Cooling electrons from 1 K to 400 mK with V-based nanorefrigerators

The fabrication and operation of V-based superconducting nanorefrigerators is reported. Specifically, electrons in an Al island are cooled thanks to hot-quasiparticle extraction provided by tunnel-coupled V electrodes. Electronic temperature reduction down to 400 mK starting from 1 K is demonstrated with a cooling power ~20 pW at 1 K for a junction area of 0.3 micron^2. The present architecture extends to higher temperatures refrigeration based on tunneling between superconductors and paves the way to the implementation of a multi-stage on-chip cooling scheme operating from above 1 K down to the mK regime.Comment: 3+ pages, 4 color figure

Knowledge, attitudes, and behavior concerning dental trauma among parents of children attending primary school

BACKGROUND: Traumatic dental injuries occur frequently in children and adolescents. The purpose of the present study is to examine the levels of knowledge and behaviors regarding dental trauma among parents of children attending primary schools in the Apulia region of Italy. METHODS: The study was carried out using an anonymous questionnaire with closed answers distributed to 2,775 parents who were enrolled based on the entire regional school population. Analyses were conducted using the PROC CORRESP (procedure to perform multiple correspondence analysis) and PROC FASTCLUS (procedure to perform cluster analysis). Statistical significance was set at p-value <0.05. RESULTS: A total 15.5% of the sample reported that their children had experienced dental trauma. Overall, 53.8% of respondents stated that they knew what to do in cases of dental injury. Regarding the time limit within which it is possible to usefully intervene for dental trauma, 56.8% of respondents indicated "within 30 minutes". Of the total sample, 56.5% knew how to preserve a displaced tooth. A total 62.9% of parents felt it was appropriate for their children to use dental guards during sports activities. The multivariate analysis showed that wrong knowledge are distributed among all kinds of subject. Parents with previous experience of dental trauma referred right behaviours, instead weak knowledge and wrong behaviours are associated with parents that easily worried for dental events. CONCLUSIONS: This study showed that most parents reported no experience of dental trauma in their children, and half of them did not know what to do in case of traumatic dental injury and they would intervene within 30 minutes, suggesting that dental trauma may trigger panic. However, they did not have the information needed to best assist the affected child. Motivating parents to assume a preventive approach towards dental trauma may produce positive changes that would result an increase of long-term health benefits among both parents and children

Robust Stability Analysis: a Tool to Assess the Impact of Biodynamic Feedthrough on Rotorcraft

Biodynamic feedthrough (BDFT) may significantly affect the closed-loop behavior of rotorcraft, reducing the stability and increasing the proneness to Rotorcraft-Pilot Couplings (RPC). Leveraging robust stability analysis, the inherently uncertain pilot BDFT can be treated as the uncertain portion of a feedback system, allowing analytical, numerical or graphical determination of proneness to RPC by comparing robust stability margins of helicopter models with BDFT data. The application of the proposed approach to collective bounce is exemplified using simple analytical helicopter and pilot BDFT models, and applied to detailed helicopter models and BDFT measurement data

Multi-Walled Carbon Nanotubes Composites for Microwave Absorbing Applications

The response of materials to impinging electromagnetic waves is mainly determined by their dielectric (complex permittivity) and magnetic (complex permeability). In particular, radar absorbing materials are characterized by high complex permittivity (and eventually large values of magnetic permeability), Indeed, energy dissipation by dielectric relaxation and carrier conduction are principally responsible for diminishing microwave radiation reflection and transmission in non-magnetic materials. Therefore, the scientific and technological community has been investigating lightweight composites with high dielectric permittivity in order to improve the microwave absorption (i.e., radar cross-section reduction) in structural materials for the aerospace industry. Multiwalled carbon nanotubes films and their composites with different kind of polymeric resins are regarded as promising materials for radar absorbing applications because of their high permittivity. Nanocomposites based on commercial multi-wall carbon nano-tube (MWCNT) fillers dispersed in an epoxy resin matrix were fabricated. The morphology of the filler was analyzed by Field emission scanning electron microscopy (FESEM) and Raman spectroscopy, while the complex permittivity and the radiation reflection coefficient of the composites was measured in the radio frequency range. The reflection coefficient of a single-layer structure backed by a metallic plate was simulated based on the measured permittivity. Simulation achievements were compared to the measured reflection coefficient. Besides, the influence of morphological MWCNT parameters (i.e., aspect ratio and specific surface area) on the reflection coefficient was evaluated. Results verify that relatively low weight percent of MWCNTs are suitable for microwave absorption applications when incorporated into polymer matrix (i.e., epoxy resin)

