Algumas considerações sobre a mortalidade infantil em São Paulo

A mortalidade infantil ascende na capital de S. Paulo e no interior a algarismos que pedem meditação. Uma das causas do phenomeno está no apparelho official de hygiene infantil. de acção extremamente limitada e só exercida em diminuta proporção na capital do Estado e que justifica o sempre alto e constante coefficiente lethal

Serviço de Estatistica sanitaria

A primeira exigencia de um bom serviço de ·estatística sanitaria é naturalmente um perfeito recenseamento geral da população; o censo do povo é a necessidade basica ou preliminar de todos os trabalhos desta natureza, que a simples conjecturas se reduzem, quando lhes falte esse elemento essencial, semelhantemente a syllogismos em que sejam vacillantes as premissas maiores

Suggestões para a melhoria da Legistação Sanitaria Estadual, sobre generos alimenticios

A questão da alimentação publica constitue capitulo importante de hygiene e merece de todas as administrações cuidadosa attenção. Envolve attribuiçôes que, segundo os paizes e suas organízaçôcs po1itícas, devem ser perfeitamente definidas para melhor e maior rendimento de serviço. É necessarío prever e evitar conflictos entre as autoridades, crear e intensificar a cooperação effíciente entre os varios poderes e agentes da segurança sanitaria

Poder calorífico de algumas substâncias alimentares da cozinha paulista

Apresentamos neste trabalho os primeiros resultados de experiências de nutriição, que sob vários aspectos encetamos no Instituto de Higiene

Au+Au central collisions at 150, 250 and 400 AMeV energies in QMD with relativistic forces

An extensive comparison of the recent experimental data published by the FOPI collaboration at GSI with the results of a relativistically covariant formulation of a QMD code is presented. For most of the quantities we find agreement with the experimental results showing that the derived force has a reasonable momentum dependence.Comment: 33 pages with 18 EPSF figures included. Final version to appear in Nucl. Phys.

Interpretação do mapa pedológico do Município do Rio de Janeiro para usos alternativos dos solos.

O presente trabalho e constituído por um mapa de solos, acompanhado de um texto explicativo para planejamento do uso dos solos do município do Rio de Janeiro, visando usos alternativos, ou seja, não estritamente agrícolas. A fonte básica do trabalho e o levantamento pedológico deste município (escala 1:50.000). Foram selecionados perfis representativos do solos dominantes no município, dos quais foram extraídas amostras para ensaios em laboratório. Como resultado final dos dados colhidos em campo e em laboratório serão elaboradas recomendações para os usos mais adequados dos solos

Conjugation with L, L-diphenylalanine Self-Assemblies Enhances In Vitro Antitumor Activity of Phthalocyanine Photosensitizer

We present the synthesis and characterization of new peptide conjugates obtained by hierarchical co-assembly of L,L-diphenylalanine (FF) and zinc phthalocyanine complexes (ZnPc) in water. Self-assembly capabilities under defined conditions were investigated by scanning electron microscopy, and photophysical properties were evaluated using UV-Vis and fluorescence spectroscopy. AFM observations demonstrated that these ZnPcs form different highly ordered arrays on the crystalline faces of the FF microplates and that surface roughness significantly changes with the presence of differently substituted phthalocyanine units. XRD assays showed that the overall molecular packing of the conjugates is organized according to a hexagonal symmetry, with ZnPcs hosted in the interstices of the peptide phase. In vitro photodynamic studies were conducted on human breast cancer MCF-7 cells to investigate both cellular uptake and cytotoxicity. It was shown that FF self-assemblies are not toxicity and enhance accumulation of ZnPc in MCF-7 cells, improving apoptotic cell death upon irradiation. Our findings demonstrate enhancement of ZnPc antitumor efficiency by FF conjugates and a proof-of-concept for new photosensitizer carriers based on peptide conjugates

Inhibitory action of Lippia gracilis Schauer essential oil on pathogenic bacteria and its effects as a growth promoter on quail

Aim of the study: To examine the in vitro sensitivity of Salmonella sp. and Escherichia coli strains to the microbial activity of Lippia gracilis Schauer essential oil (LGSEO) and to determine the optimal level of LGSEO as a growth promoter in diets for Japanese quail up to 35 days of age.Area of study: São Cristovão, Sergipe, Brazil.Material and methods: A total of 504 female Japanese quails (Coturnix coturnix japonica) at an initial average body weights of 6.80±0.10 g was allotted to one of six treatments (0, 100, 200, 300, 400 mg/kg of LGSEO and a diet containing 500 mg/kg of bacitracin methylene disalicylate) in 7 replicates, using 12 birds per experimental unit.Main results: In the age period of 21 to 35 days, feed intake declined linearly (p=0.04) and feed efficiency improved (p<0.01), whereas no changes were observed in production performance (p>0.05). The estimated (p=0.01) maximum relative weights of proventriculus and pancreas were obtained at the LGSEO inclusion levels of 196.5 and 251 mg/kg, respectively. Inclusion of 100 to 300 mg/kg of LGSEO in the diet reduced the total Salmonella sp. bacterial count.Research highlights: The use of 196.5 mg/kg of LGSEO in the diet of Japanese quail improved production performance and organ development and demonstrated potential antimicrobial capacity against Salmonella sp. bacteria. Due its pharmacological composition, LGSEO can potentially substitute to antimicrobials, because contains thymol and carvacrol as main active constituents

Comparison of different delivery systems of DNA vaccination for the induction of protection against tuberculosis in mice and guinea pigs

The great challenges for researchers working in the field of vaccinology are optimizing DNA vaccines for use in humans or large animals and creating effective single-dose vaccines using appropriated controlled delivery systems. Plasmid DNA encoding the heat-shock protein 65 (hsp65) (DNAhsp65) has been shown to induce protective and therapeutic immune responses in a murine model of tuberculosis (TB). Despite the success of naked DNAhsp65-based vaccine to protect mice against TB, it requires multiple doses of high amounts of DNA for effective immunization. In order to optimize this DNA vaccine and simplify the vaccination schedule, we coencapsulated DNAhsp65 and the adjuvant trehalose dimycolate (TDM) into biodegradable poly (DL-lactide-co-glycolide) (PLGA) microspheres for a single dose administration. Moreover, a single-shot prime-boost vaccine formulation based on a mixture of two different PLGA microspheres, presenting faster and slower release of, respectively, DNAhsp65 and the recombinant hsp65 protein was also developed. These formulations were tested in mice as well as in guinea pigs by comparison with the efficacy and toxicity induced by the naked DNA preparation or BCG. The single-shot prime-boost formulation clearly presented good efficacy and diminished lung pathology in both mice and guinea pigs