Mesenchymal Stromal Cells for Articular Cartilage Repair: Preclinical Studies

[Abstract] Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment option for OA and other cartilage diseases. However, the main cellular strategy used to repair articular cartilage, the transplantation of autologous chondrocytes, is limited to a small number of patients with traumatic lesions. The use of joint replacement after years of disease progression proves the great medical need in current practice. Mesenchymal stromal/stem cells (MSCs) provide an alternative cell source for cartilage regeneration due to numerous advantages, comprising relative ease to isolate and culture, chondrogenic capacity, and antiinflammatory effects. Initial clinical trials with MSCs have led to encouraging results, but many variables have to be considered to attain true amelioration of disease or repair (type and status of cartilage disease, source and conditions of cells, administration regime, combinatorial approaches). Particularly, allogeneic MSCs are an advantageous cellular product. The animal models chosen for preclinical evaluation are also relevant for successful translation into clinical practice. Considering the limitations in the field, rigorous comparative and validating studies in well-established animal models (including large animals) are still needed to set up the bases for additional clinical trials. The present review of studies performed in small and large animal models should help clarify the applicability of MSC-based therapies for articular cartilage repair

Wearable Technology to Detect Motor Fluctuations in Parkinson’s Disease Patients: Current State and Challenges.

Monitoring of motor symptom fluctuations in Parkinson’s disease (PD) patients is currently performed through the subjective self-assessment of patients. Clinicians require reliable information about a fluctuation’s occurrence to enable a precise treatment rescheduling and dosing adjustment. In this review, we analyzed the utilization of sensors for identifying motor fluctuations in PD patients and the application of machine learning techniques to detect fluctuations. The review process followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Ten studies were included between January 2010 and March 2021, and their main characteristics and results were assessed and documented. Five studies utilized daily activities to collect the data, four used concrete scenarios executing specific activities to gather the data, and only one utilized a combination of both situations. The accuracy for classification was 83.56–96.77%. In the studies evaluated, it was not possible to find a standard cleaning protocol for the signal captured, and there is significant heterogeneity in the models utilized and in the different features introduced in the models (using spatiotemporal characteristics, frequential characteristics, or both). The two most influential factors in the good performance of the classification problem are the type of features utilized and the type of model.post-print900 K

El yacimiento arqueológico de Orpesa la Vella (Oropesa del Mar, Castellón). Resultados de las campañas de 2005 a 2008 y su contextualización

Tras un breve resumen de la primera etapa de intervenciones, se presentan los resultados de las campañas de excavación realizadas entre los años 2005 y 2008 en el yacimiento arqueológico de Orpesa la Vella (Oropesa del Mar, Plana Alta, Castellón). Finalmente se efectúa un ensayo de contextualización completa de la secuencia del yacimiento.First we present a brief summary of the interventions carried out previously in the archaeological site of Orpesa la Vella (Oropesa del Mar, Plana Alta, Castellón). Subsequently, the results of the excavation campaigns carried out between 2005 and 2008 are presented. Finally, we try to make a contextualization of the complete archaeological sequence

Mesenchymal stromal cells for articular cartilage repair: preclinical studies

Rheumatic diseases such as osteoarthritis (OA) are a major social and economic burden because of the population aging and the lack of curative solutions. An effective cell therapy may be the best treatment option for OA and other cartilage diseases. However, the main cellular strategy used to repair articular cartilage, the transplantation of autologous chondrocytes, is limited to a small number of patients with traumatic lesions. The use of joint replacement after years of disease progression proves the great medical need in current practice. Mesenchymal stromal/stem cells (MSCs) provide an alternative cell source for cartilage regeneration due to numerous advantages, comprising relative ease to isolate and culture, chondrogenic capacity, and anti-inflammatory effects. Initial clinical trials with MSCs have led to encouraging results, but many variables have to be considered to attain true amelioration of disease or repair (type and status of cartilage disease, source and conditions of cells, administration regime, combinatorial approaches). Particularly, allogeneic MSCs are an advantageous cellular product. The animal models chosen for preclinical evaluation are also relevant for successful translation into clinical practice. Considering the limitations in the field, rigorous comparative and validating studies in well-established animal models (including large animals) are still needed to set up the bases for additional clinical trials. The present review of studies performed in small and large animal models should help clarify the applicability of MSC-based therapies for articular cartilage repair

