Pressure distribution on a 1- by 3-meter semispan wing at sweep angles from 0 deg to 40 deg in subsonic flow

A 1- by 3-meter semispan wing of taper ratio 1.0 with NACA 0012 airfoil section contours was tested in the Langley V/STOL tunnel to measure the pressure distribution at five sweep angles, 0 deg, 10 deg, 20 deg, 30 deg, and 40 deg, through an angle-of-attack range from -6 deg to 20 deg. The pressure data are presented as plots of pressure coefficients at each static-pressure tap location on the wing. Flow visualization wing-tuft photographs are also presented for a wing of 40 deg sweep. A comparison between theory and experiment using two inviscid theories and a viscous theory shows good agreement for pressure distributions, normal forces, and pitching moments for the wing at 0 deg sweep

Pressure distributions on a 1- by 3-meter semispan wing with a nonstreamwise tip in subsonic flow

Pressure distributions on a 1- by 3-meter semispan wing with a tip that is streamwise at 0 deg sweep are presented. The tip becomes nonstreamwise as the wing is swept. At 0 deg sweep angle, the semispan wing has a taper ratio of 1.0 and NACA 0012 airfoil section contours. The test was conducted in the Langley V/STOL tunnel at a freestream dynamic pressure of 2.46 kPa. Pressure distributions are presented for sweep angles of 10, 20, 30, and 40 with an angle of attack range from -6 deg to 20 deg. The data are presented without analysis or discussion

An Assessment of the Housing Needs of Persons with HIV/AIDS: New York City Eligible Metropolitan Statistica Area, Final Report

This report is the final deliverable of a study of the housing needs of persons with HIV/AIDS in the New York City Eligible Metropolitan Statistical Area that was commissioned in 2001 by the New York City Mayor’s Office of AIDS Policy Coordination under the U.S. Department of Housing and Urban Development’s Housing Opportunities for Persons with AIDS (HOPWA) program. The Hudson Planning Group (HPG) and a team of professionals including the University of Pennsylvania Center for Mental Health Policy and Services Research, the Center for Urban Community Services, and Public Sector Research was selected to perform the assessment under the direction of the Postgraduate Center for Mental Health (PCMH), as the City’s Master Contractor, and with the help of an Advisory Group composed of consumers, service providers, government representatives and experts in health and housing policy. The release of the report has been delayed close to a year beyond its due date. The assessment was scheduled to take two years and to be completed in the fall of 2003, in accordance with the terms of an agreement between HPG and the PCMH. HPG submitted a complete draft of the report to the York City Department of Health and Mental Hygiene’s Bureau of HIV/AIDS in February 2004. Review and comment by City agencies and HPG’s revisions to the draft took an extended time and the final report is being released in November 2004. Accordingly, data in the report are current as of December 2003, with the exception of a few cases where it is noted that more recent data were provided at the request of a City agency reviewing the report

The utility of chest ultrasound-guided fine-needle biopsy in the diagnosis of plasmacytoma

Background. Plasmacytoma is a plasma cell dyscrasia originating from a single clone of plasma cells of B-lymphocyte lineage and produces a monoclonal immunoglobulin. Transthoracic fine-needle aspiration (TTNA) under ultrasound (US) guidance is a well-validated technique for the diagnosis of many neoplasms and has been shown to be safe and cost effective, with diagnostic yields comparable to more invasive techniques. However, the role of TTNA in the diagnosis of thoracic plasmacytoma is not well established. Objective. The aim of this study was to assess the utility of TTNA and cytology in confirming a diagnosis of plasmacytoma. Methods. All cases of plasmacytoma diagnosed from January 2006 to December 2017 by the Division of Pulmonology, Tygerberg Hospital, were retrospectively identified. All patients who underwent an US-guided TTNA and of whose clinical records could be retrieved were included in this cohort. The International Myeloma Working Group’s definition of a plasmacytoma was used as the gold standard. Results. A total of 12 cases of plasmacytoma were identified and 11 patients included (one patient was excluded owing to missing medical records). Six of the 11 patients (mean age 59.5 ± 8.5 years) were male. Radiologically, most had multiple lesions (n=7), most commonly bony (n=6) with vertebral body involvement (n=5) and pleural-based lesions (n=2). Rapid onsite evaluation (ROSE) was performed and documented in 6 of the 11 cases, and a provisional diagnosis of plasmacytoma was suggested in 5 of the 6 patients (83.3%). The final laboratory cytological diagnoses of all 11 cases were compatible with plasmacytoma which was further confirmed via a bone marrow biopsy (n=4) and by serum electrophoresis (n=7). Conclusion. US-guided fine-needle aspiration is feasible and is useful to confirm a diagnosis of plasmacytoma. Its minimally invasive nature may be the ideal investigation of choice in suspected cases

