Behind innovation clusters: Individual, cultural, and strategic linkages

As observed by Porter [1] and Enright [2], clusters occupy a key position in the economy of developed countries, most notably because they bring several benefits resulting from economic and social factors. Although these authors alert us to the importance of social capital mechanisms in clustering processes, they fail to fully explore the psychological and social basis that underlay clusters and clustering processes. In the same vein, while Porter and Sölvell [3] mention that a cluster allows a shared language, social ties, and a set of standards and values to develop, they do not fully expand on how such phenomena develops. Addressing these gaps in the literature, the aim of this study is to investigate the dimensions (i.e. individual and social) which sustain and nurture the existence of macro structures (i.e. clusters). In particular, the current research looked at convergence and divergence mechanisms within a cluster. The exploratory nature of the research required a case study strategy; for this reason a cluster in the Portuguese textile sector was chosen. Data from three companies in the same cluster were gathered using several instruments, namely: a questionnaire, interviews, observation and documentary analysis. The results show that although the three companies operate in the same cluster, they are considerably different in terms of commercial orientations as well as cultural and strategic profiles, which is matched by a low presence of isomorphic mechanisms [4]; this result contradicts that of the Pouder and St. John [5] study. It was also observed that informal relations in the heart of the cluster are commonplace and that managers’ differences play a role. In this way, they strengthen and motivate the aspects of the business that unite the cluster.info:eu-repo/semantics/publishedVersio

Stress and coping connected to higher education study structures: combined views from teachers and students

Experienced stress by students and teachers in higher education has attracted increasing interest, but the two groups are rarely studied together. We combine their perspectives by considering the stress and coping among students and teachers concerning the development of study structures in a business school context. The findings indicate a strong connection between stress experienced by students and teachers, reflecting their interactive nature in this context. We categorize factors causing stress to those for which effective coping mechanisms exist, those causing tensions and requiring active management, and stressors that are difficult to remove because a coping mechanism for one group increases the stress of the other. Our findings add to existing knowledge on stress and coping mechanisms in higher education by combining the perspectives of students and teachers concerning study structures in business education

Social media and international business : views and conceptual framing

Purpose The objective of this paper is to increase understanding of social media in international business context. To this end, the authors make an attempt to integrate the existing, still somewhat limited views in a framework that advances the knowledge of scholars and decision-makers on this topic. Design/methodology/approach The authors conduct a conceptual study supported by use of a systematic literature review method. Findings This study shows marketing as a dominant area of discussion and reveals that many firm functions where social media plays a role have received relatively little attention. Furthermore, the study shows that the positive features of social media in international activity tend to be more widely acknowledged and better understood than the potentially problematic aspects. Research limitations/implications The number of articles analyzed in this study was relatively small, resonating with the nature of an emerging research area. Research on social media has only taken off over the last years, and it is understandable that there is limited research that connects it specifically to phenomena of international business. Practical implications This study reminds managers to be cautious when using social media in international markets. The relationship between social media and international business exhibits dynamism and is dependent on a variety of factors. Social media does not come without costs, nor is easily transferred from one market to another. Efficient use of this media in the international context may increase the need of specific and qualified human resources, and it may necessitate having the whole process from R&D to delivery, and beyond, ready for adaptation. Originality/value It can be argued that we know too little about the relevant factors and relationships between social media and international business. The authors hope that this study revealing the scarcely studied aspects and suggesting a tentative framework for capturing the dynamics of social media and international business can guide subsequent research and accelerate its emergence.© Matti Saari, Lauri Haapanen and Pia Hurmelinna-Laukkanen. Published by Emerald Publishing Limited. This article is published under the Creative Commons Attribution (CC BY 4.0) licence. Anyone may reproduce, distribute, translate and create derivative works of this article (for both commercial and non-commercial purposes), subject to full attribution to the original publication and authors. The full terms of this licence may be seen at http://creativecommons.org/licences/by/4.0/legalcodefi=vertaisarvioitu|en=peerReviewed

