BPR UNTUK MEMBANGUN SISTEM INFORMASI BAGIAN ADMINISTRASI TATA USAHA DAN PERPUSTAKAAN Di SMUN 1 BINJAI, SUMUT BUSSINESS PROCESS REENGINEERING To BUILD An INFORMATION SYSTEM PART IN BUSINESS ADMINISTRATION AND LIBRARY SECTION AT SMUN 1 BINJAI, SUMUT

ABSTRAKSI: Sebuah organisasi badan usaha/perusahaan maupun lembaga pendidikan pasti memiliki proses-proses bisnis yang digunakan sebagai pedoman dalam melaksanakan seluruh aktivitas bisnis organisasi tersebut. Proses bisnis yang baik dan benar merupakan suatu kebutuhan paling mendasar dalam mendukung kelancaran aktivitas bisnis sebuah organisasi. Prosedur – prosedur untuk membangun suatu proses bisnis tentu saja harus dilakukan dengan ketentuan yang jelas sehingga menjadi salah satu strategi dalam memenangkan persaingan bisnis, dilakukan dengan membuat standarisasi mutu dalam segala aspek.SMUN 1 Binjai adalah sebuah organisasi lembaga pendidikan (Sekolah) yang mempunyai wewenang dibidang pendidikan menengah umum. Layanan yang diberikan berupa pendidikan akademis tingkat menengah umum. Dalam pelayanannya, ’SMUN 1 Binjai,’ menerapkan proses-proses bisnis yang dimiliki sehingga visi dan misi Sekolah dapat diwujudkan sebagai sebuah lembaga pendidikan unggulan yang kompeten di kota Binjai.Sampai saat ini semua proses bisnis yang ada di SMUN 1 Binjai masih dilakukan secara manual. Bagian Administrasi tata usaha dan Perpustakaan SMUN 1 Binjai belum mempunyai sistem informasi yang dapat mendukung kegiatan operasional sekolah sehingga kurang dapat mengoptimalkan proses bisnis existing yang diterapkan melalui kegiatan operasionalnya setiap hari.Pembangunan suatu aplikasi sistem informasi yang dapat mengakomodasi semua proses bisnis dapat mempermudah dan mempersingkat waktu kerja di bagian administrasi tata usaha dan perpustakaan SMUN 1 Binjai didalam menjalankan kegiatan operasionalnya sehingga mencapai perbaikan dalam performansi bisnis dan layanan. Hal ini dilakukan dengan mengkaji BPR [HAM93] yang merupakan pemikiran ulang secara fundamental dan perancangan ulang secara radikal terhadap proses-proses bisnis yang telah ada sebelumnya untuk mendapatkan perbaikan dramatis dalam hal ukuran kinerja yang penting dan kontemporer seperti biaya, kualitas SDM, pelayanan, dan kecepatan akses.Kata Kunci : Rekayasa Ulang Proses Bisnis (RPB), proses bisnis, Bagian Administrasi tata usaha dan Perpustakaan.ABSTRACT: An organization like a company or an educational institution surely has business processes that used as a guide for doing all its business activities. The right and good business process is as a basic necessary to supporting the fluency of business activities in an organization. Procedures for building a business process of course must done in clear rules so it’s become one of the strategies for winning the business competition, done by making a standardization of quality in all aspects.SMUN 1 Binjai is an education institution (school) which has right in educational side service that given as a high school academic eduation. In its services, SMUN 1 Binjai use business processes that they have with the result that vision and mission of the school can be realized as a competent and best educational institution in Binjai city.Until now, all of business processes in SMUN 1 Binjai still done as manual. The business administration and library section of SMUN 1 Binjai don’t have the information system yet that can accomodate the daily operational activities of school that cause it less optimalize the existing business process which applicate through its daily operational activities.The development of an information system application which can accomodate all of business process make easier and short in time the working of business administration and library section in SMUN 1 Binjai for doing their operational activities with result that can achieve better performance in business and service. This thing done by teaching the BPR [HAM93] that is the fundamental rethingking and radical redesign of business process to achieve dramatic improvements in critical, contemporary measures of performance, such as cost, quality, service, and speed.Keyword: Business Process Reengineering (BPR), Business Process, Business Administration and Library Section

High-resolution structure of the M14-type cytosolic carboxypeptidase from <em>Burkholderia cenocepacia </em>refined exploiting <em>PDB_REDO </em>strategies