Perception versus reality: A National Cohort Analysis of the surgery-first approach for resectable pancreatic cancer

INTRODUCTION: Although surgical resection is necessary, it is not sufficient for long-term survival in pancreatic ductal adenocarcinoma (PDAC). We sought to evaluate survival after up-front surgery (UFS) in anatomically resectable PDAC in the context of three critical factors: (A) margin status; (B) CA19-9; and (C) receipt of adjuvant chemotherapy. METHODS: The National Cancer Data Base (2010-2015) was reviewed for clinically resectable (stage 0/I/II) PDAC patients. Surgical margins, pre-operative CA19-9, and receipt of adjuvant chemotherapy were evaluated. Patient overall survival was stratified based on these factors and their respective combinations. Outcomes after UFS were compared to equivalently staged patients after neoadjuvant chemotherapy on an intention-to-treat (ITT) basis. RESULTS: Twelve thousand and eighty-nine patients were included (n = 9197 UFS, n = 2892 ITT neoadjuvant). In the UFS cohort, only 20.4% had all three factors (median OS = 31.2 months). Nearly 1/3rd (32.7%) of UFS patients had none or only one factor with concomitant worst survival (median OS = 14.7 months). Survival after UFS decreased with each failing factor (two factors: 23 months, one factor: 15.5 months, no factors: 7.9 months) and this persisted after adjustment. Overall survival was superior in the ITT-neoadjuvant cohort (27.9 vs. 22 months) to UFS. CONCLUSION: Despite the perceived benefit of UFS, only 1-in-5 UFS patients actually realize maximal survival when known factors highly associated with outcomes are assessed. Patients are proportionally more likely to do worst, rather than best after UFS treatment. Similarly staged patients undergoing ITT-neoadjuvant therapy achieve survival superior to the majority of UFS patients. Patients and providers should be aware of the false perception of \u27optimal\u27 survival benefit with UFS in anatomically resectable PDAC

Basic Subsistence Needs and Overall Health Among Human Immunodeficiency Virus-infected Homeless and Unstably Housed Women

Some gender differences in the progression of human immunodeficiency virus (HIV) infection have been attributed to delayed treatment among women and the social context of poverty. Recent economic difficulties have led to multiple service cuts, highlighting the need to identify factors with the most influence on health in order to prioritize scarce resources. The aim of this study was to empirically rank factors that longitudinally impact the health status of HIV-infected homeless and unstably housed women. Study participants were recruited between 2002 and 2008 from community-based venues in San Francisco, California, and followed over time; marginal structural models and targeted variable importance were used to rank factors by their influence. In adjusted analysis, the factor with the strongest effect on overall mental health was unmet subsistence needs (i.e., food, hygiene, and shelter needs), followed by poor adherence to antiretroviral therapy, not having a close friend, and the use of crack cocaine. Factors with the strongest effects on physical health and gynecologic symptoms followed similar patterns. Within this population, an inability to meet basic subsistence needs has at least as much of an effect on overall health as adherence to antiretroviral therapy, suggesting that advances in HIV medicine will not fully benefit indigent women until their subsistence needs are met