The role of inbreeding and outbreeding in herbivore resistance and tolerance in Vincetoxicum hirundinaria

Background and Aims Inbreeding via self-fertilization may have negative effects on plant fitness (i.e. inbreeding depression). Outbreeding, or cross-fertilization between genetically dissimilar parental plants, may also disrupt local adaptation or allelic co-adaptation in the offspring and again lead to reduced plant fitness (i.e. outbreeding depression). Inbreeding and outbreeding may also increase plant vulnerability to natural enemies by altering plant quality or defence. The effects of inbreeding and outbreeding on plant size and response to herbivory in the perennial herb, Vincetoxicum hirundinaria, were investigated. Methods Greenhouse experiments were conducted using inbred and outbred (within- and between-population) offspring of 20 maternal plants from four different populations, quantifying plant germination, size, resistance against the specialist folivore, Abrostola asclepiadis, and tolerance of simulated defoliation. Key Results Selfed plants were smaller and more susceptible to damage by A. asclepiadis than outcrossed plants. However, herbivore biomass on selfed and outcrossed plants did not differ. The effects of inbreeding on plant performance and resistance did not differ among plant populations or families, and no inbreeding depression at all was found in tolerance of defoliation. Between-population outcrossing had no effect on plant performance or resistance against A. asclepiadis, indicating a lack of outbreeding depression. Conclusions Since inbreeding depression negatively affects plant size and herbivore resistance, inbreeding may modify the evolution of the interaction between V. hirundinaria and its specialist folivore. The results further suggest that herbivory may contribute to the maintenance of a mixed mating system of the host plants by selecting for outcrossing and reduced susceptibility to herbivore attack, and thus add to the growing body of evidence on the effects of inbreeding on the mating system evolution of the host plants and the dynamics of plant-herbivore interaction

Climate change, consumer lifestyles and legitimation strategies of sustainability-oriented firms

This study explores the links between climate change, consumer lifestyles, and legitimation strategies of sustainable firms. Our findings offer new insight into this under-researched area based on qualitative case studies of four Nordic firms operating in industrial and consumer contexts. We find that climate change consciousness is a major driver for all case firms’ sustainability-focused operations, but the dynamics differed. Achieving sociopolitical legitimacy emerges as an important factor for the case firms operating in the energy sector, especially as it connects to government incentives and regulative pressures. However, cognitive legitimacy is increasingly important for them also, and the firms are trying to connect to their consumers’ lifestyles as well. In turn, for the case firms operating in the consumer (clothing) industry, functionality and the use of products are highlighted even though cognitive legitimacy based on linking to their consumers’ lifestyle is visible. Finally, the findings reveal that despite the sustainable lifestyles are increasingly important and better recognized in firm strategies and practices, other practicalities of running the business successfully in a highly competitive marketplace are relevant. Building legitimacy in such a way that captures and justifies different approaches, therefore, emerges as the connecting factor between the changing consumer behavior and pro-environmental firm practices.publishedVersio

Plant Chemistry and Local Adaptation of a Specialized Folivore

Local adaptation is central for creating and maintaining spatial variation in plant-herbivore interactions. Short-lived insect herbivores feeding on long-lived plants are likely to adapt to their local host plants, because of their short generation time, poor dispersal, and geographically varying selection due to variation in plant defences. In a reciprocal feeding trial, we investigated the impact of geographic variation in plant secondary chemistry of a long-lived plant, Vincetoxicum hirundinaria, on among-population variation in local adaptation of a specialist leaf-feeding herbivore, Abrostola asclepiadis. The occurrence and degree of local adaptation varied among populations. This variation correlated with qualitative and quantitative differences in plant chemistry among the plant populations. These findings provide insights into the mechanisms driving variation in local adaptation in this specialized plant-herbivore interaction

