192 research outputs found
Prolegomena to the Study of Early Modern Commentators on Johannes de Sacrobosco’s Tractatus de Sphaera
The Inner Rings of Beta Pictoris
We present Keck images of the dust disk around Beta Pictoris at 17.9 microns
that reveal new structure in its morphology. Within 1" (19 AU) of the star, the
long axis of the dust emission is rotated by more than 10 degrees with respect
to that of the overall disk. This angular offset is more pronounced than the
warp detected at 3.5" by HST, and in the opposite direction. By contrast, the
long axis of the emission contours at ~ 1.5" from the star is aligned with the
HST warp. Emission peaks between 1.5" and 4" from the star hint at the presence
of rings similar to those observed in the outer disk at ~ 25" with HST/STIS. A
deconvolved image strongly suggests that the newly detected features arise from
a system of four non-coplanar rings. Bayesian estimates based on the primary
image lead to ring radii of 14+/-1 AU, 28+/-3 AU, 52+/-2 AU and 82+/-2 AU, with
orbital inclinations that alternate in orientation relative to the overall disk
and decrease in magnitude with increasing radius. We believe these new results
make a strong case for the existence of a nascent planetary system around Beta
Pic.Comment: 5 pages, 2 figures, PDF format. Published in ApJL, December 20,200
H5N2 Highly Pathogenic Avian Influenza Viruses from the US 2014-2015 outbreak have an unusually long pre-clinical period in turkeys
An overview of the mid-infrared spectro-interferometer MATISSE: science, concept, and current status
MATISSE is the second-generation mid-infrared spectrograph and imager for the
Very Large Telescope Interferometer (VLTI) at Paranal. This new interferometric
instrument will allow significant advances by opening new avenues in various
fundamental research fields: studying the planet-forming region of disks around
young stellar objects, understanding the surface structures and mass loss
phenomena affecting evolved stars, and probing the environments of black holes
in active galactic nuclei. As a first breakthrough, MATISSE will enlarge the
spectral domain of current optical interferometers by offering the L and M
bands in addition to the N band. This will open a wide wavelength domain,
ranging from 2.8 to 13 um, exploring angular scales as small as 3 mas (L band)
/ 10 mas (N band). As a second breakthrough, MATISSE will allow mid-infrared
imaging - closure-phase aperture-synthesis imaging - with up to four Unit
Telescopes (UT) or Auxiliary Telescopes (AT) of the VLTI. Moreover, MATISSE
will offer a spectral resolution range from R ~ 30 to R ~ 5000. Here, we
present one of the main science objectives, the study of protoplanetary disks,
that has driven the instrument design and motivated several VLTI upgrades
(GRA4MAT and NAOMI). We introduce the physical concept of MATISSE including a
description of the signal on the detectors and an evaluation of the expected
performances. We also discuss the current status of the MATISSE instrument,
which is entering its testing phase, and the foreseen schedule for the next two
years that will lead to the first light at Paranal.Comment: SPIE Astronomical Telescopes and Instrumentation conference, June
2016, 11 pages, 6 Figure
Role of Position 627 of PB2 and the Multibasic Cleavage Site of the Hemagglutinin in the Virulence of H5N1 Avian Influenza Virus in Chickens and Ducks
Highly pathogenic H5N1 avian influenza viruses have caused major disease outbreaks in domestic and free-living birds with transmission to humans resulting in 59% mortality amongst 564 cases. The mutation of the amino acid at position 627 of the viral polymerase basic-2 protein (PB2) from glutamic acid (E) in avian isolates to lysine (K) in human isolates is frequently found, but it is not known if this change affects the fitness and pathogenicity of the virus in birds. We show here that horizontal transmission of A/Vietnam/1203/2004 H5N1 (VN/1203) virus in chickens and ducks was not affected by the change of K to E at PB2-627. All chickens died between 21 to 48 hours post infection (pi), while 70% of the ducks survived infection. Virus replication was detected in chickens within 12 hours pi and reached peak titers in spleen, lung and brain between 18 to 24 hours for both viruses. Viral antigen in chickens was predominantly in the endothelium, while in ducks it was present in multiple cell types, including neurons, myocardium, skeletal muscle and connective tissues. Virus replicated to a high titer in chicken thrombocytes and caused upregulation of TLR3 and several cell adhesion molecules, which may explain the rapid virus dissemination and location of viral antigen in endothelium. Virus replication in ducks reached peak values between 2 and 4 days pi in spleen, lung and brain tissues and in contrast to infection in chickens, thrombocytes were not involved. In addition, infection of chickens with low pathogenic VN/1203 caused neuropathology, with E at position PB2-627 causing significantly higher infection rates than K, indicating that it enhances virulence in chickens
Water in the terrestrial planet-forming zone of the PDS 70 disk
Terrestrial and sub-Neptune planets are expected to form in the inner
(AU) regions of protoplanetary disks. Water plays a key role in their
formation, although it is yet unclear whether water molecules are formed
in-situ or transported from the outer disk. So far Spitzer Space Telescope
observations have only provided water luminosity upper limits for dust-depleted
inner disks, similar to PDS 70, the first system with direct confirmation of
protoplanet presence. Here we report JWST observations of PDS 70, a benchmark
target to search for water in a disk hosting a large (AU)
planet-carved gap separating an inner and outer disk. Our findings show water
in the inner disk of PDS 70. This implies that potential terrestrial planets
forming therein have access to a water reservoir. The column densities of water
vapour suggest in-situ formation via a reaction sequence involving O, H,
and/or OH, and survival through water self-shielding. This is also supported by
the presence of CO emission, another molecule sensitive to UV
photodissociation. Dust shielding, and replenishment of both gas and small dust
from the outer disk, may also play a role in sustaining the water reservoir.
