The meillers Autunian hydrothermal chalcedony : first evidence of a similar to 295 Ma auriferous epithermal sinter in the Frech Massif Central.

The Meillers "quartzite" deposit represents a major hydrothermal siliceous sinter, some 50 m thick and covering an area of some 30 ha within Autunian sandstone of the northern Massif Central. This siliceous sinter comprises three facies of microcrystalline quartz: (i) a dark-colored facies (black chalcedony), locally rich in pyrite, at the base, (ii) a gray-brown fairly massive facies (gray-brown chalcedony) in the middle; and (iii) a white, finely banded, facies (white chalcedony) at the top. Orientation measurements of the banding have revealed the paleo-flow channels of the silica-saturated fluids. The geochemistry of the deposits shows modest metal values, in particular for gold (average of 0.58 g/t Au, giving a gold metal content of some 20 t). The hydrothermal event is stratigraphically well correlated with the basal Autunian (around 295 Ma); an age that has been confirmed through radiochronological determination (300±21 Ma; SHRIMP on hydrothermal zircon). The lead isotopic composition is not very radiogenic (206Pb/204Pb=18.20) and is similar to that of the Late Hercynian gold lodes in the Massif Central. The mineralized sinter appears to have derived from a geyser-type hot springs. This hydrothermal activity coincides with the auriferous metallogenic peak that occurred in the Hercynides around 300 Ma. This is the first known epithermal-type surface manifestation described for the Hercynian gold event

Early Cretaceous biogeographic and oceanographic synthesis of Leg 123 (off Northwestern Australia)

Biogeographic observations made by Leg 123 shipboard paleontologists for Lower Cretaceous nannofossils, foraminifers, radiolarians, belemnites, and inoceramids are combined in this chapter to evaluate the paleoceanographic history of the northwestern Australian margin and adjacent basins. Each fossil group is characterized at specific intervals of Cretaceous time and compared with data from Tethyan and Southern Hemisphere high-latitude localities. Special attention is given to the biogeographic observations made for the Falkland Plateau (DSDP Legs 36 and 71) and the Weddell Sea (ODP Leg 113). Both areas have yielded valuable Lower Cretaceous fossil records of the circumantarctic high latitudes. In general, the Neocomian fossil record from DSDP and ODP sites off northwestern Australia has important southern high-latitude affinities and weak Tethyan influence. The same is true for the pelagic lithofacies: radiolarian chert and/or nannofossil limestone, dominant in the Tethyan Lower Cretaceous, are minor lithologies in the Exmouth-Argo sites. These observations, together with the young age of the Argo crust and plate tectonic considerations, suggest that the Argo Basin was not part of the Tethys Realm. The biogeography of the Neocomian radiolarian and nannofossil assemblages suggests opening of a seaway during the Berriasian that connected the circumantarctic area with the Argo Basin, which resulted in the influx of southern high-latitude waters. This conclusion constrains the initial fit and break-up history of Gondwana. Our results favor the loose fit of the western Australian margin with southeast India by Ricou et al. (1990), which accounts for a deeper water connection with the Weddell-Mozambique basins via drowned marginal plateaus as early as the Berriasian. In fits of the du Toit-type (1937), India would remain attached to Antarctica, at least until the late Valanginian, making such a connection impossible. After the Barremian, increasing Tethyan influence is evident in all fossil groups, although southern high-latitude taxa are still present. Biogeographic domains, such as the southern extension of Nannoconus and Ticinella suggest paleolatitudes of about 50°S for the Exmouth-Argo area. Alternatively, if paleolatitudes of about 35° are accepted, these biogeographic limits were displaced northward at least 15° along Australia in comparison to the southern Atlantic. In this case, the proto-circumantarctic current was deflected northward into an eastern boundary current off Australia and carried circumantarctic cold water into the middle latitudes. Late Aptian/early Albian time is characterized by mixing of Tethyan and southern faunal elements and a significant gradient in Albian surface-water temperatures over 10° latitude along the Australian margin, as indicated by planktonic foraminifers. Both phenomena may be indicative of convergence of temperate and antarctic waters near the Australian margin. High fertility conditions, reflected by radiolarian cherts, are suggestive of coastal upwelling during that time

