14 research outputs found
Active Brownian Particles. From Individual to Collective Stochastic Dynamics
We review theoretical models of individual motility as well as collective
dynamics and pattern formation of active particles. We focus on simple models
of active dynamics with a particular emphasis on nonlinear and stochastic
dynamics of such self-propelled entities in the framework of statistical
mechanics. Examples of such active units in complex physico-chemical and
biological systems are chemically powered nano-rods, localized patterns in
reaction-diffusion system, motile cells or macroscopic animals. Based on the
description of individual motion of point-like active particles by stochastic
differential equations, we discuss different velocity-dependent friction
functions, the impact of various types of fluctuations and calculate
characteristic observables such as stationary velocity distributions or
diffusion coefficients. Finally, we consider not only the free and confined
individual active dynamics but also different types of interaction between
active particles. The resulting collective dynamical behavior of large
assemblies and aggregates of active units is discussed and an overview over
some recent results on spatiotemporal pattern formation in such systems is
given.Comment: 161 pages, Review, Eur Phys J Special-Topics, accepte
Efeito do genótipo sobre as medidas objetivas e subjetivas da carcaça de cordeiros terminados em confinamento
Genetic Sharing with Cardiovascular Disease Risk Factors and Diabetes Reveals Novel Bone Mineral Density Loci.
Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, but the nature of the suggestive comorbidity is still unknown. We used a novel genetic pleiotropy-informed conditional False Discovery Rate (FDR) method to identify single nucleotide polymorphisms (SNPs) associated with BMD by leveraging cardiovascular disease (CVD) associated disorders and metabolic traits. By conditioning on SNPs associated with the CVD-related phenotypes, type 1 diabetes, type 2 diabetes, systolic blood pressure, diastolic blood pressure, high density lipoprotein, low density lipoprotein, triglycerides and waist hip ratio, we identified 65 novel independent BMD loci (26 with femoral neck BMD and 47 with lumbar spine BMD) at conditional FDR < 0.01. Many of the loci were confirmed in genetic expression studies. Genes validated at the mRNA levels were characteristic for the osteoblast/osteocyte lineage, Wnt signaling pathway and bone metabolism. The results provide new insight into genetic mechanisms of variability in BMD, and a better understanding of the genetic underpinnings of clinical comorbidity
Mal (MyD88 adapter-like) is a novel Toll IL-1 receptor (TIR) domain-containing adapter which recruits IRAK-2 during Toll-like receptor-4 signal transduction
Biomodel Engineering – From Structure to Behavior
Abstract. Biomodel engineering is the science of designing, constructing and analyzing computational models of biological systems. It forms a systematic and powerful extension of earlier mathematical modeling approaches and has recently gained popularity in systems biology and synthetic biology. In this brief review for systems biologists and computational modelers, we introduce some of the basic concepts of successful biomodel engineering, illustrating them with examples from a variety of application domains, ranging from metabolic networks to cellular signaling cascades. We also present a more detailed outline of one of the major techniques of biomodel engineering – Petri net models – which provides a flexible and powerful tool for building, validating and exploring computational descriptions of biological systems
Blueberry protects LPS-stimulated BV-2 microglia through inhibiting activities of p38 MAPK and ERK1/2
Fish processing work: the impact of two sex dependent exposure profiles on musculoskeletal health
Características da carcaça e dos não-componentes da carcaça de ovelhas de descarte abatidas em diferentes estágios fisiológicos
El color en la arquitectura de Bruno Taut
La vinculación del arquitecto Bruno Taut con los ideales que albergaba el movimiento para la reforma de la vida, desarrollado en la Alemania de Guillermo II como contraposición a las consecuencias del enorme desarrollo económico e industrial, se materializó, esencialmente, en la proyección de ciudades jardín y Siedlungen, en las que se refuerza el principio de cultura comunitaria. Esta práctica constructiva en el ámbito de la vivienda es expresión de su pensamiento social e intenta hacer efectiva la idea de una “nueva construcción” acorde con las necesidades de la sociedad moderna