Our observations also reveal a strong variability of the mid-infrared spectral
energy distribution, pointing to a change of inner disk geometry.Comment: To appear in Nature on 24 July 2023. 21 pages, 10 figures; includes
extended data. Part of the JWST MINDS Guaranteed Time Observations program's
science enabling products. Spectra downloadable on Zenodo at
https://zenodo.org/record/799102
Circumstellar disks and planets. Science cases for next-generation optical/infrared long-baseline interferometers
We present a review of the interplay between the evolution of circumstellar
disks and the formation of planets, both from the perspective of theoretical
models and dedicated observations. Based on this, we identify and discuss
fundamental questions concerning the formation and evolution of circumstellar
disks and planets which can be addressed in the near future with optical and
infrared long-baseline interferometers. Furthermore, the importance of
complementary observations with long-baseline (sub)millimeter interferometers
and high-sensitivity infrared observatories is outlined.Comment: 83 pages; Accepted for publication in "Astronomy and Astrophysics
Review"; The final publication is available at http://www.springerlink.co
Evidence of Infection by H5N2 Highly Pathogenic Avian Influenza Viruses in Healthy Wild Waterfowl
The potential existence of a wild bird reservoir for highly pathogenic avian influenza (HPAI) has been recently questioned by the spread and the persisting circulation of H5N1 HPAI viruses, responsible for concurrent outbreaks in migratory and domestic birds over Asia, Europe, and Africa. During a large-scale surveillance programme over Eastern Europe, the Middle East, and Africa, we detected avian influenza viruses of H5N2 subtype with a highly pathogenic (HP) viral genotype in healthy birds of two wild waterfowl species sampled in Nigeria. We monitored the survival and regional movements of one of the infected birds through satellite telemetry, providing a rare evidence of a non-lethal natural infection by an HP viral genotype in wild birds. Phylogenetic analysis of the H5N2 viruses revealed close genetic relationships with H5 viruses of low pathogenicity circulating in Eurasian wild and domestic ducks. In addition, genetic analysis did not reveal known gallinaceous poultry adaptive mutations, suggesting that the emergence of HP strains could have taken place in either wild or domestic ducks or in non-gallinaceous species. The presence of coexisting but genetically distinguishable avian influenza viruses with an HP viral genotype in two cohabiting species of wild waterfowl, with evidence of non-lethal infection at least in one species and without evidence of prior extensive circulation of the virus in domestic poultry, suggest that some strains with a potential high pathogenicity for poultry could be maintained in a community of wild waterfowl
Environmental and Demographic Determinants of Avian Influenza Viruses in Waterfowl across the Contiguous United States
Outbreaks of avian influenza in North American poultry have been linked to wild waterfowl. A first step towards understanding where and when avian influenza viruses might emerge from North American waterfowl is to identify environmental and demographic determinants of infection in their populations. Laboratory studies indicate water temperature as one determinant of environmental viral persistence and we explored this hypothesis at the landscape scale. We also hypothesized that the interval apparent prevalence in ducks within a local watershed during the overwintering season would influence infection probabilities during the following breeding season within the same local watershed. Using avian influenza virus surveillance data collected from 19,965 wild waterfowl across the contiguous United States between October 2006 and September 2009 We fit Logistic regression models relating the infection status of individual birds sampled on their breeding grounds to demographic characteristics, temperature, and interval apparent prevalence during the preceding overwintering season at the local watershed scale. We found strong support for sex, age, and species differences in the probability an individual duck tested positive for avian influenza virus. In addition, we found that for every seven days the local minimum temperature fell below zero, the chance an individual would test positive for avian influenza virus increased by 5.9 percent. We also found a twelve percent increase in the chance an individual would test positive during the breeding season for every ten percent increase in the interval apparent prevalence during the prior overwintering season. These results suggest that viral deposition in water and sub-freezing temperatures during the overwintering season may act as determinants of individual level infection risk during the subsequent breeding season. Our findings have implications for future surveillance activities in waterfowl and domestic poultry populations. Further study is needed to identify how these drivers might interact with other host-specific infection determinants, such as species phylogeny, immunological status, and behavioral characteristics
- …