Phylogenetic reconstruction of dengue virus type 2 in Colombia

Background: Dengue fever is perhaps the most important viral re-emergent disease especially in tropical and subtropical countries, affecting about 50 million people around the world yearly. In Colombia, dengue virus was first detected in 1971 and still remains as a major public health issue. Although four viral serotypes have been recurrently identified, dengue virus type 2 (DENV-2) has been involved in the most important outbreaks during the last 20 years, including 2010 when the fatality rate highly increased. As there are no major studies reviewing virus origin and genotype distribution in this country, the present study attempts to reconstruct the phylogenetic history of DENV-2 using a sequence analysis from a 224 bp PCR-amplified product corresponding to the carboxyl terminus of the envelope (E) gene from 48 Colombian isolates. Results: As expected, the oldest isolates belonged to the American genotype (subtype V), but the strains collected since 1990 represent the American/Asian genotype (subtype IIIb) as previously reported in different American countries. Interestingly, the introduction of this genotype coincides with the first report of dengue hemorrhagic fever in Colombia at the end of 1989 and the increase of cases during the next years. Conclusion: After replacement of the American genotype, several lineages of American/Asian subtype have rapidly spread all over the country evolving in new clades. Nevertheless, the direct association of these new variants in the raise of lethality rate observed during the last outbreak has to be demonstrated

Products of cultured neuroglial cells: II. The production of fibronectin by C6 glioma cells

The possibility of fibronectin production by C6 glioma cells was examined with assays which require protein synthesis. Proteins produced by C6 cells using radiolabeled amino acid precursors were tested for affinity to collagen by binding to immobilized gelatin. The predominant collagen binding protein made by C6 coelectrophoresed with fibronectin synthesized by control fibroblasts and with the larger of the two proteins in unlabeled fibronectin when applied to polyacrylamide gels with sodium dodecyl sulfate (SDS). In addition, C6 produced a larger collagen binding protein of approximately 270,000 molecular weight. Solubilities in urea solutions of the collagen-binding proteins made by C6 cells and fibroblasts were similar. Immunofluorescence showed fibronectin associated with the C6 cell monolayer, but less abundant than the fibronectin associated with fibroblasts. Results provide evidence for the production of fibronectin by the C6 glioma cell line.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45400/1/11064_2004_Article_BF00964399.pd

Geography, death and finitude

publication-status: PublishedRomanillos J L, 2011. The definitive, peer-reviewed and edited version of this article is published Environment and Planning A, 2011, Vol. 43, Issue 11, pp. 2533 – 2553 DOI: 10.1068/a4474Copyright © 2011 PionDespite growing interest in the geographies of death, loss, and remembrance, comparatively little geographical research has been devoted either to the historical and cultural practices of death, or to an adequate conceptualisation of finitude. Responding to these absences, in this paper I argue for the importance of the notion of finitude within the history and philosophy of geographical thought. Situating finitude initially in the context of the work of Torsten Hägerstrand and Richard Hartshorne, the notion is argued to be both productive of a geographical ethics, and as epistemologically constitutive of phenomenological apprehensions of ‘earth’ and ‘world’. In order to better grasp the sense and genealogy of finitude, I turn to the work of Martin Heidegger, Michel Foucault, and Georges Bataille. These authors are drawn upon precisely because their writings present powerful conceptual frameworks which demonstrate the intimate relations between spatiality, death, and finitude. At the same time, their writings are critically interrogated in the light of perhaps the most important aspect of the conceptual history of finitude: the way in which it has been articulated as a site of anthropocentric distinction. I argue for a critical deconstruction of this anthropocentric basis to finitude; a deconstruction which raises a series of profound questions over the ethics, normativities, and understandings of responsibility shaping contemporary ethical geographies of the human and nonhuman. In so doing, I demonstrate the geographical importance of the notion of finitude for a variety of arenas of debate which include: phenomenological understandings of spatiality; the biopolitical boundaries drawn between human and animal; and contemporary theorisations of corporeality, materiality, and hospitality