Oscillatory neural networks underlying resting-state, attentional control and social cognition task conditions in children with ASD, ADHD and ASD+ADHD

Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are common and impairing neurodevelopmental disorders that frequently co-occur. The neurobiological mechanisms involved in ASD and ADHD are not fully understood. However, alterations in large-scale neural networks have been proposed as core deficits in both ASD and ADHD and may help to disentangle the neurobiological basis of these disorders and their co-occurrence. In this study, we examined similarities and differences in large-scale oscillatory neural networks between boys aged 8-13 years with ASD (n = 19), ADHD (n = 18), ASD + ADHD (n = 29) and typical development (Controls, n = 26). Oscillatory neural networks were computed using graph-theoretical methods from electroencephalographic (EEG) data collected during an eyes-open resting-state and attentional control and social cognition tasks in which we previously reported disorder-specific atypicalities in oscillatory power and event-related potentials (ERPs). We found that children with ASD showed significant hypoconnectivity in large-scale networks during all three task conditions compared to children without ASD. In contrast, children with ADHD showed significant hyperconnectivity in large-scale networks during the attentional control and social cognition tasks, but not during the resting-state, compared to children without ADHD. Children with co-occurring ASD + ADHD did not differ from children with ASD when paired with this group and vice versa when paired with the ADHD group, indicating that these children showed both ASD-like hypoconnectivity and ADHD-like hyperconnectivity. Our findings suggest that ASD and ADHD are associated with distinct alterations in large-scale oscillatory networks, and these atypicalities present together in children with both disorders. These alterations appear to be task-independent in ASD but task-related in ADHD, and may underlie other neurocognitive atypicalities in these disorders. [Abstract copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chiral perturbation theory calculation for pn -> dpipi at threshold

We investigate the reaction pn -> dpipi in the framework of Chiral Perturbation Theory. For the first time a complete calculation of the leading order contributions is presented. We identify various diagrams that are of equal importance as compared to those recognized in earlier works. The diagrams at leading order behave as expected by the power counting. Also for the first time the nucleon-nucleon interaction in the initial, intermediate and final state is included consistently and found to be very important. This study provides a theoretical basis for a controlled evaluation of the non-resonant contributions in two-pion production reactions in nucleon-nucleon collisions.Comment: 24 pages, 3 figures, 3 table

Toward an internally consistent astronomical distance scale

Accurate astronomical distance determination is crucial for all fields in astrophysics, from Galactic to cosmological scales. Despite, or perhaps because of, significant efforts to determine accurate distances, using a wide range of methods, tracers, and techniques, an internally consistent astronomical distance framework has not yet been established. We review current efforts to homogenize the Local Group's distance framework, with particular emphasis on the potential of RR Lyrae stars as distance indicators, and attempt to extend this in an internally consistent manner to cosmological distances. Calibration based on Type Ia supernovae and distance determinations based on gravitational lensing represent particularly promising approaches. We provide a positive outlook to improvements to the status quo expected from future surveys, missions, and facilities. Astronomical distance determination has clearly reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press (chapter 8 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

Limits on νμ(νˉμ)→ντ(νˉτ)\nu_\mu(\bar{\nu}_\mu)\to\nu_\tau(\bar{\nu}_\tau) and νμ(νˉμ)→νe(νˉe)\nu_\mu(\bar{\nu}_\mu)\to\nu_e(\bar{\nu}_e) Oscillations from a Precision Measurement of Neutrino-Nucleon Neutral Current Interactions