Large-Scale Integration of Nanoelectromechanical Systems for Gas Sensing Applications

We have developed arrays of nanomechanical systems (NEMS) by large-scale integration, comprising thousands of individual nanoresonators with densities of up to 6 million NEMS per square centimeter. The individual NEMS devices are electrically coupled using a combined series-parallel configuration that is extremely robust with respect to lithographical defects and mechanical or electrostatic-discharge damage. Given the large number of connected nanoresonators, the arrays are able to handle extremely high input powers (>1 W per array, corresponding to <1 mW per nanoresonator) without excessive heating or deterioration of resonance response. We demonstrate the utility of integrated NEMS arrays as high-performance chemical vapor sensors, detecting a part-per-billion concentration of a chemical warfare simulant within only a 2 s exposure period

L'hydrologie urbaine: nouvelles problématiques, nouvelles approches de solutions

La pratique de l'hydrologie, appliquée au milieu urbain, a beaucoup évolué depuis les années 1960. De nouveaux outils scientifiques, méthodologiques et technologiques ont été mis au point. En ce qui concerne les eaux pluviales urbaines, un changement de philosophie complet s'est produit. Aujourd'hui, des développements rapides continuent à se produire pour faire face de la meilleure manière possible aux graves problèmes qui se posent en zone urbaine : inondation et pollution du milieu naturel. Deux approches récentes illustrent ces développements : la gestion des risques et l'approche globale sur le bassin versant. Une évaluation de plus en plus précise de l'aléa et de la vulnérabilité s'avère nécessaire ainsi qu'une planification hydrologique bassin versant par bassin versant. Celle-ci devrait conduire à définir et à hiérarchiser les principaux objectifs que l'on se fixe dans les domaines du contrôle des inondations, du contrôle de l'érosion, de l'amélioration du milieu naturel et de la protection de l'environnement. Les actions à mener doivent utiliser les outils de modélisation des phénomènes hydrologiques sur les bassins versants. L'efficacité de ces approches est illustrée par un exemple pris sur le bassin versant de la rivière Beauport au Québec.Urban hydrology practice has evolved a great deal, keeping up with the evolution of urban problems. Thus, professional engineers have had to keep up with this evolution, in order to understand the effects of urbanization on the hydrological behavior of the systems for which they have to recommend best solutions. Engineers have also had to evolve from the traditional approach of a limited vision of the problem, of its extent and of its impacts on the system. A global vision of the entire system, grouping every watershed element, such as forestry, agriculture or urbanization, is necessary if one is to circumscribe the problem, to analyze it and to reach to the best long-lasting solution. This article represents a synthesis of the hydrological disturbance phenomenon caused by uncontrolled urbanization, not properly planned, which is often characterized by numerous short-term solutions, often ineffective in the context of a long-lasting approach.Examples of natural disasters caused by meteorological events are more and more frequent. Take the case of Vaison-la-Romaine, in September 1992, where the Groseau devastated the Vaison community. More recently, the 1996 summer floods in the Saguenay region, in Québec, demonstrate once more that water always tends to return to its original bed, now occupied by artificial structures. When these types of events are analyzed in detail, we notice that meteorological phenomena are not always the main cause of the disaster cause and that often part of the responsibility lies with the occurrence of human activity in the catchment. This observation shows the importance of using wisdom and humility towards these natural forces and of anticipating, during design, a "secure" passage for the inevitable flows that one day will exceed the structure capacity. Knowing all the interactions that exist in the heart of the stormwater management problems, it is risky to intervene in isolation without analyzing the impact of the action. The approach must then be global and coherent; the tool necessary for success is the stormwater master plan made on a watershed basis. The master plan allows us to properly describe the problematical elements, to identify the real causes and to optimize the location of the control solutions. It also allows us to manage the increase in stormwater due to urbanization, with the "flow set point" concept of each watercourse tributary.This article presents an application example where the global analysis approach is used and where the solution involves different interventions and developments, which, when combined, effectively treat backwater effects, flooding and erosion in the presented area. The master plan of the watershed containing this sector had already been conceived and the specific flows of each of its tributaries had been identified; the global approach method therefore allowed us to settle the local problems in the studied area while respecting the flow granted by the master plan. Finally, a floodable plain, containing marshes, completes the intervention plan by combining the restoration of certain watercourse ecological characteristics with the need for flood control. This example demonstrates the necessity and the advantages of approaching urban drainage problems at the watershed level. However, watershed management concepts lead planners and designers to deal with antagonisms: urbanization or renaturalization? Obviously, in urban areas, the return to natural conditions is impossible and the disturbances to watercourses generated by urbanization cannot all be compensated for. Rather, we must aspire to the establishment of a balanced environment by controlling inflows produced by the watershed and by supporting the system to receive them. The notion of feasibility must always occupy the thoughts of the master plan designers and planners. The credibility and the continuity of the master plan depend on all these considerations; any unrealistic flow order, on an implementation level, can compromise the balance of the management plan and its applicability, which in turn can lead to a confused plan, possibly having disastrous consequences. The ultimate consequence of the management plan is the protection of the watercourse, the development of which can be designed to meet different criteria, such as flood control, erosion control, ecological potential enhancement, etc. It is at this stage that management becomes most complex: flood control, for example, does not apply to the same type of events as erosion control. The former requires management of major hydrological events, whereas the second needs implies control of frequent flows, which are at the origin of bank undermining caused by differential volume excesses. The management scheme must then handle multiple events and multiple criteria; consequently, it becomes more complex but also grows in value and justifies itself more adequately. Furthermore, the whole question of watercourse quality, in the broad sense of the term, must be managed from a frequent-event point of view, as this yields the best physical, ecological and aesthetic image of the aquatic environment. To this effect, present efforts in the control of combined sewage network overflows can be seen as a predecessor of what will later be extended to the entire stormwater network. This whole aspect of management has not been treated in this paper, as many others are dedicated to doing so. The evolution of the situation is similar in France and in Québec; coherent watershed management must rest on clear political goals regarding environmental use, risk protection and urban development. The stormwater master plan must, permanently, become part of the water resource master plan for the whole watershed, with its objectives of flood control, erosion control and maintenance of acceptable physical-chemical and biochemical water quality, as well as assured resource use (drinking water--, hydroelectricity, agriculture, industrial waters, etc.). This water resource master plan will have to be integrated in the same way as the French Water Agencies do today, and as Québec is preparing to do so