Microvesicle- and exosome- mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Background: Extracellular vesicles (EVs) are naturally occurring membrane particles that mediate intercellular communication by delivering molecular information between cells. In this study, we investigated the effectiveness of two different populations of EVs (microvesicle- and exosome-enriched) as carriers of Paclitaxel to autologous prostate cancer cells. Methods: EVs were isolated from LNCaP- and PC-3 prostate cancer cell cultures using differential centrifugation and characterized by electron microscopy, nanoparticle tracking analysis, and Western blot. The uptake of microvesicles and exosomes by the autologous prostate cancer cells was assessed by flow cytometry and confocal microscopy. The EVs were loaded with Paclitaxel and the effectiveness of EV-mediated drug delivery was assessed with viability assays. The distribution of EVs and EV-delivered Paclitaxel in cells was inspected by confocal microscopy. Results: Our main finding was that the loading of Paclitaxel to autologous prostate cancer cell-derived EVs increased its cytotoxic effect. This capacity was independent of the EV population and the cell line tested. Although the EVs without the drug increased cancer cell viability, the net effect of enhanced cytotoxicity remained. Both EV populations delivered Paclitaxel to the recipient cells through endocytosis, leading to the release of the drug from within the cells. The removal of EV surface proteins did not affect exosomes, while the drug delivery mediated by microvesicles was partially inhibited. Conclusions: Cancer cell-derived EVs can be used as effective carriers of Paclitaxel to their parental cells, bringing the drug into the cells through an endocytic pathway and increasing its cytotoxicity. However, due to the increased cell viability, the use of cancer cell-derived EVs must be further investigated before any clinical applications can be designed. (C) 2015 The Authors. Published by Elsevier B.V.Peer reviewe

In the riptide of control and trust: Emergence of control practices, suspicion, and distrust in new technology deployment

In this study, we focus on the unintended consequences of new technology deployment for control-trust dynamics. When addressing these dynamics, managers and management researchers often focus on consciously designed and implemented controls and management actions that build, repair, or preserve trust. At the same time, unowned processes—processes that have no single source or purpose—easily go unnoticed. These processes may have effects that are inadvertent and sometimes detrimental. A close-up ethnographic study of a technology deployment provides insight into the emergence of unintended control practices and shifts in trust. Our findings demonstrate how deployment of new technology prompted a shift in the loci and forms of control and how trust, suspicion, and distrust surfaced asymmetrically as organizational members interpreted in different ways how others were using the new technological features. These developments contributed to the emergence of four unintended control practices: incidental monitoring, organizational surveillance, individual concealment, and collective resistance. Our study highlights the role of unowned processes in the control-trust dynamics and emphasizes that whether or not control and trust are consciously addressed, both play interactive and evolving roles in organizations.publishedVersionPeer reviewe

Syöpä muuttaa solunulkoisten vesikkelien metabolista sormenjälkeä

Cancer alters cell metabolism. How these changes are manifested in the metabolite cargo of cancer-derived extracellular vesicles (EVs) remains poorly understood. To explore these changes, EVs from prostate, cutaneous T-cell lymphoma (CTCL), colon cancer cell lines, and control EVs from their noncancerous counterparts were isolated by differential ultracentrifugation and analyzed by nanoparticle tracking analysis (NTA), electron microscopy (EM), Western blotting, and liquid chromatography-mass spectrometry (LC-MS). Although minor differences between the cancerous and non-cancerous cell-derived EVs were observed by NTA and Western blotting, the largest differences were detected in their metabolite cargo. Compared to EVs from noncancerous cells, cancer EVs contained elevated levels of soluble metabolites, e.g., amino acids and B vitamins. Two metabolites, proline and succinate, were elevated in the EV samples of all three cancer types. In addition, folate and creatinine were elevated in the EVs from prostate and CTCL cancer cell lines. In conclusion, we present the first evidence in vitro that the altered metabolism of different cancer cells is reflected in common metabolite changes in their EVs. These results warrant further studies on the significance and usability of this metabolic fingerprint in cancer.Peer reviewe