We present limits on $\nu_\mu(\bar{\nu}_\mu)\to\nu_\tau(\bar{\nu}_\tau)$ and $\nu_\mu(\bar{\nu}_\mu)\to\nu_e(\bar{\nu}_e)$ oscillations based on a study of inclusive $\nu N$ interactions performed using the CCFR massive coarse grained detector in the FNAL Tevatron Quadrupole Triplet neutrino beam. The sensitivity to oscillations is from the difference in the longitudinal energy deposition pattern of $\nu_\mu N$ versus $\nu_\tau N$ or $\nu_e N$ charged current interactions. The $\nu_\mu$ energies ranged from 30 to 500 GeV with a mean of 140 GeV. The minimum and maximum $\nu_\mu$ flight lengths are 0.9 km and 1.4 km respectively. For $\nu_\mu\to\nu_\tau$ oscillations, the lowest 90% confidence upper limit in $\sin^22\alpha$ of $2.7\times 10^{-3}$ is obtained at $\Delta m^2\sim50$~eV$^2$. This result is the most stringent limit to date for $25<\Delta m^2<90$ eV$^2$. For $\nu_\mu\to\nu_e$ oscillations, the lowest 90% confidence upper limit in $\sin^22\alpha$ of $1.9\times 10^{-3}$ is obtained at $\Delta m^2\sim350$~eV$^2$. This result is the most stringent limit to date for $250<\Delta m^2<450$ eV$^2$, and also excludes at 90% confidence much of the high $\Delta m^2$ region favored by the recent LSND observation.Comment: Revised version contains limit on $\nu_\mu\to\nu_e$ oscillations as well as limit on $\nu_\mu\to\nu_\tau$ oscillations found in original. 15 pages, ReVTeX, 3 figures in uuencoded file, submitted to PR

Anomalous accelerations in spacecraft flybys of the Earth

[EN] The flyby anomaly is a persistent riddle in astrodynamics. Orbital analysis in several flybys of the Earth since the Galileo spacecraft flyby of the Earth in 1990 have shown that the asymptotic post-encounter velocity exhibits a difference with the initial velocity that cannot be attributed to conventional effects. To elucidate its origin, we have developed an orbital program for analyzing the trajectory of the spacecraft in the vicinity of the perigee, including both the Sun and the Moon¿s tidal perturbations and the geopotential zonal, tesseral and sectorial harmonics provided by the EGM96 model. The magnitude and direction of the anomalous acceleration acting upon the spacecraft can be estimated from the orbital determination program by comparing with the trajectories fitted to telemetry data as provided by the mission teams. This acceleration amounts to a fraction of a mm/s2 and decays very fast with altitude. 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The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

Baryons: What, When and Where?

We review the current state of empirical knowledge of the total budget of baryonic matter in the Universe as observed since the epoch of reionization. Our summary examines on three milestone redshifts since the reionization of H in the IGM, z = 3, 1, and 0, with emphasis on the endpoints. We review the observational techniques used to discover and characterize the phases of baryons. In the spirit of the meeting, the level is aimed at a diverse and non-expert audience and additional attention is given to describe how space missions expected to launch within the next decade will impact this scientific field.Comment: Proceedings Review for "Astrophysics in the Next Decade: JWST and Concurrent Facilities", ed. X. Tielens, 38 pages, 10 color figures. Revised to address comments from the communit

Eocene global warming events driven by ventilation of oceanic dissolved organic carbon

‘Hyperthermals’ are intervals of rapid, pronounced global warming known from six episodes within the Palaeocene and Eocene epochs (65–34 million years (Myr) ago)1–13. The most extreme hyperther-( mal was the 170 thousand year (kyr) interval2 of 5–7 ºC global warming3 during the Palaeocene–Eocene Thermal Maximum (PETM, 56Myr ago). The PETM is widely attributed to massive release of greenhouse gases from buried sedimentary carbon reservoirs1,3,6,11,14–17, and other, comparatively modest, hyperthermals have also been linked to the release of sedimentary carbon3,6,11,16,17. Here we show, using new 2.4-Myr-long Eocene deep ocean records, that the comparatively modest hyperthermals are much more numerous than previously documented, paced by the eccentricityof Earth’s orbit and have shorter durations ( recovery phases than the PETM. These findings point to the operation of fundamentally different forcing and feedback mechanisms than for the PETM, involving redistribution of carbon among Earth’s readily exchangeable surface reservoirs rather than carbon exhumation from, and subsequent burial back into, the sedimentary reservoir. Specifically, we interpret our records to indicate repeated, large-scale releases of dissolved organic carbon (at least 1,600 gigatonnes) from the ocean by ventilation (strengthened oxidation) of the ocean interior. The rapid recovery of the carbon cycle following each Eocene hyperthermal strongly suggests that carbon was resequestered by the ocean, rather than the much slower process of silicate rock weathering proposed for the PETM1,3. Our findings suggest that these pronounced climate warming events were driven not by repeated releases of carbon from buried sedimentary sources3,6,11,16,17, but, rather, by patterns of surficial carbon redistribution familiar from younger intervals of Earth history

Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

Contains fulltext : 144496.pdf (publisher's version ) (Open Access)Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 x 10-4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model