Author's reply to the Letter to the Editor "Therapeutic strategies in the treatment of Menière's disease: the Italian experience"

There is still controversy on the role of hyperinsulinemia and endogenous antisecretory factor (EAF) in Meniere's disease. In the literature, there is no mention on glucose uptake or specially processed cereals (SPC). Nevertheless, the role of EAF and its inhibition by SPC should be taken into account in future research. In case of patients not responding to medical treatment and dietary changes, intratympanic (IT) treatment has been suggested. In Italy, generalists consider IT steroids as the first-line treatment, while neurotologists suggest IT gentamicin. We agree with the authors that low-dose IT gentamicin has a high chance to treat vertigo with minimal risks for hearing; however, a recent randomized, double-blind, comparative trial has not proven the superiority of gentamicin to IT steroids suggesting the choice "should be made based on clinical knowledge and patient circumstances". IT steroids have the advantage to preserve both cochlear and vestibular function, while IT gentamicin has an ablative effect especially on the vestibular function

Exploring the Use of Experiential Learning Methods to Increase CBRNe Awareness and Emergency Preparedness of Children

In recent years, there has been an increase in chemical, biological, radiological, nuclear, and explosive incidents, often involving or specifically targeting children. These emerging threats pose a significant risk to the physical, psychological, and social wellbeing of children and can cause damaging effects on their development and growth. Children are more susceptible to the lethal effects of CBRNe agents and require increased protection, specialized intervention and medical countermeasures, and expert mental health support post-incident. The Hyogo Framework established a widely adopted international commitment to educating children about disasters, through which many nations have implemented disaster risk reduction education platforms focused on increasing their knowledge about potential hazards. However, few countries have begun to explore the benefits of introducing a comprehensive CBRNe awareness and preparedness curriculum to children. Studies have shown that experiential learning methods offer a highly engaging and immersive learning experience and increase educational outcomes. This work aims to explore the potential benefits of developing an interactive educational tool to introduce basic skills to prepare children and communities against CBRNe incidents

Investigating Metropolitan Hierarchies through a Spatially Explicit (Local) Approach

Assuming a non-neutral impact of space, an explicit assessment of metropolitan hierarchies based on local regression models produces a refined description of population settlement patterns and processes over time. We used Geographically Weighted Regressions (GWR) to provide an enriched interpretation of the density gradient in Greece, estimating a spatially explicit rank–size relationship inspired by Zipf’s law. The empirical results of the GWR models quantified the adherence of real data (municipal population density as a predictor of metropolitan hierarchy) to the operational assumptions of the rank–size relationship. Local deviations from its prediction were explained considering the peculiarity of the metropolitan cycle (1961–2011) in the country. Although preliminary and exploratory, these findings decomposed representative population dynamics in two stages of the cycle (namely urbanization, 1961–1991, and suburbanization, 1991–2011). Being in line with earlier studies, this timing allowed a geographical interpretation of the evolution of a particularly complex metropolitan system with intense (urban) primacy and a weak level of rural development over a sufficiently long time interval. Introducing a spatially explicit estimation of the rank–size relationship at detailed territorial resolutions provided an original contribution to regional science, covering broad geographical scales

The contribution of age structure to cell population responses to targeted therapeutics

Cells grown in culture act as a model system for analyzing the effects of anticancer compounds, which may affect cell behavior in a cell cycle position-dependent manner. Cell synchronization techniques have been generally employed to minimize the variation in cell cycle position. However, synchronization techniques are cumbersome and imprecise and the agents used to synchronize the cells potentially have other unknown effects on the cells. An alternative approach is to determine the age structure in the population and account for the cell cycle positional effects post hoc. Here we provide a formalism to use quantifiable age distributions from live cell microscopy experiments to parameterize an age-structured model of cell population response

Paradoxical movement of the lower ribcage at rest and during exercise in COPD patients

