Pe(n)sare: Note per un realismo della transimmanenza in Jean-Luc Nancy

The aim of this paper is to fathom the places in Jean-Luc Nancy’s philosophical production by which the scene of real’s foundation appears as a breakthrough. In 1976 work Ego sum, for example, the deconstruction of the cartesian subject’s foundation is aimed to show how this place is, instead, a scene of a primary alteration of the ego caused by the body in its being partes extra partes. But also the foundational scene of what Nancy calls “singularity” seems to be an altered breakthrough. Singularity, in Nancy’s view, doesn’t have any ontological firmness; it is, on the contrary, always caught in a relational space testifying of a plurality as the very foundation of the world. That is why “world” has no sense but this relationality in which beings are exposed oneself to another. Transimmanence, here, means nothing but this immanent exposition of the world in beings that, being exposed, transcend themselves. The realist accent that raises up from this philosophical position is supposed to be found also in what tradition has always meant as a mark of human being: language. In fact, this relational plurality “based”, let’s say, at the ground of the real, is, as we demonstrate, always exceeding language and knowledge, and, moreover, makes thought discovering itself as a material weighty thing

High CTLA-4 expression correlates with poor prognosis in thymoma patients

Thymomas, tumors that arise from epithelial cells of the thymus gland, are the most common neoplasms of the anterior mediastinum, with an incidence rate of approximately 2.5 per million/year. Cytotoxic T Lymphocyte Antigen 4 (CTLA-4 or CD152) exerts inhibitory activity on T cells, and since its oncogenic role in the progression of different types of tumors, it has emerged as a potential therapeutic target in cancer patients. In this study, we assessed the expression of CTLA-4 both at mRNA and protein levels in paraffin embedded-tissues from patients with thymomas. Furthermore, we evaluated the relationship between CTLA-4 expression and the clinical-pathologic characteristics and prognosis in patients with thymomas. Sixty-eight patients with median age corresponding to 62 years were included in this analysis. Thymomas were classified accordingly to the WHO and Masaoka-Koga for histochemical analysis and for prognostic significance. A statistical difference was found between CTLA-4 mRNA levels in human normal thymus compared with thymoma specimens. CTLA-4 expression was statistically found to progressively increase in A, B1, B2, AB and it was maximal in B3 thymomas. According to Masaoka-Koga pathological classification, CTLA-4 expression was lower in I, IIA and IIB, and higher in invasive III and IV stages. By confocal microscopy analysis we identified the expression of CTLA-4 both in tumor cells and in CD45+ tumor-infiltrating leukocytes, mainly in B3 and AB thymomas. Finally, CTLA-4 overexpression significantly correlates with reduced overall survival in thymoma patients and in atypical thymoma subgroup, suggesting that it represents a negative prognostic factor

Co-axial heterostructures integrating palladium/titanium dioxide with carbon nanotubes for efficient electrocatalytic hydrogen evolution

Considering the depletion of fossil-fuel reserves and their negative environmental impact, new energy schemes must point towards alternative ecological processes. Efficient hydrogen evolution from water is one promising route towards a renewable energy economy and sustainable development. Here we show a tridimensional electrocatalytic interface, featuring a hierarchical, co-axial arrangement of a palladium/titanium dioxide layer on functionalized multi-walled carbon nanotubes. The resulting morphology leads to a merging of the conductive nanocarbon core with the active inorganic phase. A mechanistic synergy is envisioned by a cascade of catalytic events promoting water dissociation, hydride formation and hydrogen evolution. The nanohybrid exhibits a performance exceeding that of stateof- the-art electrocatalysts (turnover frequency of 15000 H2 per hour at 50mVoverpotential). The Tafel slope of B130mV per decade points to a rate-determining step comprised of water dissociation and formation of hydride. Comparative activities of the isolated components or their physical mixtures demonstrate that the good performance evolves from the synergistic hierarchical structure

Electromagnetic propagation features of ground-penetrating radars for the exploration of Martian subsurface

In this work, the effects of magnetic inclusions in a Mars-like soil are considered with reference to the electromagnetic propagation features of ground-penetrating radars (GPRs). Low-frequency and time-domain techniques, using L-C-R meters and TDR instruments, respectively, are implemented in laboratory experimental set-ups in order to evaluate complex permittivity and permeability and wave velocity for different scenarios of a dielectric background medium (silica) with magnetic inclusions (magnetite). Attenuation and maximum detection ranges have also been evaluated by taking into account a realistic GPR environment, which includes the transmitting/receiving antenna performance and the complex structure of the subsurface. The analysis and the interpretation of these results shed new light on the significant influence of magnetic inclusions on the performance of Martian orbiting and rover-driven GPRs.Published5-11reserve

Corrigendum: oscillatory activities in neurological disorders of elderly: biomarkers to target for neuromodulation

No abstract availble

Performance isolation for network slices in Industry 4.0: The 5Growth approach

Network slicing plays a key role in the 5G ecosystem for verticals to introduce new use cases in the industrial sector, i.e., Industry 4.0. However, a widely recognized challenge of network slicing is to provide traffic isolation and concurrently satisfy diverse performance requirements, e.g., bandwidth and latency. Such challenge becomes even more important when serving a large number of network traffic flows under a resource-limited condition between distributed sites, e.g., factory floor and remote office. In this work, we present the capability to retain these two goals at the same time, by applying the virtual queue notion over a priority queuing based pipeline in P4 switch over software-defined networks. To examine the effectiveness of our approach, a proof-of-concept is setup to serve different requests of Industry 4.0 use cases over a mixed data path, including P4 switch and Open vSwitch, for a large number of network flows.This work was supported in part by the EU H2020 5GROWTH Project under Grant 856709

Fast algorithm for real-time rings reconstruction

The GAP project is dedicated to study the application of GPU in several contexts in which real-time response is important to take decisions. The definition of real-time depends on the application under study, ranging from answer time of μs up to several hours in case of very computing intensive task. During this conference we presented our work in low level triggers [1] [2] and high level triggers [3] in high energy physics experiments, and specific application for nuclear magnetic resonance (NMR) [4] [5] and cone-beam CT [6]. Apart from the study of dedicated solution to decrease the latency due to data transport and preparation, the computing algorithms play an essential role in any GPU application. In this contribution, we show an original algorithm developed for triggers application, to accelerate the ring reconstruction in RICH detector when it is not possible to have seeds for reconstruction from external trackers

Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV

The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO