71 research outputs found
An in situ transmission electron microscopy study of the ion irradiation induced amorphisation of silicon by He and Xe
Transmission electron microscopy with in situ ion irradiation has been used to examine the ionbeam-induced amorphisation of crystalline silicon under irradiation with light (He) and heavy (Xe) ions at room temperature. Analysis of the electron diffraction data reveal the heterogeneous amorphisation mechanism to be dominant in both cases. The differences in the amorphisation curves are discussed in terms of intra-cascade dynamic recovery, and the role of electronic and nuclear loss mechanisms
Surface state atoms and their contribution to the surface tension of quantum liquids
We investigate the new type of excitations on the surface of liquid helium.
These excitations, called surfons, appear because helium atoms have discrete
energy level at the liquid surface, being attracted to the surface by the van
der Waals force and repulsed at a hard-core interatomic distance. The
concentration of the surfons increases with temperature. The surfons propagate
along the surface and form a two-dimensional gas. Basing on the simple model of
the surfon microscopic structure, we estimate the surfon activation energy and
effective mass for both helium isotopes. We also calculate the contribution of
the surfons to the temperature dependence of the surface tension. This
contribution explains the great and long-standing discrepancy between theory
and experiment on this temperature dependence in both helium isotopes. The
achieved agreement between our theory and experiment is extremely high. The
comparison with experiment allows to extract the surfon activation energy and
effective mass. The values of these surfon microscopic parameters are in a
reasonable agreement with the calculated from the proposed simple model of
surfon structure.Comment: 10 pages, 6 figure
eta-prime photoproduction on the proton for photon energies from 1.527 to 2.227 GeV
Differential cross sections for the reaction gamma p -> eta-prime p have been
measured with the CLAS spectrometer and a tagged photon beam with energies from
1.527 to 2.227 GeV. The results reported here possess much greater accuracy
than previous measurements. Analyses of these data indicate for the first time
the coupling of the etaprime N channel to both the S_11(1535) and P_11(1710)
resonances, known to couple strongly to the eta N channel in photoproduction on
the proton, and the importance of j=3/2 resonances in the process.Comment: 6 pages, 3 figure
Measurement of the Deuteron Structure Function F2 in the Resonance Region and Evaluation of Its Moments
Inclusive electron scattering off the deuteron has been measured to extract
the deuteron structure function F2 with the CEBAF Large Acceptance Spectrometer
(CLAS) at the Thomas Jefferson National Accelerator Facility. The measurement
covers the entire resonance region from the quasi-elastic peak up to the
invariant mass of the final-state hadronic system W~2.7 GeV with four-momentum
transfers Q2 from 0.4 to 6 (GeV/c)^2. These data are complementary to previous
measurements of the proton structure function F2 and cover a similar
two-dimensional region of Q2 and Bjorken variable x. Determination of the
deuteron F2 over a large x interval including the quasi-elastic peak as a
function of Q2, together with the other world data, permit a direct evaluation
of the structure function moments for the first time. By fitting the Q2
evolution of these moments with an OPE-based twist expansion we have obtained a
separation of the leading twist and higher twist terms. The observed Q2
behaviour of the higher twist contribution suggests a partial cancellation of
different higher twists entering into the expansion with opposite signs. This
cancellation, found also in the proton moments, is a manifestation of the
"duality" phenomenon in the F2 structure function
In vitro and in vivo evaluation of a single chain antibody fragment generated in planta with potent rabies neutralisation activity.
