Del simbolisme eròtic de la imatge del cavall

In this paper the author analyses some passages from the Greek literature, earlier than the hellenistic epigramm, where there appears some horse images with an erotic interpretation which are the starting point to study the transmition of the elements from these images throught tradition

The land–sea coastal border: a quantitative definition by considering the wind and wave conditions in a wave-dominated, micro-tidal environment

A quantitative definition for the land–sea (coastal) transitional area is proposed here for wave-driven areas, based on the variability and isotropy of met-ocean processes. Wind velocity and significant wave height fields are examined for geostatistical anisotropy along four cross-shore transects on the Catalan coast (north-western Mediterranean), illustrating a case of significant changes along the shelf. The variation in the geostatistical anisotropy as a function of distance from the coast and water depth has been analysed through heat maps and scatter plots. The results show how the anisotropy of wind velocity and significant wave height decrease towards the offshore region, suggesting an objective definition for the coastal fringe width. The more viable estimator turns out to be the distance at which the significant wave height anisotropy is equal to the 90th percentile of variance in the anisotropies within a 100&thinsp;km distance from the coast. Such a definition, when applied to the Spanish Mediterranean coast, determines a fringe width of 2–4&thinsp;km. Regarding the probabilistic characterization, the inverse of wind velocity anisotropy can be fitted to a log-normal distribution function, while the significant wave height anisotropy can be fitted to a log-logistic distribution function. The joint probability structure of the two anisotropies can be best described by a Gaussian copula, where the dependence parameter denotes a mild to moderate dependence between both anisotropies, reflecting a certain decoupling between wind velocity and significant wave height near the coast. This wind–wave dependence remains stronger in the central bay-like part of the study area, where the wave field is being more actively generated by the overlaying wind. Such a pattern controls the spatial variation in the coastal fringe width.</p

Metafísica de la debilidad y pedagogía del cuidado en Jean Vanier

En el presente artículo presentamos una investigación que se ha propuesto como objetivo analizar el concepto de debilidad así como el de pedagogía del cuidado en las experiencias y escritos de Jean Vanier. La obra y los proyectos de Vanier son fundamentales en la historia del pensamiento pedagógico europeo. Para ello se ha trabajado desde un enfoque metodológico de corte cualitativo y a través del análisis y la crítica documental. El estudio ha analizado tres grandes categorías que atraviesan el pensamiento y la praxis de Vanier: teorías sobre la debilidad, pedagogías del cuidado y pedagogía espiritual. El análisis se acompaña de una revisión biográfica del autor para poder situar su pensamiento de forma encarnada.In the present article we present a research that has been proposed as an objective to analyze the concept of weakness and the pedagogy of care in the experiences and writings of Jean Vanier. Vanier’s work and projects are fundamental in the history of European pedagogical thinking. To this end, a methodological and qualitative approach has been worked on through analysis and documentary criticism. The study has analyzed three major categories that go through Vanier’s thinking and praxis: Theories about Weakness, Pedagogies of Care and Spiritual Pedagogy. The analysis is accompanied by a biographical review of the author to be able to situate his thought in an embodied way

A high-throughput screening identifies microRNA inhibitors that influence neuronal maintenance and/or response to oxidative stress

Oxidative stress; Small RNA sequencing; NeurodegenerationEstrés oxidativo; Secuenciación de ARN pequeño; NeurodegeneraciónEstrès oxidatiu; Seqüenciació d'ARN petit; NeurodegeneracióSmall non-coding RNAs (sncRNAs), including microRNAs (miRNAs) are important post-transcriptional gene expression regulators relevant in physiological and pathological processes. Here, we combined a high-throughput functional screening (HTFS) platform with a library of antisense oligonucleotides (ASOs) to systematically identify sncRNAs that affect neuronal cell survival in basal conditions and in response to oxidative stress (OS), a major hallmark in neurodegenerative diseases. We considered hits commonly detected by two statistical methods in three biological replicates. Forty-seven ASOs targeting miRNAs (miRNA-ASOs) consistently decreased cell viability under basal conditions. A total of 60 miRNA-ASOs worsened cell viability impairment mediated by OS, with 36.6% commonly affecting cell viability under basal conditions. In addition, 40 miRNA-ASOs significantly protected neuronal cells from OS. In agreement with cell viability impairment, damaging miRNA-ASOs specifically induced increased free radical biogenesis. miRNAs targeted by the detrimental ASOs are enriched in the fraction of miRNAs downregulated by OS, suggesting that the miRNA expression pattern after OS contributes to neuronal damage. The present HTFS highlighted potentially druggable sncRNAs. However, future studies are needed to define the pathways by which the identified ASOs regulate cell survival and OS response and to explore the potential of translating the current findings into clinical applications.This work was supported by the Spanish Ministry of Economy and Competitiveness and FEDER funds (SAF2014-60551-R and SAF2017-88452-R). We acknowledge the support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership and the Centro de Excelencia Severo Ochoa 2013-2017 (SEV-2012-0208). We acknowledge the support of the Spanish Ministry of Science Innovation and Universities, Maria Maeztu Unit of Excellence Programme. We thank the staff of the Genomics Unit for the preparation of sRNA libraries and sequencing and the staff of the Biomolecular Screening and Protein Technologies Unit for their help in the setting up the high-throughput screening

