4,395 research outputs found
Empirical Studies Applied to Software Process Models
Working Group Report: ICSE'99 Workshop on Empirical Studies of Software Development and Evolutio
Planck Observations of M33
We have performed a comprehensive investigation of the global integrated flux
density of M33 from radio to ultraviolet wavelengths, finding that the data
between 100 GHz and 3 THz are accurately described by a single modified
blackbody curve with a dust temperature of = 21.670.30 K
and an effective dust emissivity index of = 1.350.10,
with no indication of an excess of emission at millimeter/sub-millimeter
wavelengths. However, sub-dividing M33 into three radial annuli, we found that
the global emission curve is highly degenerate with the constituent curves
representing the sub-regions of M33. We also found gradients in
and across the disk of M33, with both
quantities decreasing with increasing radius. Comparing the M33 dust emissivity
with that of other Local Group members, we find that M33 resembles the
Magellanic Clouds rather than the larger galaxies, i.e., the Milky Way and M31.
In the Local Group sample, we find a clear correlation between global dust
emissivity and metallicity, with dust emissivity increasing with metallicity. A
major aspect of this analysis is the investigation into the impact of
fluctuations in the Cosmic Microwave Background (CMB) on the integrated flux
density spectrum of M33. We found that failing to account for these CMB
fluctuations would result in a significant over-estimate of
by 5 K and an under-estimate of by 0.4.Comment: Accepted for publication in MNRA
Participants' uptake of clinical trial results: a randomised experiment
BJC OPENInternational audienceBACKGROUND: Participants are showing great interest these days in obtaining the results of clinical trials. The aim of this study was to assess patients' uptake and understanding of the results of the trial in which they have participated and the impact of a letter offering patients the possibility of consulting the trial results on a specific website. METHODS: Breast cancer patients participating in a trial on the efficacy of Trastuzumab were randomly subdivided into an Internet group (who received the letter of invitation) and a control group (who did not receive it). Among 115 HER2-positive women from 21 centres, 107 (93%) answered a self-administered questionnaire. RESULTS: Most of the patients in both groups had access to the Internet (72.0%). The majority (97.2%) stated that receiving information about the trial results would be useful, and the oncologist was the most frequently preferred information provider. The Internet group's declared uptake of the trial results was only slightly higher (47.1% vs 33.9%; P=0.166); however, they understood the results significantly more accurately (18.8% vs 5.6%; P=0.039). INTERPRETATION: Although Internet was not the respondents' preferred source of information, the possibility of using this source slightly increased the uptake and understanding of the results
Violation of the Cauchy-Schwarz inequality with matter waves
The Cauchy-Schwarz (CS) inequality -- one of the most widely used and
important inequalities in mathematics -- can be formulated as an upper bound to
the strength of correlations between classically fluctuating quantities.
Quantum mechanical correlations can, however, exceed classical bounds.Here we
realize four-wave mixing of atomic matter waves using colliding Bose-Einstein
condensates, and demonstrate the violation of a multimode CS inequality for
atom number correlations in opposite zones of the collision halo. The
correlated atoms have large spatial separations and therefore open new
opportunities for extending fundamental quantum-nonlocality tests to ensembles
of massive particles.Comment: Final published version (with minor changes). 5 pages, 3 figures,
plus Supplementary Materia
Characterization of Dicer-deficient murine embryonic stem cells
Dicer is an RNase III-family nuclease that initiates RNA interference (RNAi) and related phenomena by generation of the small RNAs that determine the specificity of these gene silencing pathways. We have previously shown that Dicer is essential for mammalian development, with Dicer-deficient mice dying at embryonic day 7.5 with a lack of detectable multipotent stem cells. To permit a more detailed investigation of the biological roles of Dicer, we have generated embryonic stem cell lines in which their single Dicer gene can be conditionally inactivated. As expected, Dicer loss compromises maturation of microRNAs and leads to a defect in gene silencing triggered by long dsRNAs. However, the absence of Dicer does not affect the ability of small interfering RNAs to repress gene expression. Of interest, Dicer loss does compromise the proliferation of ES cells, possibly rationalizing the phenotype previously observed in Dicer-null animals. Dicer loss also affects the abundance of transcripts from mammalian centromeres but does so without a pronounced affect on histone modification status at pericentric repeats or methylation of centromeric DNA. These studies provide a conditional model of RNAi deficiency in mammals that will permit the dissection of the biological roles of the RNAi machinery in cultured mammalian cells
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Evolution of the eyes of vipers with and without infrared-sensing pit organs
We examined lens and brille transmittance, photoreceptors, visual pigments, and visual opsin gene sequences of viperid snakes with and without infrared-sensing pit organs. Ocular media transmittance is high in both groups. Contrary to previous reports, small as well as large single cones occur in pit vipers. Non-pit vipers differ from pit vipers in having a twotiered retina, but few taxa have been examined for this poorly understood feature. All vipers sampled express rh1, sws1 and lws visual opsin genes. Opsin spectral tuning varies but not in accordance with the presence/absence of pit organs, and not always as predicted from gene sequences. The visual opsin genes were generally under purifying selection, with positive selection at spectral tuning amino acids in RH1 and SWS1 opsins, and at retinal pocket stabilization sites in RH1 or LWS (and without substantial differences between pit and nonpit vipers). Lack of evidence for sensory trade-off between viperid eyes (in the aspects examined) and pit organs might be explained by the high degree of neural integration of vision and infrared detection; the latter representing an elaboration of an existing sense with addition of a novel sense organ, rather than involving the evolution of a wholly novel sensory system
Flow and critical velocity of an imbalanced Fermi gas through an optical potential
Optical lattices offer the possibility to investigate the superfluid
properties of both Bose condensates and Fermionic superfluid gases. When a
population imbalance is present in a Fermi mixture, this leads to frustration
of the pairing, and the superfluid properties will be affected. In this
contribution, the influence of imbalance on the flow of a Fermi superfluid
through an optical lattice is investigated. The flow through the lattice is
analysed by taking into account coupling between neighbouring layers of the
optical lattice up to second order in the interlayer tunneling amplitude for
single atoms. The critical velocity of flow through the lattice is shown to
decrease monotonically to zero as the imbalance is increased to 100%.
Closed-form analytical expressions are given for the tunneling contribution to
the action and for the critical velocity as a function of the binding energy of
pairs in the (quasi) two-dimensional Fermi superfluid and as a function of the
imbalance.Comment: 8 pages, 1 figure, contribution for the QFS 2007 conferenc
The Atacama Cosmology Telescope: CO(J = 3 - 2) mapping and lens modeling of an ACT-selected dusty star-forming galaxy
We report Northern Extended Millimeter Array (NOEMA) CO()
observations of the dusty star-forming galaxy ACT-S\,J020941+001557 at , which was detected as an unresolved source in the Atacama Cosmology
Telescope (ACT) equatorial survey. Our spatially resolved spectral line data
support the derivation of a gravitational lens model from 37 independent
velocity channel maps using a pixel-based algorithm, from which we infer a
velocity-dependent magnification factor with a
luminosity-weighted mean \left\approx 13. The resulting
source-plane reconstruction is consistent with a rotating disk, although other
scenarios cannot be ruled out by our data. After correction for lensing, we
derive a line luminosity , a cold gas mass , a dynamical mass , and a gas mass
fraction . The line brightness
temperature ratio of relative to a Green Bank Telescope
CO() detection may be elevated by a combination of external heating of
molecular clouds, differential lensing, and/or pointing errors.Comment: 8 pages, 5 figures, accepted to Ap
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