1,461 research outputs found
The Rise and Fall of Water Net (Hydrodictyon reticulatum) in New Zealand
During the late 1980s to early 1990s a range of aquatic habitats in the central North Island of New Zealand were invaded by the filamentous green alga, water net Hydrodictyon reticulatum (Linn. Lagerheim). The alga caused significant economic and recreational impacts at major sites of infestation, but it was also associated with enhanced invertebrate numbers and was the likely cause of an improvement in the trout fishery. The causes of prolific growth of water net and the range of control options pursued are reviewed. The possible causes of its sudden decline in 1995 are considered, including physical factors, increase in grazer pressure, disease, and loss of genetic vigour
A gauge model for quantum mechanics on a stratified space
In the Hamiltonian approach on a single spatial plaquette, we construct a
quantum (lattice) gauge theory which incorporates the classical singularities.
The reduced phase space is a stratified K\"ahler space, and we make explicit
the requisite singular holomorphic quantization procedure on this space. On the
quantum level, this procedure furnishes a costratified Hilbert space, that is,
a Hilbert space together with a system which consists of the subspaces
associated with the strata of the reduced phase space and of the corresponding
orthoprojectors. The costratified Hilbert space structure reflects the
stratification of the reduced phase space. For the special case where the
structure group is , we discuss the tunneling probabilities
between the strata, determine the energy eigenstates and study the
corresponding expectation values of the orthoprojectors onto the subspaces
associated with the strata in the strong and weak coupling approximations.Comment: 38 pages, 9 figures. Changes: comments on the heat kernel and
coherent states have been adde
Network development in biological gels: role in lymphatic vessel development
In this paper, we present a model that explains the prepatterning of lymphatic vessel morphology in collagen gels. This model is derived using the theory of two phase rubber material due to Flory and coworkers and it consists of two coupled fourth order partial differential equations describing the evolution of the collagen volume fraction, and the evolution of the proton concentration in a collagen implant; as described in experiments of Boardman and Swartz (Circ. Res. 92, 801–808, 2003). Using linear stability analysis, we find that above a critical level of proton concentration, spatial patterns form due to small perturbations in the initially uniform steady state. Using a long wavelength reduction, we can reduce the two coupled partial differential equations to one fourth order equation that is very similar to the Cahn–Hilliard equation; however, it has more complex nonlinearities and degeneracies. We present the results of numerical simulations and discuss the biological implications of our model
Dynamic Changes in High-Sensitivity Cardiac Troponin I in Response to Anthracycline-Based Chemotherapy
Aims:
Treatment advances have improved cancer-related outcomes and shifted interest towards minimising long-term iatrogenic complications, particularly chemotherapy-related cardiotoxicity. High-sensitivity cardiac troponin I (hs-cTnI) assays accurately quantify very low concentrations of plasma troponin and enable early detection of cardiomyocyte injury prior to the development of myocardial dysfunction. The profile of hs-cTnI in response to anthracycline-based treatment has not previously been described.
Materials and methods:
This was a multicentre prospective observational cohort study. Female patients with newly diagnosed invasive breast cancer scheduled to receive anthracycline-based (epirubicin) chemotherapy were recruited. Blood sampling was carried out before and 24 h after each cycle. Hs-cTnI concentrations were measured using the Abbott ARCHITECTSTAT assay.
Results:
We recruited 78 women with a median (interquartile range) age of 52 (49–61) years. The median baseline troponin concentration was 1 (1–4) ng/l and the median cumulative epirubicin dose was 394 (300–405) mg/m2. Following an initial 33% fall 24 h after anthracycline dosing (P < 0.001), hs-cTnI concentrations increased by a median of 50% (P < 0.001) with each successive treatment cycle. In total, 45 patients had troponin measured immediately before the sixth treatment cycle, 21 (46.6%) of whom had hs-cTnI concentrations ≥16 ng/l, indicating myocardial injury. Plasma hs-cTnI concentrations before the second treatment cycle were a strong predictor of subsequent myocardial injury.