A potential cytosolic metallocarboxypeptidase from Burk­holderia cenocepacia has been crystallized and a synchrotron-radiation microfocus beamline allowed the acquisition of diffraction data to 1.9 Å resolution. The asymmetric unit comprises a tetramer containing over 1500 amino acids, and the high-throughput automated protocols embedded in PDB_REDO were coupled with model–map inspections in refinement. This approach has highlighted the value of such protocols for efficient analyses. The subunit is constructed from two domains. The N-terminal domain has previously only been observed in cytosolic carboxypeptidase (CCP) proteins. The C-terminal domain, which carries the Zn(2+)-containing active site, serves to classify this protein as a member of the M14D subfamily of carboxypeptidases. Although eukaryotic CCPs possess deglutamylase activity and are implicated in processing modified tubulin, the function and substrates of the bacterial family members remain unknown. The B. cenocepacia protein did not display deglutamylase activity towards a furylacryloyl glutamate derivative, a potential substrate. Residues previously shown to coordinate the divalent cation and that contribute to peptide-bond cleavage in related enzymes such as bovine carboxypeptidase are conserved. The location of a conserved basic patch in the active site adjacent to the catalytic Zn(2+), where an acetate ion is identified, suggests recognition of the carboxy-terminus in a similar fashion to other carboxypeptidases. However, there are significant differences that indicate the recognition of substrates with different properties. Of note is the presence of a lysine in the S1′ recognition subsite that suggests specificity towards an acidic substrate

Investigating relationships between cost and CO₂ emissions in reinforced concrete structures using a BIM-based design optimisation approach

An integrated design approach for the cost and embodied carbon optimisation of reinforced concrete structures is presented in this paper to inform early design decisions. A BIM-based optimisation approach that utilises Finite Element Modelling (FEM) and a multi-objective genetic algorithm with constructability constraints is established for that purpose. A multilevel engineering analysis model is developed to perform structural layout optimisation, slab and columns sizing optimisation, and slab and columns reinforcement optimisation. The overall approach is validated using real buildings and the relationships between cost and carbon optimum solutions are explored. The study exhibits how cost effective and carbon efficient solutions could be obtained without compromising the feasibility of the optimised designs. Results demonstrate that the structural layout and the slab thickness are amongst the most important design optimisation parameters. Finally, the overall analysis suggests that the building form can influence the relationships between cost and carbon for the different structural components

Provision of smoking cessation support for pregnant women in England: results from an online survey of NHS Stop Smoking Services for Pregnant women

Background: Smoking during pregnancy is a major public health concern and an NHS priority. In 2010, 26% of UK women smoked immediately before or during their pregnancy and 12% smoked continuously. Smoking cessation support is provided through free at the point of use Stop Smoking Services for Pregnant women (SSSP). However, to date, little is known of how these services provide support across England. The aim of this study was to describe the key elements of support provided through English SSSP. Methods: SSSP managers were invited to participate in this survey by email. Data were then collected via an online questionnaire; one survey was completed for each SSSP. Up to four reminder emails were sent over a two month period. Results: 86% (121 of 141) of services completed the survey. Responding services were, on average, larger than non-responding services in terms of the number of pregnant women setting quit dates and successfully quitting (p&thinsp;&lt;&thinsp;0.01). In line with the 2010 NICE guidelines, Stop Smoking in Pregnancy and following Childbirth, one in five SSSP identified pregnant smokers using carbon monoxide (CO) testing and refer via an opt-out pathway. All services offered nicotine replacement therapy (NRT) to pregnant women and 87% of services also offered dual therapy NRT, i.e. combination of a patch and short acting NRT product.. The 2010 NICE guidelines note that services should be flexible and client-centred. Consistent with this, SSSP offer pregnant women a range of support types (median 4) including couple/family, group (open or closed) or one-to-one. These are available in a number of locations (median 5), including in community venues, clinics and women's homes. Conclusions: English Stop Smoking Services offer behavioural support and pharmacotherapy to pregnant women motivated to quit smoking. Interventions provided are generally evidence-based and delivered in a variety of both social and health care settings

Do serum biomarkers really measure breast cancer?

Background Because screening mammography for breast cancer is less effective for premenopausal women, we investigated the feasibility of a diagnostic blood test using serum proteins. Methods This study used a set of 98 serum proteins and chose diagnostically relevant subsets via various feature-selection techniques. Because of significant noise in the data set, we applied iterated Bayesian model averaging to account for model selection uncertainty and to improve generalization performance. We assessed generalization performance using leave-one-out cross-validation (LOOCV) and receiver operating characteristic (ROC) curve analysis. Results The classifiers were able to distinguish normal tissue from breast cancer with a classification performance of AUC = 0.82 ± 0.04 with the proteins MIF, MMP-9, and MPO. The classifiers distinguished normal tissue from benign lesions similarly at AUC = 0.80 ± 0.05. However, the serum proteins of benign and malignant lesions were indistinguishable (AUC = 0.55 ± 0.06). The classification tasks of normal vs. cancer and normal vs. benign selected the same top feature: MIF, which suggests that the biomarkers indicated inflammatory response rather than cancer. Conclusion Overall, the selected serum proteins showed moderate ability for detecting lesions. However, they are probably more indicative of secondary effects such as inflammation rather than specific for malignancy.United States. Dept. of Defense. Breast Cancer Research Program (Grant No. W81XWH-05-1-0292)National Institutes of Health (U.S.) (R01 CA-112437-01)National Institutes of Health (U.S.) (NIH CA 84955