Quality Parameters, Volatile Composition, and Sensory Profiles of Highly Endangered Spanish Citrus Fruits

There is very little information available on the chemical composition and the quality attributes of the citrus species studied which are truly endangered in Spain. None of the fruits studied is available for commercial purposes, which is the main interest and novelty of this study. The aim of this work was to fully describe the morphology, volatile composition, and sensory profile of traditional citrus fruits: sour lime (SoLi), sweet lime (SwLi), and sweet lemon (SwLe), to have the information to convince farmers and growers to cultivate these fruits again. The predominant sugar was fructose while citric acid prevails in SoLi and SwLe. Regarding volatiles compounds, monoterpenes, monoterpenoids, and esters predominated in the juices, and these three families plus sesquiterpenes in the peels. The juice of SoLi presented the highest content of esters (14.8%), SwLi juice presented similar values of both monoterpenes and monoterpenoids (46.1 and 46.0%, resp.), and SwLe juice had the highest content of monoterpenes (72.2%). The results demonstrated the high potential of these citrus materials for the agrofood industry. Therefore, it will be possible to recover these vegetal materials at risk of disappearing for potential uses by the food industry and simultaneously help maintaining the biodiversity

Actas del Congreso Virtual Avances en Tecnologías, Innovación y Desafíos de la Educación Superior ATIDES 2018

Actes del Congres Virtual Avances en Tecnologías, Innovación y Desafíos de la Educación Superior ATIDES 201

Implementation of the Control Rod Movement Option by means of Control Variables in RELAP5/PARCS v2.7 Coupled Code (NUREG/IA-0402)

The objective of this work is to introduce an improvement in best estimate coupled neutronicthermalhydraulic 3D codes simulations, by adding a model for the control rod movement in the coupled code RELAP5/PARCS v2.7, by means of control variables, with the aim of being able to dynamically analyze asymmetric transient accidents, as the reactivity insertion accidents (RIA) in a nuclear reactor, reproducing all the reactors control systems. The modification developed in this work permits the automatic movement of the control rods, activated by the RELAP5 code control system, and also they can depend on signals related to the reactor reactivity, like pressure, fuel temperature or moderator temperature, etc., improving the realism of the calculation and increasing the simulation capabilities. This report was prepared by the Nuclear Engineering Group belonging to the Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM) at the Universitat Politècnica de València (UPV), which collaborates in the simulation area with the Spanish company Centrales Nucleares Almaraz-Trillo (CNAT). The Asociación Española de la Industria Eléctrica (UNESA, Electric Industry Association of Spain), equivalent to the American EPRI sponsored this work.Miró Herrero, R.; Ana Ibáñez, P.; Barrachina Celda, TM.; Martínez-Murillo, J.; Pereira, C.; Verdú Martín, GJ. (2014). Implementation of the Control Rod Movement Option by means of Control Variables in RELAP5/PARCS v2.7 Coupled Code (NUREG/IA-0402). United States Nuclear Regulatory Commission. http://hdl.handle.net/10251/58958

Effect of Aging Vessel (Clay-Tinaja versus Oak Barrel) on the Volatile Composition, Descriptive Sensory Profile, and Consumer Acceptance of Red Wine

Consumers look for unique wines, offering pleasant experiences. Wine producers need to open new markets and are targeting countries with fewer traditions in drinking red and complex wines, such as Poland, Russia and Germany. The use of less popular aging vessels (e.g., clay-tinajas) will help in creating unique wines. The aim of this study was to evaluate the effect of the aging vessel on the volatile and sensory profiles and consumer acceptance of red wine in Spain and Poland (model of potential new markets). Three wines were studied: (i) wine A, aged in a clay-tinaja with non-permeable coating); (ii) wine B, aged in clay-tinaja without coating; and (iii) wine C, aged in oak barrels (control). The key families in the volatile profiles were esters (wines B and C) and organic acids and terpenes (wine A). Wine A was described as sour and bitter, wine B had a distinctive mineral note, and wine C had a complex profile with typical wood notes. Finally, wines C and A were the preferred ones for Spanish and Polish consumers, respectively. Clay-tinaja wine A can be a good option to introduce clay-tinaja wines in Polish and similar markets because it is a unique product and fulfills the sensory demands/habits of Polish consumers

Los pactos parasociales. El caso de los protocolos familiares

Treball Final del Màster Universitari en Advocacia. Codi: SRJ010. Curs acadèmic 2013-201