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24.

Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets. However, distinguishing the binding of drugs to membrane proteins from that of detergents, lipids and cofactors is challenging. Here, we use high-resolution mass spectrometry to study the effects of HIV protease inhibitors on the human zinc metalloprotease ZMPSTE24. This intramembrane protease plays a major role in converting prelamin A to mature lamin A. We monitored the proteolysis of farnesylated prelamin A peptide by ZMPSTE24 and unexpectedly found retention of the C-terminal peptide product with the enzyme. We also resolved binding of zinc, lipids and HIV protease inhibitors and showed that drug binding blocked prelamin A peptide cleavage and conferred stability to ZMPSTE24. Our results not only have relevance for the progeria-like side effects of certain HIV protease inhibitor drugs, but also highlight new approaches for documenting off-target drug binding

Piezoelectric nanoelectromechanical resonators based on aluminum nitride thin films

We demonstrate piezoelectrically actuated, electrically tunable nanomechanical resonators based on multilayers containing a 100-nm-thin aluminum nitride (AlN) layer. Efficient piezoelectric actuation of very high frequency fundamental flexural modes up to ~80 MHz is demonstrated at room temperature. Thermomechanical fluctuations of AlN cantilevers measured by optical interferometry enable calibration of the transduction responsivity and displacement sensitivities of the resonators. Measurements and analyses show that the 100 nm AlN layer employed has an excellent piezoelectric coefficient, d_(31)=2.4 pm/V. Doubly clamped AlN beams exhibit significant frequency tuning behavior with applied dc voltage

Demographics and the Cost of Pharmaceuticals in a Private Third-Party Prescription Program

