Impaired regulation of emotion: Neural correlates of reappraisal and distraction in bipolar disorder and unaffected relatives

Deficient emotion regulation has been proposed as a crucial pathological mechanism in bipolar disorder (BD). We therefore investigated emotion regulation impairments in BD, the related neural underpinnings and their etiological relevance for the disorder. Twenty-two euthymic patients with bipolar-I disorder and 17 unaffected first-degree relatives of BD-I patients, as well as two groups of healthy gender-, age- and education-matched controls (N=22/17, respectively) were included. Participants underwent functional magnetic resonance imaging while applying two different emotion regulation techniques, reappraisal and distraction, when presented with emotional images. BD patients and relatives showed impaired downregulation of amygdala activity during reappraisal, but not during distraction, when compared with controls. This deficit was correlated with the habitual use of reappraisal. The negative connectivity of amygdala and orbitofrontal cortex (OFC) observed during reappraisal in controls was reversed in BD patients and relatives. There were no significant differences between BD patients and relatives. As being observed in BD patients and unaffected relatives, deficits in emotion regulation through reappraisal may represent heritable neurobiological abnormalities underlying BD. The neural mechanisms include impaired control of amygdala reactivity to emotional stimuli and dysfunctional connectivity of the amygdala to regulatory control regions in the OFC. These are, thus, important aspects of the neurobiological basis of increased vulnerability for BD

The Optical Emission from Gamma-ray Quasars

We present photometric observations of six radio-loud quasars that were detected by the COMPTEL gamma-ray telescope. The data encompasses seven wavebands in the optical and near-infrared. After correction for Galactic extinction, we find a wide range in optical slopes. Two sources are as blue as optically-selected quasars, and are likely to be dominated by the accretion disc emission, while three others show colours consistent with a red synchrotron component. We discuss the properties of the COMPTEL sample of quasars, as well as the implications our observations have for multi-wavelength modelling of gamma-ray quasars.Comment: 12 pages, 3 figures, accepted for publication in P.A.S.A; minor typos correcte

Gamma-Ray Telescopes (in "400 Years of Astronomical Telescopes")

The last half-century has seen dramatic developments in gamma-ray telescopes, from their initial conception and development through to their blossoming into full maturity as a potent research tool in astronomy. Gamma-ray telescopes are leading research in diverse areas such as gamma-ray bursts, blazars, Galactic transients, and the Galactic distribution of aluminum-26.Comment: 11 pages, 6 figures/ in "400 Years of Astronomical Telescopes: A Review of History, Science and Technology", ed. B.R. Brandl, R. Stuik, & J.K. Katgert-Merkeli (Exp. Astron. 26, 111-122 [2009]

The all-sky distribution of 511 keV electron-positron annihilation emission

We present a map of 511 keV electron-positron annihilation emission, based on data accumulated with the SPI spectrometer aboard ESA's INTEGRAL gamma-ray observatory, that covers approximately 95% of the celestial sphere. 511 keV line emission is significantly detected towards the galactic bulge region and, at a very low level, from the galactic disk. The bulge emission is highly symmetric and is centred on the galactic centre with an extension of 8 deg. The emission is equally well described by models that represent the stellar bulge or halo populations. The disk morphology is only weakly constrained by the present data, being compatible with both the distribution of young and old stellar populations. The 511 keV line flux from the bulge and disk components is 1.05e-3 ph cm-2 s-1 and 0.7e-3 ph cm-2 s-1, respectively, corresponding to a bulge-to-disk flux ratio in the range 1-3. Assuming a positronium fraction of 0.93 this translates into annihilation rates of 1.5e43 s-1 and 3e42 s-1, respectively. The ratio of the bulge luminosity to that of the disk is in the range 3-9. We find no evidence for a point-like source in addition to the diffuse emission, down to a typical flux limit of 1e-4 ph cm-2 s-1. We also find no evidence for the positive latitude enhancement that has been reported from OSSE measurements; our 3 sigma upper flux limit for this feature is 1.5e-4 ph cm-2 s-1. The disk emission can be attributed to the beta+ decay of the radioactive species 26Al and 44Ti. The bulge emission arises from a different source which has only a weak or no disk component. We suggest that Type Ia supernovae and/or low-mass X-ray binaries are the prime candidates for the source of the galactic bulge positrons. Light dark matter annihilation could also explain the observed 511 keV bulge emission characteristics.Comment: accepted for publication in A&

Oppida, agglomerations and suburbia: The Bibracte environs and new perspectives on Late Iron Age urbanism in central-eastern France