Rabies causes more than 60,000 human deaths annually in areas where the virus is endemic. Importantly, rabies is one of the few pathogens for which there is no treatment following the onset of clinical disease with the outcome of infection being death in almost 100% of cases. Whilst vaccination, and the combination of vaccine and rabies immunoglobulin treatment for post-exposure administration are available, no tools have been identified that can reduce or prevent rabies virus replication once clinical disease has initiated. The search for effective antiviral molecules to treat those that have already developed clinical disease associated with rabies virus infection is considered one of the most important goals in rabies research. The current study assesses a single chain antibody molecule (ScFv) based on a monoclonal antibody that potently neutralises rabies in vitro as a potential therapeutic candidate. The recombinant ScFv was generated in Nicotiana benthamiana by transient expression, and was chemically conjugated (ScFv/RVG) to a 29 amino acid peptide, specific for nicotinic acetylcholine receptor (nAchR) binding in the CNS. This conjugated molecule was able to bind nAchR in vitro and enter neuronal cells more efficiently than ScFv. The ability of the ScFv/RVG to neutralise virus in vivo was assessed using a staggered administration where the molecule was inoculated either four hours before, two days after or four days after infection. The ScFv/RVG conjugate was evaluated in direct comparison with HRIG and a potential antiviral molecule, Favipiravir (also known as T-705) to indicate whether there was greater bioavailability of the ScFv in the brains of treated mice. The study indicated that the approach taken with the ScFv/RVG conjugate may have utility in the design and implementation of novel tools targetting rabies virus infection in the brain
Measurement of the - and -Dependence of the Asymmetry on the Nucleon
We report results for the virtual photon asymmetry on the nucleon from
new Jefferson Lab measurements. The experiment, which used the CEBAF Large
Acceptance Spectrometer and longitudinally polarized proton (NH) and
deuteron (ND) targets, collected data with a longitudinally
polarized electron beam at energies between 1.6 GeV and 5.7 GeV. In the present
paper, we concentrate on our results for and the related ratio
in the resonance and the deep inelastic regions for our lowest
and highest beam energies, covering a range in momentum transfer from
0.05 to 5.0 GeV and in final-state invariant mass up to about 3 GeV.
Our data show detailed structure in the resonance region, which leads to a
strong --dependence of for below 2 GeV. At higher , a
smooth approach to the scaling limit, established by earlier experiments, can
be seen, but is not strictly --independent. We add
significantly to the world data set at high , up to . Our data
exceed the SU(6)-symmetric quark model expectation for both the proton and the
deuteron while being consistent with a negative -quark polarization up to
our highest . This data setshould improve next-to-leading order (NLO) pQCD
fits of the parton polarization distributions.Comment: 7 pages LaTeX, 5 figure
Beam Spin Asymmetries in DVCS with CLAS at 4 .8 GeV
We report measurements of the beam spin asymmetry in Deeply Virtual Compton
Scattering (DVCS) at an electron beam energy of 4.8 GeV using the CLAS detector
at the Thomas Jefferson National Accelerator Facility. The DVCS beam spin
asymmetry has been measured in a wide range of kinematics, 1(GeV/c)
(GeV/c), , and 0.1 (GeV/c)
(GeV/c), using the reaction \pEpX. The number of
H and H events are separated in
each bin by a fit to the line shape of the H
distribution. The validity of the method was studied in detail using
experimental and simulated data. It was shown, that with the achieved missing
mass squared resolution and the available statistics, the separation of DVCS-BH
and events can reliably be done with less than 5% uncertainty. The
- and -dependences of the moments of the asymmetry are
extracted and compared with theoretical calculations
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved
Engineering geological and geophysical investigations of a slope failure at Edinburgh Castle, Scotland
Edinburgh Castle is one of Scotlands most important heritage sites. It was built on a classic crag and tail structure where the crag consists of columnar jointed basalt and the tail of sediments protected from glacial erosion by the crag.
In 1997 apparent instability was observed on the southern side of the tail. A shallow slope failure was proved to have taken place within saturated, layered, cohesive to non-cohesive, loose to dense heterogeneous fill on a slope of 44°. The date of the initial failure is not known, but is likely to have taken place over a period of many years, since at least the 1950s.
Remediation works were subsequently undertaken to stabilise the slope, consisting mainly of the installation of soil nails, a bi-axial geo-grid and minor filling to mitigate the effects of the ground movements and to facilitate repair of the retaining wall
Amorphisation and Recrystallisation of Nanometre Sized Zones in Silicon
In this paper we present a detailed study in which the formation, by heavy ion impact, and thermal recrystallisation of individual amorphous zones have been studied using in-situ transmission electron microscopy. In agreement with previous work, we observe a reduction in the total volume of amorphous material contained within the amorphous zones following thermal annealing over a wide range of temperatures. When the evolution of the individual amorphous zones is followed, those with similar starting sizes are observed to recrystallise over a range of temperatures from 70 ºC to 500 ºC. The temperature at which an amorphous zone fully recrystallises does not appear to be correlated with initial size. In addition, zones are occasionally observed to increase in size temporarily on some isochronal annealing steps. Furthermore, observations during a ramp anneal show that many zones recrystallise in a stepwise manner separated by periods of stability. These phenomenon are discussed in terms of the I-V pair
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