Symptoms of Gastro-Oesophageal Reflux Disease and the Severity of Obstructive Sleep Apnoea Syndrome Are Not Related in Sleep Disorders Center Patients

Background: Studies suggest obstructive sleep apnea syndrome (OSAS) frequently manifests in patients with gastroesophageal reflux disease (GERD) and that there may be a causal relationship. Aim: To determine the relationship between OSAS and symptoms of GERD. Methods: Consecutive patients referred to the Sleep Disorders Center (SDC) 18 years and older with polysomnographically defined OSAS were evaluated prospectively for GERD using a validated symptoms questionnaire. The GERD and OSAS relationship was assessed by 1) determining frequency of GERD in patients with and without OSAS; 2) ascertaining the relationship between OSAS severity categories and presence of GERD; 3) examining GERD score in relation to those factors that might affect both GERD and OSAS, e.g. obesity. Results: One thousand and twenty-three SDC patients met entry citeria. Amongst participants, GERD was common (29% of women and 17% of males) and OSAS extremely common (58% of women and 80% of males). GERD score did not correlate with OSAS variables. The severity of OSAS did not influence the prevalence of GERD. Conclusion: In a large group of patients referred to a sleep disorders center, there was no relationship between OSAS and GERD symptoms. Also, there was no relationship between the severity of OSAS and the likelihood of GERD symptoms

Improving the Sphere of Customs Administration in Russia Based on the Chinese Experience

The widespread use of new technologies based on digitalization has recently intensified, due to the processes associated with changes in business organization. Serious attention is paid to this direction of development by business representatives engaged in economic activities in international trade and governments of the leading economies of the world, including China and Russia. The introduction of digitalization processes in various sectors of the economy has become a conscious necessity. In order to theoretically substantiate and subsequently achieve the necessary level of development of information technologies and communications, analytical studies and testing of changes in this area are being conducted in many countries. The economy based on the introduction of digital technologies determines the vector of development of the economies of countries for the long term.Aim. Analyze the digital transformation of the Chinese economy, identify positive experience in the application of digital solutions and their impact on the simplification of customs procedures and correlate the results with Russia.Tasks. Consider technological trends in digital transformation; to study the results of the policy in carrying out the digitalization of the economy of China and Russia; to consider possible promising areas for the development of cooperation between China and Russia in the field of digital.Methods. Statistical analysis of data and synthesis of the results obtained for comparison purposes.Results. As a result of the study, the following results were obtained: a) a comparative analysis of the changes in the values of indicators on the Global Connectivity Index (GCI) of China and Russia in 2020 compared to 2015 was carried out, the reasons for the changes that occurred were substantiated; b) the dynamics of exports and imports of China, as well as data on trade turnover between China and Russia for the period from 1991 to October 2021; c) the experience of customs administration in China is considered and possible directions of its application in Russia are determined.Conclusion. The positive experience of China’s customs administration in the light of the digitalization of economic processes can be used in Russia, which can certainly improve the current situation in the field of customs administration in our country

Relative concentration and structure of native defects in GaP

The native defects in the compound semiconductor GaP have been studied using a pseudopotential density functional theory method in order to determine their relative concentrations and the most stable charge states. The electronic and atomic structures are presented and the defect concentrations are estimated using calculated formation energies. Relaxation effects are taken into account fully and produce negative-U charge transfer levels for VP and PGa. The concentration of VGa is in good agreement with the results of positron annihilation experiments. The charge transfer levels presented compare qualitatively well with experiments where available. The effect of stoichiometry on the defect concentrations is also described and is shown to be considerable. The lowest formation energies are found for PGa +2 in p-type and VGa −3 in n-type GaP under P-rich conditions, and for GaP −2 in n-type GaP under Ga-rich conditions. Finally, the finite size errors arising from the use of supercells with periodic boundary conditions are examined

The total neutron cross section for natural carbon in the energy range 2 to 148 keV

Abstract. An experimental investigations of the total neutron cross section for natural carbon were done at Kyiv Research Reactor using neutron filtered beams with energies 2, 3.5, 12, 24, 55, 59, 133 and 148 keV. The intense neutron beams formed by composite neutron filters at reactor horizontal channels had the fluxes of about 10 6 -10 7 neutron/cm 2. s at the fixed neutron energies and this enabled to measure the neutron cross sections with accuracy better than 3%. Transmission method was used in these measurements. The results are presented together with the analysis of the known previous experimental data and the evaluated nuclear data from ENDF libraries