Objective: To compare variance in the cost of pharmaceuticals attributable to demographic variables with variance explained by plan characteristics, using prescription claims data within various therapeutic categories, and to examine differences in average cost of pharmaceuticals among demographic variables after controlling for covariates. Design: Retrospective, cross-sectional study. Data Collection: Data for this study were obtained from 1996 prescription claims information for the commercial population administered by a Rhode Island-based pharmacy benefit management (PBM) company. Six therapeutic categories with the highest expenditures were analyzed. Information on claims for six drug categories was extracted using database management software. Statistical analyses using multiple regression and analysis of covariance were carried out. Results: Plan characteristics outperformed demographic variables sixteenfold for all drug categories combined in explaining variance in cost of pharmaceuticals among plan enrollees. Average cost of pharmaceuticals differed among demographic variables such as age, gender, location, and place of employment after controlling for average wholesale price and days supply. Conclusions: The results obtained in this study have practical significance in the determination of capitation rates when utilization history of prospective members is not available. In this situation, managed care organizations (MCOs) or PBMs may have to set capitation rates based solely on eligibility data. Significant differences in average drug costs among the members based on place of employment suggest that benefit managers should consider differentiating capitation rates according to their clients\u27 businesses. Finally, the data from this study indicated that commercial members residing in Tennessee had the lowest average cost of pharmaceuticals among all states evaluated. The fact that one PBM manages more than 80% of the TennCare prescription program along with a significant commercial client base suggests that a spillover effect may exist

Early Cretaceous Biogeographic and Oceanographic Synthesis of Leg 123 (off Northwestern Australia)

Biogeographic observations made by Leg 123 shipboard paleontologists for Lower Cretaceous nannofossils, foraminifers, radiolarians, belemnites, and inoceramids are combined in this chapter to evaluate the paleoceanographic history of the northwestern Australian margin and adjacent basins. Each fossil group is characterized at specific intervals of Cretaceous time and compared with data from Tethyan and Southern Hemisphere high-latitude localities. Special attention is given to the biogeographic observations made for the Falkland Plateau (DSDP Legs 36 and 71) and the Weddell Sea (ODP Leg 113). Both areas have yielded valuable Lower Cretaceous fossil records of the circumantarctic high latitudes. In general, the Neocomian fossil record from DSDP and ODP sites off northwestern Australia has important southern high-latitude affinities and weak Tethyan influence. The same is true for the pelagic lithofacies: radiolarian chert and/or nannofossil limestone, dominant in the Tethyan Lower Cretaceous, are minor lithologies in the Exmouth-Argo sites. These observations, together with the young age of the Argo crust and plate tectonic considerations, suggest that the Argo Basin was not part of the Tethys Realm. The biogeography of the Neocomian radiolarian and nannofossil assemblages suggests opening of a seaway during the Berriasian that connected the circumantarctic area with the Argo Basin, which resulted in the influx of southern high-latitude waters. This conclusion constrains the initial fit and break-up history of Gondwana. Our results favor the loose fit of the western Australian margin with southeast India by Ricou et al. (1990), which accounts for a deeper water connection with the Weddell-Mozambique basins via drowned marginal plateaus as early as the Berriasian. In fits of the du Toit-type (1937), India would remain attached to Antarctica, at least until the late Valanginian, making such a connection impossible. After the Barremian, increasing Tethyan influence is evident in all fossil groups, although southern high-latitude taxa are still present. Biogeographic domains, such as the southern extension of Nannoconus and Ticinella suggest paleolatitudes of about 50°S for the Exmouth-Argo area. Alternatively, if paleolatitudes of about 35° are accepted, these biogeographic limits were displaced northward at least 15° along Australia in comparison to the southern Atlantic. In this case, the proto-circumantarctic current was deflected northward into an eastern boundary current off Australia and carried circumantarctic cold water into the middle latitudes. Late Aptian/early Albian time is characterized by mixing of Tethyan and southern faunal elements and a significant gradient in Albian surface-water temperatures over 10° latitude along the Australian margin, as indicated by planktonic foraminifers. Both phenomena may be indicative of convergence of temperate and antarctic waters near the Australian margin. High fertility conditions, reflected by radiolarian cherts, are suggestive of coastal upwelling during that time