Accions musicals per millorar els hàbits lectors a l’ESO

El nivell de comprensió lectora entre els estudiants de l’ESO al nostre país és especialment baix, com es constata a partir dels resultats de l’informe PISA i d’altres proves de rendiment acadèmic establertes per l’Administració. Moltes investigacions interdisciplinàries vinculen aspectes musicals amb l’aprenentatge de les llengües i amb les habilitats per a la lectura en educació primària i secundària i posen en relleu el gran poder formatiu, socialitzador, mnemònic, motivacional i emocional de la música en aquestes edats. El poder emocional de la música permet la creació d’ambients sonors proclius a la lectura. La revisió bibliogràfica d’aquestes aportacions apunta possibilitats per investigar com la motivació a la lectura és un dels aspectes fonamentals que es pot propiciar des de l’educació musical a secundària.The level of reading comprehension among students in compulsory secondary education is particularly low, which can be seen in the results of the PISA report and other academic performance tests established by the Government. Many interdisciplinary studies link aspects of music with language learning and reading skills in primary and secondary education and place great emphasis on the great power that music has on learning, socialization, mnemonics and emotional development at these ages. The emotional power of music allows it to create sonic environments that favour reading. A review of these studies indicates that music is an essential aspect in motivating students in compulsory secondary education to read

Structural tuning of photoluminescence in nanoporous anodic alumina by hard anodization in oxalic and malonic acids

We report on an exhaustive and systematic study about the photoluminescent properties of nanoporous anodic alumina membranes fabricated by the one-step anodization process under hard conditions in oxalic and malonic acids. This optical property is analysed as a function of several parameters (i.e. hard anodization voltage, pore diameter, membrane thickness, annealing temperature and acid electrolyte). This analysis makes it possible to tune the photoluminescent behaviour at will simply by modifying the structural characteristics of these membranes. This structural tuning ability is of special interest in such fields as optoelectronics, in which an accurate design of the basic nanostructures (e.g. microcavities, resonators, filters, supports, etc.) yields the control over their optical properties and, thus, upon the performance of the nanodevices derived from them (biosensors, interferometers, selective filters, etc.).Abel Santos, Maria Alba, Mahbubur M Rahman, Pilar Formentín, Josep Ferré-Borrull, Josep Pallarès, Lluis F Marsa

A propensity-score-matched analysis of laparoscopic vs open surgery for rectal cancer in a population-based study

Aim: the oncological risk/benefit trade-off for laparoscopy in rectal cancer is controversial. Our aim was to compare laparoscopic vs open surgery for resection of rectal cancer, using unselected data from the public healthcare system of Catalonia. Methods: this was a multicentre retrospective cohort study of all patients who had surgery with curative intent for primary rectal cancer at Catalonian public hospitals from 2011 to 2012. We obtained follow-up data for up to 5 years. To minimize the differences between the two groups, we performed propensity score matching on baseline patient characteristics. We used multivariate Cox proportional hazards regression analyses to assess locoregional relapse at 2 years and death at 2 and 5 years. Results: of 1513 patients with Stage I-III rectal cancer, 933 (61.7%) had laparoscopy (conversion rate 13.2%). After applying our propensity score matching strategy (2:1), 842 laparoscopy patients were matched to 517 open surgery patients. Multivariate Cox analysis of death at 2 years [hazard ratio (HR) 0.65, 95% CI 0.48, 0.87; P = 0.004] and 5 years (HR 0.61, 95% CI 0.5, 0.75; P < 0.001) and of local relapse at 2 years (HR 0.44, 95% CI 0.27, 0.72; P = 0.001) showed laparoscopy to be an independent protective factor compared with open surgery. Cconclusions: laparoscopy results in lower locoregional relapse and long-term mortality in rectal cancer in unselected patients with all-risk groups included. Studies using long-term follow-up of cohorts and unselected data can provide information on clinically relevant outcomes to supplement randomized controlled trials