Состояние плазменного гемостаза и морфометрических параметров тромбоцитов при плацентарной недостаточности

БЕРЕМЕННОСТЬПЛАЦЕНТАРНАЯ НЕДОСТАТОЧНОСТЬТРОМБОЦИТЫГЕМОСТА

European lipodystrophy registry: Background and structure

Background: Lipodystrophy syndromes comprise a group of extremely rare and heterogeneous diseases characterized by a selective loss of adipose tissue in the absence of nutritional deprivation or catabolic state. Because of the rarity of each lipodystrophy subform, research in this area is difficult and international co-operation mandatory. Therefore, in 2016, the European Consortium of Lipodystrophies (ECLip) decided to create a registry for patients with lipodystrophy. Results: The registry was build using the information technology Open Source Registry System for Rare Diseases in the EU (OSSE), an open-source software and toolbox. Lipodystrophy specific data forms were developed based on current knowledge of typical signs and symptoms of lipodystrophy. The platform complies with the new General Data Protection Regulation (EU) 2016/679 by ensuring patient pseudonymization, informational separation of powers, secure data storage and security of communication, user authentication, person specific access to data, and recording of access granted to any data. Inclusion criteria are all patients with any form of lipodystrophy (with the exception of HIV-associated lipodystrophy). So far 246 patients from nine centres (Amsterdam, Bologna, Izmir, Leipzig, M\ufcnster, Moscow, Pisa, Santiago de Compostela, Ulm) have been recruited. With the help from the six centres on the brink of recruitment (Cambridge, Lille, Nicosia, Paris, Porto, Rome) this number is expected to double within the next one or 2 years. Conclusions: A European registry for all patients with lipodystrophy will provide a platform for improved research in the area of lipodystrophy. All physicians from Europe and neighbouring countries caring for patients with lipodystrophy are invited to participate in the ECLip Registry. Study registration: ClinicalTrials.gov (NCT03553420). Registered 14 March 2018, retrospectively registered

Body weight, metabolism and clock genes

Biological rhythms are present in the lives of almost all organisms ranging from plants to more evolved creatures. These oscillations allow the anticipation of many physiological and behavioral mechanisms thus enabling coordination of rhythms in a timely manner, adaption to environmental changes and more efficient organization of the cellular processes responsible for survival of both the individual and the species. Many components of energy homeostasis exhibit circadian rhythms, which are regulated by central (suprachiasmatic nucleus) and peripheral (located in other tissues) circadian clocks. Adipocyte plays an important role in the regulation of energy homeostasis, the signaling of satiety and cellular differentiation and proliferation. Also, the adipocyte circadian clock is probably involved in the control of many of these functions. Thus, circadian clocks are implicated in the control of energy balance, feeding behavior and consequently in the regulation of body weight. In this regard, alterations in clock genes and rhythms can interfere with the complex mechanism of metabolic and hormonal anticipation, contributing to multifactorial diseases such as obesity and diabetes. The aim of this review was to define circadian clocks by describing their functioning and role in the whole body and in adipocyte metabolism, as well as their influence on body weight control and the development of obesity

Національна доповідь про стан і перспективи розвитку освіти в Україні: монографія (До 30-річчя незалежності України)

The publication provides a comprehensive analysis of the state and development of national education over the 30 years of Ukraine’s independence, identifies current problems in education, ascertains the causes of their emergence, offers scientifically reasoned ways to modernise domestic education in the context of globalisation, European integration, innovative development, and national self-identification. Designed for legislators, state officials, education institutions leaders, teaching and academic staff, the general public, all those who seek to increase the competitiveness of Ukrainian education in the context of civilisation changes.У виданні здійснено всебічний аналіз стану і розвитку національної освіти за 30-річний період незалежності України, визначено актуальні проблеми освітньої сфери, виявлено причини їх виникнення, запропоновано науково обґрунтовані шляхи модернізації вітчизняної освіти в умовах глобалізації, європейської інтеграції, інноваційного розвитку та національної самоідентифікації. Розраховано на законодавців, державних управлінців, керівників закладів освіти, педагогічних і науково-педагогічних працівників, широку громадськість, усіх, хто прагне підвищення конкурентоспроможності української освіти в контексті цивілізаційних змін