This paper explores the nature and chronology of La Tène and early Roman unenclosed agglomerations in central-eastern France. It has been prompted by the discovery of a c. 115 ha La Tène D2b/Augustan (c. 50 bc to ad 15) site close to Bibracte in the Morvan, located around the source of the River Yonne. This complex provides a new perspective on the chronology and role of Late La Tène and early Roman unenclosed settlements, adding further complexity to the story of the development of Late La Tène oppida. It indicates that these ‘agglomerations’ followed remarkably varied chronological trajectories, raising important issues concerning the nature of landscape and social change at the end of the Iron Age

The Vela Pulsar in the Near-Infrared

We report on the first detection of the Vela pulsar in the near-infrared with the VLT/ISAAC in the Js and H bands. The pulsar magnitudes are Js=22.71 +/- 0.10 and H=22.04 +/- 0.16. We compare our results with the available multiwavelength data and show that the dereddened phase-averaged optical spectrum of the pulsar can be fitted with a power law F_nu propto nu^(-alpha_nu) with alpha_nu = 0.12 +/- 0.05, assuming the color excess E(B-V)=0.055 +/-0.005 based on recent spectral fits of the emission of the Vela pulsar and its supernova remnant in X-rays. The negative slope of the pulsar spectrum is different from the positive slope observed over a wide optical range in the young Crab pulsar spectrum. The near-infrared part of the Vela spectrum appears to have the same slope as the phase-averaged spectrum in the high energy X-ray tail, obtained in the 2-10 keV range with the RXTE. Both of these spectra can be fitted with a single power law suggesting their common origin. Because the phase-averaged RXTE spectrum in this range is dominated by the second X-ray peak of the pulsar light curve, coinciding with the second main peak of its optical pulse profile, we suggest that this optical peak can be redder than the first one. We also detect two faint extended structures in the 1.5''-3.1'' vicinity of the pulsar, projected on and aligned with the south-east jet and the inner arc of the pulsar wind nebula, detected in X-rays with Chandra. We discuss their possible association with the nebula.Comment: 12 pages, 8 figures, accepted for publication in A&A, the associated near-infrared images in the fits format are available at http://www.ioffe.ru/astro/NSG/obs/vela-ir

Polarisation measurements with a CdTe pixel array detector for Laue hard X-ray focusing telescopes

Polarimetry is an area of high energy astrophysics which is still relatively unexplored, even though it is recognized that this type of measurement could drastically increase our knowledge of the physics and geometry of high energy sources. For this reason, in the context of the design of a Gamma-Ray Imager based on new hard-X and soft gamma ray focusing optics for the next ESA Cosmic Vision call for proposals (Cosmic Vision 2015-2025), it is important that this capability should be implemented in the principal on-board instrumentation. For the particular case of wide band-pass Laue optics we propose a focal plane based on a thick pixelated CdTe detector operating with high efficiency between 60-600 keV. The high segmentation of this type of detector (1-2 mm pixel size) and the good energy resolution (a few keV FWHM at 500 keV) will allow high sensitivity polarisation measurements (a few % for a 10 mCrab source in 106s) to be performed. We have evaluated the modulation Q factors and minimum detectable polarisation through the use of Monte Carlo simulations (based on the GEANT 4 toolkit) for on and off-axis sources with power law emission spectra using the point spread function of a Laue lens in a feasible configuration.Comment: 10 pages, 6 pages. Accepted for publication in Experimental Astronom

INTEGRAL/SPI Limits on Electron-Positron Annihilation Radiation from the Galactic Plane

The center of our Galaxy is a known strong source of electron-positron 511-keV annihilation radiation. Thus far, however, there have been no reliable detections of annihilation radiation outside of the central radian of our Galaxy. One of the primary objectives of the INTEGRAL (INTErnational Gamma-RAy Astrophysics Laboratory) mission, launched in Oct. 2002, is the detailed study of this radiation. The Spectrometer on INTEGRAL (SPI) is a high resolution coded-aperture gamma-ray telescope with an unprecedented combination of sensitivity, angular resolution and energy resolution. We report results from the first 10 months of observation. During this period a significant fraction of the observing time was spent in or near the Galactic Plane. No positive annihilation flux was detected outside of the central region (|l| > 40 deg) of our Galaxy. In this paper we describe the observations and data analysis methods and give limits on the 511-keV flux.Comment: Accepted for publication in the Astrophysical Journal. 13 pages, 3 figure