Tunable Fabry-Perot interferometer based on nanoporous anodic alumina for optical biosensing purposes

Here, we present a systematic study about the effect of the pore length and its diameter on the specular reflection in nanoporous anodic alumina. As we demonstrate, the specular reflection can be controlled at will by structural tuning (i.e., by designing the pore geometry). This makes it possible to produce a wide range of Fabry-Pérot interferometers based on nanoporous anodic alumina, which are envisaged for developing smart and accurate optical sensors in such research fields as biotechnology and medicine. Additionally, to systematize the responsiveness to external changes in optical sensors based on nanoporous anodic alumina, we put forward a barcode system based on the oscillations in the specular reflection.Abel Santos, Victor S Balderrama, María Alba, Pilar Formentín, Josep Ferré-Borrull, Josep Pallarès, Lluís F Marsa

Focal adhesion genes refine the intermediate-risk cytogenetic classification of acute myeloid leukemia

© 2018 by the authors.In recent years, several attempts have been made to identify novel prognostic markers in patients with intermediate-risk acute myeloid leukemia (IR-AML), to implement risk-adapted strategies. The non-receptor tyrosine kinases are proteins involved in regulation of cell growth, adhesion, migration and apoptosis. They associate with metastatic dissemination in solid tumors and poor prognosis. However, their role in haematological malignancies has been scarcely studied. We hypothesized that PTK2/FAK, PTK2B/PYK2, LYN or SRC could be new prognostic markers in IR-AML. We assessed PTK2, PTK2B, LYN and SRC gene expression in a cohort of 324 patients, adults up to the age of 70, classified in the IR-AML cytogenetic group. Univariate and multivariate analyses showed that PTK2B, LYN and PTK2 gene expression are independent prognostic factors in IR-AML patients. PTK2B and LYN identify a patient subgroup with good prognosis within the cohort with non-favorable FLT3/NPM1 combined mutations. In contrast, PTK2 identifies a patient subgroup with poor prognosis within the worst prognosis cohort who display non-favorable FLT3/NPM1 combined mutations and underexpression of PTK2B or LYN. The combined use of these markers can refine the highly heterogeneous intermediate-risk subgroup of AML patients, and allow the development of risk-adapted post-remission chemotherapy protocols to improve their response to treatment.Pallarès, VictorThis work was supported by Instituto de Salud Carlos III (Co-funding from FEDER) [CD13/00074 to V.P., PI15/00378 and PIE15/00028 to R.M., FIS PI17/01246, RD12/0036/0071 and FIS PI14/00450 to J.S., RD12/0036/0069 to M.G.., ISCIII-PS13/1640 and PI16/0665 to E.B., and RD12/0036/0014 and PIE13/00046 to M.A.S.] CIBERONC [CB16/12/00284 to M.A.S.]; CIBER-BBN [CBV6/01/1031 and Nanomets3 to R.M.]; AGAUR [2017 FI_B 00680 to A.F.; 2017-SGR-865 and 2014PROD0005 to R.M. and 2014-SGR-1281 to J.S.]; Fundació La Marató TV3 [416/C/2013-2030 to R.M., 100830/31/32 to J.S., M.G.. and M.A.S.]; Josep Carreras Leukemia Research Institute [P/AG 2017 to R.M.]; Spanish Health Research Program [PI12/02321 to M.G..]; Spanish Association Against Cancer (AECC) [to M.C.C.]; a grant from the Cellex Foundation, Barcelona [to J.S.]; a grant from La Generalitat de Catalunya (PERIS) [SLT002/16/00433 to J.S.]; and a grant from Fundación Española de Hematología y Hemoterapia (FEHH) [to V.P.]

Photoluminescence and cathodoluminescence of Eu:La2O3 nanoparticles synthesized by several methods

Abstract : Europium-doped La2O3 nanocrystalline powders with sizes ranging from 4 nm to 300 nm have been obtained by the modified Pechini, hydrothermal with conventional furnace, hydrothermal with microwave furnace, and precipitation with ultrasonic bath methods. X-ray diffraction techniques were used to study the evolution of the prepared gels towards the desired crystalline phase. We determined the size and the morphology of the nanoparticles by electronic microscopy. Finally, we studied and analyzed the luminescence properties of the trivalent europium in the hexagonal La2O3 nanocrystals by photoluminescence and cathodoluminescence