correlation was positive between weight gain and placental NF-κB expression (1, p≤0.01). In placenta, women with nutritional advice had lower enzymatic activity of GPx (p≤0.038) and showed a tendency of IKK to be higher than in women without a nutritional supervised program. Conclusion: A supervised nutritional program in pregnancy offers a proven option to control weight gain, hypertension, NF-κB/IKK complex expression and oxidative stress reactions in placenta

The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription

Small RNAs play a crucial role in genome defense against transposable elements and guide Argonaute proteins to nascent RNA transcripts to induce co-transcriptional gene silencing. However, the molecular basis of this process remains unknown. Here, we identify the conserved RNA helicase Aquarius/EMB-4 as a direct and essential link between small RNA pathways and the transcriptional machinery in $\textit{Caenorhabditis elegans}$. Aquarius physically interacts with the germline Argonaute HRDE-1. Aquarius is required to initiate small-RNA-induced heritable gene silencing. HRDE-1 and Aquarius silence overlapping sets of genes and transposable elements. Surprisingly, removal of introns from a target gene abolishes the requirement for Aquarius, but not HRDE-1, for small RNA-dependent gene silencing. We conclude that Aquarius allows small RNA pathways to compete for access to nascent transcripts undergoing co-transcriptional splicing in order to detect and silence transposable elements. Thus, Aquarius and HRDE-1 act as gatekeepers coordinating gene expression and genome defense.A.C.B. was supported by an HFSP grant to E.A.M. (RPG0014/2015). This work was supported by Cancer Research UK (C13474/A18583, C6946/A14492), the Wellcome Trust (104640/Z/14/Z, 092096/Z/10/Z), and The European Research Council (ERC, grant 260688). The work of P.M. and X.Z. is supported by NIH grant R01GM113242 and NIH grant R01GM122080. R.M. was a Commonwealth Scholar, funded by the UK Government. J.M.C., A.N., and C.J.W. were supported by the CIHR (MOP-274660) and the Canada Research Chairs Program. A.I.L. was supported by a Wellcome Trust Programme Grant (108058/Z/15/Z) and M.L was supported by 2013/RSE/SCOTGOV/ MARIECURIE

NCAM180 Regulates Ric8A Membrane Localization and Potentiates β-Adrenergic Response

Cooperation between receptors allows integrated intracellular signaling leading to appropriate physiological responses. The Neural Cell Adhesion Molecule (NCAM) has three main isoforms of 120, 140 and 180 kDa, with adhesive and signaling properties, but their respective functions remains to be fully identified. Here we show that the human NCAM180 intracellular domain is a novel interactor of the human guanosine exchange factor (GEF) Ric8A using the yeast two hybrid system and immunoprecipitation. Furthermore, NCAM, Ric8A and Gαs form a tripartite complex. Colocalization experiments by confocal microscopy revealed that human NCAM180 specifically induces the recruitment of Ric8A to the membrane. In addition, using an in vitro recombinant system, and in vivo by comparing NCAM knock-out mouse brain to NCAM heterozygous and wild type brains, we show that NCAM expression dose dependently regulates Ric8A redistribution in detergent resistent membrane microdomains (DRM). Previous studies have demonstrated essential roles for Ric8 in Gα protein activity at G protein coupled receptors (GPCR), during neurotransmitter release and for asymmetric cell division. We observed that inhibition of Ric8A by siRNA or its overexpression, decreases or increases respectively, cAMP production following β-adrenergic receptor stimulation. Furthermore, in human HEK293T recombinant cells, NCAM180 potentiates the Gαs coupled β-adrenergic receptor response, in a Ric8A dependent manner, whereas NCAM120 or NCAM140 do not. Finally, in mouse hippocampal neurons expressing endogenously NCAM, NCAM is required for the agonist isoproterenol to induce cAMP production, and this requirement depends on Ric8A. These data illustrate a functional crosstalk between a GPCR and an IgCAM in the nervous system