Conclusions:
Cardiotoxicity arising from anthracycline therapy is detectable in the earliest stages of breast cancer treatment and is cumulative with each treatment cycle. This injury is most reliably determined from blood sampling carried out before rather than after each treatment cycle
Detecting Microscopic Black Holes with Neutrino Telescopes
If spacetime has more than four dimensions, ultra-high energy cosmic rays may
create microscopic black holes. Black holes created by cosmic neutrinos in the
Earth will evaporate, and the resulting hadronic showers, muons, and taus may
be detected in neutrino telescopes below the Earth's surface. We simulate such
events in detail and consider black hole cross sections with and without an
exponential suppression factor. We find observable rates in both cases: for
conservative cosmogenic neutrino fluxes, several black hole events per year are
observable at the IceCube detector; for fluxes at the Waxman-Bahcall bound,
tens of events per year are possible. We also present zenith angle and energy
distributions for all three channels. The ability of neutrino telescopes to
differentiate hadrons, muons, and possibly taus, and to measure these
distributions provides a unique opportunity to identify black holes, to
experimentally constrain the form of black hole production cross sections, and
to study Hawking evaporation.Comment: 20 pages, 9 figure
CP Violation in Fermion Pair Decays of Neutral Boson Particles
We study CP violation in fermion pair decays of neutral boson particles with
spin 0 or 1. We study a new asymmetry to measure CP violation in decays and discuss the possibility of measuring it
experimentally. For the spin-1 particles case, we study CP violation in the
decays of to octet baryon pairs. We show that these decays can
be used to put stringent constraints on the electric dipole moments of
, and .Comment: 14p, OZ-93/22, UM-93/89, OITS 51
Spatio-temporal genetic tagging of a cosmopolitan planktivorous shark provides insight to gene flow, temporal variation and site-specific re-encounters
Migratory movements in response to seasonal resources often influence population structure and dynamics. Yet in mobile marine predators, population genetic consequences of such repetitious behaviour remain inaccessible without comprehensive sampling strategies. Temporal genetic sampling of seasonally recurring aggregations of planktivorous basking sharks, Cetorhinus maximus, in the Northeast Atlantic (NEA) affords an opportunity to resolve individual re-encounters at key sites with population connectivity and patterns of relatedness. Genetic tagging (19 microsatellites) revealed 18% of re-sampled individuals in the NEA demonstrated inter/multi-annual site-specific re-encounters. High genetic connectivity and migration between aggregation sites indicate the Irish Sea as an important movement corridor, with a contemporary effective population estimate (Ne) of 382 (CI = 241–830). We contrast the prevailing view of high gene flow across oceanic regions with evidence of population structure within the NEA, with early-season sharks off southwest Ireland possibly representing genetically distinct migrants. Finally, we found basking sharks surfacing together in the NEA are on average more related than expected by chance, suggesting a genetic consequence of, or a potential mechanism maintaining, site-specific re-encounters. Long-term temporal genetic monitoring is paramount in determining future viability of cosmopolitan marine species, identifying genetic units for conservation management, and for understanding aggregation structure and dynamics
Black Holes from Cosmic Rays: Probes of Extra Dimensions and New Limits on TeV-Scale Gravity
If extra spacetime dimensions and low-scale gravity exist, black holes will
be produced in observable collisions of elementary particles. For the next
several years, ultra-high energy cosmic rays provide the most promising window
on this phenomenon. In particular, cosmic neutrinos can produce black holes
deep in the Earth's atmosphere, leading to quasi-horizontal giant air showers.
We determine the sensitivity of cosmic ray detectors to black hole production
and compare the results to other probes of extra dimensions. With n \ge 4 extra
dimensions, current bounds on deeply penetrating showers from AGASA already
provide the most stringent bound on low-scale gravity, requiring a fundamental
Planck scale M_D > 1.3 - 1.8 TeV. The Auger Observatory will probe M_D as large
as 4 TeV and may observe on the order of a hundred black holes in 5 years. We
also consider the implications of angular momentum and possible exponentially
suppressed parton cross sections; including these effects, large black hole
rates are still possible. Finally, we demonstrate that even if only a few black
hole events are observed, a standard model interpretation may be excluded by
comparison with Earth-skimming neutrino rates.Comment: 30 pages, 18 figures; v2: discussion of gravitational infall, AGASA
and Fly's Eye comparison added; v3: Earth-skimming results modified and
strengthened, published versio
The CLIMPACTS synthesis report: An assessment of the effects of climate change and variation in New Zealand using the CLIMPACTS system
In the late 1980s, New Zealand undertook the first national assessment of climate change and its possible impacts on the country.The landmark report, reflecting the judgement of scores of national experts, called for greater efforts in building the national research capacity in order to better quantify the range of impacts that could occur in New Zealand from climate change and variability. In response, the collaborative CLIMPACTS Programme was established to provide this capacity. Ten years on from the first national assessment, the present synthesis offers some results from, as well as a demonstration of, the capacity developed by the CLIMPACTS Programme. The purpose of the present document is to provide a summary report from the CLIMPACTS Programme on climate change and its effects on New Zealand.The chapters and their contents are not comprehensive. Rather, they are focused on a specific set of questions, which conform to the particular expertise of the CLIMPACTS Programme members and which employ a limited set of the wide range of tools available within the CLIMPACTS Model. Other important areas such as forests, indigenous ecosystems and pests and diseases are not yet covered
Supernova Bounds on Majoron-emitting decays of light neutrinos
Neutrino masses arising from the spontaneous violation of ungauged
lepton-number are accompanied by a physical Goldstone boson, generically called
Majoron. In the high-density supernova medium the effects of Majoron-emitting
neutrino decays are important even if they are suppressed in vacuo by small
neutrino masses and/or small off-diagonal couplings. We reconsider the
influence of these decays on the neutrino signal of supernovae in the light of
recent Super-Kamiokande data on solar and atmospheric neutrinos. We find that
majoron-neutrino coupling constants in the range 3\times 10^{-7}\lsim g\lsim
2\times 10^{-5} or g \gsim 3 \times 10^{-4} are excluded by the observation
of SN1987A. Then we discuss the potential of Superkamiokande and the Sudbury
Neutrino Observatory to detect majoron neutrino interactions in the case of a
future galactic supernova. We find that these experiments could probe majoron
neutrino interactions with improved sensitivity.Comment: 28 pages, 5 figure
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