Paradoxical inward displacement of the costal margin during inspiration is observed in many chronic obstructive pulmonary disease patients at rest but its importance is unclear.The current authors studied 20 patients (forced expiratory volume in one second 32.6 +/- 11.7, functional residual capacity 186 +/- 32% predicted) and 10 healthy controls at rest and during symptom-limited incremental exercise. With optoelectronic plethysmography, the phase shift between pulmonary and abdominal ribcage volumes and the percentage of inspiratory time the ribcage compartments moved in opposite directions were quantified, using control data to define the normal range of movement.Eight patients showed lower ribcage inspiratory paradox at rest (P+), while 12 patients did not (P-). This was unrelated to resting lung function or exercise tolerance. Total end-expiratory chest wall volume (EEVcw) increased immediately when exercise began in P+ patients, but later in exercise in P- patients. This difference in EEVcw was mainly due to a greater increase of end-expiratory pulmonary ribcage volume in P+ patients. During exercise, dyspnoea increased similarly in the two groups, while leg effort increased more markedly in the patients without paradox.In conclusion, lower ribcage paradox at rest is reproducible and associated with early-onset hyperinflation of the chest wall and predominant dyspnoea at end-exercise. When paradox is absent, the sense of leg effort becomes a more important symptom limiting exercise.British Lung FoundationEuropean Respiratory Society (ERS)ERS COEDPolitecn Milan, TBM Lab, Dipartimento Bioingn, I-20133 Milan, ItalyUniv Liverpool, Ctr Clin Sci, Univ Hosp Aintree, Liverpool L69 3BX, Merseyside, EnglandUniversidade Federal de São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilEuropean Respiratory Society (ERS): 69Web of Scienc

Tinnitus revival during COVID‑19 lockdown: how to deal with it?

To the Editor, The novel Coronavirus Disease, officially designated as COVID-19 by the WHO, is a serious issue for public health. To contain the COVID-19, the Italian Government stated on March 9th 2020 the prohibition of any movement throughout the national area unless for work/health reasons and the obligation to remain as much as possible inside one’s own home. With the start of the so-called “Phase Two” on May 4th 2020, circulation within the same region was allowed again, due to the progressive slowdown of the outbreak. Therefore, since lockdown measures were relaxed and access to the emergency room or ENT clinic became less worrying for patients, specialists of Otolaryngology Units in Bari (Italy) observed an increase in the amount of subjects complaining of the revival of intense tinnitus. We attempt in this letter to focus on patients affected by chronic subjective tinnitus, that already had a diagnosis and self-stabilized without a massive treatment. Research studies have reported tinnitus wide impact on quality of life of subjects experiencing it, involving their emotional state, concentration and sleep quality; at this regard, Tinnitus Handicap Inventory (THI) is a self-reported tool regularly used to quantify the grade of perceived handicap as slight (0–16), mild (18–36), moderate (38–56), severe (58–76) or catastrophic (78–100) on the basis of 25 questions [1]. During the past 2 weeks, we have collected data from 16 patients among our population of chronic sufferers: THI observed was moderate in 62.5% and severe in 18.75% of cases, catastrophic in 12.5% and mild in 6.25% of subjects. Interestingly, the grade of handicap resulted increased by one-level in 12 out of 16 patients (75%); in particular, THI shifted from mild to moderate in 9 patients and from moderate to severe in 3 patients. As shown in the literature, tinnitus generation, maintenance and recrudescence are still debated. A cortical reorganization secondary to sensory deprivation has been proposed as one on the most frequent cause of tinnitus [2]. The avoidance of silence and acoustic masking have been proposed as effective measures to overcome sensory deprivation and increase masking of the symptom [3]. It is reasonable to think that, during the lockdown, the absence of environmental masking sounds from everyday life may have enhanced the tinnitus perception. Furthermore, proneness to worry and incoming stress during pandemic could be included as further potential risk factors for tinnitus worsening. As proficiently reviewed in a recent work [4], some internet/smartphone-based applications provide in tinnitus patients adequate counseling and interactive information together with sound therapy. As brain networks implicated in adaptive responses to sound stimuli and to worry are shared in many cases, an early decrease of anxiety status may release neural resources crucial for tinnitus habituation/distress perception [5]. In general, interactive platforms have been widely implemented during lockdown period due to the forced lack of real personal and working relationships; since smart-working seems to be successful for future plans, the development of smart applications and mobile services in the health care field may be promising in terms of cost-effectiveness, tolerability and simplicity of use